Gene T01H10.4 (Nematode worm)

T01H10.4

Species: Nematode worm
Alias: T01H10.4, aSWK150, CE18917
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:6.91, WormBase Physical Map location: X: 12121492-12120344

Classification

Group: CK1
Family: Worm7

Sequence

Name Sequence Type Origin Length Description Download
T01H10.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 239 Kinase domain by global Sugen HMM Fasta, JSON
T01H10.4.AA Protein Genbank 278 None Fasta, JSON

Protein domain

Protein domains of T01H10.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T01H10.4.AA Worm7 15-253 66 1e-207 696.38 In-house 1-263 (263) Show / Hide 
Range on Protein: 15-253
Range on HMM: 1-263/263
Sequence Identity: 66% (176 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKN--MKRDVSFDRELEVFKSCGHVSGIPKLLHHFTHVGWNCIVLSLEGPSLSDVVARNNNKPLS
|.|..||||||||.||.||||||..|||..||..||||  ||||.|.|||.|.||.|.||..||||.||||||||||||.|.||..|.|||.||||||.|
YKLIHKIGNGQFGEVWQVIDKQDGNVPMIVKIINKYKNGSMKRDISYDREIEFFKYCHHVPNIPKLFHHFTHVGWNCIVMSEEGQNLRDVVKRNNNKPFS

TENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLLTLEKKLA---------------------PQKED-YQFHRCVHSSLSVMKGNPHTCRDDWISLIYL
|.||.||||..||||..|||..||||||||||||.||..|..                     ||..| ||.|.|||.|..|||||||||||||||||||
TNNVIRIAWQIGSTLCFIHNKSFIHRDVHSQNVLVTLKNKVCKMVLIDFGNAVRFKDVNGNELPQFNDGYQYHHCVHKSINVMKGNPHTCRDDWISLIYL

CVELHGKNLGGSLTEMYDAKMEFHSNRDWLYIGNRKWTYELYNVIMNWMTEDTLDNQEILRFL
|||.||||.|...||||..||||||||||.||.|.||....|||||||||.||.|||||||||
CVEMHGKNWGSRTTEMYMNKMEFHSNRDWIYIDNMKWIHKMYNVIMNWMTQDTVDNQEILRFL
Kinase T01H10.4.AA CK1 15-147 23 1.3e-33 114.65 In-house 1-165 (339) Show / Hide 
Range on Protein: 15-147
Range on HMM: 1-165/339
Sequence Identity: 23% (38 aa)

YTLVRKIGNGQFG-AVWRV-----IDKQD-------LSVPMVAKIVSK--YKNMKRDVSFDRELEVF---------------KSCGHVSGIPKLLHHFTH
...|.||| | || ....|     .|...         .  | .. |.  .  ..... . ..|.                 |.||.  ...   |....
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

VGWNCIVLSLEGPSLSDVVA--RNNNKPLSTENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLL
 ..| .|..| ||.|.|. .  |..|. .|   .|.||. . . | ..|..||||||.  .|...
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCM
Kinase T01H10.4.AA Worm5 15-146 30 3.3e-26 75.74 In-house 1-138 (260) Show / Hide 
Range on Protein: 15-146
Range on HMM: 1-138/260
Sequence Identity: 30% (42 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKN-MKRDVSFDRELEVFK---SCGHV--SGIPKLLHHFTHVG-WNCIVLSLEGPSLSDVVARNN
|  .  .| | .| .. . |  |.    . | . .      .  .|  || ||.   . | .  .. |..   |   .   |.|.. || .| ||  || 
YYIIYVLGEGEYGTIYACVDMDDRHNQLAIKAM-NFEHGIQCENCFKLELMVFQRIDTLGNNERNRFPQFCDNFQVDSTYYCFVMHKEGDCLNDVWMRNK

NKPLSTENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVL
||  |  |||.|    .  |. .|  ||||||.| ||..
NKRFSRKNVLKIMCCMSHSLQTLHSIGFIHRDCHWQNIM
Kinase T01H10.4.AA CK1-A 15-151 27 2.1e-13 43.59 In-house 1-132 (261) Show / Hide 
Range on Protein: 15-151
Range on HMM: 1-132/261
Sequence Identity: 27% (38 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMKRDVSFDRELEVFKSCGHVSGIPKLLHHFTHVGWNCIVLSLEGPSLSDVVARNNNKPLSTE
| |||||| | || ..  |  .. .   ||  . . |     . .  |  |..      |||..... .   .| .|. | |||| |.    . .  .  
YRLVRKIGSGSFGDIYLGINITNGE--EVAIKMESNKARHPQLIY--EAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRR-FTMK

NVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLLTLEK
 || .| .. . .  .|. .|||||.   | |. ...
TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR
Kinase T01H10.4.AA Ciliate-E2-Unclassified 15-148 17 7.7e-13 40.88 In-house 1-178 (352) Show / Hide 
Range on Protein: 15-148
Range on HMM: 1-178/352
Sequence Identity: 17% (31 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMK-RDVSFD-------RELEVFKSCGHVS----------------GIPKLLHHFTHVGWNCI
|.....||.|.|| |.....|..     . |. .|... | . . .         |..  |.  |..                 | |....|.     .|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLSL-EGPSLSDVVARNNN---------------KPLSTENVL-----RIAWKLGSTL-SEIHNAGFIHRDVHSQNVLLT
|. . || .|..    ...               | .. ....     .... . . | . .|. ..||||   .|.|..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFD
Kinase T01H10.4.AA CMGC 15-154 13 1.4e-11 33.35 In-house 1-246 (513) Show / Hide 
Range on Protein: 15-154
Range on HMM: 1-246/513
Sequence Identity: 13% (33 aa)

YTLVRKIGNGQFGAVWRVIDKQ-------------DLSVPMVAKIVSKYKNMKRDVS-------FD----RELEVFKSCG----------------HVSG
|. ..||| | .| |.. .||.             .       |.... . ....         |     ||..  |                   |   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IPKLLHHFTHVG-----------------WNCIVLSLEGPSLSDVVARNN--------------------------NKPLSTENVLRIAWKLGSTLS--E
| ||. .|.| .                   ..|  . . .| ..  .|.                           | ..  ..  ... .   |    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHNAG--FIHRDVHSQNVLLTLEK----------------------KLA
.| ..  .||||   .|.|.. ..                      |..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase T01H10.4.AA Worm8 15-144 28 1.8e-11 29.4 In-house 1-129 (261) Show / Hide 
Range on Protein: 15-144
Range on HMM: 1-129/261
Sequence Identity: 28% (37 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMKRDVSFDRELEVFKSCGHVSGIPKLLHHFTHVGWNCIVLSLEGPSLSDVVARNNNKPLSTE
||| .. | | .| |    |.    .  |.| . | .|  || .  .|         |.|.|..         | ||. .    |  .. || ||  |  
YTLEKVLGRGMYGDVHLCQDDRNNEW-RVMKLIHKEHNGHRDETWRHETFALTALADVNGVPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKP

NVLRIAWKLGSTLSEIHNAGFIHRDVHSQN
   .| | |   |  ||  | .| |.   |
TGYQIMWQLVKILQDIHSFGIVHGDIKADN
Kinase T01H10.4.AA CK1 162-249 16 2.4e-11 35.9 In-house 233-339 (339) Show / Hide 
Range on Protein: 162-249
Range on HMM: 233-339/339
Sequence Identity: 16% (18 aa)

FHRCVHSSLSVMKGNPHTCRDDWISLIYLCVELH-GKN---LGGSLTEMY-------DAKMEFHSNRDWLYIGN----------RKWTYELYNVIMNWMT
.  . . |.....| ... |||. |..|. .|.. |..     .   ||        ..|.||...  ... ..          ...  .....|.... 
C-TARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKY

EDTLDNQEI
.|. | ..|
YDRPDYEMI
Kinase T01H10.4.AA Pkinase 15-147 23 9.5e-11 39.08 Pfam 1-141 (293) Show / Hide 
Range on Protein: 15-147
Range on HMM: 1-141/293
Sequence Identity: 23% (34 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMK-RDVSFDR--ELEVFKSCGHVSGIPKLLHHFTHVGWNCIVLSLEGP-----SLSDVVARN
|...|||| | || |.. ..| .     . ||..| .. .  |..  |  |... |...|   | .|.. |.  .. ..|. . .      .|.|.. . 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

NNKPL--STENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLL
.....  | . . .... . . |  .|. |.||||. ..|.|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase T01H10.4.AA S_TKc 15-258 16 3.5e-10 -27.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-258
Range on HMM: 1-231/231
Sequence Identity: 16% (45 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMKRDVSFDRELEVFKSCGHVSGIPKLLHHFTHVGWNCIVLSLEGP---SLSDVVARNNN---
|...|||| | || |.....|      .  ||..         .. ||... |.  |   | ||. .| . .  ..|. . .    .| |.  ...    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KPLSTENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLLTLEK---------KLAPQKEDYQFHRCVHSS-------LSVMKGNPHTC-RDDWISL---
 .|..   . .... . . |  .|. |.||||.  .|.||.            ..         . .. .        |      .... . || |.   
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

IYLCVE---LHGKNLGGSLTEMYDAKMEFHSNRDWLYIGNRKWTYELYNVIMNWMTEDTL---DNQEILR----FLRKSIV
.| ..    .        . .|..  .                . |. . |.. .. |        |.|.          .
LYEMLCGYPPFP-----QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase T01H10.4.AA TTBKL 90-147 35 8.2e-09 25.96 In-house 77-135 (288) Show / Hide 
Range on Protein: 90-147
Range on HMM: 77-135/288
Sequence Identity: 35% (21 aa)

IVLSLEGPSLSDVVARNNNKP-LSTENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLL
.|..| ||.|.|. ....||  .| . ..||. ..   | ..| .|||||||  .|. .
MVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCW
Kinase T01H10.4.AA CK1-D 15-152 29 1.5e-08 26.12 In-house 1-133 (261) Show / Hide 
Range on Protein: 15-152
Range on HMM: 1-133/261
Sequence Identity: 29% (41 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMKRDVSFDRELEVFKSCGHVSGIPKLLHHFTHVGWNCIVLSLEGPSLSDVVARNNNKPLSTE
| . |||| | || ..   . |  .   ||  .   |     . .  |  ..|      |||..        .| .|. | |||| |.    . |  |  
YRIGRKIGSGSFGDIYHGTNIQ--TNEEVAIKLECIKTKHPQLHI--ESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRK-FSLK

NVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLLTLEKK
 || .| .. . .  ||   |||||.   | |. | |.
TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKR
Kinase T01H10.4.AA Worm6 15-37 52 1e-06 19.91 In-house 1-23 (279) Show / Hide 
Range on Protein: 15-37
Range on HMM: 1-23/279
Sequence Identity: 52% (12 aa)

YTLVRKIGNGQFGAVWRVIDKQD
.....||| | ||||  | ||.|
WKVTKKIGEGGFGAVYKVEDKSD
Kinase T01H10.4.AA TyrKc 15-203 13 8e-06 -128.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-203
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

YTLVRKIGNGQFGAVWRVIDKQDLSVPMVAKIVSKYKNMKRDVSFDRELEVFKSCG-HVSGIPKLLHHFTHV-------GWNCIVL-SLEGPSLSDVVAR
 || .|.|.|.|| |.. . |    ..   | . ...       | ||... .. | |   | .|.   |.        .  .||.   .. .| |   .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NNNKPLSTENVLRIAWKLGSTLSEIHNAGFIHRDVHSQNVLLTLEK----------KLAPQK-------EDYQF-----HR-------------------
. .| |...  | ..|   .  . .|  ..||||    |.|.. ..          .    .       . |        .                   
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

------------------CVHSSLS--------------VMKG----NPHT--------CRDDWISLIYLCVEL------HGKNLGGSL
                  .                    |..|     |.         | |.  ...  | .         ...   .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase T01H10.4.AA TTBKL 15-37 43 8.4e-05 12.23 In-house 1-23 (288) Show / Hide 
Range on Protein: 15-37
Range on HMM: 1-23/288
Sequence Identity: 43% (10 aa)

YTLVRKIGNGQFGAVWRVIDKQD
.. |..|| | ||.| .|.|..|
WMIVKMIGEGGFGQVYHVWDMKD
Kinase T01H10.4.AA Worm6 86-140 38 0.002765 8.04 In-house 76-130 (279) Show / Hide 
Range on Protein: 86-140
Range on HMM: 76-130/279
Sequence Identity: 38% (21 aa)

GWNCIVLSLEGPSLSDVVARNNNKPLSTENVLRIAWKLGSTLSEIHNAGFIHRDV
| | ||. | |..|.|  .  ... .|    |.||      . . ||.|||||||
GFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDV