Gene F39F10.3 (Nematode worm)

F39F10.3

Species: Nematode worm
Alias: CE07205, F39F10.3, aSWK154
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 16891293-16892329, WormBase Genetic Map location: X:24.05,

Classification

Group: CK1
Family: Worm8

Sequence

Name Sequence Type Origin Length Description Download
F39F10.3.AA Protein Genbank 298 None Fasta, JSON
F39F10.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F39F10.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F39F10.3.AA Worm8 10-270 73 3.6e-263 770.46 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 73% (193 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEARVAKLILKEHNGIRDKSWAHETLALNAVAGVNGVPRMFATGSTDYHNWIVMDLLSDDLEVIICRNENKKFAKAT
|||||.||.||||.||||.||||||.||.|||.|||||.||..|.|||.||.|.|.||||||||..|||||||||||..|||||..||||||||.|.|.|
YTLEKVLGRGMYGDVHLCQDDRNNEWRVMKLIHKEHNGHRDETWRHETFALTALADVNGVPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKPT

GYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSNMFQLVLVDFGCARRFKDVNGNRTPPAPYPSNCIKGLHIPPHSALGMPHMEAEDIMQVAYLSCL
||||.||.||||.||||.||||||||..|||||||..||.||||||||...|||.|||||||||.||||....|.|.|.|.|.|||||||.||||||||.
GYQIMWQLVKILQDIHSFGIVHGDIKADNLMVSHSNRMFMLVLVDFGCSCWFKDHNGNRTPPAPFPSNCMHLIHTPAHTANGHPHMEAEDLMQVAYLSCI

LRQYAPWKDDDEFKMTRKKMSLALNPEKFLEEHQDLLPVIKLLAAQKHYAEPDYIAILDLL
.|||.||||.||.|||..||..|.||.|||.|||||.|.||.||.||||.||||..|.|||
CRQYMPWKDIDEHKMTKMKMKFAKNPKKFLGEHQDLKPIIKMLAKQKHYKEPDYKEIMDLL
Kinase F39F10.3.AA CK1 10-266 17 8.4e-56 191.71 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-266
Range on HMM: 1-339/339
Sequence Identity: 17% (61 aa)

YTLEKLLGKGMYG-EVHLC-----KDDRNN-----EARVAKLILKE-----HNGIRDKSWAHETLALN---------------AVAGVNGVPRMFATGST
....|..|.| .| .....     ||  ||     |  . |.  |.     .  ...  .  .. ...               . .   .........  
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

DYHNWIVMDLLSDDLEVIIC--RNENKKFAKATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSH-------------SSNMFQLVLVDFGCAR-RFK
||.|..||.||  .|| . .  |. |.|| . |...| .| .. |...|..|..| |||| |....              .... |....||| || ...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DVNGNR---------TPPAPYPS--------NCIKGLHIPPHSALGMPHMEAEDIMQVAYLSCLLRQYA---PWKDDDEFKM-------TRKKMSLALNP
| .|..           . |...         |    . .... ||....   |.  ..|. . .       ||..... ..         |. . . ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGC-TARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

EKFLEE----------HQDLLPVIKLLAAQKHYAEPDYIAI
 ... .          .|.. ...| . ..|.| .||| .|
MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F39F10.3.AA TTBKL 10-170 24 3.4e-22 71.78 In-house 1-180 (288) Show / Hide 
Range on Protein: 10-170
Range on HMM: 1-180/288
Sequence Identity: 24% (44 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEARVAKLILKEHNGIRDKSWAHETLALNAVA--GVNGVPRMFATGSTDYHNWIVMDLLSDDLEVIICRNENKK-FA
.. .|..|.| .|.| . .|  . . . |. . |  ..  |.    |   |.. .  |   .|.. . | ..  |..|| |....| ..  .. ||| | 
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

KATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSN----MFQLVLVDFGCARRFKDVNGN------------RTP
. | . |  |... ||..|..|..| |.|| | ..  ...       . |.||| ||.... .|.            |.|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRP
Kinase F39F10.3.AA Worm7 10-170 34 1.3e-18 58.97 In-house 1-164 (263) Show / Hide 
Range on Protein: 10-170
Range on HMM: 1-164/263
Sequence Identity: 34% (56 aa)

YTLEKLLGKGMYGEVHLCKDDRN-NEARVAKLILKEHN--GIRDKSWAHETLALNAVAGVNGVPRMFATGSTDYHNWIVMDLLSDDLEVIICRNENKKFA
|.| .  | | .|||    |  . | ....| | |  |  . || |.  |         | ..|..|   .    | ||| .    |  .. || || | 
YKLIHKIGNGQFGEVWQVIDKQDGNVPMIVKIINKYKNGSMKRDISYDREIEFFKYCHHVPNIPKLFHHFTHVGWNCIVMSEEGQNLRDVVKRNNNKPFS

KATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSNMFQLVLVDFGCARRFKDVNGNRTP
      | ||.   |  || |. .| |..  | .|.    . ..||.||| | ||||||||  |
TNNVIRIAWQIGSTLCFIHNKSFIHRDVHSQNVLVTLKNKVCKMVLIDFGNAVRFKDVNGNELP
Kinase F39F10.3.AA VRK 68-163 28 1.3e-15 46.91 In-house 86-185 (284) Show / Hide 
Range on Protein: 68-163
Range on HMM: 86-185/284
Sequence Identity: 28% (29 aa)

GVPRMFATGSTDYH----NWIVMDLLSDDLEVIICRNENKKFAKATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSNMFQLVLVDFGCARRFKD
|.|  .. |..|.       .||. .  ||. |.  . ...|.. | .|   .   .|  .|... ||||||  |...... |  | .|||.| | |...
GIPYCWGFGYHDFNGEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCP
Kinase F39F10.3.AA CK1-A 10-163 28 4.4e-15 49.58 In-house 1-150 (261) Show / Hide 
Range on Protein: 10-163
Range on HMM: 1-150/261
Sequence Identity: 28% (44 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEARVAKLILKEHNGIRDKSWAHETLALNAVAGVNGVPRMFATGSTDYHNWIVMDLLSDDLEVIICRNENKKFAKAT
| | . .| | .|.. |    .| |    |.   | |  |      |.   . ..|  |.|.|   |.   .| .|||||   || .    . ..|.  |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKM---ESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKT

GYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSNMFQLVLVDFGCARRFKD
   .  |..  .  .| |. .| |||| | ..       .| |.||| |....|
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRD
Kinase F39F10.3.AA CAMK 15-168 15 6.7e-15 43.75 In-house 1-253 (425) Show / Hide 
Range on Protein: 15-168
Range on HMM: 1-253/425
Sequence Identity: 15% (39 aa)

LLGKGMYGEVHLCKDDRNN------------EARVAKLILKE------------------------HNGIRDKSWA---HETLALNAVAG------VNGV
 ||.| .|.|.||.. ...            .   .| | |.                        .. .|.|. .   .|   .. . |         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PRMFA---------------TGST-----DYHNWIVM---DLLSDD------LEVIICRNEN------------KKFAKATGYQILWQVVKILKDIHSKG
 ...                | |.     | | ..||   .. |        .. |. .  .            ..|  .   .. .|..  .. .||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHGDIKPNNLMVSHSS--NM------------FQLVLVDFGCARRFKDVNGNR
||| |.|| |.......  .             ... ..||| |..|.. ..|.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNF
Kinase F39F10.3.AA S_TKc 10-286 14 1.2e-13 23.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-286
Range on HMM: 1-231/231
Sequence Identity: 14% (46 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEARVAKLILKEHNGIRDKSWAHETLALNAVAGVNGVPRMFATGSTDYHNWIVMDLLSD---DLEVIICRNENKK--
|.. ...||| .|.|..|.. . ..    | |         ..   |   |    .   . ... .  .  | ..||....    ||  .|...  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FAKATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSNMFQLVLVDFGCARRFKDVNGNRTPPAPYPSNCIKGLHIPPHSALGMPHMEAEDIMQ
  |   .   ...|... |. .||.||.| |.|| |.....     .. . ||| ||..                         ..  | |.  |  .. 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------------------TTFCGTPWYMAPEVL-

VAYLS-------------CLLRQYAPWKDDDEFKMTRKKMSLALNPEKFLEEHQDLLPVIKLLAAQKHYAEPDYIAILDLLQQMLH-------SSGGGLA
  |                .|  | |.   ....| .| .                                     .|.....|.       .    |.
-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------NGSL
          .
DEWDIKCHPWF
Kinase F39F10.3.AA Ciliate-E2 112-169 28 1.6e-12 39.29 In-house 149-214 (365) Show / Hide 
Range on Protein: 112-169
Range on HMM: 149-214/365
Sequence Identity: 28% (21 aa)

QILWQVVK---------------ILKDIHSKG-IVHGDIKPNNLMVSHSSNMFQLVLVDFGCARRFKDVNGNRT
.| .|...                |. .|||. |.| ||||.|...        . ..||| .....| | |||
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRT
Kinase F39F10.3.AA Ciliate-E2a 112-163 28 6.9e-12 31.3 In-house 105-161 (275) Show / Hide 
Range on Protein: 112-163
Range on HMM: 105-161/275
Sequence Identity: 28% (16 aa)

QILWQVV-KILKDIHSKGIVHGDIKPNNLMVS-HSSNM---FQLVLVDFGCARRFKD
.|..|   . |  .|...|.| |.|| |..    |.|    ......||| |.....
DIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDK
Kinase F39F10.3.AA Worm6 60-170 26 1.8e-10 34.07 In-house 52-174 (279) Show / Hide 
Range on Protein: 60-170
Range on HMM: 52-174/279
Sequence Identity: 26% (32 aa)

LNAVAGVN--GVPRMFATGSTDY--HNWIVMDLLSDDLEVIICRNENKKFAKATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSH-----SSNMFQL
|.||.  .  ......  | .|    |.||| |.  .|. ...  ...||  .||..|  |  . . | |. | .| |.|| |  .       . .. ..
LKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTI

VLVDFGCAR--RFKDVNG-NRTP
 ..||| .|  .... ..  |||
YMLDFGMCRRKKYCNKGNELRTP
Kinase F39F10.3.AA Pkinase 71-169 23 1e-06 24.87 Pfam 67-169 (293) Show / Hide 
Range on Protein: 71-169
Range on HMM: 67-169/293
Sequence Identity: 23% (26 aa)

RMFATGSTDYHNWIVMDLLSD-----DLEVIICRNENKKF--AKATGYQILWQVVKILKDIHSKGIVHGDIKPNNLMVSHSSNMF--QLVLVDFGCARRF
..| .   . | ..||...       ||  .| . ....|     .   ...|... |. .||.||.| |.|| |.... . .     . . |||.|. |
DWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQF

-KDVNGNRT
    |.  |
DY-NNS-MT
Kinase F39F10.3.AA Ciliate-E2a 10-46 27 4e-06 14.04 In-house 1-36 (275) Show / Hide 
Range on Protein: 10-46
Range on HMM: 1-36/275
Sequence Identity: 27% (10 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEARVAKLILKEHN
| ..|..||| .| | | .  .... ...| . | ..
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KM
Kinase F39F10.3.AA Ciliate-E2 10-34 32 5.1e-05 13.16 In-house 1-25 (365) Show / Hide 
Range on Protein: 10-34
Range on HMM: 1-25/365
Sequence Identity: 32% (8 aa)

YTLEKLLGKGMYGEVHLCKDDRNNE
| . |..|.| .| | .||......
YKFIKKIGQGNFGSVYKCKVWKVQK
Kinase F39F10.3.AA Worm6 10-38 23 0.000113 13.08 In-house 1-30 (279) Show / Hide 
Range on Protein: 10-38
Range on HMM: 1-30/279
Sequence Identity: 23% (7 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEA-RVA
....|..|.| .| | ...|. ...  ..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFA
Kinase F39F10.3.AA Pkinase 10-38 27 0.030491 9.01 Pfam 1-28 (293) Show / Hide 
Range on Protein: 10-38
Range on HMM: 1-28/293
Sequence Identity: 27% (8 aa)

YTLEKLLGKGMYGEVHLCKDDRNNEARVA
|.... .|.| .|.| .|..  ... .||
YHIGRKIGSGSFGCVYKCHHKGTGK-IVA
Kinase F39F10.3.AA TTBKL 215-270 17 0.043225 2.94 In-house 227-288 (288) Show / Hide 
Range on Protein: 215-270
Range on HMM: 227-288/288
Sequence Identity: 17% (11 aa)

PWKDDD-EFKMTRKKMSLALNPEKFLEEH-------QDLLPVIKLLAAQKHYAEPDYIAILDLL
||.. . . ..  .|... .  |..  ..       . .... | | . . | .|||  |. ..
PWTNMEDKMEIEHMKKNMKD--EDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF