DNAPK

Species: Slime mold
Alias: DNAPK, DdisK278, DDB0229336c, PRKDC
External Links: DictyBase Link ,
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: DNAPK

Sequence

Name Sequence Type Origin Length Description Download
DNAPK.AA Protein None 4299 None Fasta, JSON
DNAPK.kin_dom Protein Kinase Domain None 8 None Fasta, JSON

Protein domain

Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT DNAPK.AA HEAT 997-1028 21 2.617302 4.93 Pfam 1-31 (31) Show / Hide
Range on Protein: 997-1028
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

ILPNVVNLAEKSPNRQIKVAAGELLHSVLLMM
||| .... . .|. ... || . | ...  .
ILPHLLKCLN-DPDWEVREAACWCLGQLCEHC

HEAT DNAPK.AA HEAT 1094-1125 21 0.527116 7.34 Pfam 1-31 (31) Show / Hide
Range on Protein: 1094-1125
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

LLNAIVDAVGNPLDGARRDFAGQCLCEFAKWS
.|.... .   | |   |. | .||..... .
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC

HEAT DNAPK.AA HEAT 1144-1174 25 0.004983 14.35 Pfam 1-31 (31) Show / Hide
Range on Protein: 1144-1174
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

ILKRIYSLAHHPDPYKRLGAAISFNQLYRIF
||  . .. ..||.  |. |. .. ||....
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT DNAPK.AA HEAT 1483-1496 42 57.890651 0.27 Pfam 1-14 (31) Show / Hide
Range on Protein: 1483-1496
Range on HMM: 1-14/31
Sequence Identity: 42% (6 aa)

FVQLLVKCLMDPQS
....|.||| || .
ILPHLLKCLNDPDW

NUC194 DNAPK.AA NUC194 1979-2377 37 8.8e-250 840.89 Pfam 1-446 (446) Show / Hide
Range on Protein: 1979-2377
Range on HMM: 1-446/446
Sequence Identity: 37% (169 aa)

DELKITLIDKFCVPLISHMKENILVQIFSQHLSSLMSIIQPLQPKYLSDSQERKSSIIEKICCFHLIEALYQSLPSAIIKE---KINPFFYDKPDG----
.....|..|..|..|..|......||.||.|....|..|.....|||....|....||.|.||...||..|..||...|..   .||...|.....    
NNVRQTMLDRYCCTLLWHCSYDTIVQFFSRHIKDIMDMIMSRFTKYLTNEWEFEHQIIKKMCCYKMIEVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGA

--KGTELTAAIMKAAHSAKSEKL-TSDDKYVTRSLCTKYHGAAFSALASVIVSTQTKENFFHVFFFKENKDKNEYLWENIIDTDQVF---NFQPETNFLV
  .|.|||.|.||..|.|..|.. |.|.......||.|||.||...|...|..|.|...|.|||.|.||..||||.|||.||.|...   .|..|.....
PIEGNELTKALMKSCHDAFTENMPTGDSQLLEKRLCRKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEVPM

SYSTPQSLFANDLR-----------------YLSSQ--YLVDSSLSQDFIAKNFLEGDNNSTTNNNNGDDGIIMQGQSQSGDNENQISND----------
.............|                 |||||  |..||||||......|..|...||.|....|||||||..||.......|..|          
ERKKKYVAIRKEARVQSDQVDAWNSHQDEPKYLSSQLSYMMDSSLSQEMSQFDFSTGVQSSTFNYSSQDDGIIMQKASQHHFRKQEIAEDMSMTQDDVME

IEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFGQQSQQPKPTVGDMPKWMFEIYQKL-QQGVHPNIVIFMIKIIINRPQYFERFHELWIPILMDYV
.|.|..|....|..|...|.|.......||..|||||.|..||||||||||.||....||| .|..|.||..|..|.|||..|.|......||..||...
LEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWFRPYAKFWIGPLMQLI

V----SEGNGGNGLHYFVRDVCFILLKWPNIYKSQDGGGGTTLEKH
|    ..||||.||||.|.|.|...|.|..|...||||||.|...|
VKLIECDGNGGRGLHYMVVDICVTILSWTSIATPQDGGGGNTRDEH

Kinase DNAPK.AA PIKK 3883-4178 32 2.3e-97 329.79 In-house 1-290 (290) Show / Hide
Range on Protein: 3883-4178
Range on HMM: 1-290/290
Sequence Identity: 32% (97 aa)

TISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREILE
 | ..|  | || ...|||.  | | |.  ||.| ||.||||.|||..|||..|| .| .|..| || |. .|| |.||... |.|||.... .|.||. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EQLAHQLKTPRSNVSISKLESTKYHNDWINSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSPESYLFIRNSFARSLA
.  .   .  | .  ..  . |    ||.     |.|    ..  . .|  |.....  . ...| ...| .....  |. ...||...  | ...||.|
QWCQKKHI--RHEQEAQMNYQTCMYRDWLKQMS-YYK---HQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYA

SFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLTTMDVF
. ..  |..|.||||.||..| .  | ...||||..|. |.|.|| ||..||||||... .. |    |..   .  .. .. ...|.|.|...||
VMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase DNAPK.AA DNAPK 4031-4188 39 1.5e-63 217.48 In-house 144-301 (301) Show / Hide
Range on Protein: 4031-4188
Range on HMM: 144-301/301
Sequence Identity: 39% (62 aa)

MFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPE
|.  . ||   .   || .|.|  .... .  .|...| ||  |  |.|. |   .  .. |||||||.||..    |  |.|||||.|| ||||||.||
MYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPE

LMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLTTMDVFVKEPLLDWSK
||||||||.|.  . |.   |..   |   . |.. .. ||. ..|||...|..|| .
LMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN

Kinase DNAPK.AA PI3_PI4_kinase 3912-4188 19 1.5e-60 212.3 Pfam 1-300 (300) Show / Hide
Range on Protein: 3912-4188
Range on HMM: 1-300/300
Sequence Identity: 19% (67 aa)

DYPFLIKGGEDLR--LDQRIQQLF-----------------------GIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREILEEQL-
.|||. |||.|||   |.|. |..                       ..|| ..| | ....|......| ..|. .. |.|||.... ...||. . . 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

--------------------AHQLKTPRSNVSISKLESTKYHNDWINSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSS
                    . .|.                                              | .  .. |.. .|.| . | .  |. . 
KCKHKHFNKEHKMWMKMWPDWWHLM----------------------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNP

SP-ESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLI--SQRDGRLIGIDFGHAFG-TATQFLPIPELMPFRLTR------QFTSFL------RPLDS
.. | ..  |. |.||.|  .| .|..|.||||..|...     .| |..|||||.|. ....... ||..|||.|.      .. . .       |.  
DAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGD

VGLLNHNMTYTLTALQNQKEILLTTM-------DVFVKEPLLDWSK
 |.. . .  .. ||  .........       . .|. .|..|..
YGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS

Kinase DNAPK.AA PI3Kc 3914-4238 20 4.3e-54 186.93 SMART 1-336 (336) Show / Hide
Range on Protein: 3914-4238
Range on HMM: 1-336/336
Sequence Identity: 20% (72 aa)

PFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREIL--EEQLAHQLKTPRSNVSISKLESTKYHNDWI
... |.|.||| |.|..|.|..|| |...|..|..|.| ...| ..|. .| |.||| .....|..|.   .  ... .. .  ..  .|    .     
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEI----Q

NSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSP-ESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRL
 . ..|. ... ..   . | .|.|..   |  |.. ...... |..  |. . .| |..   |. |.||.|  .. .|. ||||||..|...   .| .
-K-NMYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHC

IGIDFGHAFGTATQFLPIP-----ELMPFRLTRQFTSFLR----PLDSVGLLNHNMTYTLTALQNQKEILLTTMDVFVKEPL-LDWSKLATRLVKEQGKH
..|||||.|| . ...| .     |..|||||...         | .  |.    .  ...|.  ... ..... ..|. |.  .|..   .. ... . 
FHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRF

PKD--TKNVWFPKQ----KIQIAKKKLELVNPAYITLEELSGSV
. |  ... ....     .... .. .|  ....... ..    
RLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase DNAPK.AA DNAPK 3881-3981 52 2.3e-49 170.32 In-house 1-101 (301) Show / Hide
Range on Protein: 3881-3981
Range on HMM: 1-101/301
Sequence Identity: 52% (53 aa)

HVTISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREI
|| |  ||  | || |||.|||. | | || . ||..||.||||.|||| ||| .|| |.  | .|  | |.  || ..|||.  | |||.. |  |..|
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI

L
|
L

Kinase DNAPK.AA ATR 4067-4178 28 9e-23 74.06 In-house 157-267 (267) Show / Hide
Range on Protein: 4067-4178
Range on HMM: 157-267/267
Sequence Identity: 28% (32 aa)

PESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQN
|...   |. . || |....  |.||.|||| .| || .  | .. .|.   |.   ||  .||..|||||.     . |. . ||  . .  ..  ...
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

QKEILLTTMDVF
... ..  .| |
HRDDIMSVWDCF

Kinase DNAPK.AA ATR 3882-3983 34 1.4e-21 69.89 In-house 1-102 (267) Show / Hide
Range on Protein: 3882-3983
Range on HMM: 1-102/267
Sequence Identity: 34% (35 aa)

VTISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREIL
  |. ||  | .. ||.|||.. ..| |   |  . |  .||| | | ..   ..| ....|    .| ... || |.|. .. .|||| |.|  || ||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

EE
..
DK

Kinase DNAPK.AA ATM 4074-4186 37 5.3e-20 60.24 In-house 137-248 (304) Show / Hide
Range on Protein: 4074-4186
Range on HMM: 137-248/304
Sequence Identity: 37% (42 aa)

RNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLT
|  . || |  |.  |..|.||||  | ||      |. || | ||    . || || .||||||     .      |        |.  . | .| |||
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLT

TMDVFVKEPLLDW
 ..| . .|| ||
IVEVLLYDPLFDW

Kinase DNAPK.AA FRAP 4060-4188 30 1.9e-18 64.47 In-house 123-251 (251) Show / Hide
Range on Protein: 4060-4188
Range on HMM: 123-251/251
Sequence Identity: 30% (39 aa)

IWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTY
.|  | . | ..  |  . ||||  |.  |..|.||||. | ..    |... ||||  |  | .   .||. ||||||  .  .      |  .     
LWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCEL

TLTALQNQKEILLTTMDVFVKEPLLDWSK
 .  .  .|| ..  .. ||  ||. |  
VMKVIREHKESVMAVLEAFVYDPLFYWRL

Kinase DNAPK.AA FRAP 3912-3970 38 3.2e-17 59.92 In-house 1-59 (251) Show / Hide
Range on Protein: 3912-3970
Range on HMM: 1-59/251
Sequence Identity: 38% (23 aa)

DYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEW
.| ||.|| ||.| | |. ||||..| .|. ..  .|. |... | ..|.  . |.| |
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW

Kinase DNAPK.AA ATM 3916-3988 41 3.4e-17 51.1 In-house 3-77 (304) Show / Hide
Range on Protein: 3916-3988
Range on HMM: 3-77/304
Sequence Identity: 41% (31 aa)

LIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLRE--ILEEQLAHQ
|.|| .||| |  .|| | . | .|.| |   || | . ||.|||.  . |..||   | |  .  |  |  ||.
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHK

Kinase DNAPK.AA SMG1 4052-4115 42 6.4e-13 38.99 In-house 165-228 (242) Show / Hide
Range on Protein: 4052-4115
Range on HMM: 165-228/242
Sequence Identity: 42% (27 aa)

PENLLQNGIWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDF
| |||   .||    |. .  .  |.||| |  |.  |.||.|||||.| ||    |  . ||.
PPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY

Kinase DNAPK.AA SMG1 3891-3977 32 9.3e-12 35.07 In-house 1-87 (242) Show / Hide
Range on Protein: 3891-3977
Range on HMM: 1-87/242
Sequence Identity: 32% (28 aa)

VLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPL
. ..    |||..   | |   ||.| || ||| || || |   |.| .                | | |.  . |.| |     ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL

FATC DNAPK.AA FATC 4267-4295 41 7.8e-10 34.53 Pfam 1-29 (33) Show / Hide
Range on Protein: 4267-4295
Range on HMM: 1-29/33
Sequence Identity: 41% (12 aa)

VCSSVKEQIDCLIDQSTDPNILSRAWVGW
.  || .|.|.||.. |||. |.....||
EPLSVEQQVDRLIQEATDPENLCQMYIGW