Gene 12227 (Tetrahymena)

12227

Species: Tetrahymena
Alias: 12227, 755, 299.m00012, TTHERM_01263930, PreTt12227
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
12227.AA Protein None 632 None Fasta, JSON
12227.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
12227.NA RNA None 1899 None Fasta, JSON
12227.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of 12227.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12227.AA C2 12-86 52 1.3e-28 94.92 In-house 166-245 (245) Show / Hide 
Range on Protein: 12-86
Range on HMM: 166-245/245
Sequence Identity: 52% (42 aa)

KVNIAYFLLQAQCDLAFASALKNHESRISFSKFKGTQSY----CAPEVDQGIFKKSSDIFS-VGLVLLELDNIQTFDFTK
|  . .   | .||..|||.||. .|||.|||||.||.|     ||||.|.|.|| ||.|| ||.|||||||.|.... .
KLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 12227.AA Ciliate-C8 23-73 40 3.2e-18 62.12 In-house 170-238 (238) Show / Hide 
Range on Protein: 23-73
Range on HMM: 170-238/238
Sequence Identity: 40% (28 aa)

QCDLAFASALKNHESRISFSKFKGTQSY-----------CAPEVDQGIFKKSSDIFS-------VGLVL
|||..|||.|.. .|.....|||||. |           .|||| ... .. |||||       |||||
QCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12227.AA C8 24-73 39 2.5e-15 49.74 In-house 169-226 (226) Show / Hide 
Range on Protein: 24-73
Range on HMM: 169-226/226
Sequence Identity: 39% (23 aa)

CDLAFASALKNHESRISFSKF--KGTQSYCAPEVDQG------IFKKSSDIFSVGLVL
||..|||...  .| |   |.   ||. | |||. ..      .... ||.|||||||
CDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12227.AA TKL 42-76 23 4e-06 18.27 In-house 231-282 (364) Show / Hide 
Range on Protein: 42-76
Range on HMM: 231-282/364
Sequence Identity: 23% (12 aa)

SKFKGTQSYCAPEV-----------------DQGIFKKSSDIFSVGLVLLEL
..  ||  ..||||                  .. . ...|..| |.|| |.
MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 12227.AA Dicty3 46-75 36 0.000186 10.41 In-house 257-289 (351) Show / Hide 
Range on Protein: 46-75
Range on HMM: 257-289/351
Sequence Identity: 36% (12 aa)

GTQSYCAPEVDQGIFK---KSSDIFSVGLVLLE
|| .| |||.  .  .   ..|||.| |....|
GTIHYMAPEIKLNNQCCACRKSDIWSLGCTVWE
Kinase 12227.AA Ciliate-E2-Unclassified 44-139 19 0.000489 9.92 In-house 222-352 (352) Show / Hide 
Range on Protein: 44-139
Range on HMM: 222-352/352
Sequence Identity: 19% (25 aa)

FKGTQSYC----APEVDQG-IFK----KSSDIFSVGLVLLELDNIQTFDFTKTTNQ---------------EKLEIQFGKVFTSF--------QINRQSQ
| || .|     |||| ||        ...||.|.| .| |.   .   . .. .|               . ..... | .  .        ..  ...
FCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEA

IYRIA---QQCLEFDPKNRIPAVDLLIQFII
.  |    |..|. .|..|| . ..|   ..
KDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 12227.AA Ciliate-E2 46-139 17 0.000588 9.45 In-house 249-365 (365) Show / Hide 
Range on Protein: 46-139
Range on HMM: 249-365/365
Sequence Identity: 17% (22 aa)

GTQSYCAPEVDQGIFK----------KSSDIFSVGLVLLELDNIQT-FDFTKTTNQEKLEIQFGKVFTSFQ----------------INRQSQIYRIAQQ
||  | |||. .|             ...||.|.| .| |.   .. |           .|. .|.  ...                 .   .   . ..
GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----CLEFDPKNRIP-AVDLLIQFII
    .|. ||..||  . ..|   ..
FGKRMLQKDPEKRITGWEQILNHPWF
Kinase 12227.AA Dicty3 117-134 33 0.000626 8.64 In-house 334-351 (351) Show / Hide 
Range on Protein: 117-134
Range on HMM: 334-351/351
Sequence Identity: 33% (6 aa)

QQCLEFDPKNRIPAVDLL
|.|. .||..|. .  |.
QHCWQIDPNHRWDMHELI
Kinase 12227.AA CAMK 24-73 19 0.078709 0.87 In-house 238-324 (425) Show / Hide 
Range on Protein: 24-73
Range on HMM: 238-324/425
Sequence Identity: 19% (17 aa)

CDLAFASALKNHESRI---------------------SFSKFKGTQSYCA-PEVDQG-------------IFK--KSSDIFSVGLVL
.|  ||  ..  |.                        .. | || .|.| ||| .|             .    ...|. |.| .|
IDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 12227.AA Pkinase 44-76 37 0.277281 5.62 Pfam 171-205 (293) Show / Hide 
Range on Protein: 44-76
Range on HMM: 171-205/293
Sequence Identity: 37% (13 aa)

FKGTQSYCAPEV--DQGIFKKSSDIFSVGLVLLEL
| ||  |.||||  ..    ...|..|.|..| |.
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 12227.AA C2 238-441 38 1.2e-102 347.29 In-house 1-245 (245) Show / Hide 
Range on Protein: 238-441
Range on HMM: 1-245/245
Sequence Identity: 38% (94 aa)

GATGLILGVYNKSQKRHSALKIQRVTS-----KHEIIREIGIIRDCQ-MPLVIKFYGFYYLDVIKKED------------------------FVVYEIEK
||.||.|...||.|.||.|||||.. |     .||...|.||.|.|| ||..||.|...||.| ||||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYFNRLKKEKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDVKLENILYIDSQSQVPIIKLTD----------FDQARKMYYINIRIYD-DIVK
|.|||||||||..|.........||..|||..|.|||||...|||||.|..|.||...|...|.|||.|          ||.|.|. | ..||..  ...
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

VFQPVKGAVKFFSQKKNNQNYNKKCGTLGYISPEIFNTLLYTFQE
  |.............  ..  ....|.||...|..|. .||...
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 12227.AA Ciliate-C8 238-450 28 4.7e-74 252.34 In-house 1-238 (238) Show / Hide 
Range on Protein: 238-450
Range on HMM: 1-238/238
Sequence Identity: 28% (72 aa)

GATGLILG-------VYNKSQKRHSALKIQRVTSKHEIIREIGIIRDCQMPLVIKFYGFYYLD-VIKKED-----------------FVVYEIEKCS--G
||.|..|.        ......|....|||.. ..|||.....| ..||||.|...|...||. ..||||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYFNRLKKEKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDVKLENILYIDSQSQVPIIKLTD------FDQARKMYYINIRIYDDI-VKVFQPVKG
||||||.|..|.........|..||||.||..||||...|.||| |..|.|....|...|.||| |      |..|... .   ....   ..  |....
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

AVKFFSQKKNNQNYNKKCGTLGYISPEIFNT------LLYTFQEFVQLLLIIL
..               ||..||. ||. .        .....  .. . ..|
YF---------------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12227.AA C8 230-447 28 2.1e-43 148.48 In-house 2-226 (226) Show / Hide 
Range on Protein: 230-447
Range on HMM: 2-226/226
Sequence Identity: 28% (71 aa)

SNFEFISVGATGLILGVYNKSQKRHSALKIQRVTSKHEIIREIGIIRDCQMPLVIKFYGFYYLD-VIKKEDFVVYEIEKCS-------------------
.||...| || |..|  .|  ..|. .||.| ...|..|  .. | . ..||.|.. | ||... ....|...|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYFNRLKKEKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDVKLENILYIDSQSQVPIIKLTDFDQARKMYYINIRIYDDIVKVFQPVKGAVKF
   ||||..  ..... |...|.| .||||.|| .||.|   |.|||.|..|.|   .|.....||| ||. | .       |..  ..           
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----------

FSQKKNNQNYNKKCGTLGYISPEIFNT-----LLYTFQE---FVQLLL
             |||..|. ||| .        |. |     | |.|
-------------CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12227.AA CAMK 234-433 16 9.9e-20 59.59 In-house 1-293 (425) Show / Hide 
Range on Protein: 234-433
Range on HMM: 1-293/425
Sequence Identity: 16% (53 aa)

FISVGATGLILGVYNKSQK------------RHSALKI---QRVT----------------------------SKHEIIREIGIIRDCQ-------MPLV
 .  |. |    ...|. .            .. | ||   ....                            ..... ||| | . .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYGFYYLDVI----------------KKEDFVVY-EIEKCSG-NLKQY-FNRLKKE--------------KIQLNDEEKMQIAIQVIDVINYLHYNHI
||.| .|  .                  .|. . |    | |||  | .. |.....               .  .. .|  ..  |... ..|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDVKLENILYIDSQSQVP-------------IIKLTDFDQARKM--------------------YYINIRIYDDIVKVFQPVKGAVKFFSQKKNNQNY
|||| |.||||. |. .  .              ||..||  |.|.                    .                        .. . .| .
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW------------------------TTPTEGQKM

NKKCGTLGYIS-PEIFN
.  |||..|.. ||..|
KTFCGTPEYMAAPEVLN
Kinase 12227.AA Ciliate-E2 244-433 21 7.9e-17 54.29 In-house 36-260 (365) Show / Hide 
Range on Protein: 244-433
Range on HMM: 36-260/365
Sequence Identity: 21% (54 aa)

LGVYN----KSQKRHSALKIQRVTSKHEIIREIGIIR----------------DCQMPLVIKFYGFYYLDVIKKEDFVVYEIEKCSG-NLKQYFN--RLK
. ...    | ..   |.||..   . .| .|| |.|                  . | .||.| ...    |... . .  | |.| .|..| .  ..|
Q-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQE---KDDNNIYLVMEYCQGGDLFDYIKNNKKK

KEKI-----QLNDEEKMQIAIQVID---------------VINYLHYNH-IVHRDVKLENILYIDSQSQVPIIKLTDFD---------------QARKMY
. ..     .....|  .|  |...                ..||| .. |.||| |.||||.         ||..||                | .|.|
RNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWY

YINI----RIYDDIVKVFQPVKGAVKFFSQKKNNQNYNKKCGTLGYISPEIFN
        | . ..               |.   . .|  |||.|| .|||.|
MF-KNDTSRTPGYMD--------------QIIQQNMFNTICGTPGYMAPEILN
Kinase 12227.AA Ciliate-E1 235-424 19 5.4e-16 48.91 In-house 1-202 (202) Show / Hide 
Range on Protein: 235-424
Range on HMM: 1-202/202
Sequence Identity: 19% (40 aa)

ISVGATGLILGVYNKSQK-RHSALKIQRVT---SKHEIIREIGIIRDCQMPLVIKFYGFYYLDVIKKED--FVVYEIEKCSGNLKQYFN---------RL
|. |  ....  ...... .. |.||. .    .. ..  ||  .   .. .  ..| ....|.||...  . .  .|.|. .||.|..          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KKEKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDVKLENILYIDSQSQVPII--KLTDFDQARKMYYINIRIYDDIVKVFQPVKGAVKFFSQKKNNQNY
.....|.....||||..| || ...||.. | ||| | .|||. .. ..  .    . .| .  . ...... | . ..  . ..       . ..||..
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP--EQ-EHNKNQKI

NKKCGTL
|.|    
NYKSDIY
Kinase 12227.AA Ciliate-E2a 316-377 32 2.5e-15 41.59 In-house 87-153 (275) Show / Hide 
Range on Protein: 316-377
Range on HMM: 87-153/275
Sequence Identity: 32% (22 aa)

FNRLKKEK-IQLNDEEKMQIAIQVI-DVINYLHYNHIVHRDVKLENILYI--DSQS-QVPIIKLTDF
....|. | .. ...| ..|  | . . ..|.| ..|.||| |.||||.   ...| |   ||. ||
YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDF
S_TKc 12227.AA S_TKc 229-531 16 3.3e-14 31.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 229-531
Range on HMM: 1-231/231
Sequence Identity: 16% (53 aa)

DSNFEFISVGATGLILGVYNKSQKRHSALKIQRVTSKHEIIREIGIIRDCQMPLVIKFYGFYYLDVIKKEDFVVYEIEKCSG---NLKQYFNRLKKEK--
    . |  || |    ...|. .|. |.|| .      |.||| | .  . | ..|.|....       |..    | |.|   .|..|  . ....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IQLNDEEKMQIAIQVIDVINYLHYNHIVHRDVKLENILYIDSQSQVPIIKLTDFDQARKMYYINIRIYDDIVKVFQPVKGAVKFFSQKKNNQNYNKKCGT
 ...  .   .. |... ..|.| ..|.|||.| ||||  .       ||..||  ||..                                  .  |||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------------------------------TTFCGT

LGYISPEIFNTLLYTF------------QEFVQLLLIILKHWNHLLNKKILIPYMALKFHLNQVILLKMNQQKEIQKSMIQFQKPQPRWSESSSFRNSQM
. |..||..    |..             |..        . . ...|                                           |.....  .
PWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------------------------SPEAKD-FI

SYSLHFKPL---AIAQMGR-------KQQL
.  |.. |     . .  .        . .
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12227.AA Ciliate-E2-Unclassified 290-432 19 2.1e-12 39.39 In-house 85-238 (352) Show / Hide 
Range on Protein: 290-432
Range on HMM: 85-238/352
Sequence Identity: 19% (33 aa)

YYLDVIKKEDFVVYEIEKC-SGNLKQYFN-------------RLKKEKIQLNDEEKM-----QIAIQVIDVINYLHYNH-IVHRDVKLENILYIDSQSQV
..... .... .    |.|  |.|.|| .             . .|.. .. ...       ... |... ..|||... |.||| |.||||. ....  
KMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-N

PIIKLTDFDQARKMYYINIRIYDDIVKVFQPVKGAVKFFSQKKNN--QNYNKKCGTLGYI----SPEIF
  ||..||  ..|  . |    ..            .   .....  |... .|||..|.    .||..
YYIKIIDFGISKKYQQNNNCD-TNQ-----------Q--QKMQIWKQQMMWTFCGTPNYMPQYTAPEVL
Kinase 12227.AA Pkinase 337-431 27 5.3e-12 43.51 Pfam 116-182 (293) Show / Hide 
Range on Protein: 337-431
Range on HMM: 116-182/293
Sequence Identity: 27% (26 aa)

QVIDVINYLHYNHIVHRDVKLENILYIDSQSQV-PIIKLTDFDQARKMYYINIRIYDDIVKVFQPVKGAVKFFSQKKNNQNYNKKCGTLGYISPEI
|..  ..|.| . |.|||.|.|||| ||.. .. ...|..||  |....                            ||. ..  |||..|..||.
QILRGLEYCHSMGIIHRDLKPENIL-IDNNGHIDACVKICDFGLAKQFD--------------------------Y-NNS-MTTFCGTPWYMAPEV
Kinase 12227.AA Dicty3 320-431 18 6.8e-10 28.65 In-house 102-266 (351) Show / Hide 
Range on Protein: 320-431
Range on HMM: 102-266/351
Sequence Identity: 18% (34 aa)

KKEKIQLNDEEKMQIAIQVIDVINYLHYN-HIVHRDVKLENILYIDSQS----------QVP-------------IIKLTDFDQARKM-YYI--------
|... ..|..|   |... .  .||.| | ||.||| | .||. .| ..          . .             ..|| ||.      ||         
KHKNNRFNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIM-LDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGLSKNISYYSNNNNNNNY

---------------------------------------NIRIYDDIVKVFQPVKGAVKFFSQKKNNQNYNKKCGTLGYISPEI
                                       |.                   .| |   |...  ||| .|..|||
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNVKIINNN------------------IYSNKQYKQKCYSICGTIHYMAPEI
Kinase 12227.AA TKL 331-438 18 1.1e-09 30.99 In-house 134-251 (364) Show / Hide 
Range on Protein: 331-438
Range on HMM: 134-251/364
Sequence Identity: 18% (26 aa)

KMQIAIQVIDVINYLHYNH--------IVHRDVKLENILYIDSQSQ----VPI-------IKLTDFDQARKMYYIN------------IRIYDDIVKVFQ
....|...   .|||| ..        |.||| | .||| .|.  .    ...       .|..||  .| |   .            .           
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNIL-VDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA-----------

PVKGAVKFFSQKKNNQNYNKKCGTLGYISPEIFNTLLYT
    .    .| .|... ...|||... .||...  ...
----E----HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNY
Kinase 12227.AA Ciliate-E2a 406-433 35 1.8e-05 12.1 In-house 157-183 (275) Show / Hide 
Range on Protein: 406-433
Range on HMM: 157-183/275
Sequence Identity: 35% (10 aa)

KFFSQKKNNQNYNKKCGTLGYISPEIFN
.|........ . .|||| ||. ||..|
TFIDKDEKKYMF-QKCGTPGYVAPEVLN
TyrKc 12227.AA TyrKc 229-449 15 2e-05 -134.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 229-449
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

DSNFEFISVGATGLI-LGVYNKSQKRHSALKIQRVTSKHEIIREIGIIRDC--QMPLVIKFYGFYYLD----VIKKEDFVVYEIEKCSGNLKQYFNRLKK
 .  . .  || | . .|...    .  | |  .  .. ...||. | .    . | ....||    .    .  .  ..| |  .  |.||.|   |.|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDY---LRK

EKIQLNDEEKMQIAIQVIDVINYLHYNHIVHRDVKLENILYIDSQSQVPIIKLTDFDQARKMYYI-----NIRIYDD----IVK----------------
 . .|. ... ....|. .  .||| ....|||    |.|. . .    ..| .||  .|. |       .   |.       |                
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

-----------------------VFQPV-----KGAVKFFSQKKNNQNYNKKCGTLGY------ISPEIFNTLLYTFQE-------FVQLLLII
                          |      . .   . . |  | |  ..   .|       ..|...  .   .|       | ..  ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF