Gene ZC581.2 (Nematode worm)
ZC581.2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| ZC581.2.AA | Protein | Genbank | 350 | None | Fasta, JSON |
| ZC581.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 280 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of ZC581.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | ZC581.2.AA | TTBKL | 48-311 | 33 | 1.6e-130 | 439.93 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-288/288 Sequence Identity: 33% (98 aa) FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQ--GRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKR-LS .|....||.|||||.|...| . ..|. ...|.. ... .||..|..||..|| | ||.|....||.... ||.||.|.|||..||.|..|.|. .| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS QTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQST---RHVLKLVDYGMVRRFKNVDGTR-----------RKQRY---KPGFRGTLRYSSVRV ..|..||.|| ..||...|. |.|||||||.|.|.|..... .... |.|.||.|.... || . |..|. |..||||.|| |... DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HDGKEQTPVDDFVSMAYSGAELLLVNLPWKLVS-TDDIRQTKVDFNTPNSPYLLL----TGPYFSVFCGAIFNLRSEDEPDHSSLQNLL ||.|||...||..|. |. .||.. |||. .. ...| ..|.. .. . . . ..| |. .. .|| |.||........ HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | ZC581.2.AA | CK1 | 48-307 | 26 | 4.1e-93 | 315.64 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 48-307 Range on HMM: 1-339/339 Sequence Identity: 26% (91 aa) FMVKGLIGRGGFG-QIYYG-----SDATFP-----EDVVIKIEPVVLKGRPRRRMILEQKVLYRLQG-------------------RPHVPIMCASGHTE ..|. .|| |||| ||| . .| . . |....|.||. .|.....|...| ... .| .||.... .|... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED QLN-FIVMQLLGPNIGDLKK--RSPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQS------------TRHVLKLVDYGMVR-RFK . . ..||.|||||..||.| | . ...| .|. .|.|| . ||...|. |.||||.||.|.|.|. .| ..... ..|.||.| ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR NVDGTR------------RKQRY---KPGFRG-TLRYSSVRVHDGKEQTPVDDFVSMAYSGAELLLVN--LPWKLVSTDD------IRQTKVDFNTPNSP . ||.. | .| | |||| |.|| |...|.||||...|| .|..| .|.| . |||. .. . ... | .| . . . DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM YLLL----------TGPYFSVFCGAIFNLRSEDEPDHSSL .... ..| . | .|. .|.|| . STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | ZC581.2.AA | Worm6 | 48-263 | 32 | 7.6e-47 | 161.95 | In-house | 1-228 (279) | Show / Hide |
Range on Protein: 48-263 Range on HMM: 1-228/279 Sequence Identity: 32% (75 aa) FMVKGLIGRGGFGQIYYGSDATFPE--DVVIKIEPVVL--KGRPRRRMILEQKVLYRLQGRP--HVPIMCASGHTEQ--LNFIVMQLLGPNIGDLKKRSP . | .|| |||| .| .|.. . ...| | ....|. .| || .. .. |.. . | ... |.|||.|.|.| .||.| .| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCE---KQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP VKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGV----TQSTRHVLKLVDYGMVR--RFKNVDGTRRKQR-YKPGFRGTLRYSSVRVHDGKE ...| .| .| || ..|..|.|. |.|||||||.| |.|. . .| . ..|.|| | ...| ....|..| . |||||.|| .. |.|.| DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE QTPVDDFVSMAYSGAELLLVNLPWKLVSTDD | . || | | .|... .|||. .. .| QCRKDDCESWFYMMVEMIVGCLPWRHMKDHD |
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| Kinase | ZC581.2.AA | TTBK | 48-307 | 34 | 1.7e-46 | 160.83 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 48-307 Range on HMM: 1-257/257 Sequence Identity: 34% (90 aa) FMVKGLIGRGGFGQIYYGSDATFP-EDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQT |. || |||| || . | | | ||.| . |. . .| || .|||..|| | .. |..||||.| | || | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQ---QPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS TVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTPVDDFVSMAYSG | |. .| . ... .||.|. |||.|| | | . ||. ..|.|. |.. | | | | ||||| || |. | .| || |. | TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML AELLLVNLPW-KLVSTDDIRQTKVDFNTPNSPYLLLTGPY-FSVFCGAIFNLRSEDEPDHSSL | . ||| |. |.. ..| ... . || | |..| | | || || . VEFVQGQLPWRKIKDKDQVGEMKEKYDH---RMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | ZC581.2.AA | CK1-Unclassified | 48-244 | 31 | 1e-31 | 90.89 | In-house | 1-204 (244) | Show / Hide |
Range on Protein: 48-244 Range on HMM: 1-204/244 Sequence Identity: 31% (66 aa) FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRP-------HVPIMCASGHTEQ--LNFIVMQLLGPNIGDLKKRS ..|. || | ||.|| . . | | ||.| | . | |....||.. ..| | .| || |..|| ||||.. ||.. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK---HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM- PVK-RLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNV--DGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTP . ..| || |. | | . .|. ..|||| || | . | .. .|.. ..|.| |.. .|. .| . .. || ||.|.. | |.|| -CNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSR VDDFVSMAY || |..| RDDLESLGY |
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| Kinase | ZC581.2.AA | CK1 | 48-244 | 33 | 2.2e-29 | 98.4 | In-house | 1-204 (271) | Show / Hide |
Range on Protein: 48-244 Range on HMM: 1-204/271 Sequence Identity: 33% (70 aa) FMVKGLIGRGGFGQIYYGSDATFPED--VVIKIEPVVLKGRPRRRMILEQKVLYRLQG------RPHVPIMCASGHTEQ--LNFIVMQLLGPNIGDLKKR ..| || | ||.|| | . | | | ||.|. | | | |....||| ...| | .| || |..|| ||||. ||.. YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSK-HP--QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF SPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFK-NVDGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTPV ...| || |. | | . ||. ..||||.|| | . |... |.. ..|.|. |.. ... .| . .. || || |. | |.|| C-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRR DDFVSMAY || |..| DDMESLGY |
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| Kinase | ZC581.2.AA | CK1-D | 48-257 | 29 | 1.6e-27 | 94.06 | In-house | 1-206 (261) | Show / Hide |
Range on Protein: 48-257
Range on HMM: 1-206/261
Sequence Identity: 29% (63 aa)
FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTT
. . || | ||.||.| . . |.| ||.|.. | . .| |. .|| .| . |. . | .||.|||| . || .. | |
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK---HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKT
VARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRR-KQRYKPGFRGTLRYSSVRVHDGKEQTPVDDFVSMAYSG
| . | |. . .|. .||||.|| | |. . .. ..|.|. .|.. . | . || || |. | | || ||. |. |
VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRG-NMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL
AELLLVNLPWK
. |||.
MYFNRGSLPWQ
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| Kinase | ZC581.2.AA | CK1-A | 48-257 | 33 | 1.7e-27 | 94.11 | In-house | 1-206 (261) | Show / Hide |
Range on Protein: 48-257
Range on HMM: 1-206/261
Sequence Identity: 33% (71 aa)
FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTT
. . || | || || | | |.| ||.| . .| | || ||| . .| | |. . | .||.|||| . || .| . |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKAR---HPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKT
VARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRRKQRYKP--GFRGTLRYSSVRVHDGKEQTPVDDFVSMAYS
| . | |. . || ..||||.|| | |. .. |.|.|. .... ||. |. || || |. | | ||. ||. ||.|
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLF-LIDFGLAKKYRDSR-TRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYV
GAELLLVNLPWK
. |||.
MMYFNRGKLPWQ
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| Kinase | ZC581.2.AA | Worm8 | 107-207 | 34 | 4e-20 | 54.86 | In-house | 60-159 (261) | Show / Hide |
Range on Protein: 107-207 Range on HMM: 60-159/261 Sequence Identity: 34% (35 aa) VPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGT || | . | |. |.||| .| | |. | | .|| | . |.|.|| | .| |.|. |. .. | |||.|. ..|| . | VPRMFDYGSTDYHNWIVMEQLSDDLINIICRNENKMFSKPTGYQIMWQLVKILQDIHSFGIVHGDIKADNLMVSHSNRMFM-LVLVDFGCSCWFKDHNGN R | R |
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| Kinase | ZC581.2.AA | Dual | 116-224 | 28 | 6e-17 | 53.4 | In-house | 83-191 (282) | Show / Hide |
Range on Protein: 116-224 Range on HMM: 83-191/282 Sequence Identity: 28% (31 aa) TEQLNFIVMQLLGPNIGDLKKRSPVKRLSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKN-VDGTRRKQRYKP . ....|| . || . . . .. || . . || . |..| ||.||.||..|||| |. | . |...|| . . | | | QDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVY-MQDFRIVRKYIDPENKKHRTARKKV GFRGTLRYSS . |..|| . KMYGCGRYAC |
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| Kinase | ZC581.2.AA | S_TKc | 48-334 | 16 | 6.4e-12 | -2.06 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 48-334 Range on HMM: 1-231/231 Sequence Identity: 16% (51 aa) FMVKGLIGRGGFGQIYYGSDATFPEDVVIKIEPVVLKGRPRRRMILEQKVLYRLQGRPHVPIMCASGHTEQLNFIVMQLLGPNIGDLKKRSPVKR----- . . .||.|.||. | . . . | ||| . .... | ..| . . |.. . . .. . ..|| ... . |||... .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LSQTTVARIMIQGIAALRDVHSLGYIHRDVKPANMCFGVTQSTRHVLKLVDYGMVRRFKNVDGTRRKQRYKPGFRGTLRYSSVRVHDGKEQTPVDDFV .. .....| | . || ||.| ||||.||.| . ..|. | |. |.. | ||. | . | FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------ SMAYSG------------AELLLVNLPWKLVSTDDIRQTKVDFNTPNSPYLLLTGPYFSVFCGAIFNLRSEDEPDHSSLQNLLC-DMTRGKSLREAYD-- |.. .|.| |. . . . . ... . ....|. | .. . || --GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE WDENYRDAL || . . WDIKCHPWF |
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