Gene 13367 (Tetrahymena)
13367
Sequence
Protein domains of 13367.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 13367.AA | C2 | 47-293 | 48 | 8.60000000001e-132 | 444.13 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 47-293 Range on HMM: 1-245/245 Sequence Identity: 48% (125 aa) GAFSFVLKSTNKKTGQIVALKVTECNDNEINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQKNQKNLFFVV |||..|||..|||....||||..||..|.||||.|...||...||..|..||..|.|.|.||.....|||..|||||....| ||.|||.|..|.|. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQEN----IKKQKNEKKIFVVY EQEFCQTNLENFFTQCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD----------LSFASALKNNKSIITVS ||||||.||...|..|| ..||||||.|..|.|||.|||.||||||..||||||||||...|...|||.|.|| ..|||.||.||| |..| EQEFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFS KIV-TQTYNKHLIQLQSNKILKERNLSLFCSRSRKRHLQKRGLVLLELDNMSTFNFND |.. ||.|..|.............|..||. ..|.||||||||....... KFKWTQQYYQHIFAPEVYQNIYKKNSDLFS---------TVGYVLLELDNMQQYTICC |
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Kinase | 13367.AA | Ciliate-C8 | 47-280 | 37 | 3.3e-89 | 302.69 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 47-280 Range on HMM: 1-238/238 Sequence Identity: 37% (94 aa) GAFSFVLKSTNKKTGQIVALKVTEC-NDNEINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQKNQKNLFFV |||..|||..|||....||||..|| |....|.|.....||....||......|||..||.|.||.....|..||..........| .||| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK----------SFFV VEQEFCQTN--LENFFTQCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD------LSFASALKNNKSIITVSK .|.|.||.| |...|..|| |.|||.||.||...|||.||..|||.|. .||||||.|||...|....||.|.|| . |||.|..|||.....| MEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKK IV-TQTYNKHL-------IQLQSNKILKERNLSLFCSRSRKRHLQKRGLVL .. |..|.... . . | ..... .|... ..... |||| FKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKK---SDSYSVGLVL |
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Kinase | 13367.AA | C8 | 38-243 | 32 | 2.6e-40 | 137.6 | In-house | 1-197 (226) | Show / Hide |
Range on Protein: 38-243 Range on HMM: 1-197/226 Sequence Identity: 32% (69 aa) YTDFSYSGNGAFSFVLKSTNKKTGQIVALKVTECNDN-EINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQ .| | .||.. ||| | | . ..||. .| .. .|... .|. ||... |. . .| . .|| . .|. |. ||. | || | FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNE------KIVQTEEKS- KNQKNLFFVVEQEFCQTNLENFFTQCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLSFASALKNNKSIITVS .|| | | |. ||.... ..| |. .. ...|| ..|||.|.. |.| . .||||||.|||. ||.......|.||. |||... ||| | ------CFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSK K---IVTQTY | . |..| KMNTCGTWAY |
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Kinase | 13367.AA | CMGC | 38-223 | 15 | 1.1e-24 | 77.27 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 38-223 Range on HMM: 1-251/513 Sequence Identity: 15% (42 aa) YTDFSYSGNGAFSFVLKSTN--------------KKTGQIVALKVTECNDNEINGMK----------EIEEEYRLLRQFS----------------NCKY |. .. | |... | | .. ..|..|||.| . . ...| . | ..|.... . .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQKNQKNLFFVVEQEFCQTNLENFFTQCR--------LKKSYPC----------QQQKEVM-- ||. ...| ........... | .| . ..|..| |.....| .. ... .. | .. | | IVKLYDIFYHKNSDGNEYEDKHI------------I-SQ-HFNHLYLV--FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIH ---TIQMLDSIA--YLHRFD--LLHRDIKPSNFLLSLDEKEI----------------PTVKICDLSFA . |.| ... |.|. . .|||.||.| |.. . . | ..|||| .| IRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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Kinase | 13367.AA | Ciliate-E1 | 124-243 | 24 | 1.2e-11 | 34.6 | In-house | 52-176 (202) | Show / Hide |
Range on Protein: 124-243 Range on HMM: 52-176/202 Sequence Identity: 24% (32 aa) EGKKNVQKSIKQQKNQKNLFFVVEQEFCQTNLENFFT---------QCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPT ...... . |...| ..|.... .|.|. .|.. .. ||. .. . .|||. ...|..| ...|| . ..||||||.| | . . .. KKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNY-- VKICDLSFASALKNNKSIITVSKIVTQTY ..||.. .. ||||. .. | |. | -VYCDFGISKFLKNNQNQQCQYKGYTHYY |
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Kinase | 13367.AA | CAMK | 180-219 | 26 | 1.4e-11 | 32.87 | In-house | 187-239 (425) | Show / Hide |
Range on Protein: 180-219 Range on HMM: 187-239/425 Sequence Identity: 26% (14 aa) QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIP-------------TVKICD |... ..|.| . |||.|| | ||. .... . ..||.| QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID |
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Kinase | 13367.AA | CAMKL | 180-219 | 37 | 4e-10 | 28.34 | In-house | 135-172 (297) | Show / Hide |
Range on Protein: 180-219 Range on HMM: 135-172/297 Sequence Identity: 37% (15 aa) QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD |... ..|.|. . |||||| | ||. . .. ..||.| QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIID |
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Kinase | 13367.AA | CDKL | 180-234 | 37 | 7.9e-10 | 29.79 | In-house | 106-157 (286) | Show / Hide |
Range on Protein: 180-234 Range on HMM: 106-157/286 Sequence Identity: 37% (21 aa) QMLDSIAYLHRFDLLHRDIKPSNFLLS-LDEKEIPTVKICDLSFASALKNNKSIIT | | .|...| . .|||||| | |.. . .||.|| || |... |.| QILKAINFCHKHNCIHRDIKPENILITPKNG----QVKLCDFGFARMLAKPGEIYT |
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Kinase | 13367.AA | STE | 38-106 | 20 | 1.2e-09 | 30.32 | In-house | 1-100 (359) | Show / Hide |
Range on Protein: 38-106 Range on HMM: 1-100/359 Sequence Identity: 20% (20 aa) YTDFSYSGNGAFSFVLKSTNKK---------------TGQIVALKVTECNDNE---------------INGMKEIEEEYRLLRQFSN-CKYIVQVFNCFF ... . |.||| | | |.| ||.|.| |. . .... .. |..|..| ........ ...||. . |.| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF |
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Kinase | 13367.AA | Pkinase | 180-219 | 41 | 1.5e-09 | 34.82 | Pfam | 116-155 (293) | Show / Hide |
Range on Protein: 180-219 Range on HMM: 116-155/293 Sequence Identity: 41% (17 aa) QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEI-PTVKICD |.| ..|.|. .|||.||.|.|.. .. .| ..||||| QILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICD |
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Kinase | 13367.AA | Ciliate-E2 | 127-223 | 21 | 7.1e-09 | 26.59 | In-house | 92-203 (365) | Show / Hide |
Range on Protein: 127-223 Range on HMM: 92-203/365 Sequence Identity: 21% (26 aa) KNVQKSIKQQK--NQKNLFFVVEQEFCQT-NLENFFTQCRLKK-------SYPCQQQKEVMTIQMLD---------------SIAYLHRFD-LLHRDIKP .|. | . . ...|...| |.|| .|. . ....|. |. .. .. | |. . ||| .|||||| PNIIKMYECFQEKDDNNIYLVM--EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP SNFLLSLDEKEIPTVKICDLSFA .| |. .||.|. .. ENILF---------IKIIDFGLS |
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Kinase | 13367.AA | STE | 176-228 | 35 | 1e-08 | 27.02 | In-house | 155-199 (359) | Show / Hide |
Range on Protein: 176-228 Range on HMM: 155-199/359 Sequence Identity: 35% (19 aa) VMTIQMLDS-IAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLSFASALKN ... | | .|||. ||||||.| || ||.|| ... | . YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTD |
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Kinase | 13367.AA | Ciliate-E1 | 45-109 | 29 | 4.9e-08 | 22.74 | In-house | 2-68 (202) | Show / Hide |
Range on Protein: 45-109 Range on HMM: 2-68/202 Sequence Identity: 29% (20 aa) GNGAFSFVLKSTNKKTG-QIVALKVTECNDN--EINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTE ||| ||.|.| .... . ||.|. .|..| ... .||.|.| .. | . .||.|....... . GNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQ |
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Kinase | 13367.AA | CDKL | 38-92 | 32 | 2e-06 | 18.35 | In-house | 1-55 (286) | Show / Hide |
Range on Protein: 38-92 Range on HMM: 1-55/286 Sequence Identity: 32% (18 aa) YTDFSYSGNGAFSFVLKSTNKKTGQIVALKVTECNDNEINGMKEIEEEYRLLRQF | .. | |. |.| || |||||| | ..... | .. | ..|.|. YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQL |
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Kinase | 13367.AA | CAMK | 45-105 | 12 | 0.000314 | 8.74 | In-house | 3-107 (425) | Show / Hide |
Range on Protein: 45-105 Range on HMM: 3-107/425 Sequence Identity: 12% (13 aa) GNGAFSFVLKSTNKKTG------------QIVALKV----TECNDN----------------------EINGMKEIEEEYRLLRQFS------NCKYIVQ | |.|. | . ..|.|. | || |. ... . . .|... |...... . . . |.. GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK VFNCF . . LYEVY |
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Kinase | 13367.AA | Pkinase | 45-105 | 26 | 0.000721 | 14.76 | Pfam | 8-69 (293) | Show / Hide |
Range on Protein: 45-105 Range on HMM: 8-69/293 Sequence Identity: 26% (17 aa) GNGAFSFVLKSTNKKTGQIVALKVTECNDNEINGMKEIEE--EYRLLRQFSNCKYIVQVFNCF | |.|. | | ..|.||.|||.|. . ... . .. | .... . |...||. . .| GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWF |
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Kinase | 13367.AA | Ciliate-E2 | 45-105 | 16 | 0.030868 | 3.46 | In-house | 8-101 (365) | Show / Hide |
Range on Protein: 45-105 Range on HMM: 8-101/365 Sequence Identity: 16% (16 aa) GNGAFSFVLKSTNKKTGQIVALKVTECND-----------------NEI--NGMKEIEEEYRLLR---------------QFSNCKYIVQVFNCF |.|.|. | | ...|... .|.|. . . . . |. ..|. | ...| .. |...|.. . || GQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECF |
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Kinase | 13367.AA | STE | 324-345 | 36 | 0.254989 | 0.57 | In-house | 335-359 (359) | Show / Hide |
Range on Protein: 324-345 Range on HMM: 335-359/359 Sequence Identity: 36% (9 aa) NQCLNYSVENRKQAIDLLI---QFI |.||.. ..| | .|| || NKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 13367.AA | C2 | 421-597 | 39 | 1e-92 | 314.31 | In-house | 1-232 (245) | Show / Hide |
Range on Protein: 421-597 Range on HMM: 1-232/245 Sequence Identity: 39% (91 aa) GAKGLVLGTFNKTLGIKTVLKIQQVQS-----KHEVVQEVGIMRDCQ-MPLVIKFYGYFYLSVNKKDD------------------------FVVYEIEK ||.||||..|||. .....||||..|| .|||..|.||||.|| ||..||.|.||||.||||.| |||||.|. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CSGNLKQYLTRLQKENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTD----------FDQSRKVPYELYYRDD-ELVK |.||||||..|..|.|.......||..|.|..|..|||....|||||||..|.||...|...|||||.| ||...|..|. .. . .... CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW DYFPVQGI-------------CEIFS-VGVCL .. ..|.| ...|| || .| TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVL |
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Kinase | 13367.AA | Ciliate-C8 | 421-597 | 31 | 4e-70 | 239.27 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 421-597 Range on HMM: 1-238/238 Sequence Identity: 31% (74 aa) GAKGLVLG-------TFNKTLGIKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLS-VNKKDD-----------------FVVYEIEKCS--G ||.|.||. ... .. |.|||..|..||......||..||||.|...|..|||. .|||.| |.|.|.|||. . GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC NLKQYLTRLQKENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTD------FDQSRKVPYELY-YRDDELVKDYFP--- |||||..|..|... .....|..||.|.||.||||... |.|||||..|.|....|...||||| | |......|.. | . . .. . . NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM -------------VQG----ICEIFS-------VGVCL ... ||| ||..| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 13367.AA | C8 | 413-567 | 31 | 1e-35 | 121.47 | In-house | 2-178 (226) | Show / Hide |
Range on Protein: 413-567 Range on HMM: 2-178/226 Sequence Identity: 31% (55 aa) SNFEFISVGAKGLVLGTFNKTLGIKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLS-VNKKDDFVVYEIEKCS------------------- .||...| ||.|.|| . | . |||.|..|.|.. .. ||. ..||.|.. | ... . ......|.| |||| NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL --GNLKQYLTRLQKENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDFDQSRKVP ||||. ..... .....| .||.|.|| |||.. |.|||||..|.| ..|. ...||| ||. . .|. CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVS |
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Kinase | 13367.AA | Ciliate-E1 | 418-548 | 24 | 2.5e-16 | 50.02 | In-house | 1-145 (202) | Show / Hide |
Range on Protein: 418-548 Range on HMM: 1-145/202 Sequence Identity: 24% (35 aa) ISVGAKGLVLGTFNKTLG-IKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYF--YLSVNKKDD--FVVYEIEKCSGNLKQYLT---------RLQ |. | ..|. ... .. .||.... . . ... . . .. .. .|.. | .. . |.|. . . .|.|. .||.||. .| IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ KENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIES .... .|. |||||..|.|| ...| ...| ||||| .|||. . QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ |
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Kinase | 13367.AA | Ciliate-E2 | 440-560 | 23 | 1.4e-15 | 49.96 | In-house | 52-200 (365) | Show / Hide |
Range on Protein: 440-560 Range on HMM: 52-200/365 Sequence Identity: 23% (38 aa) LKIQQVQSKHEVVQEVGIMR----------------DCQMPLVIKFYGYFYLSVNKKDDFVVYEIEKCSG-NLKQYLT--RLQKENI-----VLTDNQKM .||.. . . .. || ||| . | .||.| .|. .|.|. . . | |.| .|..|. .... .. .|... MKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIK QIAVQIID---------------VVNYLNYNG-IVHRDIKLDNILYIESQSDVPTIKLTDF .| ||.. ..|| .. |.|||||..|||. ||..|| YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDF |
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Kinase | 13367.AA | CAMK | 446-567 | 19 | 5.1e-14 | 40.87 | In-house | 73-247 (425) | Show / Hide |
Range on Protein: 446-567 Range on HMM: 73-247/425 Sequence Identity: 19% (35 aa) QSKHEVVQEVGIMRDCQ-------MPLVIKFYGYFYL-----------SVNK-----KDDFVVYE--IEKCSG-NLKQY-LTRLQKE------------- .....| .|. ||. .| | .||.| .. . .| ..... | ||| | .. . .... KDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV -NIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVP-------------TIKLTDFDQSRKVP . .| . .. ||.. |.|. ..|||||.|..|||. .. .| . .||..|| ..|.. ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD |
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S_TKc | 13367.AA | S_TKc | 412-672 | 17 | 1.6e-12 | 6.56 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 412-672 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) DSNFEFISVGAKGLVLGTFNKTLGIKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLSVNKKDDFVVYEIEKCSG---NLKQYLTRLQKEN-- . | || | | .| | . .|| . .|. |.. . | ..|.|..|. |.. | |.| .|..|. . ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR IVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDFDQSRKVPYELYYRDD----------ELVKDYFPVQG-ICEIFSVGV ... . .. ||.. ..|. .||.|||.| .||| | .||..|| .|.. . |.. . . | . |.|. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC CLALLDN----FEKLEPVILKKAQDYFFGFKIPFEQNFNVKEELINRKSQIYDILLQTVVFQPK----NQKLLKGDARKIASEIA .|. . |. . ...|| .. |.. . .. |. ..|... . . ILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 13367.AA | STE | 440-560 | 23 | 8.5e-12 | 38.06 | In-house | 64-191 (359) | Show / Hide |
Range on Protein: 440-560 Range on HMM: 64-191/359 Sequence Identity: 23% (33 aa) LKIQQVQSKHEVVQEVGIMRDCQ--MPLVIKFYGYFYLS---VNKKDDFVVYEIEKCS-GNLKQYLTRLQKENIVLT----------DNQKMQIAVQIID |.. . . . .. .|. ||..|. | ..|.||... . .|. .. | .. | | . . . . . |. .| |..||. LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILK V-VNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDF .|| ..|.||||| .||| .||.|| GLLYYLHSHHIIHRDIKPANILL---------VKLCDF |
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Kinase | 13367.AA | CAMKL | 520-560 | 51 | 1.7e-11 | 32.78 | In-house | 135-173 (297) | Show / Hide |
Range on Protein: 520-560 Range on HMM: 135-173/297 Sequence Identity: 51% (21 aa) QIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDF ||.. |||. .||||||||..||| |... .||..|| QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDF |
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Kinase | 13367.AA | CMGC | 489-560 | 17 | 1.3e-09 | 26.8 | In-house | 135-248 (513) | Show / Hide |
Range on Protein: 489-560 Range on HMM: 135-248/513 Sequence Identity: 17% (20 aa) EKCSGNLKQYLTRLQK-----ENIVLTDNQ------------KMQIA------VQIIDVVN--YLNYNG--IVHRDIKLDNILYIESQSDV--------- | . .|.||. . |. .. |.. . . . ||. .. |. .. |.|||.| ||| . . EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSED -------PTIKLTDF ..|. || WNPCQKNGRLKICDF |
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Kinase | 13367.AA | Pkinase | 453-572 | 20 | 6.2e-09 | 32.66 | Pfam | 49-169 (293) | Show / Hide |
Range on Protein: 453-572 Range on HMM: 49-169/293 Sequence Identity: 20% (27 aa) QEVGIMRDCQMPLVIKFYGYFYLSVNKKDDFVVYEIEKCSG-----NLKQYLTRLQKENIVL--TDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILY .|. ||. .. | ....|..|. .| . | | | |. |... ... .. .... .. ||. ..|. .||.|||.|..|||. SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI IESQSDV-PTIKLTDFDQSR---KVPYELYY .. .. ...|..|| .. ... .. D-NNGHIDACVKICDFGLAKQFDY-NNS-MT |
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Kinase | 13367.AA | TyrKc | 428-646 | 17 | 5.8e-07 | -110.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 428-646 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) GTFNKTLG-----------------IKTVLKIQQVQSKHEVVQEVGIMRDC--QMPLVIKFYGYFYLS----VNKKDDFVVYEIEKCSGNLKQYLTRLQK |..|.|| .|.. . . . .| ||. . | ....||. . . . ..| | . |.||.|| . .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP ENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDFDQSRKVPYE-------LYYRDDE--LVKDYFPV---------QG . |. .. ....|| . .|| ....|||. |.|. | . |.| .|| ||.. . ||| | |. .|. | K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG IC--------------EIFSVGVCLALL-----DNFEKLEPVILKKAQDYFFGFKIPFEQN-------------FNVKEELINR-------KSQIYDIL .. |||. | . . . . . |. | .| ... .. .. |.|.... KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-------GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 13367.AA | CDKL | 509-560 | 30 | 2.2e-05 | 14.38 | In-house | 95-143 (286) | Show / Hide |
Range on Protein: 509-560 Range on HMM: 95-143/286 Sequence Identity: 30% (16 aa) LTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDF . ... ... ||. .|... . ..||||| ||| | .... .|| || VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENIL-ITPKNGQ--VKLCDF |