Gene TNK1 (Human)

TNK1

Species: Human
Alias: TNK1, MGC46193
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17p13.3,

Classification

Group: TK
Family: Ack

Sequence

Name Sequence Type Origin Length Description Download
TNK1.NA RNA Sugen Kinome 2850 None Fasta, JSON
TNK1.AA Protein Sugen Kinome 666 None Fasta, JSON
TNK1.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of TNK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SAM_Ack TNK1.AA SAM_Ack 5-69 50 1e-26 92.43 In-house 1-65 (65) Show / Hide 
Range on Protein: 5-69
Range on HMM: 1-65/65
Sequence Identity: 50% (33 aa)

AGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSG
 .  ||...||..|| |.|  | ..|.|||..|||.||.|||. |||.||.|||| || |. .  
EECQWLYEFLREAQLEQYYNQIRDHLKVTRLDHFDYVKDEDLECIGMSRPEQRRLWEAYKKMCPH
Sam7 TNK1.AA sam7 5-67 18 1.5e-08 28.29 In-house 1-70 (70) Show / Hide 
Range on Protein: 5-67
Range on HMM: 1-70/70
Sequence Identity: 18% (13 aa)

AGSLWLLKLLRDIQL---AQFYWPILEELN---VTRPEHFDFVKPEDLDGIGMGRPA-QRRLSEALKRLR
    ..   |..|..    |..  .....    ||  .|.. .. |||  .|. ||  .... ......|
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
Kinase TNK1.AA Ack 116-377 52 3.3e-176 591.69 In-house 1-266 (266) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-266/266
Sequence Identity: 52% (139 aa)

VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPL-QMVMELAPLGSLHARLTAPAPT
....|.||.||||||.||.||.|.||...||||.||.. .........||||||..|..|.|||..||.|.||.||. .||.||||.|||. .|.....|
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSD-KMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

PPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASP-RTIKVADFGLVRPLGGARGRYVMGGPR--PIPYAWCAPESLRHGAFSSASDVWMFGV
...|...|| |..|.|..|.||......|||||.||.||.|. |..|..||||.|.||.....|.|...|  ..|.||||||.|||..||.|||||||||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TLWEMFSGGEEPWAGVPPYLILQRLE-DRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLL
|||||||.|||||||...|.|||... ...|||||..|....|.....||..||||||.||.....|
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase TNK1.AA Pkinase_Tyr 116-377 36 7.2e-116 393.04 Pfam 1-270 (270) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-270/270
Sequence Identity: 36% (101 aa)

VCRGELLGSGCFGVVHRGLWT-LPSGKSVPVAVKSLRVGPEGPMGTE--LGDFLREVSVMMNL-EHPHVLRLHGLVL--GQP--LQMVMELAPLGSLHAR
.  |. ||.|.||.|..| |. .|... .|||||.|.   || |  .  . ||.||...|..|  ||...||.| ..  |.|  . .|||..|.|.|.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LTAP-APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRY-VMGGPRPIPYAWCAPESLRHGAFSSASD
| ..  . .|| .  |. . .| | .|.|| .....|||||.|| |.......|..|||| | .    . | ...|  ..|  |.|||....| |...||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VWMFGVTLWEMFSGGEEP-WAGVPPYLILQRL-EDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLL
||.|||..||.|. ||.| ..|.... ..... ||. |.|.|..|.  .|.| ..||.. |.|||.|| .   |
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TNK1.AA TyrKc 116-377 32 1.2e-113 384.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-280/280
Sequence Identity: 32% (95 aa)

VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNL--EHPHVLRLHGLVLG--------QPLQMVMELAPLGSLH
.  |. ||.|.||.|..| |.      ..||||.|. .        . ||.|| ..|..|  .||...||.| ..         .|| .|||..|.|.|.
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

ARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGA-----RGRYVM-----GGPRPIPYAWCAPESL
 .| .. |.  | .. |. |  | |  |.||  ....|||||.|| |.....|.|..|||| | ..       .. | .     ||  ..|. |.|||..
DYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

RHGAFSSASDVWMFGVTLWEMFSGGEEPWAG-----VPPYLILQRLEDRARLPRPPL--------CSRALYSLALRCWAPHPADRPSFSHLEGLL
..| |...||||.|||..||.|. |..|. |     .... ........ |.|.||         |. ..|.. ..||.  |.|||.|| .  ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TNK1.AA TK 116-377 20 1.8e-92 310.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

VCRGELLGSGCFG---VVHRGLWTL----------------------PSGKSVPVAVKSLRVGPEGPMGTELG----------DFLREVSVMMNLE----
.  |. ||.| ||   .|..|.|                        ..|. .||||| |. | .  .  ..           |||.|...|. .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHVLRLHGLVLGQ-------------PLQMVMELAPLGS----LHARLTAPAPTPP------------------------------------------
 ||...||.| .. .             |. .|||..|.|.    |.  | .  |.                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LLVALLCLFLRQLAGAMAYLGAR------GLVHRDLATRNLLLASPRT-----------IKVADFG---
                               | .. |. . .|.| .|.|| ..      ..||||||.|| |...  .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LVRPLGGARGRYVMGGPR-----------------------PIPYAWCAPESLR---------HGAFSSASDVWMFGVTLWEMFSGGEEPWAG-V
     | | ..     |......                        .|  |.|||.|.         .| |...||||.|||..||.|. |.||..| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PP---------YLILQRLED--------------RARLPRPPLCS--------------RALYSLALRCWAPHPADRPSFSHLEGLL
.            ....|..              | |.|.||.|.               ..| | ..||.. |.|||.|| |   |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TNK1.AA UTK 116-377 30 3.9e-74 252.61 In-house 1-296 (296) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-296/296
Sequence Identity: 30% (92 aa)

VCRGELLGSGCFGVVHRGLWTLPS--GKSVPVAVKSLRVGPEGPMGTELGD----FLREVS---VMMNLE-HPHVLRLHGLVL-GQPLQMVMELAPLGSL
| .|..||.| ||.||.. .| .|  .. . |||| ..   .. ...   .    |..|     .|.... ||.|||| |... ..|. .|.|... |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDL

HARLTAPAPTPP-----LLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPR-------TIKVADFG---LVRPLGG--------ARGRYVMGG
 . |   .||||     |    .  . .. | .|.||  .|.|||||| || |... |       ..|.||||   . | ...            | . .
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

PRPIPYAWCAPESLRHG-AFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDR--ARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLL
 ...| .|.|||.| |.  |...|||| |||..||....|  |..|     ........  .|.|.|. |....| | .|||.. |..||.|  |.  .
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TNK1.AA TK-Unique 116-377 32 3e-67 229.71 In-house 1-294 (294) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-294/294
Sequence Identity: 32% (97 aa)

VCRGELLGSGCFGVVHRGLWTLPS---GKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLE-HPHVLRLHGLVL--GQPLQMVMELAPLGSLHARLT
.  |...|.| || |.||  . ..   .| . |||| |.   ..  .|.  |||.| ..|..|  ||..... |     ..| ...|| .| |.|   | 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK---DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

APAPT--PP---------------------LLVALLCLFLRQLAGAMAYLGA--RGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMG-GPR
  .|.  ..                     .   .|  |. |.| .|.||    .. |||||..|| ||..  ..|..|||. | .   .| |.|  .  
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQG

PIPYAWCAPESLR--HGAF-SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLC-SRALYSLALRCWAPHPADRPSFSHLEGLL
.||..|.|||||.  || . .. ||||.|||..||.|. |. |  |.|.  |.....|  |.|.|. | |...|.|  .||   | .||||. .   |
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TNK1.AA EGFR 116-378 35 1.4e-64 213.31 In-house 1-258 (258) Show / Hide 
Range on Protein: 116-378
Range on HMM: 1-258/258
Sequence Identity: 35% (93 aa)

VCRGELLGSGCFGVVHRGLWTLPSGKSV--PVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAP
. ..  |||| || |..|.|  | |..|  |||.| ||   |        ..|.|  ||  ..|||..|| |. ... .|.|  . |.|.|   .     
LKKVKVLGSGAFGTVYKGIW-IPEGENVKIPVAIKVLR---EQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKD

TPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTL
.  .   .| ..  | |  | ||  . .||||||.|| |. ||  .|..|||| . |      | . | . .|  | | |...|. . ..|||| .|||.
N--IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGK-MPIKWMALECIHHRCYTHQSDVWSYGVTC

WEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQ
||.   |..|..|.|   | . ||.  ||| || |.  .| . ..||   .. || |  |   ..
WELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase TNK1.AA FAK 116-382 32 3e-61 203.93 In-house 1-285 (285) Show / Hide 
Range on Protein: 116-382
Range on HMM: 1-285/285
Sequence Identity: 32% (96 aa)

VCRGELLGSGCFGVVHRGLWTLPSG------------------------KSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQP
.  .  .| | || |. | .|.. .                          . ||.|  .   . .  .|   |. |  .| .. |||. .| |..  .|
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCD-DDNKE--KFMQEAYIMKQFDHPHIVKLIGICEEMP

LQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGG-PRPIPYAWC
  ..|||...| | . | .      | .| | |.  ||. |||||  .  |||| | ||.| .||  .| .|||| | .      |         |  | 
IWIIMELCKYGELRHYLQRNKNS--LKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDH--SYYKASPKGKLPIKWM

APESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGP
.|||     | .||||||||| .||  . |  |  .|    .  |.|   ||| ||.|   ||||  ||||  | .|| |  |   |..   
SPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase TNK1.AA Syk 116-371 33 1.1e-56 193.62 In-house 1-257 (257) Show / Hide 
Range on Protein: 116-371
Range on HMM: 1-257/257
Sequence Identity: 33% (89 aa)

VCRGELLGSGCFGVVHRGLWTLP----SGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAP
. ... .|.| || || |          .. ..||.| |.   ..    .   |.|| .||. |.||.. |. |  .. .. ||||.|.||..|  |   
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKA--DHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQH

APTPPLLV-ALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVM--GGPRPIPYAWCAPESLRHGAFSSASDVWM
       . . | |   | |  | ||  .  |||||| || ||      |. |||. . ||     |.   .|  |.   | |||.   . ||..|||| 
RHE--ITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPV--KWYAPECIYYYKFSHKSDVWS

FGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFS
||||.||||| |  | ..     ... .|   |...|..| . .|.|  .||   . ||| |.
FGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase TNK1.AA Src 116-377 34 2e-55 186.74 In-house 1-255 (255) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-255/255
Sequence Identity: 34% (91 aa)

VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQ-PLQMVMELAPLGSLHARLTAPAPT
. . . ||.|.|| |  |.|     ....||||.|. |    | .|  .||.|  .| .| |.....|.  .    |   | |.   ||| . | .   .
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGT---MSPE--AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEG

PPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLW
  | .  |  .  | |  ||||... ..||||| || |       ||||||| | .      |..     .|. | ||| ...| |.  |||| ||. |.
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

EMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYS-LALRCWAPHPADRPSFSHLEGLL
|... |  |  |      ||..|   |.|.|. |   ||  . |.||   | .|| |  |   |
EIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TNK1.AA CTKA 116-377 35 2e-55 184.63 In-house 1-290 (290) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-290/290
Sequence Identity: 35% (106 aa)

VCRGELLGSGCFGVVHRG-LWTLPS------GKSVPVAVKSLRVGPEGPMGTELGD--FLREVSVMM--NLEHPHVLRLHGLVL-GQPLQMVMELAPLGS
 |    .|.| .| | |  |   |        |   ||||.|.       .||     || |. |     ..|| |||| |...  .|. |.||  ..| 
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKD-----HATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGD

LHARLTAPAPTP-----------------PLLVALL--CLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRP
||  |.| .| .                 |. |         .| |  | || ..|.|||||| || || .  .||.||||. | | .    |..   | 
LHCYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRV

IPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDR--ARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLL
.|  | ||| |. | ||.||||| ||| |||..|.|| ||..     . |        ||| |. |   ||..   || . |. ||.|  |   |
MPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase TNK1.AA Eph 116-377 36 2.6e-55 184.17 In-house 1-264 (264) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-264/264
Sequence Identity: 36% (98 aa)

VCRGELLGSGCFGVVHRGLWTLP-SGKSV---PVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLV-LGQPLQMVMELAPLGSLHARLTA
.   . .|.| || | .|   ||   . |   |||.| |..   | .  .  |||.| |.|   .||...|| | |  ..|.  | |   .||| . |  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKA---GYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQ

PAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARG---RYVMGGPRPIPYAWCAPESLRHGAFSSASDVW
      . |. |   || .| .| ||   . |||||| || |. |    ||.|||| | |    .    |   | . ||  | ||| . .. |.||||||
HDG--QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGK-IPIRWTAPEAIAYRKFTSASDVW

MFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLL
 .|. .||  | || |    .   ...  |.  ||| |. | .||. |.| ||.  ...|| |...   |
SYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase TNK1.AA S_TKc 116-377 20 9.9e-41 142.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 116-377
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPL--GSLHARLTAPAP
   ....|.| ||.|... ..        ||.| ..            ...||......  ||.. .|..    . | ||||...   |.|. ..    .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGR

TPP---LLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSS-ASDVWMF
 ..   .     . ...|.. |..|.  .| .||||   |.|| .  .||..|||| | |                  ..||| |    ..  ..|.| .
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEG---------LL
|..|.||.. |. |.    ........            |. . ..  .|.   |..||.   .            .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TNK1.AA Pkinase 116-373 21 6.1e-30 106.96 Pfam 1-287 (293) Show / Hide 
Range on Protein: 116-373
Range on HMM: 1-287/293
Sequence Identity: 21% (65 aa)

VCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTE----LGDFLREVSVMMNLEHPHVLRLHGLVL-GQPLQMVMELAPLG----SLHA
 ..|. .||| ||.| .. .   .||   |||| ...  | .   .    |    .|...| .| ||...||.. .  .. . ||||... |    .|..
YHIGRKIGSGSFGCVYKCHH-KGTGK--IVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

RLTAPAPTPPL--LVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTI----KVADFGLVRP--LGGARGRYVMGGPRPIPYAWCAPESLR-H
....     ..      .. ...|.. ...|. ..| .||||   |.|. .  .|    |..|||| .   .   .  ..  | ..    ..||| .| .
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW----YMAPEVIRGG

GAFSSASDVWMFGVTLWEMFSGGEEPWAGV-------PPYLILQRLEDRARLPRPPLCS-------------------RALYSLALRCWAPHPADRPSFS
   ....|.| .|..|.||.. |. |. |        . ..| .... . . ..| .||                   ... ..  .|... |..||.. 
QYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

HL
..
QI
Kinase TNK1.AA SH3 381-444 31 7e-06 26.79 SMART 1-58 (58) Show / Hide 
Range on Protein: 381-444
Range on HMM: 1-58/58
Sequence Identity: 31% (20 aa)

GPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAVTLAD
.   | .  . ..|. | .. || |||.| .      |.  |||...|| ..| ||.. |.. |
PYVRALYDYQAQNPDELSFKKGDIITVLEKD------DDGWWKGRCNRTGQEGWFPSNYVEEID