Gene CDC7 (Human)
CDC7
Sequence
Protein domains of CDC7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CDC7.AA | CDC7 | 58-569 | 58 | 0.0 | 1168.16 | In-house | 1-522 (522) | Show / Hide |
Range on Protein: 58-569 Range on HMM: 1-522/522 Sequence Identity: 58% (305 aa) FKIEDKIGEGTFSSVYLATAQLQVG-----------PEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL .|..||||||||||||.||.|.| . ...|.|.||.|||||| ||..||||||..||..||||...|||.||||.|.|||..|.||.|.. YKVHDKIGEGTFSSVYKATCQRQPHVNKFASHFWNYCRRKFAIKHHIPTSHPERIMNELQCLTRMGGHHNVMGMCCCFRYNDHVHIVMPYFPHCSFQDFY NSLS--FQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPK .... ..|...|| |||.||...|||||.||||||||||||||.||..||||||||...|.........||..|||||.|||.|.|.|||..|..|.|| FHMNRDMEEIKHYMYNLFYALRHVHQFGIIHRDVKPSNFLYNRRTKKFLLVDFGLAQHMMDYNECSRSHQQSKMQQERCNQNKYHSISGNKALLRRPPPK ELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASS ..|||...|..|||.|.|.|..||||||.|......||.|.|||.||||.||..||..|..|.|||...||...||..|.|...|||.|| ..|||.|.| TQDQQHSNKNNVKRNYNNNQHHIKQGKDDKNDHNNFSVMRNVFGNRNFNMHSNNSHNNPNNKNMKQNNNVDNNNRKNNTQKRICSTKAMN-GTMRKNAMS CPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFG |.....|.||..||.|..|....||.|.|||||||||||||.|||.||||||.||.||||||||||||||..|.||.|||||||||.||.|.|..|..|| CDPQCCCCCYKSDKCCNCCMCPKQQHANRAGTPGFRAPEVLLKCPDQTTAIDIWSCGVIFLSLLSGRYPFFMAPDDMTALAQIMTIFGSEEIIKMAHFFG KSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYD |.|.||.|.||||.|.||.....|||.... ||||||||.||||.|..|||||| .||....|.|..||.|.||..|.||..........|.|.|||||| KKIECSHEFPAQDWRELCRCYWYMDSLPNR-TSDIQGHAQHQPAKSKQTDHKAS-RVQRSQNQHSPDSFYKRDSDECWHCGPICSKHMWKWEEFPDEAYD LLDKLLDLNPASRITAEEALLHPFF |||..|..||..||||||||.|||| LLDRCLEMNPHKRITAEEALKHPFF |
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| Kinase | CDC7.AA | S_TKc | 58-569 | 13 | 5.2e-60 | 206.59 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 58-569
Range on HMM: 1-231/231
Sequence Identity: 13% (73 aa)
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEH--ESFLDILNS-------
..| .|||.|.|..||... .. |.| . ..| |.|.| . .|. ...|. ||. . | |... . .|.. .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--LSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKEL
.. ..| || ...||. .|. ||.|||.||.| | .. . |||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------------------------------
DQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCP
----------------------------------------------------------------------------------------------------
ASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKS
||| ..||||| . . ..|.|| |.|. .|.|. ||. .. .. ...
------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------------
ILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLL
..|| |..
--------------------------------------------------------------------------------------------SPEAKDFI
DKLLDLNPASRITAEEALL-------HPFF
.|.|. .|. |.|| ||| ||.|
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | CDC7.AA | CMGC | 380-569 | 14 | 1.1e-28 | 90.62 | In-house | 292-513 (513) | Show / Hide |
Range on Protein: 380-569
Range on HMM: 292-513/513
Sequence Identity: 14% (42 aa)
RAPEVLTKCPNQT---------TAIDMWSAGVIFLSLLSG-------RYPFYK-----------ASDDLTALAQIMTIRG------------------SR
||||.| ... | |.|||||.| || .. | ..|. . .... |..|. . | ..
RAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEE
ETIQ-------------------------AAKTFGKSILCSKEVPAQDLRKLCERLRG---------MDSSTPKLTSDIQGHASHQPAISEKTDHKASCL
| .. |... .| . ...| .....|. ... . . .. .
EWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IY-E-----------------------
VQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVP--------------DEAYDLLDKLLDLNPASRITAEEALLHPFF
.... ..| |||.|.| ..|. |||||.|| ||.|
-----------------------------------EKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
|
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| Kinase | CDC7.AA | Ciliate-E2 | 374-569 | 14 | 3.1e-25 | 83.54 | In-house | 248-365 (365) | Show / Hide |
Range on Protein: 374-569
Range on HMM: 248-365/365
Sequence Identity: 14% (33 aa)
AGTPGFRAPEVLTKCPN--------QTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERL
.||||. |||.| . .. ....|.||.|||. .|.|..||
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------------------------------------------
RGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLE--------------GWNEVPDEAYDLLDK---
... ... . . |.....|. ||. |
------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK
-LLDLNPASRIT-AEEALLHPFF
.|. .| ||| .|..| ||.|
RMLQKDPEKRITGWEQILNHPWF
|
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| Kinase | CDC7.AA | CK2 | 58-200 | 29 | 3.4e-22 | 62.37 | In-house | 1-143 (288) | Show / Hide |
Range on Protein: 58-200 Range on HMM: 1-143/288 Sequence Identity: 29% (43 aa) FKIEDKIGEGTFSSVYLATAQLQVGPEEKI--ALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVI--AMPYLEHESFLDILNSLSFQE .... ||| | .| |. . .||. | | | .| |.. |. | |.. . . | .| . | . |. . YEVIRKIGRGKYSEVFEGINIKN---NEKCKIVIKILKPVKK-KKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYD VREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLA .| || .| ||| | ||.||||||.| . . . .| |.| ||| IRYYMFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLA |
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| Kinase | CDC7.AA | Ciliate-E2-Unclassified | 373-569 | 16 | 1.3e-20 | 68.28 | In-house | 222-352 (352) | Show / Hide |
Range on Protein: 373-569
Range on HMM: 222-352/352
Sequence Identity: 16% (38 aa)
RAGTPGFR----APEVLTKCPNQT---TAIDMWSAGVIFLSLLSGRYPFYKASDDL---------------TALAQIMT--IRGSRETIQAAKTFGKSIL
..|||.. ||||| .. . . ..|.|| |||. .| |.|||| ... . .|. | . . |
FCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ---------
CSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLD-
...|| |..
-------------------------------------------------------------------------------------IPKHWSPEAKDFIND
---KLLDLNPASRITAEEALLHPFF
|.|. || .|||.|..| ||.|
LLQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | CDC7.AA | Pkinase | 58-200 | 24 | 5.9e-20 | 71.63 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 58-200
Range on HMM: 1-159/293
Sequence Identity: 24% (40 aa)
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI--RIAA----ELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHE----SFLDILN
..|. |||.|.|..||... . . |.| . . .... |.| . . .|. ...|. .||. . |.|.|. . |..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS
-----SL--SFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKK---YALVDFGLA
.. | .|.. ||. ....|. .|. ||.|||.||.|.|.... . |||||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
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| Kinase | CDC7.AA | CMGC | 58-200 | 16 | 6.5e-20 | 61.28 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 58-200 Range on HMM: 1-251/513 Sequence Identity: 16% (41 aa) FKIEDKIGEGTFSSVYLATAQL-----------QVGPEEKIALKHLI-PTSHPI-------------RIAAELQCLTVAG----------------GQDN ..| .||||||.. || .. .. . .|..|.| . | ... |. |...| | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VMGVKYCFRKND-----------------HVVIAMPYLEH--ESFLDI----------------------------LNSLSFQEVREYMLNLFKALK--R . . ...|. .. |. . . |..| ... ... .| || ....|| IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY IHQFG--IVHRDVKPSNFLYNRRLKKY-------------------ALVDFGLA .|. . |.||| ||.| | | . . . . ||||| CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | CDC7.AA | Ciliate-E2a | 535-569 | 45 | 2.9e-17 | 47.4 | In-house | 241-275 (275) | Show / Hide |
Range on Protein: 535-569 Range on HMM: 241-275/275 Sequence Identity: 45% (16 aa) WNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF |.....|..||. |.|. .| ||||..|| ||.| WEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | CDC7.AA | Ciliate-E2 | 115-201 | 19 | 9.3e-17 | 54.03 | In-house | 92-204 (365) | Show / Hide |
Range on Protein: 115-201 Range on HMM: 92-204/365 Sequence Identity: 19% (23 aa) DNVMGVKYCFR--KNDHVVIAMPYLEHESFLDILN--------------SLSFQEVREYMLNLFK---------------ALKRIHQFG-IVHRDVKPSN .|.. ..|| ..... . | |... . .|... ... .|....| ... ||. .|. . |.||| ||.| PNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN FLYNRRLKKYALVDFGLAQ |. ..||||.. ILF------IKIIDFGLSK |
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| Kinase | CDC7.AA | CDK | 530-569 | 42 | 4.6e-15 | 44.48 | In-house | 253-284 (284) | Show / Hide |
Range on Protein: 530-569 Range on HMM: 253-284/284 Sequence Identity: 42% (17 aa) TNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF | | .. |||.|.| ..|. ||.||.|| ||.| TKLPDY--------DLLNKMLCYDPKKRISAEQALQHPYF |
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| Kinase | CDC7.AA | Pkinase | 373-428 | 33 | 9.1e-14 | 49.76 | Pfam | 171-231 (293) | Show / Hide |
Range on Protein: 373-428 Range on HMM: 171-231/293 Sequence Identity: 33% (21 aa) RAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS------DDLTALAQIM ..|||...||||. ... ....||||.|.|. .|.|| ||. . |.. ...|| FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIM |
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| Kinase | CDC7.AA | CAMK | 63-201 | 14 | 1.4e-13 | 39.43 | In-house | 1-244 (425) | Show / Hide |
Range on Protein: 63-201
Range on HMM: 1-244/425
Sequence Identity: 14% (35 aa)
KIGEGTFSSVYLATAQLQVGPE---------EKIALKHLIPTSHP------------------------------IRIAAELQCLTVAGG------QDNV
..|.|.|. |.|.. . | | .| | | . . .. .. |.... | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
MGVKYCFRK-------------------NDHVVIAM---PYLEHE----SFLDILNS------------------LSFQEVREYMLNLFKALKRIHQFGI
. ..|... | | . .| . . .. .|.| |. . |.. .|. .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHRDVKPSNFLYNRRL----------------KKYALVDFGLAQ
|||| || | |.. . . ..|||.|.
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN
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| Kinase | CDC7.AA | CAMK1 | 535-569 | 33 | 2.1e-13 | 35.28 | In-house | 241-276 (276) | Show / Hide |
Range on Protein: 535-569 Range on HMM: 241-276/276 Sequence Identity: 33% (12 aa) WNEVPDE-AYDLLDKLLDLNPASRITAEEALLHPFF |... |. | |.. ..|...| |.|.|..| ||.. WDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | CDC7.AA | CK2 | 538-569 | 50 | 2.4e-13 | 35.43 | In-house | 257-288 (288) | Show / Hide |
Range on Protein: 538-569 Range on HMM: 257-288/288 Sequence Identity: 50% (16 aa) VPDEAYDLLDKLLDLNPASRITAEEALLHPFF . .|| |.|||.| .. |||| ||. ||.| AHPEAIDFLDKMLRYDHQERITAKEAMEHPYF |
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| Kinase | CDC7.AA | Ciliate-E2-Unclassified | 122-200 | 21 | 2.6e-13 | 42.56 | In-house | 88-194 (352) | Show / Hide |
Range on Protein: 122-200 Range on HMM: 88-194/352 Sequence Identity: 21% (23 aa) YCFRKNDHVVIAMPYLEHESFLDILNS--------------------LSFQEVR-----EYMLNLFKALKRIHQFG-IVHRDVKPSNFLYNRRLK--KYA |||.. ... | | |.|. . ...... .. |... |. . ..|. .|. . |.||| ||.| |.. | . YCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIK LVDFGLA . |||.. IIDFGIS |
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| Kinase | CDC7.AA | Ciliate-E2a | 372-415 | 46 | 3.9e-13 | 35.03 | In-house | 169-217 (275) | Show / Hide |
Range on Protein: 372-415 Range on HMM: 169-217/275 Sequence Identity: 46% (23 aa) PRAGTPGFRAPEVLTKCP---NQ--TTAIDMWSAGVIFLSLLSGRYPFY .. ||||. ||||| .. .| ||||.|||| ||.|. ||. QKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFK |
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| Kinase | CDC7.AA | CAMK | 375-420 | 36 | 1.4e-12 | 36.1 | In-house | 281-340 (425) | Show / Hide |
Range on Protein: 375-420 Range on HMM: 281-340/425 Sequence Identity: 36% (22 aa) GTPGFRA-PEVLTK-------------CPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD |||.. | |||| . | . ..||||.||| .|.|..||| .|. GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDN |
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| Kinase | CDC7.AA | Ciliate-E2a | 152-201 | 35 | 2.6e-12 | 32.58 | In-house | 101-157 (275) | Show / Hide |
Range on Protein: 152-201 Range on HMM: 101-157/275 Sequence Identity: 35% (20 aa) QEVREYMLNLF-KALKRIHQFGIVHRDVKPSNFLYN---RR---LKKYALVDFGLAQ ||....| .|. ..| .|| .|.||| || |.|.. ... ..|||||. QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLAT |
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| Kinase | CDC7.AA | GSK | 529-569 | 30 | 4.5e-12 | 32.57 | In-house | 287-328 (328) | Show / Hide |
Range on Protein: 529-569 Range on HMM: 287-328/328 Sequence Identity: 30% (13 aa) NTNLEGW-NEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF . .. | .. .....||. |.| .| .|... ||..|||| TVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF |
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| Kinase | CDC7.AA | CAMK1 | 373-415 | 51 | 1.2e-11 | 30.1 | In-house | 173-217 (276) | Show / Hide |
Range on Protein: 373-415 Range on HMM: 173-217/276 Sequence Identity: 51% (23 aa) RAGTPGFRAPEVLTK--CPNQTTAIDMWSAGVIFLSLLSGRYPFY . ||||. |||||. |.||||.|||. || | ||| ACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFY |
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| Kinase | CDC7.AA | CAMK | 535-569 | 32 | 1.5e-11 | 32.76 | In-house | 383-425 (425) | Show / Hide |
Range on Protein: 535-569 Range on HMM: 383-425/425 Sequence Identity: 32% (14 aa) WNEVPDE--------AYDLLDKLLDLNPASRITAEEALLHPFF |... || . ||. |.| .| |.|.|..| ||.. WDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | CDC7.AA | Pkinase | 535-569 | 25 | 4e-11 | 40.43 | Pfam | 242-293 (293) | Show / Hide |
Range on Protein: 535-569 Range on HMM: 242-293/293 Sequence Identity: 25% (13 aa) WNEVP-----------------DEAYDLLDKLLDLNPASRITAEEALLHPFF |.... .|. |.....|...|..|.|||..| ||.| WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | CDC7.AA | GSK | 152-188 | 37 | 5.9e-11 | 29.1 | In-house | 116-152 (328) | Show / Hide |
Range on Protein: 152-188 Range on HMM: 116-152/328 Sequence Identity: 37% (14 aa) QEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR .... || .|..|. .| .||.|||.||.| |.... IHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPD |
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| Kinase | CDC7.AA | CK2 | 373-444 | 25 | 3.6e-10 | 25.79 | In-house | 155-226 (288) | Show / Hide |
Range on Protein: 373-444 Range on HMM: 155-226/288 Sequence Identity: 25% (18 aa) RAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFG | .. ...|| | ..|||| |..| |.. . ||.. .| ..| .|... | . .. ...| RVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGHDNYDQLVKIVKVLGTEDLYKYLDKYG |
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| Kinase | CDC7.AA | CDK | 130-200 | 30 | 3.7e-09 | 25.28 | In-house | 93-160 (284) | Show / Hide |
Range on Protein: 130-200 Range on HMM: 93-160/284 Sequence Identity: 30% (24 aa) VVIAMPYLEHE--SFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR-------LKKYALVDFGLA ... ..|..| ...| .. ||. | ..| .|. .|.||| ||.| |.|.. || . ||||| LYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLK---IADFGLA |
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| Kinase | CDC7.AA | Ciliate-E2a | 58-76 | 57 | 4.4e-08 | 19.91 | In-house | 1-19 (275) | Show / Hide |
Range on Protein: 58-76 Range on HMM: 1-19/275 Sequence Identity: 57% (11 aa) FKIEDKIGEGTFSSVYLAT .|...|||.|.| |||||. YKFIKKIGKGNFGSVYLAQ |
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| Kinase | CDC7.AA | CAMK1 | 58-76 | 47 | 4.4e-08 | 19.51 | In-house | 1-19 (276) | Show / Hide |
Range on Protein: 58-76 Range on HMM: 1-19/276 Sequence Identity: 47% (9 aa) FKIEDKIGEGTFSSVYLAT ... ..||.|.|| |||.| YEFGKEIGRGAFSEVYLCT |
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| Kinase | CDC7.AA | CDK | 380-414 | 37 | 3.3e-07 | 18.95 | In-house | 186-225 (284) | Show / Hide |
Range on Protein: 380-414 Range on HMM: 186-225/284 Sequence Identity: 37% (15 aa) RAPEVLTKCPNQT--TAIDMWSAGVIFLSLLS---GRYPF ||||.| . . . |.|||||.| || .. ... | RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF |
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| Kinase | CDC7.AA | CDK | 58-90 | 34 | 7.3e-07 | 17.81 | In-house | 1-35 (284) | Show / Hide |
Range on Protein: 58-90 Range on HMM: 1-35/284 Sequence Identity: 34% (12 aa) FKIEDKIGEGTFSSVYLATAQLQVG--PEEKIALK ... .||||||. || | ... . ... .||| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK |
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| Kinase | CDC7.AA | TyrKc | 58-349 | 13 | 1e-06 | -116.3 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 58-349
Range on HMM: 1-280/280
Sequence Identity: 13% (48 aa)
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAG-GQDNVMGVKYCFRKN-------DHVVIAMPYLEHESFLDIL--N
. ..|.||| | ||..|. .. | | | . . . |.. .. | .|. . .. . . | | | .| . .| | .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
S--LSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALV---DFGLAQGTHDT-KI----ELLKF-----VQ---------SEAQQERC
|. .. .... . .|. ...||| | |..... | ||||. .| . . . |. ....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK
SQNKSH----------IITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQI----KQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMK
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FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------------
QSKTVDVLSRKLATKKKAISTKVMNS-----AVMRKTASSCPASL
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--------F---VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
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| Kinase | CDC7.AA | CAMK1 | 160-201 | 38 | 1e-06 | 15.24 | In-house | 116-161 (276) | Show / Hide |
Range on Protein: 160-201 Range on HMM: 116-161/276 Sequence Identity: 38% (18 aa) NLFKALKRIHQFGIVHRDVKPSNFLYNRR-----LKKYALVDFGLAQ ....|.. .|. |||||| || | || .|. . ||||.. QILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKR-SIADFGLSK |
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| Kinase | CDC7.AA | GSK | 380-401 | 54 | 8e-06 | 13.12 | In-house | 185-206 (328) | Show / Hide |
Range on Protein: 380-401 Range on HMM: 185-206/328 Sequence Identity: 54% (12 aa) RAPEVLTKCPNQTTAIDMWSAG |||| . .| | |..||.||.| RAPELIFGCTNYTCQIDVWSCG |
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| Kinase | CDC7.AA | Ciliate-E2 | 58-75 | 50 | 9e-06 | 15.73 | In-house | 1-18 (365) | Show / Hide |
Range on Protein: 58-75 Range on HMM: 1-18/365 Sequence Identity: 50% (9 aa) FKIEDKIGEGTFSSVYLA .|. |||.|.|.|||.. YKFIKKIGQGNFGSVYKC |
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| Kinase | CDC7.AA | GSK | 58-78 | 33 | 1.6e-05 | 12.15 | In-house | 1-21 (328) | Show / Hide |
Range on Protein: 58-78 Range on HMM: 1-21/328 Sequence Identity: 33% (7 aa) FKIEDKIGEGTFSSVYLATAQ ... ..|| |.|. || |... YEEMKVIGHGSFGVVYQAYMN |
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| Kinase | CDC7.AA | Ciliate-E2-Unclassified | 58-75 | 44 | 5.7e-05 | 13.21 | In-house | 1-18 (352) | Show / Hide |
Range on Protein: 58-75 Range on HMM: 1-18/352 Sequence Identity: 44% (8 aa) FKIEDKIGEGTFSSVYLA .|| .||.| |..||.. YKIIKQIGQGGFGKVYKC |
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