Gene TOR2 (Bakers Yeast)
TOR2
Sequence
Protein domains of TOR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HEAT | TOR2.AA | HEAT | 642-667 | 26 | 12.991224 | 2.52 | Pfam | 1-26 (31) | Show / Hide |
Range on Protein: 642-667 Range on HMM: 1-26/31 Sequence Identity: 26% (7 aa) LSKLLMIAITDPVAEIRLEILQHLGS . .|. ...||..|.|. .. ||. ILPHLLKCLNDPDWEVREAACWCLGQ |
|||||||||
| HEAT | TOR2.AA | HEAT | 679-708 | 26 | 41.821056 | 0.76 | Pfam | 2-31 (31) | Show / Hide |
Range on Protein: 679-708 Range on HMM: 2-31/31 Sequence Identity: 26% (8 aa) LRLLFMALNDEIFGIQLEAIKIIGRLSSVN | .|. .|||. ... |.. .|.|... LPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | TOR2.AA | HEAT | 720-750 | 16 | 39.134973 | 0.86 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 720-750 Range on HMM: 1-31/31 Sequence Identity: 16% (5 aa) LLELLTQLKFSNMPKKKEESATLLCTLINSS .|..| .. .. .. .| .. |..|. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | TOR2.AA | HEAT | 761-791 | 29 | 0.015536 | 12.64 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 761-791 Range on HMM: 1-31/31 Sequence Identity: 29% (9 aa) ILDVILPKCQDASSAVASTALKVLGELSVVG ||...| ..| .. | ..|.. ||.|. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | TOR2.AA | HEAT | 802-833 | 28 | 0.000461 | 17.93 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 802-833 Range on HMM: 1-31/31 Sequence Identity: 28% (9 aa) LMPLIINTFQDQSNSFKRDAALTTLGQLAASS ..|.... ..|. .. |.||. .||||. . ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
|||||||||
| DUF3385 | TOR2.AA | DUF3385 | 836-995 | 56 | 3.5e-95 | 327.33 | Pfam | 1-181 (181) | Show / Hide |
Range on Protein: 836-995 Range on HMM: 1-181/181 Sequence Identity: 56% (103 aa) VVGPLLDYPELLGILINILKTE-NNPHIRRGTVRLIGILGALDPYKHR--EIEVTSN-------SKSSVEQNAPSIDIALLMQGVSP-SNDEYYPTVVIH |. |..|||.|||.|.|||||| |. ||| |....|||||||||||. ||| .|. .....||.|..||.|.|||.|| |||||||||||. VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKFRDDQHQNQNNPCTDIMLMMQGYSPLSNDEYYPTVVIN NLMK-ILNDPSLSIHHT-AAIQAI----MHIF--QNLGLRC-VSFLDQIIPGIILVMRSCPP-SQLDFYFQQLGSLISIVK .||. ||.||||| ||| ...||| |.|| . .||.| |.||.||||... |||.||| | ..||||||..|.|||| SLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK |
|||||||||
| HEAT | TOR2.AA | HEAT | 922-953 | 25 | 1.579036 | 5.69 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 922-953 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) VIHNLMKILNDPSLSIHHTAAIQAIMHIFQNL .. |.| |||| . ||.... .. ... ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | TOR2.AA | HEAT | 1084-1114 | 16 | 0.237336 | 8.54 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1084-1114 Range on HMM: 1-31/31 Sequence Identity: 16% (5 aa) IMPIVVRMTEYSAGSLKKISIITLGRLAKNI |.|..... . . . .. .. .||.|.... ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| FAT | TOR2.AA | FAT | 1468-1847 | 41 | 2.6e-183 | 614.03 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 1468-1847
Range on HMM: 1-408/408
Sequence Identity: 41% (183 aa)
AP-LAAAAWGLEQWDE--IAQYTSVMK------------SQSP-----DKEFYDAILCL--HRNNFK--KAEVHIFNARDLLVTELSA-LVNESYNRAYN
|| .|.|||.| |||| . .|.|||| ..|| |..|..||||| |.|.|. |. .| .||.||.||..| |..|||||.|.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP
VVVRAQIIAELEEIIKYK-KLPQN--------SDKRLTMRETWNTRLLGC-QKNIDVWQRILRVRSLVIK--------------PKEDAQVRIKFANLCR
|.|| |..|||||||.|| ...|| ..|. .||.||..||.|| |.|..||||||..|..|.. |.||.. ||||||||
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCR
KSGRMALAKKVLNTLLE--ETDDPDHPNTAKASPPVVYAQLKYLWATGLQDEALKQLINFTS-RMAHDLGLDPNNMIAQSVPQQSKRVPRH-VEDYTKLL
|.||| |..|.|. |.. .....|| .| |...||.|||.|||| |.||. .| ||| .|.||||...||.|.............. ...|||||
KHGRMQLCEKTLKMLYTYDPSEEDWHP---RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLL
A-RCFLKQGEWRVCL---Q-PKWRLSNPDSILGSYLLATHFDNTWYK-AWHNWALANFEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAKE
| ||..|||.| . | | ..|. ..| ||..|..|||||..||| |||||||.||||...... ... ...
AMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN--------------------------
VHYSSN--LIHRHVIPAIKGFFHSISLSES-SSLQDALRLLT
. .| .||.||.|.|||||.||.. .|.||.||||.
-----YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
|
|||||||||
| HEAT | TOR2.AA | HEAT | 1877-1907 | 22 | 4.059097 | 4.27 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1877-1907 Range on HMM: 1-31/31 Sequence Identity: 22% (7 aa) VLPQLISRIHQPNQIVSRSLLSLLSDLGKAH .|| |.. .. |. | .. .. |..| . . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| Rapamycin_bind | TOR2.AA | Rapamycin_bind | 1954-2053 | 67 | 2.6e-75 | 239.73 | Pfam | 1-100 (100) | Show / Hide |
Range on Protein: 1954-2053 Range on HMM: 1-100/100 Sequence Identity: 67% (67 aa) ELIRMAVLWHEQWYEGLDDASRQFFGEHNTEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFRKIGKQ ||||.|.||||.|.|||..||||.||.|| ||||..||||.|||..||||.|||||. .|||||..|.||...||...|...|||||||||.|||.| || ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ |
|||||||||
| Kinase | TOR2.AA | FRAP | 2121-2371 | 63 | 4.5e-166 | 558.0 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 2121-2371 Range on HMM: 1-251/251 Sequence Identity: 63% (159 aa) DYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTL .| . |||||||||| |||||||.|.||.|..| .. | || | |||| ..||.|||.. || |.|||. |....| .|||. .|..|..||| |.| EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL LQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLT ..|||.| |..||| |.|| |.||||| .|| |.|||| ||||||.||| |||||||||||||.||.| |||..||||||||| |. |||||||.||||| MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT RMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGF |||. |||. |||| .|.||| ||||.|..| |.||.|||| .|||..| RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
|||||||||
| Kinase | TOR2.AA | PIKK | 2092-2361 | 44 | 1.5e-134 | 453.28 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2092-2361 Range on HMM: 1-290/290 Sequence Identity: 44% (130 aa) KISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIR | . .. |. .||.|.| |.|.||| | | .|||||.||| |||||.|.||.||.|.|| .||| |. | ||.|...||..||.|..| . ... RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK EHREAKKIPLNIE--------------------HWVMLQMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTG . ...|.| ..| . .|.|....|. ..| .||||| ....|| . .. | .|.|. ..|.|.|||. ||||.|||.| | QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAF ||||||||||.|.|.|..||...|||||.||| | |...||||||||||... ||.. |.|| || .|| ||...|.....||...|.| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
|||||||||
| Kinase | TOR2.AA | PI3Kc | 2123-2422 | 28 | 1.3e-114 | 387.98 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2123-2422
Range on HMM: 1-336/336
Sequence Identity: 28% (97 aa)
KYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQM-----------
.|...| ||| ..||.|.|.|...|.|.||.||.| ...| ||..||.|...||||..|.| . ..... ||.|.....|.|..|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
----------APDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSS-ETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGD
...|...|.......|. |.... . .||. .| .. .. | | |.|...|||.|...| .||||.||||..|.|||. ||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEAAILREKFP----EKVPFRLTRMLTYAME----VSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPL-INWGFDLPTKKIEEETGIQLPVMNA
.|. . ....|. |.||||||... |.|. .|| .| || .|. .....| .. ..|...|... ||. ..| .. . ... .. ..| ...
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD
NELLSNG------AITEEEVQRVENEHKNAIRNARAM
.| . .. |.... .. .. . | . .
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
|
|||||||||
| Kinase | TOR2.AA | PI3_PI4_kinase | 2121-2371 | 32 | 1.4e-110 | 378.46 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2121-2371 Range on HMM: 1-300/300 Sequence Identity: 32% (97 aa) DYKYVLKGHEDIR--QDSLVMQLF-----------------------GLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRE .|....||..| | ||...||.. .|.|.....|....||.. .| | ||..|..|...||||..||| ..|.... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV AKK-IPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSS-ETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLML--DRITG .| ...|.||.....|.||...|...||||||......| . .||...| .. . |.|.|.|....||.|.|.. .||||.||||..|.|. |. || KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KVIHIDFGDCFE-AAILREKFPEKVPFRLTR------MLTYAM------EVSGIEGSFRITCENVMKVLRDNKGSLMAIL-------EAFAFDPLINWGF ...|||||.||. .. ....||.||||.|. .. .|| ..|| .| || .|. .. .|| .....|. | |... |.|..| HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
|||||||||
| Kinase | TOR2.AA | ATR | 2091-2361 | 30 | 2.4e-52 | 176.46 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 2091-2361 Range on HMM: 1-267/267 Sequence Identity: 30% (84 aa) VKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLI |. |. . ...| |.|.| .|||||| | . | ..|.|.| |. |.| ... |.| || .... | ||| ..... || | | . .. AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL REHREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVE-VFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRI . . ||. . . . | . .. ||| | .| . .. ... | | | || ||..| |||.|||||| |...|.| DKLWKEKKQYMQFYQ-LRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQ---WYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI TGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAF .| ..|.|. | | || ||||||. . ..| . .| || || .|...||.. .|.....| NGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
|||||||||
| Kinase | TOR2.AA | ATM | 2253-2369 | 46 | 3.5e-36 | 112.85 | In-house | 133-248 (304) | Show / Hide |
Range on Protein: 2253-2369 Range on HMM: 133-248/304 Sequence Identity: 46% (55 aa) WLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAA-ILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNK | |.| |||| | |. |||||||||| |... ..||| | || || || ||||||| . | . |.|| || || | |.| . WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT--PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ GSLMAILEAFAFDPLINW |. | | .||| | ETLLTIVEVLLYDPLFDW |
|||||||||
| Kinase | TOR2.AA | DNAPK | 2247-2371 | 34 | 4.8e-21 | 73.2 | In-house | 177-301 (301) | Show / Hide |
Range on Protein: 2247-2371 Range on HMM: 177-301/301 Sequence Identity: 34% (43 aa) SRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKV | . ||.| | . |. || ..||| |||| | | .| .| |||| | .| . || |||||| . | .| | .. |. STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA LRDNKGSLMAILEAFAFDPLINWGF .| .. |. . | ||.. | FRKDRNILTNFCDVFINDPSFDWKN |
|||||||||
| Kinase | TOR2.AA | SMG1 | 2239-2303 | 50 | 6.1e-18 | 55.88 | In-house | 169-233 (242) | Show / Hide |
Range on Protein: 2239-2303 Range on HMM: 169-233/242 Sequence Identity: 50% (33 aa) LYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFE | | || . | | || ||||| |||.|||||| | ..| || |.|||. ||| LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE |
|||||||||
| Kinase | TOR2.AA | DNAPK | 2091-2182 | 35 | 3.7e-17 | 58.84 | In-house | 2-93 (301) | Show / Hide |
Range on Protein: 2091-2182 Range on HMM: 2-93/301 Sequence Identity: 35% (33 aa) VKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPN |.| |. |. | ||.. |.| | .. .. || || ||| . ||| | . | | | |. | ||. ||. || | VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDN |
|||||||||
| Kinase | TOR2.AA | ATM | 2123-2179 | 43 | 9e-16 | 46.49 | In-house | 1-57 (304) | Show / Hide |
Range on Protein: 2123-2179 Range on HMM: 1-57/304 Sequence Identity: 43% (25 aa) KYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGW . . || .|.||| . | | . ||||| | .| | | | .||| .|| | | RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
|||||||||
| Kinase | TOR2.AA | SMG1 | 2100-2180 | 38 | 2.7e-14 | 43.61 | In-house | 1-81 (242) | Show / Hide |
Range on Protein: 2100-2180 Range on HMM: 1-81/242 Sequence Identity: 38% (32 aa) FSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQ--NDAECFRRHLDIQQYPAIPLSPKSGLLGWV .. | .|.| ||||| | |. || ||. | .|| .|||. | | | | | || .|||. || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFH--ARHYSVTPLGTRSGLIQWV |
|||||||||
| FATC | TOR2.AA | FATC | 2441-2473 | 66 | 7.2e-24 | 79.52 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2441-2473 Range on HMM: 1-33/33 Sequence Identity: 66% (22 aa) NDLDVPEQVDKLIQQATSVENLCQHYIGWCPFW . |.|..|||.|||.||..|||||.||||||.| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
|||||||||