Gene TYRO3 (Human)

TYRO3

Species: Human
Alias: DTK, RSE, Brt, SKY, BYK, TIF, Tif, TYRO3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 15q14-q15.1,

Classification

Group: TK
Family: Axl

Sequence

Name Sequence Type Origin Length Description Download
TYRO3.NA RNA Sugen Kinome 3949 None Fasta, JSON
TYRO3.AA Protein Sugen Kinome 890 None Fasta, JSON
TYRO3.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of TYRO3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 TYRO3.AA IGc2 55-124 27 3.6e-17 64.27 SMART 1-56 (56) Show / Hide 
Range on Protein: 55-124
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

SQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGE
 .||.| |.| ..| ..|.|.|.| |  ..             | ..|..|.|...|.|.|.|...    
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG TYRO3.AA IG 49-136 23 5.9e-16 60.24 SMART 1-58 (58) Show / Hide 
Range on Protein: 49-136
Range on HMM: 1-58/58
Sequence Identity: 23% (22 aa)

PVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDA---GRYWCQVEDGGETEIS-QPVWLTVE
|  .||. |..|.|.| |.      |.|                         | . .|...|.   | |.||..  . .  | |...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set TYRO3.AA I-set 43-135 24 1e-09 35.49 Pfam 1-92 (92) Show / Hide 
Range on Protein: 43-135
Range on HMM: 1-92/92
Sequence Identity: 24% (23 aa)

LKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQH-WIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTV
 |    |  ..|. |. ....| |.|  .|...| |||. ... |  .. ... .  . .|  . |...|.| | |...     | .  . |||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP-DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV
V-set TYRO3.AA V-set 52-135 19 4.8e-07 26.11 Pfam 16-128 (128) Show / Hide 
Range on Protein: 52-135
Range on HMM: 16-128/128
Sequence Identity: 19% (22 aa)

LTVSQGQPVKLNCSVE-GM----EEPDIQWVK-DGA-------------VVQNLDQLYIPVSEQ----------HWIGFLSLKSVERSDAGRYWCQVEDG
.||..|| |.|.|..  .      . .|.|..   .             ...| .. | . . .               |.......|| | |.|.| ..
VTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNC

GETEISQPVWLTV
.|    . ..|||
NEDYFGHGTRLTV
IG TYRO3.AA IG 145-222 16 5.4e-07 30.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 145-222
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

PKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQS-----TMFSCEAHNLKGLASS-RTATVHLQ
|. . | .  . .|.| .         .||.              |.. .|. .       . |.|.  .| ..|  ..|.. |
PP-VTVKEGETVTLTC-VS-------QIWWY--------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 TYRO3.AA IGc2 151-210 17 0.004474 4.39 SMART 1-56 (56) Show / Hide 
Range on Protein: 151-210
Range on HMM: 1-56/56
Sequence Identity: 17% (11 aa)

PPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQST--MFSCEAHNLKG
 .  ...| |. .   .  .| | .  ...     . . |... || .   . .|.| | .|
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP----WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set TYRO3.AA I-set 139-169 35 0.154449 7.73 Pfam 1-31 (92) Show / Hide 
Range on Protein: 139-169
Range on HMM: 1-31/92
Sequence Identity: 35% (11 aa)

PFFTVEPKDLAVPPNAPFQLSCEAVGPPEPV
| ||  |||. |       ..|.. | |.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQ
FN3 TYRO3.AA FN3 225-307 17 1.8e-10 42.06 SMART 1-69 (69) Show / Hide 
Range on Protein: 225-307
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PAAPFN---ITVTKLSSS------NASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPA----TNYSLRVRCANA--LGPS
| .| |   ..||  .|.       ... | |         ...                       . ...|.|     |.|. |||. |.   |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TYRO3.AA FN3 323-403 14 0.001861 18.73 SMART 1-69 (69) Show / Hide 
Range on Protein: 323-403
Range on HMM: 1-69/69
Sequence Identity: 14% (14 aa)

ASAPQN---LHAI-RTDS------GLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQ----KDLIVRVCVSNA--VGCG
 ..|.|   |..   |..       . |.|..               ....               . .||  |     .   .|| . |.  .| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------------IVGYR---------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase TYRO3.AA Axl 518-784 76 3.9e-209 701.08 In-house 1-267 (267) Show / Hide 
Range on Protein: 518-784
Range on HMM: 1-267/267
Sequence Identity: 76% (203 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA
|.||.|||.||||||.|.||||||||||||||||.|.||...|.|||||.|||||||||||.|..|.||........|.|.||||||||||||||.|||.
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWA
||.|..||.||||.|..|||||||||||||.|||||||||||||||.|||||||||||||.||||||||||||..|.||||.|.|||||..||..|||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRM
||||||||||||||||.|.||.|.|.|||.|.|||||..||...||||||||.||||.||||. ||.
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase TYRO3.AA Pkinase_Tyr 518-786 42 4.5e-140 475.02 Pfam 1-270 (270) Show / Hide 
Range on Protein: 518-786
Range on HMM: 1-270/270
Sequence Identity: 42% (117 aa)

FTLGRMLGKGEFGSVREAQLK-QEDGSFVKVAVKMLKADIIASSD---IEEFLREAACMKEF-DHPHVAKLVGVSL-RSRAKGRLPIPMVILPFMKHGDL
 |.|..||.|.||.|... .| ..|.  ..|||||||    |...   .|.|.|||. ||.. .||.. .|.|| . ... .     .......|.||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDL

HAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYY-RQGCASKLPVKWLALESLADNLYT
. .| . |  |.. .|....|. . ..||.|||||.|.|.||||||||||...|...| ..||||.| ||. ||| |..  .|||.||.|.|..... .|
LDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

VQSDVWAFGVTMWEIMTRGQTP-YAGIENAEIYNYL-IGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMEL
..||||.|||.||||.|.|..| |.|. |.|.|.|.   |.|...|. | ...|||| ||| .||..||.|. .. .|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TYRO3.AA TyrKc 518-786 39 2.5e-128 433.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 518-786
Range on HMM: 1-280/280
Sequence Identity: 39% (118 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF--DHPHVAKLVGVSLRS--RAKGRL---PIPMVILPFMKHGD
 |||..|| |.|| |.....|      ..|||||||.|      .|.|.|||  |...  .||.. .|.|| . .  .        . .|... .|.|||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGD

LHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-------DYYRQGC--ASK--LPVKWL
|. .| ..|       |....|. |...||||||||.|.|.||||||||||...|. || ..||||||.||..       ||||.     .|  ||..|.
LKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

ALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAG-----IENAEIYNYLIGGNRLKQPPE--------CMEDVYDLMYQCWSADPKQRPSFTCLRMEL
|.|.. .. .| .||||.|||.||||.|.||.|| |     ..|.|...|.  |.|..|||.        | ...|..| ||| .||..||.|. .. ..
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TYRO3.AA TK 518-786 25 1.4e-113 382.32 In-house 1-486 (486) Show / Hide 
Range on Protein: 518-786
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

FTLGRMLGKGEFG---SVREAQLKQED----------------------GSFVKVAVKMLKADIIASSD-IEE-----------FLREAACMKEFD----
 |||. ||.|.||    |.........                      |  ..|||||||..  .|..  ..           ||.||. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHVAKLVGVSLRSRAKGRL------PIPMVILPFMKHGD----LHAFLLASRIGENP-----------------------------------------
 ||.. .|.||..... | ..      . .|... .|.|||    |. .| ..| ....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------FNLPLQTLIRFMVDIACGMEYLSSR------NFIHRDLAARNCMLAEDMT-----------VCVADFG---
                              .|....|. ....||||||||.|.      ||.|||||||||...|...           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRKIYSGDYYRQGC------------------------ASKLPVKWLALESLADNL---------YTVQSDVWAFGVTMWEIMTRGQTPYAG-I
     |.|.|||.|.|.                             |||..|.| |.|.|.          .| .||||.|||.||||.|.||.||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EN---------AEIYNYLIGG--------------NRLKQPPECM--------------EDVYDLMYQCWSADPKQRPSFTCLRMEL
 |         .|...||  |              .|..||| |               |..|||| |||..||..||.|. |. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TYRO3.AA Met 519-780 41 2.1e-113 373.26 In-house 1-271 (271) Show / Hide 
Range on Protein: 519-780
Range on HMM: 1-271/271
Sequence Identity: 41% (116 aa)

TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLK-ADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA
 ... .|.| || |  ... ..||   ..|.| |.   |     |..||||.  ||.||||.| .|.|..|..  .     |.|.||.||||||  |   
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGH----MPWVVLPYMKHGDLKTF---

SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI-YSGDYYRQGCASK---LPVKWLALESLA--------
  |     |.    || |  ..|.||.|. |. |.|||||.||||| |..|| ||||||.|.. |   || |        |||||.|.|.|         
--IRNPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCP

DNL-YTVQSDVWAFGVTMWEIMTRGQTPYAGIEN-AEIYNYLIGG--NRLKQPPECMEDVY-DLMYQCWSADPKQRPSFT
..  .| .|||| ||| ||| |||| .||  . |   |  .| .|  .|| ||. | . .| |.| .||.|.| .||.| 
TYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase TYRO3.AA UTK 518-786 34 1.2e-98 334.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 518-786
Range on HMM: 1-296/296
Sequence Identity: 34% (105 aa)

FTLGRMLGKGEFGSVREAQLKQED--GSFVKVAVKMLKADIIASSDIE---EFLREAA---CMKEFD-HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKH
  ||| ||.|.|| |..| ..|..  .  ..|||| ....  |  . |   .|..||.    || |. ||.|..|||| ...        .|... .|. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP------WMIVTEYMEN

GDLHAFLLASRI--GENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAED-------MTVCVADFG---LSRKIY---------SGDYYR
||| ..|  .|   ...|. | | ... ...|||.||.||.|..|.||||||||| ....       |.. .||||   .|| ..         . .||.
GDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

QGCASKLPVKWLALESLADN-LYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG--NRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRM
.  . ..|..| | |.|...  .| .||||.|||..|||.|.|..||.|. |...   .  |   |...|..| ..||.|| .|| .||  ||.|  |. 
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQ

EL
..
QM
Kinase TYRO3.AA TK-Unique 518-786 33 4.9e-88 298.78 In-house 1-294 (294) Show / Hide 
Range on Protein: 518-786
Range on HMM: 1-294/294
Sequence Identity: 33% (99 aa)

FTLGRMLGKGEFGSVREAQLKQ---EDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD-HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHA
...|. .|.|.|| |  .....   ... ...|||||||..     |  .||.|.. ||| . ||.. ...|.. .|   ..   .| |....  |.|  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDT-DKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EP---WMIIMEYCPCGNLQH

FLLASRIG----------------ENPFN----LPLQTLIRFMVDIACGMEYLSS--RNFIHRDLAARNCMLAEDMTVCVADFGLSRKIY-SGDYYRQGC
.|  .| .                .....    . ...|..|...||||||||.|  ....||||.|||..|.|| .. ..|||..|..|  |.| ... 
YLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCS

ASKLPVKWLALESLA--DNLY-TVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC-MEDVYDLMYQCWSADPKQRPSFTCLRMEL
 ...|..|.|.|||   .. | | .||||.|||.||||.| |..|| |. ...| . .  | |..||..|  ...| ||..||. .|..||||. .. .|
QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TYRO3.AA InsR 518-788 37 7.8e-83 278.04 In-house 1-278 (278) Show / Hide 
Range on Protein: 518-788
Range on HMM: 1-278/278
Sequence Identity: 37% (107 aa)

FTLGRMLGKGEFGSVREA---QLKQEDGSFV-KVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHA
 .|.| .|.| || | |     . .. ..   ..|.| ....  .. .  ||| ||  ||||.. || .| ||  |       |  .|.  .|..|||  
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNEN-ASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQ-----PM-YVVMEMMTYGDLKS

FLLASRIGEN----PFN-----LPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESL
.|.. |  |     . |      .|. ..    .|. || || ...|.|||||.|||| ..| || ..|||. | ||  |||| |  ..||| | | |||
YLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESL

ADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL-IGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELEN
 |  .| .|||| ||| .||. | |  || |  |... .|  ..|| |..|  | | ...|| .||   || ||.|. .   | .
KDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TYRO3.AA HMTK 518-785 36 2.5e-82 279.85 In-house 1-291 (291) Show / Hide 
Range on Protein: 518-785
Range on HMM: 1-291/291
Sequence Identity: 36% (111 aa)

FTLGRMLGKGEFG-----------------SVREAQLK------QEDGSFVK-VAVKMLKADIIASS-DIEEFLREAACMKEFDHPHVAKLVGVSLRSRA
 . .. .| | ||                  |  | ..      ..|.  .. .|||||..|  ||. |.|||||||  | ...||.. .||||.. .| 
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGD--ASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQR-

KGRLPIP-MVILPFMKHGDLHAFLLASRIGENPFNLPLQTL--IRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIY-SGDYYRQ
      | .. | .|. ||| ..| . | .    |..|...  . |.| .| ||.|..|  ..|.|||||||....   | .|||||.|..    ||...
------PWLCVLEYMQYGDLRNVLKTCREK----NIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHL

GCAS-KLPVKWLALESLA--DNLYTVQSDVWAFGVTMWEIMTRGQTPYA--GIENAEIYNYLIGGNRLKQPPE--CMEDVYDLMYQCWSADPKQRPSFTC
  .. |||.||.| | ..  .     .|||||||||||||.. | .||.  .|.| |.  ... |.|| |||.  | .|..|||..|| .|| |||.|  
RKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQ

LRME
|...
LQKM
Kinase TYRO3.AA Src 518-786 38 3.2e-76 258.44 In-house 1-255 (255) Show / Hide 
Range on Protein: 518-786
Range on HMM: 1-255/255
Sequence Identity: 38% (103 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA
..| | ||.| || | ..  ...    .||||| ||..     . | ||.||  ||...|... .|  |  .       ||   .  .|.|| | ..| .
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-----PI-YIVTEYMSHGSLLDYLKK

SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-DYYRQGCASKLPVKWLALESLADNLYTVQSDVW
.. |    .|.|..|| .   .| ||.||.|.|.|||||||||    |.  . |||||| | |  . | |     .|.|.|| | | .  . .|. ||||
DGEGR---HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

AFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYD-LMYQCWSADPKQRPSFTCLRMEL
 ||. ..||.|.|..|| | .|.|    .  | |. .|..| . .|. .| ||| .||.||| |  |.  |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TYRO3.AA Fer 518-787 33 5.3e-76 258.29 In-house 1-283 (283) Show / Hide 
Range on Protein: 518-787
Range on HMM: 1-283/283
Sequence Identity: 33% (97 aa)

FTLGRMLGKGEFGSVREAQ----LKQEDGSFV---KVAVKMLKADIIASSDIEEFLREAACMKE-FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHG
.||| .||.| || |. ..    .| . ...|   .|.||..|..      |.||..||  |.  .|||.| |. ||.       . || |... |...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCV-----DEQPI-MIVMEFCNGG

DLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC---VADFGLSRK--IYSGDYYRQGCASKLPVKWLALESL
.|  .|  .       .... ..||.  ..||||||| |.| ||||.||||| . .| ...   ..|||.||.   |  ||.    | |.|..||| |..
SLDSYLKKNKNK----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETW

ADNLYTVQSDVWAFGVTMWEIMTRGQTPYAG----IENAEI-----YNYLIGGNRLKQPPECMEDVYDLMY-QCWSADPKQRPSFTCLRMELE
 . .|.  .|||.|||..|||.|.|..||.|    . ....      ..  .|.... |... .... .|  ||| .||..||... .. .|.
QTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase TYRO3.AA FGFR 626-786 47 3.7e-69 234.84 In-house 132-293 (293) Show / Hide 
Range on Protein: 626-786
Range on HMM: 132-293/293
Sequence Identity: 47% (77 aa)

NLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEI
||    |...   .| ||||| ||  |||||||||    .|    ..||||.| | . ||||      ||.|| |.|.| |. ||.||||| .|| .|||
NLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

MTRGQTPYAGIE-NAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMEL
|| |..|| .|    |.| ||. | |.  |..| ...| .| ||| . |.|||.|. |  .|
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TYRO3.AA S_TKc 518-789 22 5.6e-43 150.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 518-789
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKH--GDLHAFL
....| .||| ||.|. .. |    .  .||.|..|         | ..|| ...|. .||.. || .|              ... .. .  |||. ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYI

LASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTV-QSD
   . . ..| .|  .  ..|  |.|..||. |...|||||   | .| |  .. ..||||.|..                 ..| | |    |.   .|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCD

VWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRME-----LENI
.|..|....| .. |..|.   . ..... .             ... |.. .|.  ||..||.  .|..|      . .
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase TYRO3.AA Pkinase 518-782 20 2.4e-40 143.71 Pfam 1-287 (293) Show / Hide 
Range on Protein: 518-782
Range on HMM: 1-287/293
Sequence Identity: 20% (63 aa)

FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLR--EAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHG----DL
...|| .|.| ||.|.... | .     .|||| .| . . |.  .. .|  |.. ||...||.. .| ..  .   |...    ...... .|    ||
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY---MVMEYCEGGLYVMDL

HAFLLASRIGENPFNL--PLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTV----CVADFGLSRK--IYSGDYYRQGCASKLPVKWLALES
.... .    ..  ..  . ......|  |..|.||. |...|||||   |... .....    ...||||...  . ..  .   | .     ..| | 
FDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEV

LA-DNLYTVQSDVWAFGVTMWEIMTRGQTPYAGI-----ENAEIYNYLIGGNRLKQPPECM---------------------EDVYDLMYQCWSADPKQR
.  .. |.  .|.|..|....| .. |..|. |       .     ..|.| .|. . .                       |.  |... |.  |||.|
IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PSFTCL
|.....
PTAEQI
Kinase TYRO3.AA FGFR 518-555 47 4.8e-08 23.47 In-house 1-42 (293) Show / Hide 
Range on Protein: 518-555
Range on HMM: 1-42/293
Sequence Identity: 47% (20 aa)

FTLGRMLGKGEFGSVREAQLKQEDGS----FVKVAVKMLKAD
 ||| ||| | || |  |  |  | .     ..|||||||..
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMN