Gene VRK3 (Human)
VRK3
Sequence
Protein domains of VRK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | VRK3.AA | VRK | 166-432 | 43 | 7.80000000001e-178 | 573.51 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 166-432 Range on HMM: 1-284/284 Sequence Identity: 43% (123 aa) WKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYS------------TPLLAIPTCMGFGVHQDK |.|.........|..|.|.|... .|....|....... ....|.||.|..|.||||||.|..||.| .. .|.|.||.|.|||.|... WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEP-PHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFN ---YRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP-EDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSP |||.|.|..||.||........|..|...|||.|||.||.||.|||||||||...|.||.... ....||.|..||.|.||||.|||..|.|..|.. GEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRC HEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLP--NTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYL |.|..||.|||.||||.|||||||..|||||..||||.|||..||. ..|.....||||.|........|..|........||. HNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
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| Kinase | VRK3.AA | CK1 | 209-449 | 19 | 4.9e-54 | 185.85 | In-house | 49-339 (339) | Show / Hide |
Range on Protein: 209-449 Range on HMM: 49-339/339 Sequence Identity: 19% (58 aa) GRLFNEQNFFQRAAKPLQVNKWKK-------LYSTPLLAIPTCMGFGVHQ---DKYRFLVLPSLGRSLQSALDV--SPKHVLSERSVLQVACRLLDALEF |... .. ..|. .|. . .|| | . .......| . .. |. |.|...|.. ||..|.. .. ... .| ...|..|...|.|||. GQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEY LHENEYVHGNVTAENIFVDP--------------EDQSQVTLAGYGFAF-RYCPSGKHV----------AYVEGSR----SPHEG-DLEFISMDLHKGCG .|.. ..| .. ..|. .. .. || . .|.| .|.....|. . . . .. | ... |.. |.|. MHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKE PSRRSDLQSLGYCMLKWLYGF--LPWTNCLPNTE-D---IMKQKQKFVDKPGPFVGPCGHWIRPS-----ETLQKYLKVVMALTYEEKPPYAML ..|| || |..|... || | |||.|. ... . ..|.|..| |.. . . .. . . . . |..|....|.|...|.|.|. QGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | VRK3.AA | CK1-D | 241-390 | 28 | 6.3e-11 | 34.63 | In-house | 57-205 (261) | Show / Hide |
Range on Protein: 241-390 Range on HMM: 57-205/261 Sequence Identity: 28% (43 aa) IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRYCPSG-- ||. .| | | .|. || || .. | . || .| .. .|..| ....| . .| . . . | . .| | || . IPEIRWCGQEGD-YNVMVMDLLGPSLEDLFNYCHRK-FSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTH KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPW .|..| | | . |. |.| ||| || |||| .. . | ||| QHIPYRE--NKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPW |
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| Kinase | VRK3.AA | Ciliate-E6 | 252-315 | 30 | 1.1e-10 | 30.51 | In-house | 22-87 (154) | Show / Hide |
Range on Protein: 252-315 Range on HMM: 22-87/154 Sequence Identity: 30% (20 aa) DKYRFLVLPSLGRSLQSALD-VSPKHVLSER-SVLQVACRLLDALEFLHENEYVHGNVTAENIFVD ..| | |.......|| . .. | . . ....| |. |.| || . ||..| | .|||.| ENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLD |
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| Kinase | VRK3.AA | CK1-A | 241-449 | 25 | 1.9e-09 | 29.39 | In-house | 57-261 (261) | Show / Hide |
Range on Protein: 241-449 Range on HMM: 57-261/261 Sequence Identity: 25% (54 aa) IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRY--CPSG ||. .| .| | .|. || || . .. . . || .| .. .|..|| ..| . .| . . .. | .| | .| . IPHMRWYGCEKD-YNVMVMDLLGPSLEDLFNFCKRR-FTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTR KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMA .|. | | | . |.. | | ||| |. |.||.|. . | ||| .| | | | |.| . |.. . . QHIPYREDKN--LTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGF--PAE-FCMYMNYCRN LTYEEKPPYAML | .||.| | | LRFEEQPDYMYL |
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| Kinase | VRK3.AA | Jak | 279-319 | 34 | 8.7e-08 | 23.67 | In-house | 116-156 (299) | Show / Hide |
Range on Protein: 279-319 Range on HMM: 116-156/299 Sequence Identity: 34% (14 aa) SERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ .| ...|.| .......|... |.||.| | || || |.. TEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGH |
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| Kinase | VRK3.AA | TTBKL | 241-322 | 21 | 3e-06 | 17.36 | In-house | 62-147 (288) | Show / Hide |
Range on Protein: 241-322 Range on HMM: 62-147/288 Sequence Identity: 21% (19 aa) IPTCMGFGVHQDKYRFLVLPSLGRSLQSAL-DVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQ----SQV .|.|.. | ....|.|.|. .|..|| . |...|..... .. ..|.|| .|.. ..| | |. .. .|. ... FPKCHCSG-KRKDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRH |
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| Kinase | VRK3.AA | CK1-Unclassified | 362-397 | 50 | 9e-06 | 13.02 | In-house | 188-223 (244) | Show / Hide |
Range on Protein: 362-397 Range on HMM: 188-223/244 Sequence Identity: 50% (18 aa) HKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT |.| ||| || ||||... | | ||| | .|. HLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANN |
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| S_TKc | VRK3.AA | S_TKc | 152-473 | 9 | 1e-05 | -92.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 152-473
Range on HMM: 1-231/231
Sequence Identity: 9% (34 aa)
LPTGTVL-----------TDKS-GRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLL
. .. ..|. ||. .| .. .| . .. . . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------EHIRREIQILKK----------HHPNIVKLY
AIPTCMGFGVHQDKYRFLVLPSLGR---SLQSALDVSPKHV----LSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFR
. .. ..|. .. .| . .. ..| ..| . ... ...|||..|.. .| . |||..| .. .. |.| .
DVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQ
YCPSGKHVAYVEGSRSPHEGDLEFISMD------LHKGCGPSR-RSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPS
. . . . | | .. ..| |.| .. |.| |. . . ..|.
L-------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------------
ETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQ---DLRVSPYDPIG-------LPMV
... .. .|| . | . . | .
--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | VRK3.AA | Ciliate-C3 | 284-325 | 30 | 1.2e-05 | 16.6 | In-house | 99-140 (140) | Show / Hide |
Range on Protein: 284-325 Range on HMM: 99-140/140 Sequence Identity: 30% (13 aa) LQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA ||.. .| |...||| ||| . .|| . .|. .. LQISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | VRK3.AA | CK1-G | 253-390 | 27 | 4.8e-05 | 12.94 | In-house | 69-208 (266) | Show / Hide |
Range on Protein: 253-390
Range on HMM: 69-208/266
Sequence Identity: 27% (39 aa)
KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD---PEDQSQVTLAGYGFAFRY--CPSGKHVAYVEGSR
|| .|. || || |. . | ..|..|| ... .| .|. . . . | .| . .|| . . .| | | . ..|..| | .
KYNIMVMDLLGPSLEDLFDWCDRK-FSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--H
SPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPW
| . | | | ||| |. .|| . | | |||
KSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPW
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| Kinase | VRK3.AA | CK1-G | 430-449 | 40 | 0.00253 | 7.02 | In-house | 247-266 (266) | Show / Hide |
Range on Protein: 430-449 Range on HMM: 247-266/266 Sequence Identity: 40% (8 aa) KYLKVVMALTYEEKPPYAML .||. | | ..|.| | | TYLRYVRRLDFFECPDYDYL |
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| Kinase | VRK3.AA | TTBKL | 437-453 | 29 | 0.022367 | 3.92 | In-house | 272-288 (288) | Show / Hide |
Range on Protein: 437-453 Range on HMM: 272-288/288 Sequence Identity: 29% (5 aa) ALTYEEKPPYAMLRNNL .|.| . |.| |... . SLRYYDRPDYEMIYECF |
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| Kinase | VRK3.AA | CK1-D | 426-449 | 29 | 0.055039 | 2.6 | In-house | 238-261 (261) | Show / Hide |
Range on Protein: 426-449 Range on HMM: 238-261/261 Sequence Identity: 29% (7 aa) ETLQKYLKVVMALTYEEKPPYAML . |.|. . | ...|| |. | SEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | VRK3.AA | TTBKL | 358-410 | 30 | 0.305701 | 0.03 | In-house | 197-247 (288) | Show / Hide |
Range on Protein: 358-410 Range on HMM: 197-247/288 Sequence Identity: 30% (16 aa) SMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDK |.. | .. .| || |. | . . | ||||| . ....|.. |.. |. SPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTN-MEDKMEIEHMKKNMKDE |
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