Gene E02H4.6 (Nematode worm)

E02H4.6

Species: Nematode worm
Alias: CE05552, aSWK157, E02H4.6
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: No interpolated position., WormBase Physical Map location: X: 14255864-14254449,

Classification

Group: CK1
Family: Worm9

Sequence

Name Sequence Type Origin Length Description Download
E02H4.6.AA Protein Genbank 303 None Fasta, JSON
E02H4.6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of E02H4.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase E02H4.6.AA Worm9 12-279 75 4e-234 784.07 In-house 1-270 (291) Show / Hide 
Range on Protein: 12-279
Range on HMM: 1-270/291
Sequence Identity: 75% (203 aa)

YKIRFDIGPGRIGRIFAVLDQQDQSRSRVKVIKVLPMVAGEQFLDDPQTYNEFDFLNHLRGTIGVPNIIQHFQVGRERVMMMDKYLATLEQFRTRCDDRR
||||||||.||.|.|..|||||||.|||||||||.|||.||||..|||.|.||||||||||..|||||.||||....|||||||||..|||||.||||||
YKIRFDIGKGRYGHIYSVLDQQDQTRSRVKVIKVSPMVVGEQFENDPQFYQEFDFLNHLRGINGVPNIHQHFQYEQKRVMMMDKYLENLEQFRKRCDDRR

ISDLNIIKIAVRLVNVLEAIHQKGVIHRDLKTTNVMIRSRGQSEVNLVLIDYGLSTFNG-TPPRALAPDAKSPEIMFRGHTHVSPALEEGLKADAVDDLQ
|||.||||||.||||.||.||||||||.|.||.|||.|||.|..||.||||||.||||. .|||.|..|||..|||||.|.||||||..|||||.|||||
ISDRNIIKIAFRLVNILEHIHQKGVIHQDIKTDNVMFRSRVQNKVNIVLIDYGISTFNKPKPPRDLVDDAKHCEIMFRSHVHVSPALVQGLKADPVDDLQ

MLAIMLIWCSAYHPFGPIGQESSRKKAEFITNPVKYVKG-RPFLRPLMTAIMAQPRGTRPNYQAILDAAA
||..||||||.||||||..|||||||.||||||||||.| ..||||.||.||.|.|..|||||||.|. |
MLSFMLIWCSKYHPFGPDSQESSRKKKEFITNPVKYVQGDYKFLRPVMTKIMEQKRSKRPNYQAISDKCA
Kinase E02H4.6.AA CK1 12-274 17 2.1e-45 156.29 In-house 1-339 (339) Show / Hide 
Range on Protein: 12-274
Range on HMM: 1-339/339
Sequence Identity: 17% (61 aa)

YKIRFDIGPGRIG-RIFAV-----LDQQDQ-----SRSRVKVIKVLPMVAGEQFLDDPQTYNEFDFLN---------------HLRGTIGVPNIIQHFQV
.|.   || |  |  |. |      | ...      .  .|| ..  |  . | ... | |... ...               |..  .... .. ... 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

GRERVMMMDKYLATLEQFRT--RCDDRRISDLNIIKIAVRLVNVLEAIHQKGVIHRDLKTTNVMIRSR------------GQSEVNLVLIDYGLST----
.. ..| |. .  .||..|   |. .|..|.  ...||......|| .| .| ||||.| .|...               .. . ....||.|..     
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

FNGTPP-------RALAPDAKSP---EIMFRG--HTHVSPALEEGLKADAVDDLQMLAIMLIWCSAYH---PFGPIGQESS-------RKKAEFITNPVK
...  .       .   .  . .      |||    ..|..  .|     .||| ... |||..   .   |   . .|.        ..| |||... .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

YVKG-----------RPFLRPLMTAIMAQPRGTRPNYQAI
....           .. . ..|. |... ...||.|..|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase E02H4.6.AA Dicty3 111-167 31 8.3e-13 38.42 In-house 107-186 (351) Show / Hide 
Range on Protein: 111-167
Range on HMM: 107-186/351
Sequence Identity: 31% (25 aa)

RISDLNIIKIAVRLVNVLEAIHQKG-VIHRDLKTTNVMIRSRGQS----------------------EVNLVLIDYGLST
|...  |.||.  ||  |  || .. .||||.|. |.|.  . |.                      | |. |||.|||.
RFNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGLSK
Kinase E02H4.6.AA Ciliate-E2a 114-168 32 1.5e-11 30.3 In-house 100-158 (275) Show / Hide 
Range on Protein: 114-168
Range on HMM: 100-158/275
Sequence Identity: 32% (19 aa)

DLNIIKIAVRLV-NVLEAIHQKGVIHRDLKTTNVMIRS-RGQSE--VNLVLIDYGLSTF
. .| .|   |    |. .||....|||||  |.....   .|    ....|| ||.||
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATF
Kinase E02H4.6.AA Ciliate-E2 108-185 16 2.2e-11 35.31 In-house 139-258 (365) Show / Hide 
Range on Protein: 108-185
Range on HMM: 139-258/365
Sequence Identity: 16% (22 aa)

DDRRISDLNIIKIAVRLVN---------------VLEAIHQKG-VIHRDLKTTNVMIRSRGQSEVNLVLIDYGLSTFNGTPPR-----------------
|  ....  |..|   ...                || .|.|. .||||.|  |...         . .|| |||... ..                   
D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDT

-------------------ALAPDAKSPEI
                   .  |  ..|||
SRTPGYMDQIIQQNMFNTICGTPGYMAPEI
Kinase E02H4.6.AA S_TKc 12-282 13 4.2e-11 -14.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-282
Range on HMM: 1-231/231
Sequence Identity: 13% (40 aa)

YKIRFDIGPGRIGRIFAVLDQQDQSRSRVKVIKVLPMVAGEQFLDDPQTYNEFDFLNHLRGTIGVPNIIQHFQVGRERVMMMDKYLA---TLEQFRTRCD
|.|   || |  |. . . .  .. .  .|.||              ....| . | .  .   . ... .||   .  | |.       .| ..  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

DRR----ISDLNIIKIAVRLVNVLEAIHQKGVIHRDLKTTNVMIRSRGQSEVNLVLIDYGLSTFNGTPPRALAPDAKSPEIMFRGHTH------------
 ..    ..   . ...  ... || .|..|.||||||  |... .      .. ..| ||...         |.  .||..  |...            
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL--TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

------VSPALEEGLKADAVDDLQMLAIMLIWCSAYHPFGPIGQESSRKKAEFITNPVKYVKGRPFLRPLMTAIMAQPRGTRPNYQAILD-----AAAGP
        |           .. .|. ...                                 ....  ..  ..      ||    .|      ..   
YEMLCGYPPFP---------QMQMMFKKIG--------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase E02H4.6.AA CAMK-Unique 117-167 23 2e-10 30.45 In-house 159-221 (363) Show / Hide 
Range on Protein: 117-167
Range on HMM: 159-221/363
Sequence Identity: 23% (15 aa)

IIKIAVRLVNVLEAIHQKGVIHRDLKTTNVMIRSRGQ------------SEVNLVLIDYGLST
.. |  .|. ...  |.....|||||  |.|......            |  ...|.|.||..
TCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCC
Kinase E02H4.6.AA Worm8 124-166 41 1.3e-09 23.86 In-house 108-149 (261) Show / Hide 
Range on Protein: 124-166
Range on HMM: 108-149/261
Sequence Identity: 41% (18 aa)

LVNVLEAIHQKGVIHRDLKTTNVMIRSRGQSEVNLVLIDYGLS
|| .|  || .|..| | |  | |. |       |||.|.|.|
LVKILQDIHSFGIVHGDIKADNLMV-SHSNRMFMLVLVDFGCS
Kinase E02H4.6.AA TKL 117-169 19 2.7e-09 29.61 In-house 134-204 (364) Show / Hide 
Range on Protein: 117-169
Range on HMM: 134-204/364
Sequence Identity: 19% (14 aa)

IIKIAVRLVNVLEAIHQ--------KGVIHRDLKTTNVMIRSRGQ----------SEVNLVLIDYGLSTFN
....|      ..  |.        ...||||||. |... . ..          ..... . |.|||.|.
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM
Kinase E02H4.6.AA RSK 120-166 34 2.7e-09 30.48 In-house 109-154 (278) Show / Hide 
Range on Protein: 120-166
Range on HMM: 109-154/278
Sequence Identity: 34% (16 aa)

IAVRLVNVLEAIHQKGVIHRDLKTTNVMIRSRGQSEVNLVLIDYGLS
..  .|  .| .||.|.||||||  |..  ..  .|  ..|.| |..
YMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFC
Kinase E02H4.6.AA CK2 124-168 40 2.9e-09 23.01 In-house 104-145 (288) Show / Hide 
Range on Protein: 124-168
Range on HMM: 104-145/288
Sequence Identity: 40% (18 aa)

LVNVLEAIHQKGVIHRDLKTTNVMIRSRGQSEVNLVLIDYGLSTF
|   |.  | .|..||| |  |.||     ..  | ||| ||. |
LLKALDYCHSMGIMHRDVKPHNIMI---DHEKRKLRLIDWGLAEF
Kinase E02H4.6.AA Pkinase 108-166 27 9.1e-08 28.55 Pfam 99-159 (293) Show / Hide 
Range on Protein: 108-166
Range on HMM: 99-159/293
Sequence Identity: 27% (17 aa)

DDRRI--SDLNIIKIAVRLVNVLEAIHQKGVIHRDLKTTNVMIRSRGQSEVNLVLIDYGLS
.....  |.  .....  ..  || .|..|.||||||  |..| ..|. .  . ..| ||.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase E02H4.6.AA Worm8 234-278 26 4e-06 13.78 In-house 217-261 (261) Show / Hide 
Range on Protein: 234-278
Range on HMM: 217-261/261
Sequence Identity: 26% (12 aa)

RKKAEFITNPVKYVKGRPFLRPLMTAIMAQPRGTRPNYQAILDAA
..|  |  || |.      |.|    . .|  .  |.|..|.|  
KMKMKFAKNPKKFLGEHQDLKPIIKMLAKQKHYKEPDYKEIMDLL