Gene 13367 (Tetrahymena)

13367

Species: Tetrahymena
Alias: PreTt13367, 38.m00202, TTHERM_00361520, 265, 13367
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
13367.NA RNA None 2865 None Fasta, JSON
13367.AA Protein None 954 None Fasta, JSON
13367.kin_dom Protein Kinase Domain None 139 None Fasta, JSON
13367.kin_dom2 Protein Kinase Domain None 139 None Fasta, JSON

Protein domain

Protein domains of 13367.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13367.AA C2 47-293 48 8.60000000001e-132 444.13 In-house 1-245 (245) Show / Hide 
Range on Protein: 47-293
Range on HMM: 1-245/245
Sequence Identity: 48% (125 aa)

GAFSFVLKSTNKKTGQIVALKVTECNDNEINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQKNQKNLFFVV
|||..|||..|||....||||..||..|.||||.|...||...||..|..||..|.|.|.||.....|||..|||||....|    ||.|||.|..|.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQEN----IKKQKNEKKIFVVY

EQEFCQTNLENFFTQCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD----------LSFASALKNNKSIITVS
||||||.||...|..|| ..||||||.|..|.|||.|||.||||||..||||||||||...|...|||.|.||          ..|||.||.||| |..|
EQEFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFS

KIV-TQTYNKHLIQLQSNKILKERNLSLFCSRSRKRHLQKRGLVLLELDNMSTFNFND
|.. ||.|..|.............|..||.         ..|.||||||||.......
KFKWTQQYYQHIFAPEVYQNIYKKNSDLFS---------TVGYVLLELDNMQQYTICC
Kinase 13367.AA Ciliate-C8 47-280 37 3.3e-89 302.69 In-house 1-238 (238) Show / Hide 
Range on Protein: 47-280
Range on HMM: 1-238/238
Sequence Identity: 37% (94 aa)

GAFSFVLKSTNKKTGQIVALKVTEC-NDNEINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQKNQKNLFFV
|||..|||..|||....||||..|| |....|.|.....||....||......|||..||.|.||.....|..||..........|          .|||
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK----------SFFV

VEQEFCQTN--LENFFTQCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD------LSFASALKNNKSIITVSK
.|.|.||.|  |...|..|| |.|||.||.||...|||.||..|||.|. .||||||.|||...|....||.|.||      . |||.|..|||.....|
MEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKK

IV-TQTYNKHL-------IQLQSNKILKERNLSLFCSRSRKRHLQKRGLVL
.. |..|....       .  .  |  ..... .|...   ..... ||||
FKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKK---SDSYSVGLVL
Kinase 13367.AA C8 38-243 32 2.6e-40 137.6 In-house 1-197 (226) Show / Hide 
Range on Protein: 38-243
Range on HMM: 1-197/226
Sequence Identity: 32% (69 aa)

YTDFSYSGNGAFSFVLKSTNKKTGQIVALKVTECNDN-EINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQ
  .| |  .||.. |||  | |  . ..||. .| .. .|... .|. ||...  |.  . .| . .|| . .|.   |. ||.      | ||   |  
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNE------KIVQTEEKS-

KNQKNLFFVVEQEFCQTNLENFFTQCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLSFASALKNNKSIITVS
      .|| | | |. ||.... ..| |. .. ...|| ..|||.|.. |.| .  .||||||.|||. ||.......|.||. |||... ||| |   
------CFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSK

K---IVTQTY
|   . |..|
KMNTCGTWAY
Kinase 13367.AA CMGC 38-223 15 1.1e-24 77.27 In-house 1-251 (513) Show / Hide 
Range on Protein: 38-223
Range on HMM: 1-251/513
Sequence Identity: 15% (42 aa)

YTDFSYSGNGAFSFVLKSTN--------------KKTGQIVALKVTECNDNEINGMK----------EIEEEYRLLRQFS----------------NCKY
|.  .. | |... | | ..              ..|..|||.|    .  . ...|           .  | ..|....                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQVFNCFFLTEEESSDEDSSNDEEEEGKKNVQKSIKQQKNQKNLFFVVEQEFCQTNLENFFTQCR--------LKKSYPC----------QQQKEVM--
||. ...|   ...........             | .| . ..|..|   |.....| ..  ...        .. |             .. |  |  
IVKLYDIFYHKNSDGNEYEDKHI------------I-SQ-HFNHLYLV--FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIH

---TIQMLDSIA--YLHRFD--LLHRDIKPSNFLLSLDEKEI----------------PTVKICDLSFA
   . |.| ...  |.|. .   .|||.||.| |.. . . |                 ..||||  .|
IRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 13367.AA Ciliate-E1 124-243 24 1.2e-11 34.6 In-house 52-176 (202) Show / Hide 
Range on Protein: 124-243
Range on HMM: 52-176/202
Sequence Identity: 24% (32 aa)

EGKKNVQKSIKQQKNQKNLFFVVEQEFCQTNLENFFT---------QCRLKKSYPCQQQKEVMTIQMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPT
...... . |...| ..|....  .|.|. .|.. ..         ||. .. .  .|||. ...|..| ...|| . ..||||||.| | . . ..   
KKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNY--

VKICDLSFASALKNNKSIITVSKIVTQTY
 ..||.. .. ||||.   .. |  |. |
-VYCDFGISKFLKNNQNQQCQYKGYTHYY
Kinase 13367.AA CAMK 180-219 26 1.4e-11 32.87 In-house 187-239 (425) Show / Hide 
Range on Protein: 180-219
Range on HMM: 187-239/425
Sequence Identity: 26% (14 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIP-------------TVKICD
|... ..|.|  .  |||.|| | ||. .... .             ..||.|
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID
Kinase 13367.AA CAMKL 180-219 37 4e-10 28.34 In-house 135-172 (297) Show / Hide 
Range on Protein: 180-219
Range on HMM: 135-172/297
Sequence Identity: 37% (15 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICD
|... ..|.|. .  |||||| | ||. . ..  ..||.|
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIID
Kinase 13367.AA CDKL 180-234 37 7.9e-10 29.79 In-house 106-157 (286) Show / Hide 
Range on Protein: 180-234
Range on HMM: 106-157/286
Sequence Identity: 37% (21 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLS-LDEKEIPTVKICDLSFASALKNNKSIIT
| | .|...|  . .|||||| | |..  .     .||.||  ||  |...  |.|
QILKAINFCHKHNCIHRDIKPENILITPKNG----QVKLCDFGFARMLAKPGEIYT
Kinase 13367.AA STE 38-106 20 1.2e-09 30.32 In-house 1-100 (359) Show / Hide 
Range on Protein: 38-106
Range on HMM: 1-100/359
Sequence Identity: 20% (20 aa)

YTDFSYSGNGAFSFVLKSTNKK---------------TGQIVALKVTECNDNE---------------INGMKEIEEEYRLLRQFSN-CKYIVQVFNCFF
... .  |.|||  | |  |.|               ||.|.| |. . ....               .. |..|..| ........ ...||. . |.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase 13367.AA Pkinase 180-219 41 1.5e-09 34.82 Pfam 116-155 (293) Show / Hide 
Range on Protein: 180-219
Range on HMM: 116-155/293
Sequence Identity: 41% (17 aa)

QMLDSIAYLHRFDLLHRDIKPSNFLLSLDEKEI-PTVKICD
|.|  ..|.|.   .|||.||.|.|.. .. .| ..|||||
QILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICD
Kinase 13367.AA Ciliate-E2 127-223 21 7.1e-09 26.59 In-house 92-203 (365) Show / Hide 
Range on Protein: 127-223
Range on HMM: 92-203/365
Sequence Identity: 21% (26 aa)

KNVQKSIKQQK--NQKNLFFVVEQEFCQT-NLENFFTQCRLKK-------SYPCQQQKEVMTIQMLD---------------SIAYLHRFD-LLHRDIKP
.|. | .   .  ...|...|   |.||  .|. .  ....|.        |.  ..   .. | |.                . |||     .||||||
PNIIKMYECFQEKDDNNIYLVM--EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

SNFLLSLDEKEIPTVKICDLSFA
.| |.         .||.|. ..
ENILF---------IKIIDFGLS
Kinase 13367.AA STE 176-228 35 1e-08 27.02 In-house 155-199 (359) Show / Hide 
Range on Protein: 176-228
Range on HMM: 155-199/359
Sequence Identity: 35% (19 aa)

VMTIQMLDS-IAYLHRFDLLHRDIKPSNFLLSLDEKEIPTVKICDLSFASALKN
... | |    .|||.    ||||||.| ||         ||.||  ... | .
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTD
Kinase 13367.AA Ciliate-E1 45-109 29 4.9e-08 22.74 In-house 2-68 (202) Show / Hide 
Range on Protein: 45-109
Range on HMM: 2-68/202
Sequence Identity: 29% (20 aa)

GNGAFSFVLKSTNKKTG-QIVALKVTECNDN--EINGMKEIEEEYRLLRQFSNCKYIVQVFNCFFLTE
||| ||.|.|  ....  . ||.|. .|..|  ...  .||.|.| ..  | . .||.|....... .
GNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQ
Kinase 13367.AA CDKL 38-92 32 2e-06 18.35 In-house 1-55 (286) Show / Hide 
Range on Protein: 38-92
Range on HMM: 1-55/286
Sequence Identity: 32% (18 aa)

YTDFSYSGNGAFSFVLKSTNKKTGQIVALKVTECNDNEINGMKEIEEEYRLLRQF
|  ..  | |.   |.|  || |||||| |   .....    | .. | ..|.|.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQL
Kinase 13367.AA CAMK 45-105 12 0.000314 8.74 In-house 3-107 (425) Show / Hide 
Range on Protein: 45-105
Range on HMM: 3-107/425
Sequence Identity: 12% (13 aa)

GNGAFSFVLKSTNKKTG------------QIVALKV----TECNDN----------------------EINGMKEIEEEYRLLRQFS------NCKYIVQ
| |.|. | . ..|.|.            | || |.       ...                      . . .|... |...... .      . . |..
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VFNCF
 .  .
LYEVY
Kinase 13367.AA Pkinase 45-105 26 0.000721 14.76 Pfam 8-69 (293) Show / Hide 
Range on Protein: 45-105
Range on HMM: 8-69/293
Sequence Identity: 26% (17 aa)

GNGAFSFVLKSTNKKTGQIVALKVTECNDNEINGMKEIEE--EYRLLRQFSNCKYIVQVFNCF
| |.|. | | ..|.||.|||.|. .  ... .  ..     | .... . |...||. . .|
GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWF
Kinase 13367.AA Ciliate-E2 45-105 16 0.030868 3.46 In-house 8-101 (365) Show / Hide 
Range on Protein: 45-105
Range on HMM: 8-101/365
Sequence Identity: 16% (16 aa)

GNGAFSFVLKSTNKKTGQIVALKVTECND-----------------NEI--NGMKEIEEEYRLLR---------------QFSNCKYIVQVFNCF
|.|.|. | | ...|... .|.|. . .                  . .  |. ..|. | ...|               .. |...|.. . ||
GQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECF
Kinase 13367.AA STE 324-345 36 0.254989 0.57 In-house 335-359 (359) Show / Hide 
Range on Protein: 324-345
Range on HMM: 335-359/359
Sequence Identity: 36% (9 aa)

NQCLNYSVENRKQAIDLLI---QFI
|.||..  ..|  | .||     ||
NKCLQKDPNKRPTASQLLKSEHPFI
Kinase 13367.AA C2 421-597 39 1e-92 314.31 In-house 1-232 (245) Show / Hide 
Range on Protein: 421-597
Range on HMM: 1-232/245
Sequence Identity: 39% (91 aa)

GAKGLVLGTFNKTLGIKTVLKIQQVQS-----KHEVVQEVGIMRDCQ-MPLVIKFYGYFYLSVNKKDD------------------------FVVYEIEK
||.||||..|||. .....||||..||     .|||..|.||||.|| ||..||.|.||||.||||.|                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYLTRLQKENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTD----------FDQSRKVPYELYYRDD-ELVK
|.||||||..|..|.|.......||..|.|..|..|||....|||||||..|.||...|...|||||.|          ||...|..|. ..  . ....
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

DYFPVQGI-------------CEIFS-VGVCL
.. ..|.|             ...|| || .|
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVL
Kinase 13367.AA Ciliate-C8 421-597 31 4e-70 239.27 In-house 1-238 (238) Show / Hide 
Range on Protein: 421-597
Range on HMM: 1-238/238
Sequence Identity: 31% (74 aa)

GAKGLVLG-------TFNKTLGIKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLS-VNKKDD-----------------FVVYEIEKCS--G
||.|.||.        ...   .. |.|||..|..||......||..||||.|...|..|||. .|||.|                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYLTRLQKENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTD------FDQSRKVPYELY-YRDDELVKDYFP---
|||||..|..|... .....|..||.|.||.||||... |.|||||..|.|....|...||||| |      |......|..   | . . .. . .   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

-------------VQG----ICEIFS-------VGVCL
             ...       |||       ||..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13367.AA C8 413-567 31 1e-35 121.47 In-house 2-178 (226) Show / Hide 
Range on Protein: 413-567
Range on HMM: 2-178/226
Sequence Identity: 31% (55 aa)

SNFEFISVGAKGLVLGTFNKTLGIKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLS-VNKKDDFVVYEIEKCS-------------------
.||...| ||.|.|| . |     . |||.|..|.|..  ..  ||. ..||.|.. |  ...  . ......|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYLTRLQKENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDFDQSRKVP
   ||||.   .....  .....| .||.|.|| |||..   |.|||||..|.|  ..|. ...||| ||. . .|.
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVS
Kinase 13367.AA Ciliate-E1 418-548 24 2.5e-16 50.02 In-house 1-145 (202) Show / Hide 
Range on Protein: 418-548
Range on HMM: 1-145/202
Sequence Identity: 24% (35 aa)

ISVGAKGLVLGTFNKTLG-IKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYF--YLSVNKKDD--FVVYEIEKCSGNLKQYLT---------RLQ
|. |  ..|.  ...    ..  .||.... . . ...  . . .. .. .|.. |   .. . |.|.  . .  .|.|. .||.||.          .|
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIES
.... .|. |||||..|.|| ...| ...| ||||| .|||.  .
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ
Kinase 13367.AA Ciliate-E2 440-560 23 1.4e-15 49.96 In-house 52-200 (365) Show / Hide 
Range on Protein: 440-560
Range on HMM: 52-200/365
Sequence Identity: 23% (38 aa)

LKIQQVQSKHEVVQEVGIMR----------------DCQMPLVIKFYGYFYLSVNKKDDFVVYEIEKCSG-NLKQYLT--RLQKENI-----VLTDNQKM
.||.. . . .. ||  |||                  . | .||.| .|.   .|.|. . .  | |.| .|..|.   .... ..      .|...  
MKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIK

QIAVQIID---------------VVNYLNYNG-IVHRDIKLDNILYIESQSDVPTIKLTDF
.|  ||..                ..||  .. |.|||||..|||.         ||..||
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDF
Kinase 13367.AA CAMK 446-567 19 5.1e-14 40.87 In-house 73-247 (425) Show / Hide 
Range on Protein: 446-567
Range on HMM: 73-247/425
Sequence Identity: 19% (35 aa)

QSKHEVVQEVGIMRDCQ-------MPLVIKFYGYFYL-----------SVNK-----KDDFVVYE--IEKCSG-NLKQY-LTRLQKE-------------
.....| .|. ||. .|        | .||.| ..             . .|     .....      | |||  | .. . ....              
KDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV

-NIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVP-------------TIKLTDFDQSRKVP
 .  .|  .  ..  ||.. |.|.  ..|||||.|..|||. .. .| .             .||..||  ..|..
ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
S_TKc 13367.AA S_TKc 412-672 17 1.6e-12 6.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 412-672
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

DSNFEFISVGAKGLVLGTFNKTLGIKTVLKIQQVQSKHEVVQEVGIMRDCQMPLVIKFYGYFYLSVNKKDDFVVYEIEKCSG---NLKQYLTRLQKEN--
    . |  || | |    .|  | .  .||        . .|. |..  . | ..|.|..|.       |..    | |.|   .|..|. . ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDFDQSRKVPYELYYRDD----------ELVKDYFPVQG-ICEIFSVGV
 ...  .   .. ||.. ..|.  .||.|||.| .|||  |      .||..||  .|..       .           |..    .  .  | . |.|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

CLALLDN----FEKLEPVILKKAQDYFFGFKIPFEQNFNVKEELINRKSQIYDILLQTVVFQPK----NQKLLKGDARKIASEIA
.|. .      |.  . ...||                          ..  |.. .  .. |.      ..|...    . .  
ILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13367.AA STE 440-560 23 8.5e-12 38.06 In-house 64-191 (359) Show / Hide 
Range on Protein: 440-560
Range on HMM: 64-191/359
Sequence Identity: 23% (33 aa)

LKIQQVQSKHEVVQEVGIMRDCQ--MPLVIKFYGYFYLS---VNKKDDFVVYEIEKCS-GNLKQYLTRLQKENIVLT----------DNQKMQIAVQIID
|.. . . . .. .|. ||..|.   | ..|.||...      . .|.  ..  | .. | | . . .  . .  |.           .|   |..||. 
LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILK

V-VNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDF
   .||  ..|.||||| .|||          .||.||
GLLYYLHSHHIIHRDIKPANILL---------VKLCDF
Kinase 13367.AA CAMKL 520-560 51 1.7e-11 32.78 In-house 135-173 (297) Show / Hide 
Range on Protein: 520-560
Range on HMM: 135-173/297
Sequence Identity: 51% (21 aa)

QIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDF
||.. |||.  .||||||||..|||  |...   .||..||
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDF
Kinase 13367.AA CMGC 489-560 17 1.3e-09 26.8 In-house 135-248 (513) Show / Hide 
Range on Protein: 489-560
Range on HMM: 135-248/513
Sequence Identity: 17% (20 aa)

EKCSGNLKQYLTRLQK-----ENIVLTDNQ------------KMQIA------VQIIDVVN--YLNYNG--IVHRDIKLDNILYIESQSDV---------
| .  .|.||. . |.      .. |.. .            .  .        ||.  ..  |.  ..  |.|||.|  |||  .    .         
EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSED

-------PTIKLTDF
        ..|. ||
WNPCQKNGRLKICDF
Kinase 13367.AA Pkinase 453-572 20 6.2e-09 32.66 Pfam 49-169 (293) Show / Hide 
Range on Protein: 453-572
Range on HMM: 49-169/293
Sequence Identity: 20% (27 aa)

QEVGIMRDCQMPLVIKFYGYFYLSVNKKDDFVVYEIEKCSG-----NLKQYLTRLQKENIVL--TDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILY
.|. ||. .. | ....|..|.      .| .    | | |      |. |...  ... ..  ....   .. ||.  ..|.  .||.|||.|..|||.
SEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI

IESQSDV-PTIKLTDFDQSR---KVPYELYY
  .. .. ...|..||  ..     ... ..
D-NNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase 13367.AA TyrKc 428-646 17 5.8e-07 -110.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 428-646
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

GTFNKTLG-----------------IKTVLKIQQVQSKHEVVQEVGIMRDC--QMPLVIKFYGYFYLS----VNKKDDFVVYEIEKCSGNLKQYLTRLQK
 |..|.||                 .|.. .      . .  .|  ||.    . | ....||.   .    .  .  ..| |  .  |.||.|| . ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP

ENIVLTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDFDQSRKVPYE-------LYYRDDE--LVKDYFPV---------QG
.   |.  .. ....|| .  .||  ....|||.   |.|. | .    |.| .||  ||..  .        |||  |    |. .|.          |
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

IC--------------EIFSVGVCLALL-----DNFEKLEPVILKKAQDYFFGFKIPFEQN-------------FNVKEELINR-------KSQIYDIL
..              |||. |            . . .   . .       |.  |  .|             ... ..  ..        |.|....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-------GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 13367.AA CDKL 509-560 30 2.2e-05 14.38 In-house 95-143 (286) Show / Hide 
Range on Protein: 509-560
Range on HMM: 95-143/286
Sequence Identity: 30% (16 aa)

LTDNQKMQIAVQIIDVVNYLNYNGIVHRDIKLDNILYIESQSDVPTIKLTDF
. ... ...  ||.  .|... . ..|||||  ||| |  ....  .|| ||
VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENIL-ITPKNGQ--VKLCDF