Gene ADCK1 (Human)

ADCK1

Species: Human
Alias: LOC57143, FLJ39600, ADCK1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 14q24.3-q32,

Classification

Group: Atypical
Family: ABC1
Subfamily: ABC1-B

Sequence

Name Sequence Type Origin Length Description Download
ADCK1.NA RNA Sugen Kinome 2284 None Fasta, JSON
ADCK1.AA Protein Sugen Kinome 530 None Fasta, JSON
ADCK1.kin_dom Protein Kinase Domain None 307 None Fasta, JSON

Protein domain

Protein domains of ADCK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ADCK1.AA ABC1-B 143-259 57 2.4e-74 253.31 In-house 1-125 (125) Show / Hide 
Range on Protein: 143-259
Range on HMM: 1-125/125
Sequence Identity: 57% (72 aa)

EDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFP------EFEFMWLVDEAKKNLPLELDFLNE
.|||  | | |  ||..|...|||||||.|.||||.|||||||||..|.|...|...||..| .....||      ||.|||..||..|||| ||||.||
KDLG-NIEDVFSEFDQKPIAAASLAQVHRAKLHDGETVAVKVQHPWLRKQFHYDMMMMELFVKVCDWFFPKSPDFKEFPFMWFHDEIQKNLPQELDFYNE

GRNAEKVSQMLR---HFDFLKVPRIH
.|||||..||..   |||||.|||||
ARNAEKCRQMFKKFKHFDFLYVPRIH
Kinase ADCK1.AA ABC1 143-259 51 2.3e-69 236.75 In-house 1-123 (123) Show / Hide 
Range on Protein: 143-259
Range on HMM: 1-123/123
Sequence Identity: 51% (64 aa)

EDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFP-----EFEFMWLVDEAKKNLPLELDFLNEG
.|||  . | |..||..|...||.||||.|.|.||.|||||||||.||.|...||..||..| .....||     .|..||.|||..|.||.|.||.||.
QDLG-NWEDVFSEFDEKPFAAASIAQVHRAKLKDGQTVAVKVQHPGVREQIHYDINNMEMVVKMCDWFFPGPDFKWFFLMWFVDEFQKELPWECDFNNEA

RNAEKVSQMLR--HFDFLKVPRIH
|||||..|...  |..|..|||||
RNAEKCRQLFKKFHWPFFYVPRIH
Kinase ADCK1.AA ABC1 143-259 42 1.8e-62 212.33 Pfam 1-126 (126) Show / Hide 
Range on Protein: 143-259
Range on HMM: 1-126/126
Sequence Identity: 42% (54 aa)

EDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHD-GRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPE-----FEFMWLVDEAKKNLPLELDFLNE
|.||. ....||.||..|...||.||||.|.|.| |..|||||||| |. ....|| .|.... .||..||.     |..||.|||..|||| |||...|
EELGCPWEEIFQEFDEEPIAAASIAQVHRARLKDDGEEVAVKVQHPGVKKRMMRDIYNMRWMAKWVKRFFPGYRRQRFDLMWIVDEFRKNLPWELDYRRE

GRNAEKVSQMLRHF---DFLKVPRIH
..|.|.. ...||.   ....||...
AKNMERFRENFRHWHRQPWVYVPKVY
Kinase ADCK1.AA ABC1-A 156-187 59 1.5e-12 39.93 In-house 1-32 (216) Show / Hide 
Range on Protein: 156-187
Range on HMM: 1-32/216
Sequence Identity: 59% (19 aa)

FDDTPLGTASLAQVHKAVLHDGRTVAVKVQHP
| . |   ||  |||.||| ||| ||||.| |
FEEMPFACASIGQVHQAVLKDGREVAVKIQYP
Kinase ADCK1.AA ABC1-C 301-323 65 3.9e-07 17.84 In-house 124-146 (307) Show / Hide 
Range on Protein: 301-323
Range on HMM: 124-146/307
Sequence Identity: 65% (15 aa)

MYSEMIFVNGFVHCDPHPGNVLV
|   ||||  ||| | ||||.||
MLLKMIFVDNFVHADLHPGNILV
Kinase ADCK1.AA ABC1-C 180-202 56 1.1e-05 13.2 In-house 1-23 (307) Show / Hide 
Range on Protein: 180-202
Range on HMM: 1-23/307
Sequence Identity: 56% (13 aa)

VAVKVQHPKVRAQSSKDILLMEV
||||| || . ||   |.||| .
VAVKVLHPGLLAQVHMDLLLMKI
Kinase ADCK1.AA S_TKc 155-462 11 4.9e-05 -103.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 155-462
Range on HMM: 1-231/231
Sequence Identity: 11% (39 aa)

SFDDTPLGTASLAQVHKAVLHD-GRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFL
     ..|  . ..|.|.. .. || ||.|. .                                      ...  |.. | .  . . . ... .|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------------------EHIRREIQILKK--HHPNIVKLYDVFQD-

KVPRIHWDLSTERVLLMEFVDG--GQVNDRDYMERNKIDVNE--ISRHLGKMYSEMIFV-------NGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLY
          ..  . ||..||  | .  .||.....   .   ..    . |   |.        .|..|.|  | |.|. .       .| . | || 
----------DHLYMVMEYCDGDLGDL--FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLA

QMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLG---------------AGDLYPL---FACMLTARS-WDSVNRGISQAPVTATEDLEIRNNAANYLPQ
  |                          .   |               . | . .   .. ||. .  ..              .. .. ..       
RQL--------------------------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG-----

ISHLLNHVPRQMLLILKTNDLLRGIEAAL-GTRASASSFL
 |. . .   . .|    .. .   ||   .  . .  ..
-SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ADCK1.AA ABC1-A 219-275 35 0.000603 9.85 In-house 64-120 (216) Show / Hide 
Range on Protein: 219-275
Range on HMM: 64-120/216
Sequence Identity: 35% (20 aa)

LVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDG
..| |.. | .| |   | | . |  |.|    |  ||..   ..| ||| || . |
FIDYARRELHWECDYQREARCMQKFRQLLKDWPFFYVPHVIDEYCTDRVLTMELMYG