Gene MHCK-C (Slime mold)

MHCK-C

Species: Slime mold
Alias: DDB0216199, mhkC, DdisK259, MHCK-C
External Links: DictyBase Link ,
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: MHCK

Sequence

Name Sequence Type Origin Length Description Download
MHCK-C.AA Protein None 780 None Fasta, JSON
MHCK-C.kin_dom Protein Kinase Domain None 8 None Fasta, JSON

Protein domain

Protein domains of MHCK-C.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Alpha_kinase MHCK-C.AA Alpha_kinase 45-235 36 5.5e-103 349.37 SMART 1-255 (255) Show / Hide 
Range on Protein: 45-235
Range on HMM: 1-255/255
Sequence Identity: 36% (94 aa)

KPKWTHSIVCVSI-EKTPFAKGSCRTAHKLKDWS------QPDQGLVGKFSTNKKTTRD---SYFT--------DVLMQTFCAKWAEKFNE---AKP-PK
. |||....||.| |..||||| .|......|||      .... .| |    .  ...   .||.        || ||. | .||..||    ..| ||
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQHNPCPK

PITFLPSYVYELI-------DHPPPYPV---------------CGGEPFIEGDYKKHNNNSGYVSSDARNT------------PQSFSHFSYELSNHELL
 |.|.|.|| ...       |...|| .               .. |||.||...|.|||.|.|....|.|            .|.|||..|| |||..|
KIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQML

IVDIQGV----ND--FYTDPQIHTKS--GEGFGEGNLGETGFHKFLQTHKCNPVC
..|||||    .|  .||||||||..  |.|||.||||..|..||.|||.||..|
VCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Alpha_kinase MHCK-C.AA Alpha_kinase 62-235 36 6.7e-83 286.51 Pfam 1-225 (225) Show / Hide 
Range on Protein: 62-235
Range on HMM: 1-225/225
Sequence Identity: 36% (82 aa)

FAKGSCRTAHKLKDW----SQPDQGLVGKFSTN----KKT-----TRDSYFTDVLMQTFCAKWAEKFNEA-----KPPKPITFLPSY-VYELIDHPP---
||.| .| . ...|.     ...| .| |   .    ...     ..| || |. ||. | .|.||||.      .||.||.|.... ||||.||..   
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHNKPDC

-----------PYPVCGGEPFIEG-DYKKHNNNSGYV-SSDARNTP-----QSFSHFSYELSNHELLIVDIQGVN--D---FYTDPQIHTKSGEG---F-
            ....  ||.||| ...|.|||.|.| ....||.|     |.||||.|. ||......|||||.  .   ..|||||||| |..   | 
YQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYEMDFD

-GEGNLGETGFHKFLQ-THKCNPVC
 | ||||. |..||.| .||||..|
EGMGNLGQEGIEKFFQNQHKCNHIC
Kinase MHCK-C.AA Alpha 111-235 34 5.7e-57 160.57 In-house 73-215 (215) Show / Hide 
Range on Protein: 111-235
Range on HMM: 73-215/215
Sequence Identity: 34% (49 aa)

WAEKFNEAK----PPKPITFLPSYVYELIDHPPPYPVCG-GEPFIEGDYKKHNNNSGYVS-----SDARNTPQSFSHFSYELSNHELLIVDIQ-GVN-DF
|... ....    |  ...|  .| ||||... . . .   |...||.| | |||.|.|.     .... ..| |||.... ||..|..||.| ||  . 
WEQEYTTHFNQMKPQPIKQFVHCYIYELIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWK

YTDPQIHT----KSGEGFGEGNLGETGFHKFLQTH--KCNPVC
.||||||.    . |. || ||.|..|. .|  ||  .||  |
LTDPQIHCPAKLDQGMKFGDGNCGYEGMFRFFYTHHVQCNHYC
Kinase MHCK-C.AA VWL 124-240 38 6.4e-41 119.76 In-house 84-206 (206) Show / Hide 
Range on Protein: 124-240
Range on HMM: 84-206/206
Sequence Identity: 38% (48 aa)

ITFLPSYVYELIDH-PPPYPVCGGEPFIEGDYKKHNNNSGYVSSDARNTP----QSFSHFSYELSNHELLIVDIQGVN-DFYTDPQIHTKSG-EGFGEGN
. |  .|.||...|   ..     | .||||| | |||.|....     .    | ||||.. .|   ..|||.||.     ||||||..   . ||.||
LNFVHCYIYEVTHHYNHNIKYYFVENYIEGDYQKYNNNAGWCNQTDM-EYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGN

LGETGFHKFLQTHKCNPVCDFLKL
||  |. .|  ||.||  |  | |
LGYEGMLRFFMTHQCNKYCQKLQL
Kinase MHCK-C.AA Alpha-Unclassified 147-235 27 8.3e-27 84.33 In-house 111-215 (215) Show / Hide 
Range on Protein: 147-235
Range on HMM: 111-215/215
Sequence Identity: 27% (29 aa)

EPFIEGDYKKHNNNSG------YVSSDARNTPQSFSHFSYELSNHELLIVDIQG-VN------DFYTDPQIHTKSGEGFG--EGNLGETGFHKFLQTH--
|| ..| . | .||.|        .. |    . ..|..|. .|| ....| || |          |||||||.   ...   .| | ..  .. . |  
EPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR-QRYQGFKTNCGMRFIDYWFNNHHV

KCNPVC
.||  |
QCNHYC
Kinase MHCK-C.AA ChaK 175-235 39 1.9e-10 37.55 In-house 154-219 (219) Show / Hide 
Range on Protein: 175-235
Range on HMM: 154-219/219
Sequence Identity: 39% (26 aa)

FSHFSYELSNHELLIVDIQGVNDFYTDPQI-----HTKSGEGFGEGNLGETGFHKFLQTHKCNPVC
|||. ||    |||..|.||| .  ||| .         .  ||  ||||   . |   | ||  |
FSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC
WD40 MHCK-C.AA WD40 502-537 27 0.046023 8.8 SMART 1-46 (46) Show / Hide 
Range on Protein: 502-537
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

SIKNIDTVR------GLQSECITGDS------LRLYSGSNDGQIGVWD
. | . | .      .  . |.  |.       .|.||| ||.| .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 541-580 15 0.000677 13.83 Pfam 19-57 (39) Show / Hide 
Range on Protein: 541-580
Range on HMM: 19-57/39
Sequence Identity: 15% (6 aa)

LKHVTNIKAHGKSIRAVIKRPGFDQNILTAGADSLVKEWD
 | .. . .| ......   |   . ......|. .. ||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-C.AA WD40 540-580 18 0.001147 18.92 SMART 1-46 (46) Show / Hide 
Range on Protein: 540-580
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

ELKHVTNIKAHGK--SIRAVIKRPGF-----DQNILTAGADSLVKEWD
. | |  .|.| .  ....|   |       .. ..... |. .. ||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 600-619 31 9e-06 19.24 Pfam 18-39 (39) Show / Hide 
Range on Protein: 600-619
Range on HMM: 18-39/39
Sequence Identity: 31% (7 aa)

FIQD--NLLYTGCNDKTVKVWD
. .|  ..| .|. |.|...||
WHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-C.AA WD40 583-619 22 1.1e-05 26.14 SMART 1-46 (46) Show / Hide 
Range on Protein: 583-619
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

TQQTIKEIK-ESN--EVNTI-FIQD-------NLLYTGCNDKTVKVWD
| . ....|  ..  .|... . .|       |.|..|. |.|...||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 623-659 30 3.9e-10 31.8 Pfam 1-39 (39) Show / Hide 
Range on Protein: 623-659
Range on HMM: 1-39/39
Sequence Identity: 30% (12 aa)

YECVKTLSGHTRAIKSVCAMGN---LLFSGSNDQQIYVWN
 .|..|. ||| .. ...   .   .|.||| |  | .|.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-C.AA WD40 622-659 31 1.9e-09 38.61 SMART 1-46 (46) Show / Hide 
Range on Protein: 622-659
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

SYECVKTLSGHTR--AIKSVCAMGN--------LLFSGSNDQQIYVWN
. .||.|..|||   .. .||   .        .|.||| | .|..|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 663-699 42 2.7e-11 35.14 Pfam 1-39 (39) Show / Hide 
Range on Protein: 663-699
Range on HMM: 1-39/39
Sequence Identity: 42% (17 aa)

GTILTNFQGHEGWVKTLYAHNN---MLYSGSHDETIRIWD
.. .. | ||..||  .  | .   .| |||.| ||||||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MHCK-C.AA WD40 662-699 39 1e-08 36.18 SMART 1-46 (46) Show / Hide 
Range on Protein: 662-699
Range on HMM: 1-46/46
Sequence Identity: 39% (19 aa)

TGTILTNFQGHEG--WVKTLYAHNN--------MLYSGSHDETIRIWD
| . .  |.||.|  || ..  | .        .|.||| | ||||||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 702-737 20 0.435408 2.64 SMART 1-46 (46) Show / Hide 
Range on Protein: 702-737
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

TTRCVNTIK-CKD--RVETLHVTNQG--------IFAGSGDW-LQVFS
| .|| |.|  ..  .| .. .   |        ...|| |  . ...
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 740-776 14 0.01657 11.6 SMART 1-46 (46) Show / Hide 
Range on Protein: 740-776
Range on HMM: 1-46/46
Sequence Identity: 14% (7 aa)

KYENLASLN-TRS--SILCL-WRNQ-------NQLFTGSLASNLKVWS
. . .....  ..  ...|. |          |.|..||  .....|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MHCK-C.AA WD40 741-776 12 0.08856 7.74 Pfam 1-39 (39) Show / Hide 
Range on Protein: 741-776
Range on HMM: 1-39/39
Sequence Identity: 12% (5 aa)

YENLASLNTR-SSILCLWRNQN---QLFTGSLASNLKVWS
 . ....    ... |.  ...    |..||  .....|.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD