Gene SRC (Human)

SRC

Species: Human
Alias: p60-Src, SRC, SRC1, ASV, c-SRC
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 20q11.23,

Classification

Group: TK
Family: Src
Subfamily: SrcA

Sequence

Name Sequence Type Origin Length Description Download
SRC.NA RNA Sugen Kinome 4166 None Fasta, JSON
SRC.AA Protein Sugen Kinome 543 None Fasta, JSON
SRC.kin_dom Protein Kinase Domain Sugen Kinome 249 None Fasta, JSON

Protein domain

Protein domains of SRC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 SRC.AA SH3 87-151 35 6.9e-22 79.95 SMART 1-58 (58) Show / Hide 
Range on Protein: 87-151
Range on HMM: 1-58/58
Sequence Identity: 35% (23 aa)

TTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVRREGDWWLAHSLSTGQTGYIPSNYVAPSD
 ...|||||..... .||||||. ..... .       ...|| .   .|||.|..|||||.. |
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-------DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 SRC.AA SH3_1 90-144 37 7.6e-18 63.12 Pfam 1-49 (49) Show / Hide 
Range on Protein: 90-144
Range on HMM: 1-49/49
Sequence Identity: 37% (21 aa)

VALYDYESRTETDLSFKKGERLQIVNNTRKVDVRREG-DWWLAHSLSTGQTGYIPS
||||||. ... .||||||. ..... .       .. ||| . ...|||.|..||
VALYDYQAQQPDELSFKKGDIIHVIEKS-------DDWDWWKGRCNNTGQEGWFPS
SH3_2 SRC.AA SH3_2 88-150 18 5.9e-11 41.25 Pfam 1-68 (68) Show / Hide 
Range on Protein: 88-150
Range on HMM: 1-68/68
Sequence Identity: 18% (14 aa)

TFVALYDYES-RTETD-----LSFKKGERLQIVNNTRKVDVR--REGDWWLAHSL-STGQT--GYIPSNYVAPS
 .... ||.. . ...     |.||||. . .        ..  . ..||...   ..|..  |..||..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVID------NGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 SRC.AA SH2 158-240 60 2.8e-50 149.44 Pfam 1-81 (81) Show / Hide 
Range on Protein: 158-240
Range on HMM: 1-81/81
Sequence Identity: 60% (50 aa)

WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY
||.|||.| | ||||.| .||.|||||||||.|.| | ||| |...  | .||||.|...| ||.||| |..|.|||.|| .|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SRC.AA SH2 156-246 44 2.6e-39 137.82 SMART 1-87 (87) Show / Hide 
Range on Protein: 156-246
Range on HMM: 1-87/87
Sequence Identity: 44% (41 aa)

EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITS--RTQFNSLQQLVAYYSKHADG
..||.|.|.| | |.||.| ..| |.||||.||...|.|.||| .        ||||.||..|.|..||.   |..|.|| .||..|.....|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SRC.AA SrcA 277-526 89 2.1e-225 719.95 In-house 1-250 (250) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-250/250
Sequence Identity: 89% (224 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM
.|||..||||||||||||||||||.|||||||||||||||||.|||.||||||.|||||||||||||||||||||.|||||||||.|.||||.|||||||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM
|||.|.||||.|||||.|||||||||||||||.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL
.|||||.||||||.||||..||||||.||||||||.|||||||||||.||
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase SRC.AA Src 277-526 76 2.3e-204 685.24 In-house 1-255 (255) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-255/255
Sequence Identity: 76% (196 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK-GETGKYLRLPQLV
..|. |||||.|||||||.|||.| ||.||||||||||||||||||.|||||||||||||||.|.| ||||||||||.|||||.||  ..|..|.||||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP
|||||.|.|||| |.|||.||||.|.|.|||||.|||||||||||||.  |.||.||.|||||||||||||..|||||||||||||||||||. |.||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMVNREVLDQVERGYRMPCPPECPESLHD-LMCQCWRKEPEERPTFEYLQAFL
|||| |.|||.|||||||||||..||..|.. .|.|||.|.||.|||||||| ||
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SRC.AA SFK-Src 277-530 65 4.1e-191 572.29 In-house 1-259 (259) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-259/259
Sequence Identity: 65% (169 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD
 ||| |||.| ||.|| |.||.|| ||.||||||.|| | |||||||||||||..|.|||||    |||||.|| |  |||||.|.   |. ||.|||||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY
||||.|.|||| |  |.||||| | |.|||.| ||||.|||..| .. |.| |||..|||||||||||||... || |||||||||||..|. | ||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMVNREVLDQVER--GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF
||| | ||| ||.|  |||||||| ||. .. .| .||..||..||||| |.  .||.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase SRC.AA SrcB 277-527 70 5.3e-166 557.79 In-house 1-251 (251) Show / Hide 
Range on Protein: 277-527
Range on HMM: 1-251/251
Sequence Identity: 70% (176 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM
|.|. ||| | |||||||..|. ..||.||.|.|||||||||.|| |||.| |..||.|||||. |||||.|||| ||.|||||| . |  | ||.|.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM
.|||| ||||.|||||.||||||||||| | |.||.|||||||.||||||||| |||||||||||||  .| ||||||||||||||.|. | ||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE
 | ||. ..|||||||.| .||| | ..| .||.. |||||||.|||. |.
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase SRC.AA Src-Unclassified 277-526 53 2.4e-158 532.36 In-house 1-284 (284) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-284/284
Sequence Identity: 53% (152 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG---TMSPEAFL--------QEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGET
..|  |||.| ||||| | | |   ||.||..||   ||||||||        ||||.|||.|| .||.|||| | |||.||.||||..||||..|.  .
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GKYLRLPQL------------VDMAAQIASGMAYVERMNYVHRDLRAANILVGENL-----VCKVADFGLA--RLIEDNEYTARQGAKFPIKWTAPEAAL
|.|| .. .            ||.|||.|||| | |   |||||| | |.|.|.|      | ||.|||||  .|..| .| .|.||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHD-LMCQCWRKEPEERPTFEYLQAFL
|| |.|||||||.|||| |. |||..||||| ||||| .|||||||| |    ||... . .| .|| | |. ||||. |  ..
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase SRC.AA Pkinase_Tyr 277-526 49 9.3e-151 511.21 Pfam 1-270 (270) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-270/270
Sequence Identity: 49% (133 aa)

LRLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLKPGTMSP----EAFLQEAQVMKKL-RHEKLVQLYAVVS--EEP--IYIVTEYMSKGSLLDFLKG
...  |||.|.||||..|||.     ... ||.|.||.|.|..    |.|..||..||.| .|...|.||.|..  .||  ||||.||| .|.|||.|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSF
    .. | ...|..|..|||.||.| |..|..||||.| |.||.||.|.|..||||||.| .| .| ..|.|.|.||||.|||.  ||.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTELTTKGRVP-YPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL
|.|. |. | |. | |||| | ||.... |.|||||||. ||. ..|||.|||...||.||||.... .|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SRC.AA Frk 277-530 64 8.10000000001e-146 490.72 In-house 1-260 (260) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-260/260
Sequence Identity: 64% (167 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK--GETGKYLRLPQL
..|  .|| | ||||| | || || ||.|||||||| |. ||.|||.|||||| ||.|||||   ||||||.|| | .|||...|.   ..|. ....||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR
||||||.|.||||.| .||.|||| | |.||||...||.||||||| |. |||  | .|.||.||||||||||| | .||||||||||||||||. | ||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF
.||||| |.|||..|..|||||.||.||. | ..| .||...|..||||| ||  |||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SRC.AA Src-Echino1 277-526 63 1.2e-140 473.6 In-house 1-252 (252) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-252/252
Sequence Identity: 63% (159 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD
||.. |.|.| .|||| | ||| | ||.||||..|||| .|| || ||||.||| .||.||| |.. ||||||| ||.|.|.|.|| . .| .....|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG
| |.||||| |... |.||||| | |.|||.  |||.|||||||......| ..||||.|||||||||||||||||||||||||||.||. | ||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MVNREVLDQVERGYRMPCPPECPESLHDL-MCQCWRKEPEERPTFEYLQAFL
| ||||||||.|||||| . .||.||... | .|| |.|  |||||.|  |.
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase SRC.AA TyrKc 277-526 42 9.5e-135 454.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-280/280
Sequence Identity: 42% (121 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL--RHEKLVQLYAVVSE--------EPIYIVTEYMSKGSLLDFLKGETGK
..|. ||| |.||||. |||.  . ||.|.||...   |.|..||..|.||  .|. .|.||.|...        ||..||.|||..|.|.|.|.   .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN--------EYTARQ--GAK--FPIKWTAPEAALYGRFTIKSD
 | ...|.... |||.||.| ...|..|||| | |.|||||...|..||||.| |.|          |....  |.|  .||.|.|||.  ||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTELTTKGRVPYPG-----MVNREVLDQVERGYRMPCPPE--------CPESLHDLMCQCWRKEPEERPTFEYLQAFL
|||||... |. | |  ||||     | |.||. .|..|||||.||.        ||. ....| |||. .||.||||. .  ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SRC.AA SRM 277-527 52 6.4e-127 426.67 In-house 1-253 (253) Show / Hide 
Range on Protein: 277-527
Range on HMM: 1-253/253
Sequence Identity: 52% (133 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT-MSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV
  |  |||.| ||||| | | |  .||||  |    |  . . .| | ||||||.... |.||.|  .|.||.|| | ||.|. .|.   .| |..|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP
|.| |.| ||.| |  ||.|||| | |.|||.|..|||.|||||||| |  |    . . |.|||||||| |. . .||||||||||| |. |.| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE
|| | | . |..|||||||| ||| . | || .||...||.||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase SRC.AA TK 277-526 27 5.70000000001e-125 421.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-486/486
Sequence Identity: 27% (134 aa)

LRLEVKLGQGCFG---EVWMGTWNGT--------------------------TRVAIKTLKPG-TMSPEA--------------FLQEAQVMKKLR----
..|. |||.| ||   ||..|.|.|                           |.||.|.||.| .||.|.              ||.||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HEKLVQLYAVVSEE-------------PIYIVTEYMSKGS----LLDFLK--GETGKY-----------------------------------------
 |. .|.||.|....             |..||.|||..|.    |.|.|.   ....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LRLPQLVDMAAQIASGMAYVERM------NYVHRDLRAANILVGENLV-----------CKVADFG---
                               | ..||. |..|||.||.| ...      |.||||| | |.|||||.|           ||.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARQ------------------------GAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILLTELTTKGRVPYPG-M
     ||| | .| .|....                        |.|.||.|.|||. .         ||.||.||||||||.|. |. | |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VN---------REVLDQVERG--------------YRMPCPPECP--------------ESLHDLMCQCWRKEPEERPTFEYLQAFL
 |         .||.....||              .|||.|| ||              | ..|||.|||...||.||||. |. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SRC.AA Tec 277-528 45 5.5e-110 371.71 In-house 1-254 (254) Show / Hide 
Range on Protein: 277-528
Range on HMM: 1-254/254
Sequence Identity: 45% (117 aa)

LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--L
| .   ||.| || | .| | .   ||||..| |.|| | |..||.||.|| |.|||||| | |.. |||||||||..|.||..|. | .. ..  .  |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLR-EHKHHFQKNMAIL

VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY
 .|  ..  |||| || ...|||| | | |||.. | ||.|||..| . | .||   |.|||.|| .||   | |.  |||||.||.|  |  . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED
. | | || ..| .|.|.  |  |.... . | .||. .|||||||. |   ...
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase SRC.AA S_TKc 277-530 25 4.1e-57 196.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSK--GSLLDFLKGETG----KYLR
 ..  |.|.| ||.|. .....   .|||| .|      | ...| |..|| .|. .|.|| |  .. .|.|.||..   |.|.|..|   .    ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI-KSDVWSFGILLTELTTK
  .   ...||.....|  ... .||||  .|||. |  . |..||||||..                . |||      ..  |.|.||.|..| |. . 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQA-----FLEDYF
|. |.|     ......            .... |....|..|.||.|||   . .      .  .|
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRC.AA Pkinase 277-526 26 1.8e-48 172.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 277-526
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ-----EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKG----SLLDFLKGETG
.... |.|.| ||.|. ... || . ||.|..|  . ...   .     |.|.||.|.|.  |.|| .. ..  ||.|.||. .|    .| |..... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC----KVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVW
. .     .. ... ||..|..|  .|. .||||  .|||. .| ..    |..|||||..  .  |..| . |  .   . |||  . .   . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDMW

SFGILLTELTTKGRVPYPGM-----VNREVLDQVERG--YRMPCPPECP-------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
|.|..| |. . || |.||      ..  .. .  .|  .. ..| .|.                   |.. |... |..| |..|||.| .     .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF