Gene BUB1 (Bakers Yeast)

BUB1

Species: Bakers Yeast
Alias: BUB1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
BUB1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 317 Kinase domain by global Sugen HMM Fasta, JSON
BUB1.AA Protein Refseq_NP 1021 checkpoint gene involved in permitting entry into mitosis depending upon the assembly state of microtubules; Bub1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of BUB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Mad3_BUB1_I BUB1.AA Mad3_BUB1_I 36-170 38 4.5e-63 220.66 Pfam 1-134 (134) Show / Hide 
Range on Protein: 36-170
Range on HMM: 1-134/134
Sequence Identity: 38% (53 aa)

LNQTKIAYEQRLLNDL-EDMDDPLDLFLDYMIWISTSYIEVDSESGQEVLRSTMERCLIYIQDMETYRNDPRFLKIWIWYINLFLSNNFHESENTFKYMF
|.|.. ..|... |.. |..||||.....|. |.  .| .. ....|..|. ..|||. | ...|.|.||||.||||.||.|.. .| |.|....|.||.
LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQG-GGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNN-FDEPRDIFQYMY

NKGIGTKLSLFYEEFSKLLENAQFFLEAKVLLELGA
|.|||||..|||||....||... . .|  ...|| 
NQGIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI
Mad3_BUB1_I BUB1.AA Mad3_BUB1_I 36-170 39 7.6e-62 212.7 SMART 1-133 (133) Show / Hide 
Range on Protein: 36-170
Range on HMM: 1-133/133
Sequence Identity: 39% (53 aa)

LNQTKIAYEQRLLNDLEDMDDPLDLFLDYMIWISTSYIEVDSESGQEVLRSTMERCLIYIQDMETYRNDPRFLKIWIWYINLFLSNNFHESENTFKYMFN
|.|.. ..||....|....|||||....|. |.  .| . .... |. |. ..|||. | .|.|.|.||||.|||||||..... |.|.|....|.||..
LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQ-GQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCY-NYFDEPREIFQYMYR

KGIGTKLSLFYEEFSKLLENAQFFLEAKVLLELGA
.||||...|||||.....||.. . .|  ...|| 
HGIGTQCALFYEEWAQWYENMGNYQKADEIYQLGI
Mad3_BUB1_II BUB1.AA Mad3_BUB1_II 291-359 38 3.1e-41 146.66 Pfam 1-98 (98) Show / Hide 
Range on Protein: 291-359
Range on HMM: 1-98/98
Sequence Identity: 38% (38 aa)

KTSIYADQK--------------QSNNPVYKLINTPGRKPERIVFNFNLIYPENDE------EFNTEEILA---MIKGL------YKVQRRGKKHTED
|..|..||.              ..|.||||||..||.|||.|..||.|.|||.|.      ||..|||||   |....      ||.|....|||..
KIPIFRDQEHDTFQAVPKQKICYGRNGPVYKLIEHPGKKPEKIDCNFDLLYPEDDQSKGGRLEFCIEEILAKSSMMRNCSKVSLYYKEQQNKRKHTRE
Kinase BUB1.AA BUB 705-982 37 2.9e-165 555.31 In-house 1-311 (311) Show / Hide 
Range on Protein: 705-982
Range on HMM: 1-311/311
Sequence Identity: 37% (117 aa)

YCIRGELGEGGYATVYLAESSQG--------------HLRALKVEKPASVWEYYIMSQVEFRLRKS---TILKSIINASALHLFLDESYLVLNYA-SQGT
.||..|.|||.||.||.||.|..              |..|.||.||...||.||..|...||...   ............|.. |.|.....|. ..||
FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT

VLDLINLQREKAIDGNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEPLGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPGTK
.||.||...|||...|..|.||..||......|..|..|...|||||.||||.|.. ...... ..|.|..|| .|.|||..|||||||.||||.|.|..
LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGE-AWKNKGLKLIDFGRSIDMTLFPDGQR

FKSNWKADQ--QDCWEMR----AGKPWSYEADYYGLAGVIHSMLFGKFIETIQLQNGR-CKLKNPFKRYWKKE-------IWGVIFDLLLNSG--QASNQ
||.|....|  ..||||.    ...||.|..||.|.|...|.|||||.....|...|. .||...|.|||.|.       .|...|...||..  ....|
FKFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQ

ALPMTEKIVEIR
.|||........
TLPMWHELRQQF
Kinase BUB1.AA Ciliate-E2 705-873 15 1.5e-13 42.88 In-house 1-201 (365) Show / Hide 
Range on Protein: 705-873
Range on HMM: 1-201/365
Sequence Identity: 15% (36 aa)

YCIRGELGEGGYATVYLA-ESSQGHLRALKVEKPASVWEY-----------YIMSQVEFRLRKSTILKSIIN-----------------------ASALH
| .   .|.|....||..   ..... |.|...   .  .           | | ... .  ...  .  |.                          ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

LFL---DE--SYLVLNYASQGTVLDLINLQREKA-----IDGNGIMDEYLCMFITVELMK---------------VLEKIHEVG-IIHGDLKPDNCMIRL
 .    |.   |||. |...|. .|.|. .. |      . . . ..|. . .|. .. .                || .|. . ||| |.||.| ..  
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

EKPGEPLGAHYMRNGEDGWENKGIYLIDFG
                       | .||||
-----------------------IKIIDFG
Kinase BUB1.AA S_TKc 705-975 16 1.1e-10 -20.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 705-975
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

YCIRGELGEGGYATVYLAESSQ-GHLRALKVEKPASVWEYYIMSQVEFRLRKSTILKSIINASALHLFLDESYLVLNYASQ--GTVLDLINLQREKAIDG
| |  ..|.|....||..     |.. |.|. |        .. . | .. |.   . |..        |. |.|. |...  |...|.|  .. .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG--L

NGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEPLGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPGTKFKSNWKADQQDCWEM
.  ..|  . |.. .. . || .|. |||| ||||.| ..                         | ..||| .  .                      .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------------HIKICDFGLARQL--------------------TTF

----------RAGKPWSY-EADYYGLAGVIHSMLFGKFIETIQLQNGRCKLKNPFKRYWKKEIWGVIFDLLL-------NSGQASN-----QALPMT
              .... ..| . .  ..  || |.     |.|    |..        .| .  |  .|           .| .      . |  
CGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BUB1.AA CAMK-Unique 776-873 24 1.2e-10 31.18 In-house 111-218 (363) Show / Hide 
Range on Protein: 776-873
Range on HMM: 111-218/363
Sequence Identity: 24% (28 aa)

YLVLNYASQGTVLDLINLQREKA------------IDGNGIMDE--YLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKP-GEPLGAHYMRNGED
|.|. |.  |...|.|.   |               . .|.. |  ..  ||  .|  ...  |. .|.|.|||..|.|.. . .  .       |    
YIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN-----HHRDFPY

GWENKGIYLIDFG
 | |. | |.|||
DWSNWHIKLCDFG
Kinase BUB1.AA AGC 802-841 34 4.9e-10 20.62 In-house 140-188 (395) Show / Hide 
Range on Protein: 802-841
Range on HMM: 140-188/395
Sequence Identity: 34% (17 aa)

NGIMDEYLCMFITVE-------LMKVLEKIHE-VGIIHGD-LKPDNCMI
.|..||  . |.. |       .   || .|.  |||| | |||.| ..
EGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL
Kinase BUB1.AA Worm8 817-841 56 1.1e-08 21.14 In-house 108-132 (261) Show / Hide 
Range on Protein: 817-841
Range on HMM: 108-132/261
Sequence Identity: 56% (14 aa)

LMKVLEKIHEVGIIHGDLKPDNCMI
| |.|  || .||.||| |.|| |.
LVKILQDIHSFGIVHGDIKADNLMV
Kinase BUB1.AA FNIPK 813-841 51 2.7e-08 23.33 In-house 126-156 (425) Show / Hide 
Range on Protein: 813-841
Range on HMM: 126-156/425
Sequence Identity: 51% (16 aa)

ITVELMKVLEKIHEVG--IIHGDLKPDNCMI
.. .| | | .||| |  |||.|.| || ||
CMCDLVKSLNCIHENGRHIIHRDIKCDNIMI
Kinase BUB1.AA CK1 817-873 27 1.9e-07 22.13 In-house 141-193 (339) Show / Hide 
Range on Protein: 817-873
Range on HMM: 141-193/339
Sequence Identity: 27% (18 aa)

LMKVLEKIHEVGIIHGDLKPDNCMIR----LEKPGEPLGAHYMRNGEDG--WENK--GIYLIDFG
....|| .|. |.|| |.||||...     .            .. .    |.|.   .|.||||
MLEALEYMHDCGFIHRDIKPDNFCMGRNESF-----------KYGKH-HHEWNNEHRQVYMIDFG
Kinase BUB1.AA CK1 705-736 20 7e-07 20.13 In-house 1-44 (339) Show / Hide 
Range on Protein: 705-736
Range on HMM: 1-44/339
Sequence Identity: 20% (9 aa)

YCIRGELGEGGYA-TVYLA-----ESSQGH------LRALKVEK
. .   .||||.  ..|..     ......        |.|||.
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEP
Kinase BUB1.AA TTBKL 705-736 32 1e-06 18.54 In-house 1-34 (288) Show / Hide 
Range on Protein: 705-736
Range on HMM: 1-34/288
Sequence Identity: 32% (11 aa)

YCIRGELGEGGYATVYLAESSQGHLR--ALKVEK
. | ...||||...||........    |.|.||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEK
Kinase BUB1.AA RAD53 705-722 50 1e-06 15.39 In-house 1-18 (305) Show / Hide 
Range on Protein: 705-722
Range on HMM: 1-18/305
Sequence Identity: 50% (9 aa)

YCIRGELGEGGYATVYLA
| ...||| |...||.||
YYMSKELGSGNFGTVKLA
Kinase BUB1.AA TTBKL 824-841 50 1.4e-05 14.89 In-house 118-135 (288) Show / Hide 
Range on Protein: 824-841
Range on HMM: 118-135/288
Sequence Identity: 50% (9 aa)

IHEVGIIHGDLKPDNCMI
.|..|.|| |.|| ||..
MHDCGFIHRDVKPCNCCW
Kinase BUB1.AA CAMK 710-734 18 3.3e-05 11.97 In-house 1-38 (425) Show / Hide 
Range on Protein: 710-734
Range on HMM: 1-38/425
Sequence Identity: 18% (7 aa)

ELGEGGYATVYLAESS-QG------------HLRALKV
.||.|....|.|..    .            .  | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKI
Kinase BUB1.AA CAMK 776-873 18 3.6e-05 11.81 In-house 133-241 (425) Show / Hide 
Range on Protein: 776-873
Range on HMM: 133-241/425
Sequence Identity: 18% (23 aa)

YLVL---NYASQG----TVLDLINLQREK--------AIDGNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEP--------LGA
|.|.    |.| |     ..| |  .. .         .  .| ..|  . ..   .   .. .|. .|.| ||||.| ..   .....        .  
YMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD--

HYMRNGEDGWENKG-IYLIDFG
          .|.. | .||||
----------WNNNNIKIIDFG
Kinase BUB1.AA RAD53 824-838 60 5.3e-05 10.26 In-house 125-139 (305) Show / Hide 
Range on Protein: 824-838
Range on HMM: 125-139/305
Sequence Identity: 60% (9 aa)

IHEVGIIHGDLKPDN
.|..||.| ||||.|
LHDNGICHRDLKPEN
Kinase BUB1.AA Pkinase 802-841 40 0.000116 17.57 Pfam 100-141 (293) Show / Hide 
Range on Protein: 802-841
Range on HMM: 100-141/293
Sequence Identity: 40% (17 aa)

NGIM--DEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMI
.| .  .|  | |.  .. . || .|. |||| ||||.|..|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase BUB1.AA AGC 705-734 24 0.001226 3.69 In-house 1-37 (395) Show / Hide 
Range on Protein: 705-734
Range on HMM: 1-37/395
Sequence Identity: 24% (9 aa)

YCIRGELGEGGYATVYLAES-------SQGHLRALKV
. .   .|.|.. .|||..        . |.. |.||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV
Kinase BUB1.AA Pkinase 705-722 33 0.019328 9.71 Pfam 1-18 (293) Show / Hide 
Range on Protein: 705-722
Range on HMM: 1-18/293
Sequence Identity: 33% (6 aa)

YCIRGELGEGGYATVYLA
|.| . .|.|....||..
YHIGRKIGSGSFGCVYKC
Kinase BUB1.AA Worm8 705-722 38 0.162015 0.07 In-house 1-18 (261) Show / Hide 
Range on Protein: 705-722
Range on HMM: 1-18/261
Sequence Identity: 38% (7 aa)

YCIRGELGEGGYATVYLA
|     ||.| |  |.|.
YTLEKVLGRGMYGDVHLC