TEL1

Species: Bakers Yeast
Alias: TEL1
External Links: Saccharomyces Genome Database Link
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
TEL1.AA Protein Refseq_NP 2787 Fasta, JSON

Protein domain

Protein domains of TEL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TAN TEL1.AA TAN 1-158 34 1.7e-59 208.1 Pfam 1-168 (168) Show / Hide
Range on Protein: 1-158
Range on HMM: 1-168/168
Sequence Identity: 34% (58 aa)

MEDHGIVETLNFLSSTKIKERNNALDELTTILKEDP---------ERIPTKALSTTAEALVELLASEHTKYCDLLRNLTVSTTNKLSLSENRLSTISYVL
|..| |....| |.|.|||.||.|||.|  |||..|         .|.. |.... .|||......|..|||  . ... .. .....||||||...|.|
MSTHDINKCCNLLQSDKIKDRNDALDNLEHILKSNPRNSQFHHNRNRLNDKQWHKIFEALFRCIEKEKRKYC--RNRNKKKSQSTANSSENRLSSCAYAL

RLFVEKSCE--RFKVKTLKLLLAVVPELMVKDGSKSLLDAVSVHLSFAL-DALIKSDPFKLKFMIHQWIS
|||||..|.  .||.|....... ...... ..|.||....||..| .|  .|... |.. ..| |||..
RLFVECGCHDIKFKRKHYMAIVDHITDTFPDPDSGSLCEPCSVDYSKCLLSTLLSYPPHWCHLMRHQWEH

Kinase TEL1.AA PI3Kc 2462-2755 32 4.5e-120 406.13 SMART 1-336 (336) Show / Hide
Range on Protein: 2462-2755
Range on HMM: 1-336/336
Sequence Identity: 32% (109 aa)

ALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDK------------------------
|..   .||||||. | |.|...||..|.||  |..|| .|.||..|.||| |.||.| |...||||..|.|...|                        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-ITFDQARKGMKAVQTKSNEERLKAYLKITN-EIKPQLRNFFFDSFPDP-LDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGI
 |...||...|. .|.....|.|| ... |. . .| |...| . |||| .||.||....|. .|. ..|.||||.||||..||.||. ||. .|||.| 
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

AFDQGKLLPIP-----ELVPFRLTRDIVDGFG----VTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPL-YSWVMS--PVKKYEHLFEEEHEITN
.|..|...| .     |.||||||.|.|.. |    ..|..|.||. |.|.| ..||.  ..|...... .||.  .| |.  ..|.... |...|  ..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDH--LS

FDNVSKFISN-----NDRNENQESYRALKGVEEKLMGN
 ....... .      ....|.. . ... . ......
DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase TEL1.AA PI3_PI4_kinase 2459-2704 25 1.3e-95 328.77 Pfam 1-300 (300) Show / Hide
Range on Protein: 2459-2704
Range on HMM: 1-300/300
Sequence Identity: 25% (78 aa)

TQKALMKGSNDDLR--QDAIMEQVF-----------------------QQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLH
.. ...  ..||||  ||. |.| .                       . .||....|...|. ......|...|.||. |.||.| |.|..|.|... .
WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM

TNDKITFDQARKGMKAVQTKSNE------ERLKAYLKITNEIKPQLRNFFFDSFPDP-LDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILL--DCST
...|. ... ...|.........      .... ...|... || |...| ...||.  .|.||...... .|  ..|.||||.||||..||..  |..|
VKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT

GEPIHIDLGIAFD--QGKLLPIPELVPFRLTR------DIVDGF------GVTGVDGLFRRSCERVYAVLRKDYVKVMCVL-------NILKWDPLYSWV
|. .||| |..|.  ..| .. ||.||||.|.      ..|...      ...| .|.||..|...|..||.. . .|..|       ... .|.| .| 
GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR

M
.
S

Kinase TEL1.AA ATM 2461-2708 46 6.3e-87 277.77 In-house 1-254 (304) Show / Hide
Range on Protein: 2461-2708
Range on HMM: 1-254/304
Sequence Identity: 46% (119 aa)

KALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQ--------ILSKLHTNDKITFDQARKGMKAVQT
. |.||  |||||||.| ||||  | .||     |   | | |||||||  ..|..|.        .           .   ||   | |  | |  || 
RQLVKG-RDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHKRYRPNDFSAF-QCQKKMMEVQK

KSNEERLKAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRL
|| ||.   .. .    .|  | |  . | ||  ||| .  ||. || ||||||||||||||  |||.     | .|||||.||.|||.|| || |||||
KSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRL

TRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVK
||||||| |.|||.| ||| ||.   |.|     .. .  .| .|||. | | |.|
TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLK

Kinase TEL1.AA PIKK 2429-2694 32 1.6e-77 263.82 In-house 1-290 (290) Show / Hide
Range on Protein: 2429-2694
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

YIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQI
.| .  . | . .. .  ||  ..  .||     | ||  .|||||. ..|.|| .|. ||.|.  .  .| ||||.|.|.... |.|| | |...|. |
RIRFMDRMVTVMAH-KQKPKKIYIRGHDGKEYPYLCKG-HEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI

LSKLHT-----NDKITFD-------------------QARKGMKAVQTKSNEERLKAYLKITNE-IKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSI
. ..        ... ..                   |. . .  .| .. .|....  .. .    . ....|  .|||| .|.|... ||  .| ...
YKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

VGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFD-QGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNIL
|||||||||||..||..| .||| .|||.| .|  ... || ||.|||||||..|.. |..||.|.|||.|| |  ..|..  ..| |.  .
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase TEL1.AA ATR 2429-2694 34 1.9e-58 197.62 In-house 2-267 (267) Show / Hide
Range on Protein: 2429-2694
Range on HMM: 2-267/267
Sequence Identity: 34% (92 aa)

YIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQI
||   .. | | .. |  || ...  |||     .|    ||||.|    .. . .|.... |   |   . .||| |.||  ...|||.| |  .|. |
YIAGFDDMVEILAS-LQKPKKISLKGSDGKFY-IMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPI

LSKLHTNDKI--TFDQARKGMKAVQTKSNEERLKAYLKITNEIKPQL-RNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTG
| ||.   |.  .| | |. |   . .   |..|.. ..    .| . ...|   |||| .|. ... | .  |. ..||||.|||||| .|||.|  .|
LDKLWKEKKQYMQFYQLRQCMDK-KSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING

EPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNIL
| .|.|  . | .|. . .||.||||||. .| |.|  . .||||| || .  ..|.    .| |..  
ECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase TEL1.AA FRAP 2587-2704 43 4.4e-33 116.24 In-house 133-251 (251) Show / Hide
Range on Protein: 2587-2704
Range on HMM: 133-251/251
Sequence Identity: 43% (52 aa)

WFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQG-KLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYV
||| .  ||.  |  |..||||||||||. ||.|.  ||  .||| |  |.   .   .||..|||||| .|    ..|..| .|  || |  |.| .  
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

KVMCVLNILKWDPLYSWVM
 || ||    .|||. | .
SVMAVLEAFVYDPLFYWRL

Kinase TEL1.AA SMG1 2584-2646 50 1.2e-21 68.31 In-house 180-242 (242) Show / Hide
Range on Protein: 2584-2646
Range on HMM: 180-242/242
Sequence Identity: 50% (32 aa)

PLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPE
| .|.   . | .  |  |.||||.||||||| |.|.|  ||| .|||  | |..|| | .||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE

Kinase TEL1.AA DNAPK 2603-2704 33 1.1e-19 68.17 In-house 199-301 (301) Show / Hide
Range on Protein: 2603-2704
Range on HMM: 199-301/301
Sequence Identity: 33% (35 aa)

IVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFD-QGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYS
| ..||| ||||||| .   ..|. | || | .|   .  ||.||| ||||||  .      .. |... .       .|||    .   ..   ||.  
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WVM
|. 
WKN

Kinase TEL1.AA FATC 2755-2787 54 1.1e-17 59.7 Pfam 1-33 (33) Show / Hide
Range on Protein: 2755-2787
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

NGLSVESSVQDLIQQATDPSNLSVIYMGWSPFY
..||||  |..|||.||||.||...| ||.|..
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW

Kinase TEL1.AA FRAP 2463-2526 34 2.2e-09 30.75 In-house 5-67 (251) Show / Hide
Range on Protein: 2463-2526
Range on HMM: 5-67/251
Sequence Identity: 34% (22 aa)

LMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLH
|.||  .|.|||    | |  .|. |.|.   .  .| |. | ..||  ..|.|  | .   ||
LLKG-HEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH

Kinase TEL1.AA DNAPK 2463-2531 37 4.8e-09 28.87 In-house 36-103 (301) Show / Hide
Range on Protein: 2463-2531
Range on HMM: 36-103/301
Sequence Identity: 37% (26 aa)

LMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSK
. ||   |||||   || ||  | ..  |      .|  ||| ..|.    | || | |   |  || .
CYKGI-EDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDILNN

Kinase TEL1.AA SMG1 2502-2525 45 0.223661 0.14 In-house 64-87 (242) Show / Hide
Range on Protein: 2502-2525
Range on HMM: 64-87/242
Sequence Identity: 45% (11 aa)

RTYKVVPLGPKAGIIEFVANSTSL
| | | ||| ..|.| .|   | |
RHYSVTPLGTRSGLIQWVDGATPL