Gene ATR (Human)

ATR

Species: Human
Alias: SCKL1, MEC1, ATR, FRP1, SCKL
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 3q23,

Classification

Group: Atypical
Family: PIKK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
ATR.AA Protein Sugen Kinome 2644 None Fasta, JSON
ATR.NA RNA Sugen Kinome 8323 None Fasta, JSON
ATR.kin_dom Protein Kinase Domain None 337 None Fasta, JSON

Protein domain

Protein domains of ATR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT ATR.AA HEAT 805-835 32 0.000271 18.73 Pfam 1-31 (31) Show / Hide 
Range on Protein: 805-835
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

VLGTLLNLMEDPDKDVRVAFSGNIKHILESL
.| .||....||| .|| |    .....| .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT ATR.AA HEAT 968-982 26 7.787108 3.29 Pfam 17-31 (31) Show / Hide 
Range on Protein: 968-982
Range on HMM: 17-31/31
Sequence Identity: 26% (4 aa)

REMALNTLSEIANVF
||.|...|.... ..
REAACWCLGQLCEHC
UME ATR.AA UME 1119-1225 32 2.7e-44 154.41 SMART 1-115 (115) Show / Hide 
Range on Protein: 1119-1225
Range on HMM: 1-115/115
Sequence Identity: 32% (38 aa)

MADYLQPKLLGILAFFNMQLLSSS--VGIEDKKMALNSLMSLMKLMGPKHVSSVRVK---MMTTLRTGLRFKDDFPELCCRAWDCFVRCLDH---AC-LG
.||.||...|||...|||....|.    ...||.||.|.. ..|.|..||.||.|..   .|..|.|.|. .. ....|||.| ||...|..   .  .|
FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPE-LRHHCCRCWHCFIKHLNEVSCEHYIG

SLLSHVIVALLPLIHI
.|........||... 
PLIDQIFAIILPYWPT
UME ATR.AA UME 1119-1225 30 1.3e-42 146.03 Pfam 1-112 (112) Show / Hide 
Range on Protein: 1119-1225
Range on HMM: 1-112/112
Sequence Identity: 30% (34 aa)

MADYLQPKLLGILAFFNMQLLS--SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFK-DDFPELCCRAWDCFVRCLDH--ACLGSLLS
|||.||.. |||...|.|....  ..  ...||....|.. ..|.|. ||.||.|...|..|...|... ......|.|.| .|...||.  . ||.|..
MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEVPEHLGPLID

HVIVALLPLIHI
...|...|... 
QTFVIIIPYWDT
HEAT ATR.AA HEAT 1284-1314 19 43.232338 0.71 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1284-1314
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

TLQLSMKAIQHENVDVRIHALTSLKETLYKN
 |.. .|...... .||  |. .|.. . . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT ATR.AA HEAT 1335-1365 29 0.010564 13.22 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1335-1365
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

LVTVLLKGCQDANSQARLLCGECLGELGAID
.. .|||...| ... |. . .|||.|  . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
FAT ATR.AA FAT 1771-2092 15 4e-82 275.21 Pfam 1-408 (408) Show / Hide 
Range on Protein: 1771-2092
Range on HMM: 1-408/408
Sequence Identity: 15% (64 aa)

NTYRVEAAWKLSQWDL--VENYLAADG------------KSTT----WSVRLGQLLLSA--KKRDIT--AFYDSLKLVRAEQIVPLSAASFERGSYQRGY
... .|||| |.|||.   ..|...              ....    |   . | .|.   ......   ..   . .|   .  ..|.   . ||.| |
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTAC-LPGESYNRHY

EYIVRLHMLCELEHSIKPLFQHSPG-------DSSQEDSL--NWVARLEMT-QNSYRAKEPILALRRALLSLNK-------RPDYNEMVGECWLQSARVA
 ..||..||.|||..|.   |....       ...  ...  .|  || .. |  ......||..|.  .|...       ..... .  ..|...|...
PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLC

RKAGHHQTAYNALLNAGESR----------LAELYVERAKWLWSKGDVHQALIVLQKGVELCFPEN--------------------ETPPEGKNMLIHG-
||.|..| ....|... ..           ...  ....|..|..|. ..|.  |.. .. .. ..                     | .|....  .. 
RKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAM

RAMLLVGRFMEET--------ANFESNAIMKKYKDVTACLPEWED-GHFYLAKYYDKLMPMVTDNKM-------EKQGDLIRYIVLHFGRSLQYGNQ-FI
|.... |.....          . ....|.. |. .| . |.|.   ....|.|..... . .....       ........ .| .| .|. ...   .
RCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNS

YQSMPRMLT
.|...|.|.
RQDTLRLLW
Kinase ATR.AA ATR 2291-2557 76 1.6e-199 669.12 In-house 1-267 (267) Show / Hide 
Range on Protein: 2291-2557
Range on HMM: 1-267/267
Sequence Identity: 76% (205 aa)

AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPIL
|||||||||||||||||||||||||||||||||||||||||||||||.|.||.|||.|.|||.|.|||..|.||||||||||.|.|||||||||.|||||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

TKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGEC
.||.|||..||....|||||..||....||.||||||||||||||||.||.|.||||..|||||..||||.||..|||||.||||||..|||.|...|||
DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC

VHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTF
||||.||.||.||.||||||||||||||||.|||||.|.|||||||||.|..|||.|...|||...|
VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase ATR.AA PIKK 2292-2557 47 4.8e-167 561.25 In-house 1-290 (290) Show / Hide 
Range on Protein: 2292-2557
Range on HMM: 1-290/290
Sequence Identity: 47% (138 aa)

YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILT
.|...|.||...|..||||||...|.|||.|...||...|||.|.|.|....|.|.||.||.|...|.||||||.|||....||.||||.|...|..|..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

KLYKEKG------VYM-----------------TGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVG
.....|.      ..|                 ......||| .....|.||..||||.. ...|..|..||.|.||||..|...|..|.||.|||.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHGENILFDSLTGECVHVDFNCLFN-KGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTF
|||||||||.|||..|..|||.||.||.|.|. ......|||.||||||.||||.|||||.||.|||.||..|..||..||.||.|...|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase ATR.AA PI3Kc 2323-2633 31 1.9e-128 433.97 SMART 1-336 (336) Show / Hide 
Range on Protein: 2323-2633
Range on HMM: 1-336/336
Sequence Identity: 31% (108 aa)

IMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQ--------------
 ...|..||||.|.| |....|.||...||.|.||| ||.|.|..||....||.||||.|.. |..|. |..|.|...|.......              
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------CMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDP-TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNC
          .| .. ....|.||.|.. . | .||....||...||||  .|...|. ..||.|...||.||||.||||..||..|  ||.|.|.||..
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

LFNKGETFEVP-----EIVPFRLTHNMVNGMG----PMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPL-VEWSKPVKGHSKAPLNETGEVVNEK
.|..|......     | |||||||.||..||    |.| .|.||. |. ..|.|| ... .|... ....||.  .|..   ......|... .. .  
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDH--

AKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLL
     |  |...| . .| ...  .. |.|.. . ..... . . .
-----LSDEEAAQYFMQT-MCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase ATR.AA PI3_PI4_kinase 2321-2567 30 8.49999999999e-105 359.26 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2321-2567
Range on HMM: 1-300/300
Sequence Identity: 30% (91 aa)

FYIMMCKPKDDLR--KDCRLMEFN-----------------------SLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYK
 | ...| .||||  .|.|.|..                        .|.|||..||...|||......| .||....||.||||.|. ....|. . ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

EKGVYMTGKELRQCMLPKSAALS----EKLKVFREFLLPRHPPIFHEWFLRTFPDP-TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILF--DSLTG
...  .  ||....|... ....    .|..||.... . ..|....||....||. . | ..|. ..|| |.|..|.||||.||||..||..  |  ||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

ECVHVDFNCLFN--KGETFEVPEIVPFRLTH------NMVNGM------GPMGTEGLFRRACEVTMRLMRDQREPLMSVL-------KTFLHDPLVEWSK
...|.||.. |.  |...|..|| ||||.||      .||..|      .|.| .|.||. |....|..| . . .|..|        ...||.|..|..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase ATR.AA ATM 2434-2565 48 2.2e-47 149.27 In-house 117-248 (304) Show / Hide 
Range on Protein: 2434-2565
Range on HMM: 117-248/304
Sequence Identity: 48% (64 aa)

PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFR
|.|  . .  | ||  |.  | || || |  |.|||||||||||  |||      | ||.|    | .|     || ||||||  .| |||  | || ||
PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR

RACEVTMRLMRDQREPLMSVLKTFLHDPLVEW
| || ||  ||   | |. .    | ||| .|
RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW
Kinase ATR.AA FRAP 2450-2567 47 1.4e-37 131.18 In-house 133-251 (251) Show / Hide 
Range on Protein: 2450-2567
Range on HMM: 133-251/251
Sequence Identity: 47% (56 aa)

WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQRE
|.  |  | || |.|||.||||||||||  ||. . .||  ||.||   |    . |  || .|||||  .|| |   | || .| .||. |. .|...|
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

PLMSVLKTFLHDPLVEWSK
 .| ||  |  |||  |  
SVMAVLEAFVYDPLFYWRL
Kinase ATR.AA SMG1 2447-2509 57 2.4e-26 84.18 In-house 180-242 (242) Show / Hide 
Range on Protein: 2447-2509
Range on HMM: 180-242/242
Sequence Identity: 57% (36 aa)

PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPE
|  |.    .| ||||||||||||.|||||| .|.| |  ||| ||.|..  | ||    |||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase ATR.AA DNAPK 2454-2567 32 1.2e-23 82.76 In-house 187-301 (301) Show / Hide 
Range on Protein: 2454-2567
Range on HMM: 187-301/301
Sequence Identity: 32% (37 aa)

RSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFN-KGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMS
|. . |. ||    ..||| |||| .| .    .|. . .||   |   .    |||  |||||   .| | ||.  |...      |. .| .|  |. 
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTN

VLKTFLHDPLVEWSK
    |  ||.. | .
FCDVFINDPSFDWKN
Kinase ATR.AA DNAPK 2291-2397 38 4.2e-21 73.41 In-house 2-108 (301) Show / Hide 
Range on Protein: 2291-2397
Range on HMM: 2-108/301
Sequence Identity: 38% (41 aa)

AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPIL
  |||||. | ..||| .||.| ..| | .    . |   ||| | |        |  .  |     |||  ||| .||.    | ||||.||  |. ||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

TKLYKEK
 . . .|
NNEMQQK
Kinase ATR.AA FATC 2612-2644 60 9.9e-18 59.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2612-2644
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

LPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM
.|||.|..|  |||||||.. ||||| || |..
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase ATR.AA FRAP 2322-2397 35 2.3e-15 53.01 In-house 2-76 (251) Show / Hide 
Range on Protein: 2322-2397
Range on HMM: 2-76/251
Sequence Identity: 35% (27 aa)

YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEK
|. . | ..|.| | | |    |||. |. ..|.....| |. |..|||  . |.| ||..   |. || . |..|
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH-ILIRDYRKK
Kinase ATR.AA SMG1 2300-2380 38 7.7e-14 42.09 In-house 1-81 (242) Show / Hide 
Range on Protein: 2300-2380
Range on HMM: 1-81/242
Sequence Identity: 38% (31 aa)

VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWV
. ||    ||||.   ||||| |  . |  .||  | |.| | |..|              | | |.| ||    |.| ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV
Kinase ATR.AA ATM 2324-2379 37 2e-11 32.33 In-house 2-57 (304) Show / Hide 
Range on Protein: 2324-2379
Range on HMM: 2-57/304
Sequence Identity: 37% (21 aa)

MMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEW
 . | .||||.|  .     . |  | .  | |.| | | || |.||    |..||
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW