Gene 27697 (Tetrahymena)

27697

Species: Tetrahymena
Alias: 27697, TTHERM_01483630, PreTt27697, 68, 415.m00010
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
27697.AA Protein None 811 None Fasta, JSON
27697.kin_dom Protein Kinase Domain None 190 None Fasta, JSON
27697.kin_dom2 Protein Kinase Domain None 190 None Fasta, JSON
27697.NA RNA None 2436 None Fasta, JSON

Protein domain

Protein domains of 27697.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27697.AA C2 30-148 57 6.5e-72 244.91 In-house 112-245 (245) Show / Hide 
Range on Protein: 30-148
Range on HMM: 112-245/245
Sequence Identity: 57% (77 aa)

NKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD----------LAFASALKNNETRLSISTFKGSQAY----TAP
....||||.||||.||.||..||...|||||.|||||||||||..|||.|.||.||||          ..|||.||.|..|...|.||..|.|    .||
CRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAP

EVYQNVYKKLSDLFS-VGIVLLELDNIATFDISK
|||||.||| ||||| ||.|||||||.....|..
EVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 27697.AA Ciliate-C8 27-135 43 5.9e-54 185.56 In-house 106-238 (238) Show / Hide 
Range on Protein: 27-135
Range on HMM: 106-238/238
Sequence Identity: 43% (58 aa)

LSFNKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD------LAFASALKNNETRLSISTFKGSQAY--------
. . ..|.||||||||||..||..|||..||.|...||||||.|||..|||...|| ||||      ..|||.|..|........|||...|        
FDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGN

---TAPEVYQNVYKKLSDLFS-------VGIVL
   .||||....... ||.||       ||.||
WGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 27697.AA C8 29-135 40 4.1e-37 126.39 In-house 112-226 (226) Show / Hide 
Range on Protein: 29-135
Range on HMM: 112-226/226
Sequence Identity: 40% (47 aa)

FNKQKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNNETRLSISTF--KGSQAYTAPEVYQN------
. ..|. ..|..||||..||..|.| ..| . ..||||||.|||. .||| ... ||||..|||... |.    .  .   | .|| |||. .       
ERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYK

VYKKLSDLFSVGIVL
 |.. |||||||.||
QYRIQSDLFSVGLVL
Kinase 27697.AA CAMK 48-135 22 2.6e-22 68.05 In-house 187-324 (425) Show / Hide 
Range on Protein: 48-135
Range on HMM: 187-324/425
Sequence Identity: 22% (31 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP-------------TLKLCDLAFASALKNNETRL---------------------SISTFKGSQAYT
||.. |...|  ..||||.|| | ||. . ....             ..|..|  ||  .. .|  .                       .|| |. .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVYQNV---------------YKKLSDLFSVGIVL
| ||| .                 | . .|  |.|..|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 27697.AA Pkinase 48-138 32 1.6e-18 66.61 Pfam 116-205 (293) Show / Hide 
Range on Protein: 48-138
Range on HMM: 116-205/293
Sequence Identity: 32% (31 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP--TLKLCDLAFASALKNNETRLSISTFKGSQAYTAPEVYQ--NVYKKLSDLFSVGIVLLEL
|||  ....|.  ..|||.||.|.|..  .||..  ..|.||  .|  .. .      .|| |.  | |||| .  . | . .| .|.|..| |.
QILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 27697.AA STE 44-138 29 2.3e-17 57.98 In-house 155-261 (359) Show / Hide 
Range on Protein: 44-138
Range on HMM: 155-261/359
Sequence Identity: 29% (34 aa)

IMTIQILDS-VAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNN-------------ETRLSIS-TFKGSQAYTAPEVYQN-------V
... |||    ..||.  ..||||||.| ||          ||||  ... | ..             ||. . . || |.. . |||| |.        
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

YKKLSDLFSVGIVLLEL
|   .|  |.|....|.
YDTKCDIWSLGCTIIEM
Kinase 27697.AA ULK 47-135 28 4.5e-16 52.69 In-house 137-246 (329) Show / Hide 
Range on Protein: 47-135
Range on HMM: 137-246/329
Sequence Identity: 28% (31 aa)

IQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFASALKNN--ETRLSISTF-----KGSQAYTAPEVYQ------NVYKKL
.|||    .||   ..||||||.| |.. .| .        |..||..|  ||  . |.  | ..  ..      .|.  | ||.. |      . | . 
KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYK

SDLFSVGIVL
.|..|.|...
CDIWSLGCIF
Kinase 27697.AA Ciliate-E2 31-138 18 2e-15 49.42 In-house 138-289 (365) Show / Hide 
Range on Protein: 31-138
Range on HMM: 138-289/365
Sequence Identity: 18% (30 aa)

KQKNSYPSQQMKEIMTIQILD---------------SVAFLHRFD-VVHRDIKPSNFLLNFDQNGNPTLKLCDLAFAS--ALKNNETRLSISTFK-----
| .  |.. .    .. |||.                . .||    ..||||||.| |.         .|..|. ..     .|....   .  |     
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFK

-----------------------GSQAYTAPEVYQNV----------YKKLSDLFSVGIVLLEL
                       |.  | |||....           | . .|..|.|..| |.
NDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 27697.AA ULK 47-135 28 3.1e-15 50.55 In-house 133-242 (324) Show / Hide 
Range on Protein: 47-135
Range on HMM: 133-242/324
Sequence Identity: 28% (31 aa)

IQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFASALKNNETRLSIS-TFK------GSQAYTAPEVYQ------NVYKKL
.||.    .||   ..||||||.| |.. .| .        |..||..|  ||  . ||.    .  |..      |.  | ||.. |      . | . 
KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYK

SDLFSVGIVL
.|..|.|...
CDIWSLGCIF
Kinase 27697.AA TKL 45-138 19 3.1e-13 44.01 In-house 137-282 (364) Show / Hide 
Range on Protein: 45-138
Range on HMM: 137-282/364
Sequence Identity: 19% (29 aa)

MTIQILDSVAFLHRFD--------VVHRDIKPSNFLLNFDQNGNPT------------LKLCDLAFASALKNNETRLSIST-----------------FK
. ..|   ...||  .        ..|||.|..| |.  |.|...             .|.||. ..  .....    ..|                   
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV--DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQC

GSQAYTAPEV------YQN-----------VYKKLSDLFSVGIVLLEL
|. .. ||||      |..            | . .| .| |||| |.
GTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 27697.AA RSK 48-135 26 7.1e-12 40.04 In-house 112-202 (278) Show / Hide 
Range on Protein: 48-135
Range on HMM: 112-202/278
Sequence Identity: 26% (25 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALKNN-ETRLSISTFKGSQAYTAPEVYQ----NV-YKKLSDLFSVGIVL
.|   | .||  ...|||.||.| |.. .. .. ..||.|  |.  .... . ..   || .. .| |||.      .. . |  |..| |...
EIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWT--MTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLM
Kinase 27697.AA STE 178-200 30 0.00712 6.13 In-house 334-359 (359) Show / Hide 
Range on Protein: 178-200
Range on HMM: 334-359/359
Sequence Identity: 30% (8 aa)

VMQCLKYEVDQRKPAVELLI---QFI
. .||... ..|  | .||     ||
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase 27697.AA C2 297-483 39 8e-107 361.19 In-house 1-245 (245) Show / Hide 
Range on Protein: 297-483
Range on HMM: 1-245/245
Sequence Identity: 39% (97 aa)

GATGLVLGVFNKAQNRYSALKIQRAK------KHEVVREVGIMKDCQ-MPLVIKFYDYFYLNVNNQED------------------------FVVYEIEK
||.||||..||| |||..|||||...      .|||..|.|||..|| ||..||.|.||||.||..||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD----------FDQARKMPYNWLNINGED-VK
|.|||||..|...|||.......|...|||.||.|||||..||||||||..|.||......||||||.|          ||.|.|..||. .|...  ..
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

QYYPIEG----------------ACGTIGYCPPELVRDFLYSFNS
.......                ...|.||...||.....|....
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 27697.AA Ciliate-C8 297-492 33 7.6e-88 298.15 In-house 1-238 (238) Show / Hide 
Range on Protein: 297-492
Range on HMM: 1-238/238
Sequence Identity: 33% (79 aa)

GATGLVLG-------VFNKAQNRYSALKIQRAK-KHEVVREVGIMKDCQMPLVIKFYDYFYLN-VNNQED-----------------FVVYEIEKCS--G
||.|.||.        ... ..| ...|||... .||......||..||||.|...||.|||. .|..||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD------FDQARKMPYNWL-NINGEDVKQYYPIEG
||||......|.........|..||||..|..||||...|.|||||..|.|. ... ..|||||.|      |..|...|.|.   .  . ......||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

A-CGTIGYCPPELVRD------FLYSFNSDIFQVGVCL
. ||..||..||.. .       ..|..||...||..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 27697.AA C8 290-492 30 6.4e-46 157.35 In-house 3-226 (226) Show / Hide 
Range on Protein: 290-492
Range on HMM: 3-226/226
Sequence Identity: 30% (71 aa)

NFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKH-EVVREVGIMKDCQMPLVIKFYDYFYLN-VNNQEDFVVYEIEKCS--------------------
||...| || |.||   |  .||  .||.|  .   .   .  ||| ..||.|.. || .... .  .|...|.| ||||                    
NFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC

-GNLKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYNWLNINGEDVKQYYPIEGACGTI
  ||||.   ............| .||||..| .||.|.. |.|||||..|.|  ..  ....|||.||. | . . |   |   ....       ||| 
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CGTW

GYCPPELVRD-----FLYSFNSDIFQVGVCL
.|  ||   .       |.  ||.|.||. |
AYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 27697.AA CAMK 293-485 17 1.9e-30 94.79 In-house 1-317 (425) Show / Hide 
Range on Protein: 293-485
Range on HMM: 1-317/425
Sequence Identity: 17% (55 aa)

FISVGATGLVLGVFNKAQN------------RYSALKI--------------------------------QRAKKHEVVREVGIMKDCQ-------MPLV
 .  |. | |  ...|  .            .  | ||                                .  ....| ||. ||| .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYDYFYL-----------NVNNQ----EDFVVYEI---EKCSGN------LKQFLNN-----------LKKQNKELDENQKIKIAIQIMDVINYLHIH
||.|...             . ..|    .....      | |||       .     .           .  ... ..| .  ..  || . ..|.| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

DIVHRDIKLENLLYVEQDPEIP-------------TIKLADFDQARKMPYNWLNINGEDVK------------QYYPIEGACGTIGYCP-PELVRDFL--
.|||||.|.||.|... ... .             .||..||  |.|.. .  | . .|.|            .  . .  ||| .|.. ||...     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YSFNSDI
            |.. .|.
NMQNATDEEKPYYGPKCDM
Kinase 27697.AA Ciliate-E2 308-492 21 7.5e-21 68.29 In-house 44-286 (365) Show / Hide 
Range on Protein: 308-492
Range on HMM: 44-286/365
Sequence Identity: 21% (56 aa)

KAQNRYSALKIQRAK-KHEVVREVGIMK----------------DCQMPLVIKFYDYFYLNVNNQEDFVVYEIEKCSG-NLKQFLNNL-KKQNKE-----
|... . |.||.. . . .. .|  ||.                  . | .||.|..|.   ..... . .  | |.| .|.....|  ||.|.|     
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK

-LDENQKIKIAIQIMD---------------VINYLHIHD-IVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYNWLNINGEDVKQYYPIEGA----
 ..|.. ..|  || .                ..|||    |.|||||.||.|.         ||..||  ..|   .  |. .  . ..  ..      
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTS

------------------CGTIGYCPPELVR---------DFLYSFNSDIFQVGVCL
                  ||| || .|| ..            |.. .||. .||.|
RTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 27697.AA Pkinase 327-486 23 1.2e-19 70.58 Pfam 46-196 (293) Show / Hide 
Range on Protein: 327-486
Range on HMM: 46-196/293
Sequence Identity: 23% (41 aa)

VR--EVGIMKDCQMPLVIKFYDYFYLNVNNQEDFVVYEIEKCSG-----NLKQFLNNLKKQNKEL--DENQKIKIAIQIMDVINYLHIHDIVHRDIKLEN
.|  |. ||| .. | ....||.|.      .| .    | | |      |. ..    .... .  .|.. .... ||   ..|.| . |.|||.|.||
RRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN

LLYVEQDPEI-PTIKLADFDQARKMPYNWLNINGEDVKQYYPIEGACGTIGYCPPELVR-DFLYSFNSDIF
.|.. ....| ...|..||  |...              .    . |||..|..||..| .  |.  .|..
ILID-NNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW
S_TKc 27697.AA S_TKc 288-564 21 1.4e-19 72.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 288-564
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

DPNFEFISVGATGLVLGVFNKAQNRYSALKIQRAKKHEVVREVGIMKDCQMPLVIKFYDYFYLNVNNQEDFVVYEIEKCSG---NLKQFLNNLKKQNKE-
    . |  || | |  . .|  .|. |.|| .     . ||. |.|  . | ..|.||.|.       |..    | |.|   .|.... . ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYNWLNINGEDVKQYYPIEGACGTIGYCPPELVRDFLYSF-
 ..| .  ... || . ..|.| | |.|||.| ||.|  |      .||..||  ||..                     |||  |..||..    |.. 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYGKC

NSDIFQVGVCLALIDN----FETLEPVLFKKSLDYLNNFSIPFEVKQHDQQEVVKRNTKIYDILLQTVIFKQHKRVPIPFKSQ-------YKVK
 .|.  .|..|.        |.  . ..||| .                            |.. .   .   ||  .    |           
KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27697.AA STE 291-435 21 2.4e-13 43.61 In-house 1-191 (359) Show / Hide 
Range on Protein: 291-435
Range on HMM: 1-191/359
Sequence Identity: 21% (44 aa)

FEF---ISVGATGLVLGVFNK------AQNRY---------SALKIQR---------------------AKKHEVVREVGIMKDCQ--MPLVIKFYDYFY
.|.   |  ||.| |    |.        ..           | |. .                      .. .. .|. |||.|.   | ..|.|....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LN---VNNQEDFVVYEIEKCS-GNLKQFLNNLKKQNKELD----------ENQKIKIAIQIMDV-INYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLAD
 .    .| ..  ..  | .. | | ..... .. .|.|.          |.| ..|. ||     .||| | |.|||||  | |          .||.|
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

F
|
F
Kinase 27697.AA RSK 400-490 24 2.5e-13 45.42 In-house 117-200 (278) Show / Hide 
Range on Protein: 400-490
Range on HMM: 117-200/278
Sequence Identity: 24% (25 aa)

INYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYNWLNINGEDVKQYYPIE-GA-----CGTIGYCPPELVR----DFLYSFNSDIFQVG
. .|| ..|.|||.|.|| || ... .  .||| ||. ....                ... .      |.|| |..||...    .  .. . |..  |
VEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF----------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

V
|
V
Kinase 27697.AA TKL 368-486 20 4.1e-13 43.56 In-house 123-273 (364) Show / Hide 
Range on Protein: 368-486
Range on HMM: 123-273/364
Sequence Identity: 20% (33 aa)

GN-LKQFLNNLKKQNKELDENQKIKIAIQIMDVINYLHIHD--------IVHRDIKLENLLYVEQ---------DPEIPT-IKLADFDQAR-KMPYNWLN
|. | ...            .|....|..|   .|||| ..        |.|||.| .|.|  |          .| ..  .|..||  .| . . .  |
GSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMN

INGEDVK------QYYPIEG-ACGTIGYCPPELVR----------------DFLYSFNSDIF
 .. ...      ..    .  |||.....||. |                 | ||  .|..
DTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY
Kinase 27697.AA ULK 368-435 32 8.2e-12 37.6 In-house 105-186 (329) Show / Hide 
Range on Protein: 368-435
Range on HMM: 105-186/329
Sequence Identity: 32% (27 aa)

GNLKQFLNNLKK------QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF
|.|.|.... ||       .| | |.. |.. .||.    .|| | |.|||||..| |  . .|         ....|.|||
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF
Kinase 27697.AA ULK 368-435 33 9.6e-12 38.01 In-house 102-182 (324) Show / Hide 
Range on Protein: 368-435
Range on HMM: 102-182/324
Sequence Identity: 33% (27 aa)

GNLKQFLNNLKK-----QNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPE--------IPTIKLADF
|.|.|.... ||      .| | |.. |.. .||.    .|| | |.|||||..|.|  . .|         ....|.|||
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF
Kinase 27697.AA TyrKc 294-565 18 5.6e-07 -109.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 294-565
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

ISVGAT-------GLVLGVFNKAQNRYS----ALKIQRAKKHEVVREVGIMKDC--QMPLVIKFYDYFYLNVNN----QEDFVVYEIEKCSGNLKQFLNN
|. | .         ..|. .     .      ||     . .  ||  ||.    . | ....| .      |    .  ..| |  .  |.||..| .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

LKKQNKELDENQKIKIAIQIMDVINYLHIHDIVHRDIKLENLLYVEQDPEIPTIKLADFDQARKMPYN-WLNINGEDVKQYYPIE---GAC--GTIGYCP
 ...   |   .......|| .  .||| . ..|||.   | |. |.     |.| .||  .|.     .        |.||      |.     |  ..
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMA

PELVRDFLYSFNSDIFQVGVCL-----------AL-----IDNFETLEPVLFKKSLDYLNN-----FSIPFEVKQHDQQEVVKRNTKIYDILLQTVIFKQ
||  ..  ... ||..  |||.                  ..|.| .| |   . ..   |     |              |   ...|.| .|   .. 
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--------------VCCPDEMYQIMKQCWHEDP

HKRVPIPFKSQYKVKL
..|         . ..
EDRPTFSEI---HECF