Gene Cdc7 (Slime mold)

Cdc7

Species: Slime mold
Alias: DdisK077, DDB0231210, Cdc7
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: CDC7

Sequence

Name Sequence Type Origin Length Description Download
Cdc7.AA Protein None 1061 None Fasta, JSON
Cdc7.kin_dom Protein Kinase Domain None 426 None Fasta, JSON

Protein domain

Protein domains of Cdc7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdc7.AA CDC7 622-1048 39 5.2e-291 883.32 In-house 1-522 (522) Show / Hide 
Range on Protein: 622-1048
Range on HMM: 1-522/522
Sequence Identity: 39% (209 aa)

YRILEKIGQGTFSGVYKSVCIDGP----------NIG-LIVALKRVAPTSSPARILNEIHSLLRVGGHYNVSALFGALRYKDQVTLILPFFEHDSFKDYF
|....|||.||||.|||..|...|          |.. ...|.|...|||.|.||.||...|.|.|||.||.......||.|.|....|.|.|.||.|..
YKVHDKIGEGTFSSVYKATCQRQPHVNKFASHFWNYCRRKFAIKHHIPTSHPERIMNELQCLTRMGGHHNVMGMCCCFRYNDHVHIVMPYFPHCSFQDFY

FQMS--NENIKHYLYALFDSLRHIHQNNICHRDVKPTNFLYSIKNNSFLLIDFGLAQEMPNSNSNSNSNSNSNSN-----------------------SN
|.|.  .|.||||.|.||..|||.||..|.||||||.||||......|||.||||||.|...|..|.|...|...                       ..
FHMNRDMEEIKHYMYNLFYALRHVHQFGIIHRDVKPSNFLYNRRTKKFLLVDFGLAQHMMDYNECSRSHQQSKMQQERCNQNKYHSISGNKALLRRPPPK

SNSNSNSNSNNNNNNNNNNTNNNFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASS
......||.||...|.|||......|....||.|||..|.|...|.|.|..|||..||.||.|...|||..|||..||.|..|....... ||...||.|
TQDQQHSNKNNVKRNYNNNQHHIKQGKDDKNDHNNFSVMRNVFGNRNFNMHSNNSHNNPNNKNMKQNNNVDNNNRKNNTQKRICSTKAMN-GTMRKNAMS

TSNTTSSSSSSSNKSKNLRNDPKPQPAPRAGTRGFRAPEVLLKYNKQTTAIDIWSVGVILLCMISGRYPFFISPDDMTSLAEIVSIIGTKKIVDIAHLLE
...........|.|..|....||.|.|.||||.||||||||||...|||||||||.|||.|...|||||||..|||||.||.|..|.|...|...||...
CDPQCCCCCYKSDKCCNCCMCPKQQHANRAGTPGFRAPEVLLKCPDQTTAIDIWSCGVIFLSLLSGRYPFFMAPDDMTALAQIMTIFGSEEIIKMAHFFG

KKISISHSIPPTPWRDLSRRLR------------------------------------------------------------SESSCDKQDVPVELYDLL
|||..||..|...||.|.|...                                                            |.........|.|.||||
KKIECSHEFPAQDWRELCRCYWYMDSLPNRTSDIQGHAQHQPAKSKQTDHKASRVQRSQNQHSPDSFYKRDSDECWHCGPICSKHMWKWEEFPDEAYDLL

ERCLDPNPLTRITASEALLHPFL
.|||..|| .||||.|||.|||.
DRCLEMNPHKRITAEEALKHPFF
Kinase Cdc7.AA S_TKc 622-1048 16 4.8e-66 226.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 622-1048
Range on HMM: 1-231/231
Sequence Identity: 16% (75 aa)

YRILEKIGQGTFSGVYKSVCIDGPNIGLIVALKRVAPTSSPARILNEIHSLLRVGGHYNVSALFGALRYKDQVTLILPFFEH--DSFKDYFFQ-------
|.||.|||.|.|. ||| . ..    | |||.|..       .|..||  | .  .| |.  |... .  | . ... . ..   . .||  .       
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MSNENIKHYLYALFDSLRHIHQNNICHRDVKPTNFLYSIKNNSFLLIDFGLAQEMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNFN
  ..   ...|.| ... | ..|...|.|||.|| | | .       ..||||| ..                                           
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------------------------------

GNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDPKPQ
                                                                                                    
----------------------------------------------------------------------------------------------------

PAPRAGTRGFRAPEVLLKYNKQTT-AIDIWSVGVILLCMISGRYPFFISPDDMTSLAEIVSIIGTKKIVDIAHLLEKKISISHSIPPTPWRDLSRRLRSE
     ||. ..|||||    . .. ..|.||.|.||  |..|. ||         ....  .||                                    
-TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG------------------------------------

SSCDKQDVPVELYDLLERCLDPNPLTRITASEALL-------HPFL
        . |. |....||. .|  |.|| |||        ||..
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Cdc7.AA CMGC 622-1048 14 1.1e-54 177.66 In-house 1-513 (513) Show / Hide 
Range on Protein: 622-1048
Range on HMM: 1-513/513
Sequence Identity: 14% (96 aa)

YRILEKIGQGTFSGVYKSVCIDGP-----------NIGLIVALKRVA-PTSSPA-------------RILNEIHSLLRVG----------------GHYN
| |..|||.||.. ||| .. .             . . |||.|..  |   .              |.| ||  | ..                  | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VSALFGALRYKD-----------------QVTLILPFFEHDS---FKDYFF--------QMSNEN------------IKHYL------YALFDSLR--HI
.  |.  ...|.                 .. |.  . .||     |.. |         .|               ||...      | .. .|   ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQNN--ICHRDVKPTNFLYSIKNNSF-------------------LLIDFGLAQEMPNS---------------NSNSNSNSNSNSNSNSNSNSNSNSNN
|...  |.||| || | | . .. ..                    ..|||||    .                |                         
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVN-------------------------

NNNNNNNNTNNNFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSS
                                                                                                    
----------------------------------------------------------------------------------------------------

SNKSKNLRNDPKPQ--PAPRAGTRGFRAPEVLLKYNKQT---------TAIDIWSVGVILLCMISG-------RYPFFI-----------SPDDMTSLAE
       ..| ||.    ..  ||  ||||.|| . . |         |.||.|||| |.  |. |       ..|.|              ..   |..
-------KDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFK

IVSIIG--T---------------KK--------------------------IVDIAHLLEKKISISHSIPPTPWRDLSRRLRSESSCDKQD--------
|. ..|  |               ..                          . . | .  ..      .|| ||..|  ... ..    .         
IFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWI

------------------VPVELYDLLERCLDPNPLTRITASEALLHPFL
                   . .. |||...|  .|  ||||..|| ||..
YEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase Cdc7.AA Ciliate-E2 622-1048 13 3.2e-42 142.74 In-house 1-365 (365) Show / Hide 
Range on Protein: 622-1048
Range on HMM: 1-365/365
Sequence Identity: 13% (75 aa)

YRILEKIGQGTFSGVYKSVCIDGPN--------------------IGLIVALKRVAPTSSPARILNEIHSL---------------LRVGGHYNVSALFG
| ...|||||.|. |||   .  ..                     . |.|.|..   .    |..||| .               |.   | |.  .. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIM-KKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

ALR--YKDQVTLILPFFEHDSFKD-----YFF---------QMSNENIKHYLYALFD---------------SLRHIHQNN-ICHRDVKPTNFLYSIKNN
.     .. . |.. .... . .|     . .         ... . ||.. . ...                |...|..| |.||| || | |.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

SFLLIDFGLAQ----------------EMPNSN-----------SNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNFNGNNSNNDFNNFINMNNS
   .|||||..                .... .                                                                   
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQ-------------------------------------------------------

NSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDPKPQPAPR---------AGTR
                                                                                      .         .|| 
--------------------------------------------------------------------------------------IIQQNMFNTICGTP

GFRAPEVLL--KYNK------QTTAIDIWSVGVILLCMISGRYPFFISPDDMTSLAEIVSIIGTKKIVDIAHLLEKKISI-SHSIPPTPWRDLSRRLRSE
|. |||.|   ||..       ....||||.|||| .|..|..||                             ...|     ..|.  |.. .  .  .
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------------------QQQIKQCKIDFPCPEWQKDTQ-CI-Q

SSC--DKQDVPVELYDLLER----CLDPNPLTRIT-ASEALLHPFL
     ...... |  ||. .    .|. .|  ||| ....| ||..
-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Cdc7.AA Ciliate-E2-Unclassified 622-1048 14 2.8e-39 133.91 In-house 1-352 (352) Show / Hide 
Range on Protein: 622-1048
Range on HMM: 1-352/352
Sequence Identity: 14% (72 aa)

YRILEKIGQGTFSGVYKSVCIDGP-------NIGLIVALKRVAPTSSPARILNEIHSLLRVGGHYNVS-------------------ALFGALRYKDQVT
|.|...|||| |. ||| ....         ..  ..  ..   ..   .|.||.. . .  . |...                    .| . . |. . 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD--EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LILPFFEHDSFKDYFFQMSN--------------------ENIK-----HYLYALFDSLRHIHQNN-ICHRDVKPTNFLYSIKNN--SFLLIDFGLAQ--
... ..|. . ..|  ....                    ...|     .|.. . . | ..|..| |.||| || | |.. ...     .||||..   
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

-EMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNS
 ...|.  ...                                                                                         
QQNNNCD-TNQ-----------------------------------------------------------------------------------------

QEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDPKPQPAPR--------------AGTRGFR----APEVLLK--YNKQT-TAIDIWSVGV
                                                 .              .|| ..     ||||| .  |....  ..||||.||
-------------------------------------------------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGV

ILLCMISGRYPFF--ISPDDMTSLAEIVSIIGTKKIVDIAHLLEKKISISHSIPPTPWRDLSRRLRSESSCDKQDVPVELYDLLE----RCLDPNPLTRI
|| .|. |.|||.   . .. .. ....       . ..  |.....    ..|. ||.            . .... |  |...    ..|. ||  ||
ILYEMLFGYYPFYDNNCEQHQQLITQWI-N-----NAYRKQLYQNIKQKNIQFPKFPWQQ-----------IPKHWSPEAKDFINDLLQKMLKKNPNKRI

TASEALLHPFL
|....| ||..
TFEQILNHPWF
Kinase Cdc7.AA CAMK 627-955 11 7.8e-36 112.43 In-house 267-600 (425) Show / Hide 
Range on Protein: 627-955
Range on HMM: 267-600/425
Sequence Identity: 11% (55 aa)

KIGQGTFSGVYKSVCIDGPNIGLI-----------VALKRVA------------------------------PTSSPARILNEIHSLLRVGG------HY
..|.|.|. |.   ||.  . |..           || | .                                 .. .....||. . .. |      | 
TLGRGSFGKVK--LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP

NVSALFG---------------ALRY-----KDQVTLIL-------------PFFEHDSFKDYF------------FQMSNENIKHYLYALFDSLRHIHQ
|.  |.                  ..     .... ...               |..   . ..            . .. .  ..|   . . ....|.
NIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

NNICHRDVKPTNFLYSIKN----------------NSFLLIDFGLAQEMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNFNGNNSNNDF
.||.||| || | |.. .|                |   .||||.|.... ...| . ... . .   .. .                            
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN-QW---------------------------

NNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDPKPQPAP-----
                                                                                            . |     
--------------------------------------------------------------------------------------------TTPTEGQK

---RAGTRGFRA-PEVLLK-------------YNKQTTAIDIWSVGVILLCMISGRYPF
   . || .. | ||||..                 . ..|.||.||||  | .|..||
MKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase Cdc7.AA GSK 712-1048 15 2e-31 92.81 In-house 112-328 (328) Show / Hide 
Range on Protein: 712-1048
Range on HMM: 112-328/328
Sequence Identity: 15% (58 aa)

QMSNENIKHYLYALFDSLRHIHQNNICHRDVKPTNFLYSIKNNSFLLIDFGLAQ----EMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNN
||.. .|| | | .| .|...|  .|||||.|| | |.  .. .  . ||| |.                                              
QMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNK----------------------------------------

NFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDP
                                                                                                    
----------------------------------------------------------------------------------------------------

KPQPAPRAG--------TRGFRAPEVLLKYNKQTTAIDIWSVGVILLCMISGRYPFFISPDDMTSLAEIVSIIGTKKIVDIAHLLEKKISISHS------
        .        .|  |||| .... . |..||.||.| ..  |. | .|.|   .    | ||. ..||    .|    ...  . .       
--------NEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKG-QPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQ

IPPTPWRD-------------------LSRRLRSESSCDKQDVPVELYDLLERCLDPNPLTRITASEALLHPFL
| |.||.                    . .......         ...||. .||  .|  |... ||..||| 
IKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ--------DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase Cdc7.AA Pkinase 622-776 26 1.2e-26 95.25 Pfam 1-170 (293) Show / Hide 
Range on Protein: 622-776
Range on HMM: 1-170/293
Sequence Identity: 26% (47 aa)

YRILEKIGQGTFSGVYKSVCIDGPNIGLIVALKRVAPTSSPARIL------NEIHSLLRVGGHYNVSALFGALRYKDQVTLILPFFEHD----SFKDYFF
|.|..|||.|.|. ||| . .. .    |||.|..   .     .      .||. ..|. .| |.  |... ..|| . ..... |..    . .||  
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-----QM--SNENIKHYLYALFDSLRHIHQNNICHRDVKPTNFLYSIKNNSF----LLIDFGLAQEM-PNSNSNSNS
      .  | . .|.|.| ..  | ..|...|.|||.|| |.|.. .|.       ..|||||  .   .||  ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTT
Kinase Cdc7.AA Pkinase 914-1048 22 1.2e-26 95.34 Pfam 171-293 (293) Show / Hide 
Range on Protein: 914-1048
Range on HMM: 171-293/293
Sequence Identity: 22% (32 aa)

RAGTRGFRAPEVLLKYNKQTTAIDIWSVGVILLCMISGRYPFFIS---PDDMTSLAEIVSIIGTKKIVDIAHL----LEKKISISHSIPPTPWRDLSRRL
..||....||||...... ....|.||.|.|| .|..|| ||  .   .. .. .. |. | |..   |.  .    ... ...                
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------

RSESSCDKQDVPVELYDLLERCLDPNPLTRITASEALLHPFL
    .     .. |. |....||...|  |.|| ..| ||..
-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Cdc7.AA Ciliate-E2a 712-955 16 1.7e-25 72.04 In-house 95-216 (275) Show / Hide 
Range on Protein: 712-955
Range on HMM: 95-216/275
Sequence Identity: 16% (43 aa)

QMSNE--NIKHYLYALF-DSLRHIHQNNICHRDVKPTNFLYS-IKNNS-----FLLIDFGLAQEM-PNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNN
..  |  .|....  |. . | ..||.|| ||| || |.|.  .. ||       .||||||.   ..                                
RFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD--------------------------------

NNNTNNNFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSK
                                                                                                    
----------------------------------------------------------------------------------------------------

NLRNDPKPQPAPRAGTRGFRAPEVLLKYN--KQ---TTAIDIWSVGVILLCMISGRYPF
      | .  .. || |. |||||      |.   .|  |.||.|||. ....|. ||
-----EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPF
Kinase Cdc7.AA STE 622-956 14 9.6e-24 80.79 In-house 27-295 (359) Show / Hide 
Range on Protein: 622-956
Range on HMM: 27-295/359
Sequence Identity: 14% (60 aa)

YRILEKIGQGTFSGVYKSVCIDGPNI------------GLIVALKRVAPTSSPA-------------------RILNEIHSLLRVGG-HYNVSALFGALR
....||||.|.|  ||| .... .||            | |.| |..   .. .                   .||.||  . .    | |.   .|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YK-------DQVTLILPFFEHDSFKDYFF-----------------QMSNENIKHYLYALFDS-LRHIHQNNICHRDVKPTNFLYSIKNNSFLLIDFGLA
..       |.. ... . .  |. |                     .. . |.......    | ..|...| |||.|| | |         |.|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

QEMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNS
  . .|..|. . | .| . .                                                                               
GQLTDSMANI-Q-S-NN-I-I-------------------------------------------------------------------------------

QEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDP----KPQPAPRAGTRGFRAPEVLLK-----YNKQTTAIDIWSVGVILLCMISGRYPF
                                         |     . .    .||  . ||||...      .. .|  ||||.|  .. |. |..|.
-----------------------------------------DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

F
.
H
Kinase Cdc7.AA CK2 622-764 27 6.6e-23 64.56 In-house 1-143 (288) Show / Hide 
Range on Protein: 622-764
Range on HMM: 1-143/288
Sequence Identity: 27% (40 aa)

YRILEKIGQGTFSGVYKSVCIDGPNIGLIVALKRVAPTSSPARILNEIHSLLRVGGHYNVSALFGALRYKD-QVT-LILPFFEHDSFKDYFFQMSNENIK
| . .||| | .| |.. ..|.  |  . .  | . |     .|  ||  |  . |. |. .|..  . .. .|. |. .. .   |.  . ...  .|.
YEVIRKIGRGKYSEVFEGINIKN-NEKCKIVIKILKPVKK-KKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYDIR

HYLYALFDSLRHIHQNNICHRDVKPTNFLYSIKNNSFLLIDFGLA
.|.. |   |   | . | |||||| | .   ..    ||| |||
YYMFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLA
Kinase Cdc7.AA CK2 914-1048 26 9.8e-22 60.98 In-house 155-288 (288) Show / Hide 
Range on Protein: 914-1048
Range on HMM: 155-288/288
Sequence Identity: 26% (36 aa)

RAGTRGFRAPEVLLKYNKQTTAIDIWSVGVILLCMISGRYPFFISPDDMTSLAEIVSIIGTKKIVDIAHL--LEKKISISHSIPPTPWRDLSRRLRSESS
| ..| ...|| |. |.    ..|.||.|...  ||  . |||   |  . | .|| ..||. ...  .   .. . ...  .     . ..|   .|  
RVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGHDNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQE--

CDKQDVPVELYDLLERCLDPNPLTRITASEALLHPFL
  |. .  |  |.|.. |   .  |||| ||. ||. 
-NKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase Cdc7.AA CDK 622-764 27 5.4e-18 54.0 In-house 257-416 (284) Show / Hide 
Range on Protein: 622-764
Range on HMM: 257-416/284
Sequence Identity: 27% (47 aa)

YRILEKIGQGTFSGVYKSVCID--GPNIGLIVALKRVAPTS---------SPARILNEIHSLLRVGGHYNVSALFGALRYK-----------DQVTLILP
| .|||||.||.  |||  . .  . . | |||||..   .          |   . ||  |     | |.  |.     |             .... .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FFEHD-----SFKDYFFQMSNENIKHYLYALFDSLRHIHQNNICHRDVKPTNFLYSIKNN----SFLLIDFGLA
. .||     .            ||.|.. | . | ..|.|.| ||| || | |.. . .    .  . |||||
YMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA
Kinase Cdc7.AA Ciliate-E2a 1015-1048 38 2.2e-10 26.78 In-house 242-275 (275) Show / Hide 
Range on Protein: 1015-1048
Range on HMM: 242-275/275
Sequence Identity: 38% (13 aa)

QDVPVELYDLLERCLDPNPLTRITASEALLHPFL
.... | .||. . |...|  |||| .|| ||. 
EKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase Cdc7.AA CDK 1023-1048 46 6.6e-09 24.46 In-house 259-284 (284) Show / Hide 
Range on Protein: 1023-1048
Range on HMM: 259-284/284
Sequence Identity: 46% (12 aa)

DLLERCLDPNPLTRITASEALLHPFL
|||...|  .|  ||.|..|| ||..
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Cdc7.AA CAMK 1023-1048 34 3.5e-08 21.71 In-house 400-425 (425) Show / Hide 
Range on Protein: 1023-1048
Range on HMM: 400-425/425
Sequence Identity: 34% (9 aa)

DLLERCLDPNPLTRITASEALLHPFL
||. ..| ..|  |.|....| ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Cdc7.AA TyrKc 622-1048 13 9e-08 -96.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 622-1048
Range on HMM: 1-280/280
Sequence Identity: 13% (60 aa)

YRILEKIGQGTFSGVYKSVCIDGPNIGLIVALKRVAPTSSPARILNEIHSLLRVG-GHYNVSALFGALRYK-------DQVTLILPFFEHDSFKDYFFQM
 . ..|.| | |  ||| . .      . || | . . .  . ...|.  . ..|  | |. .|.|. . .       ... ... . .| . |||    
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SN-ENIKHYLYALFDS---LRHIHQNNICHRDVKPTNFLYSIKNNSFLLIDFGLAQEMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNF
 .  . |. |.  ..     ...|..|. |||    | |.. ..                                                        
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------------------------------------------------

NGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQEEIILPSTNENGTTTSNASSTSNTTSSSSSSSNK------SKNL
                                                                                         |      |...
---------------------------------------------------------------------------------------TVKISDFGLSRDI

RND-----PKPQPAPRA--GTRGFR-----APEVLLKYNKQTTAIDIWSVGVILLCMISGRYPFFISP--DDMTSLAEIVSIIGTKKIVDIAHLLEKKIS
 .|      |    ..   |...       |||.. .|.| ||. |.|| || .  . .   .    .    | | .|..  . . .  .. .  .  .|
YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MS

ISHSIPPTPWRDLSRRLRSESSCDKQDVPVELYDLLERCLDPNPLTRITASEALLHPFL
                     .      | |.|.. ..| . .|  | | ||   | ..
---------------------F---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Cdc7.AA CDK 766-955 5 2.6e-07 19.29 In-house 199-225 (284) Show / Hide 
Range on Protein: 766-955
Range on HMM: 199-225/284
Sequence Identity: 5% (10 aa)

EMPNSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNNNNNTNNNFNGNNSNNDFNNFINMNNSNSNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNNSNNSQ
.                                                                                                   
G---------------------------------------------------------------------------------------------------

EEIILPSTNENGTTTSNASSTSNTTSSSSSSSNKSKNLRNDPKPQPAPRAGTRGFRAPEVLLKYNKQTTAIDIWSVGVILLCMIS---GRYPF
                                                                   .|.||.|||| |.  |.    ... |
-------------------------------------------------------------------GTPIDMWSVGCIFAEMFTDVTRKPLF
Kinase Cdc7.AA STE 1023-1048 42 1e-06 19.62 In-house 332-359 (359) Show / Hide 
Range on Protein: 1023-1048
Range on HMM: 332-359/359
Sequence Identity: 42% (12 aa)

DLLERCLDPNPLTRITASEALL--HPFL
| ...||. .|  | |||. |   |||.
DFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Cdc7.AA GSK 622-656 30 2e-06 15.14 In-house 170-209 (328) Show / Hide 
Range on Protein: 622-656
Range on HMM: 170-209/328
Sequence Identity: 30% (12 aa)

YRILEKIGQGTFSGVYKSVCI-DGPNIGLI----VALKRV
|.. ..||.|.|. ||. . .  . . . |    || |.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKV
Kinase Cdc7.AA Ciliate-E2a 622-638 47 0.000513 7.74 In-house 112-128 (275) Show / Hide 
Range on Protein: 622-638
Range on HMM: 112-128/275
Sequence Identity: 47% (8 aa)

YRILEKIGQGTFSGVYK
|... |||.|.|  ||.
YKFIKKIGKGNFGSVYL