SgK110

Species: Human
Alias: SgK110, LOC646643
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , GeneCards
Annotation: Consensus chromosomal location: 19q13.43,

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
SgK110.NA RNA Sugen Kinome 1390 None Fasta, JSON
SgK110.AA Protein Sugen Kinome 359 None Fasta, JSON
SgK110.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of SgK110.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK110.AA NKF1 43-304 45 1.6e-159 536.24 In-house 1-269 (269) Show / Hide
Range on Protein: 43-304
Range on HMM: 1-269/269
Sequence Identity: 45% (124 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPR--YFAFAQEYAPCGDLSGMLQ---ERGLPE
|..||.||.|.||..||....|.|...|||...........|.||||.|.|.|.|.....|.....||..  |..|||||||||||..|.|   .|||||
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

LLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDP-VCSRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLP-PDTLPLRPAVDSWGLGVLLFCA
. .||.|||||.||||.|||.|||.|.||.|||||||  |.||.|.|.|.|||.|....... ..|...||.|. || ....|..|..|.|..|||.||.
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

ATACFPWDVALAP-NPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAVLDFL
 |.||||. |... .|..|.|. | ..| |||..|.||..|.|.|......||...||.|.|. .. ...
LTGCFPWQKADWMCDPCYEWFMWWQRRK-QPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM

Kinase SgK110.AA S_TKc 43-304 19 9.7e-40 139.26 SMART 1-231 (231) Show / Hide
Range on Protein: 43-304
Range on HMM: 1-231/231
Sequence Identity: 19% (56 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPC--GDLSGMLQERG------
|...||.|.|..|.| ... .  |  ||.| ..       ...||  . .    || . . .        .. .  ||..   |||  ....||      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRP-AVDSWGLGVLL
 .||  ......|.. ||...||.| .| |.||.|.|. .    .. ..| || |          . .   .||..        .  . ..| | .|..|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

FCAATACFPWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAVLD---------FL
.  .. . |..       ... |   .                 |.|. .....|. ||| |     .|          ..
YEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase SgK110.AA Pkinase 43-304 19 4.2e-30 107.52 Pfam 1-293 (293) Show / Hide
Range on Protein: 43-304
Range on HMM: 1-293/293
Sequence Identity: 19% (58 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRST---FLR--EFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPCG----DLSGMLQ--
||..||.||||.|.| ... .  |  ||.| ....    .     .|  | .. . .. ||  ....      ...  . .||...|    ||. ...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

-ERGL--PELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVF-DPVC-SRVALGDLGLT----RPEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRPA
 ....  .|  .|... |.. .|...||.| .| |.||.|.|.  .... ..| ..| ||        .| .  . . .. ..||...    .  .  |.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPK

VDSWGLGVLLFCAATACFPWDVAL----APNPEFEAFAGWVTTKPQPPQPPPPWDQFA-----------------PPALALLQGLLDLDPETRSPPLAVL
|| |..|..|.. ..  .|..         . . . ..   . .|... . | |.                    .... .. ..|..||. |  .  .|
VDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICR--IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

DF--L
    .
QHPWF

Kinase SgK110.AA CAMK 48-171 16 8.3e-20 59.85 In-house 1-212 (425) Show / Hide
Range on Protein: 48-171
Range on HMM: 1-212/425
Sequence Identity: 16% (35 aa)

KLGSGSYGRVLLAQPHQGG------------PAVALKLLRRD-----------------------------LVLRSTFLREFCVGRCVSA------HPGL
.||.||.| | |..  . .              || | . ..                              . |  ..|| .. . ...      || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQTLA--------------GPLQT-----PRYFAFAQ---EYAPCG----DLSGMLQERG----------------LPELLVKRVVAQLAGALDFLHSRG
.. .                  ..     .... .     ||.. |    ||  ...|.|                ..|  ..|.. |.. |....||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LVHADVKPDNVLV
 || | ||.|.|.
IVHRDLKPENILL

Kinase SgK110.AA CAMKL 43-171 24 1e-18 56.19 In-house 1-160 (297) Show / Hide
Range on Protein: 43-171
Range on HMM: 1-160/297
Sequence Identity: 24% (39 aa)

YHLIRKLGSGSYGRVLLAQP-HQGGPAVALKLLRRDLVLRSTFLR----------------EFCVGRCVS--AHP---GLLQTLAGPLQ---TPRYFAFA
| ... || ||.| | ||.     |  || | . ..     .. .                | .  . ..   ||    |....  |     |  ..   
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

QEYAPCGD--LSGMLQERG-----LPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV
 ||.. |.  |  .....|     .||   .|   |.  |....||.| || | ||.|.|.
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL

Kinase SgK110.AA AGC 109-170 24 3e-15 34.4 In-house 101-187 (395) Show / Hide
Range on Protein: 109-170
Range on HMM: 101-187/395
Sequence Identity: 24% (21 aa)

QTPRY--FAFAQEYAP--------CGD-LSGMLQE-R----GLPELLVKRVVAQ-------LAGALDFLHS-RGLVHAD-VKPDNVL
|....    |  ||.|        .|.  . . .  |     ..|  ..   |.       .. ||..||| .| .| | .||.|.|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL

Kinase SgK110.AA Iota 43-171 33 3.4e-14 43.25 In-house 1-133 (271) Show / Hide
Range on Protein: 43-171
Range on HMM: 1-133/271
Sequence Identity: 33% (45 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFL----REFCVGRCVSAHPGLLQTLAGPLQTPRYFAFAQEYAPCGDLS-GMLQERGLPE
..||| .| ||| .||... ..     |.|......|     .     |  |    | ||  |  |    ||.    |  |. . |||   | . | |||
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHP-FLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPE

LLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV
   .   | .. ||.|||.||..  |.| ||||.
EHARFYSAEICLALNFLHERGIIYRDLKLDNVLL

Kinase SgK110.AA ROCK 43-171 29 4.8e-14 43.91 In-house 1-131 (263) Show / Hide
Range on Protein: 43-171
Range on HMM: 1-131/263
Sequence Identity: 29% (39 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAH--PGLLQTLAGPLQTPRYFAFAQEYAPCGDLSGMLQERGLPELLV
.|.|. .| | .| | |   ..     |.|.| .. ... .    |   | . ||     .  |    | .||     .| | |||  .. .  .||   
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

KRVVAQLAGALDFLHSRGLVHADVKPDNVLV
.   . .  ||| .|| |..| ||||||.|.
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLL

Kinase SgK110.AA NuaK 43-77 40 1.9e-11 25.8 In-house 1-35 (252) Show / Hide
Range on Protein: 43-77
Range on HMM: 1-35/252
Sequence Identity: 40% (14 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRD
| ....||.| ||.| ||  |. |  || |. ...
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKC

Kinase SgK110.AA CDK4 134-171 44 1.3e-10 32.42 In-house 106-143 (290) Show / Hide
Range on Protein: 134-171
Range on HMM: 106-143/290
Sequence Identity: 44% (17 aa)

GLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV
|.|.  .|.. .||  ..|||||   .| | ||.|.||
GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV

Kinase SgK110.AA CMGC 125-193 16 5.1e-10 28.15 In-house 140-257 (513) Show / Hide
Range on Protein: 125-193
Range on HMM: 140-257/513
Sequence Identity: 16% (20 aa)

DLSGMLQERG----------LPELL------------VKRVV------AQLAGALD--FLHSRG--LVHADVKPDNVLVFDP------------------
|| .....            |.|              .|  .       |.  .|.  ..||..   .| | || |.|. .                   
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ

VCSRVALGDLGLTRPEGSP
.  |. ..| || | ....
KNGRLKICDFGLARWYHPH

Kinase SgK110.AA TyrKc 43-304 20 1.8e-09 -69.43 SMART 1-280 (280) Show / Hide
Range on Protein: 43-304
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCV-SAHPGLLQTLAGPLQTP------RYFAFAQEYAPCGDLSGMLQERG-
 .|..|||.| .|.| ...       || | |. |   |  |.||  . . .   || ... ..  .|               ||.| |||   |.... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSP----------TP----APP--VPLPTAPPELCLLLPPDTL
 |.         | |   ..|||....| |    |.|| ..   .|  .| ||.|  ..           ..         .|.   .|| |.    .. 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE-CI----NYG

PLRPAVDSWGLGVLLF--CAATACFPWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQF----APPAL-ALLQGLLDLDPETRSPPLAVLDFL
   .. | |  ||...  .   .  ......    . .    .| .   .|||| .        .|...  . .   . ||| |    .. ...
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase SgK110.AA MARK 119-171 33 4.3e-08 22.74 In-house 82-137 (262) Show / Hide
Range on Protein: 119-171
Range on HMM: 82-137/262
Sequence Identity: 33% (19 aa)

EYAPCGDLSGMLQER---GLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLV
|||. |.| . ....    |.| . .|   |.  |. ..||.. || | ||.|.|.
EYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI

Kinase SgK110.AA AGC 43-61 31 6.2e-08 15.06 In-house 1-19 (395) Show / Hide
Range on Protein: 43-61
Range on HMM: 1-19/395
Sequence Identity: 31% (6 aa)

YHLIRKLGSGSYGRVLLAQ
..... .| ||.|.| |..
FEFLKVIGKGSFGKVYLVR

Kinase SgK110.AA CMGC 43-77 24 1e-06 16.82 In-house 1-49 (513) Show / Hide
Range on Protein: 43-77
Range on HMM: 1-49/513
Sequence Identity: 24% (12 aa)

YHLIRKLGSGSYGRVLLAQP--------------HQGGPAVALKLLRRD
|. |.|.|.|.|| |  ..               |...  ||.| ....
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNP

Kinase SgK110.AA NuaK 119-170 32 4e-06 11.44 In-house 79-131 (252) Show / Hide
Range on Protein: 119-170
Range on HMM: 79-131/252
Sequence Identity: 32% (17 aa)

EYAPCGDLSGMLQE-RGLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVL
|||  |.|   . | . |||  ....  | . |. . |  . .| | |  |.|
EYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENIL

Kinase SgK110.AA MARK 221-243 47 0.000118 11.33 In-house 185-207 (262) Show / Hide
Range on Protein: 221-243
Range on HMM: 185-207/262
Sequence Identity: 47% (11 aa)

PAVDSWGLGVLLFCAATACFPWD
|.|| | |||.|.   . .||.|
PKVDIWSLGVVLYFMVCGYFPFD

Kinase SgK110.AA CDK4 43-75 39 0.000212 10.77 In-house 1-33 (290) Show / Hide
Range on Protein: 43-75
Range on HMM: 1-33/290
Sequence Identity: 39% (13 aa)

YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLR
| ..  .|.| || |  |   . |  ||||  |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR

Kinase SgK110.AA MARK 43-61 42 0.000403 9.56 In-house 1-19 (262) Show / Hide
Range on Protein: 43-61
Range on HMM: 1-19/262
Sequence Identity: 42% (8 aa)

YHLIRKLGSGSYGRVLLAQ
| ... .| |||. | ||.
YKMLKTIGHGSYAKVKLAC

Kinase SgK110.AA NuaK 221-233 69 0.001408 4.68 In-house 178-190 (252) Show / Hide
Range on Protein: 221-233
Range on HMM: 178-190/252
Sequence Identity: 69% (9 aa)

PAVDSWGLGVLLF
| ||.| |||||.
PEVDCWSLGVLLY

Kinase SgK110.AA AGC 261-294 29 0.005478 1.97 In-house 333-373 (395) Show / Hide
Range on Protein: 261-294
Range on HMM: 333-373/395
Sequence Identity: 29% (12 aa)

TKPQPPQPP-------PPWDQFAPPALALLQGLLDLDPETR
....... |       |....| | |  |...||  ||| |
FINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR

Kinase SgK110.AA CAMKL 221-245 36 0.014048 3.88 In-house 215-239 (297) Show / Hide
Range on Protein: 221-245
Range on HMM: 215-239/297
Sequence Identity: 36% (9 aa)

PAVDSWGLGVLLFCAATACFPWDVA
|.|| | .||.|.   .  .|.| .
PKVDIWSCGVILYAMVCGYLPFDDD

Kinase SgK110.AA CAMK 221-243 30 0.018155 2.96 In-house 313-335 (425) Show / Hide
Range on Protein: 221-243
Range on HMM: 313-335/425
Sequence Identity: 30% (7 aa)

PAVDSWGLGVLLFCAATACFPWD
|..| | .||.|.   . ..|..
PKCDMWSCGVILYIMLCGYPPFY