Gene 12230 (Tetrahymena)

12230

Species: Tetrahymena
Alias: 299.m00015, 754, PreTt12230, 12230, TTHERM_01263960
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
12230.AA Protein None 1298 None Fasta, JSON
12230.kin_dom2 Protein Kinase Domain None 124 None Fasta, JSON
12230.NA RNA None 3897 None Fasta, JSON
12230.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of 12230.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12230.AA C2 72-115 51 5.2e-17 54.76 In-house 197-245 (245) Show / Hide 
Range on Protein: 72-115
Range on HMM: 197-245/245
Sequence Identity: 51% (25 aa)

TKKGTQSY----CAPEVDQGIFKKASDMFS-FGLVLLELDNIQTFDFTK
. |.||.|     ||||.|.|.||.||.|| .|.|||||||.|.... .
KFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 12230.AA Ciliate-C8 31-102 31 1.7e-16 55.88 In-house 163-238 (238) Show / Hide 
Range on Protein: 31-102
Range on HMM: 163-238/238
Sequence Identity: 31% (26 aa)

KLII----GDLAFASALQNNKSRISFSKFVFKILINHFLYFLFKYTKKGTQSYCAPEVDQGIFKKASDMFS-------FGLVL
|| .    .|..|||.|..|||.....||. .. .. ...        |.  |.|||| ... .. || ||        ||||
KLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYF-------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12230.AA C8 34-102 30 7.7e-12 37.48 In-house 168-226 (226) Show / Hide 
Range on Protein: 34-102
Range on HMM: 168-226/226
Sequence Identity: 30% (23 aa)

IGDLAFASALQNNKSRISFSKFVFKILINHFLYFLFKYTKKGTQSYCAPEVDQG------IFKKASDMFSFGLVL
. |..|||... ||| |   |..                  ||. | |||. ..      .... ||.|| ||||
LCDFGFASQVSKNKSHIQSKKMNT----------------CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12230.AA TKL 70-105 26 8.3e-08 24.21 In-house 230-282 (364) Show / Hide 
Range on Protein: 70-105
Range on HMM: 230-282/364
Sequence Identity: 26% (14 aa)

KYTKKGTQSYCAPEV-----------------DQGIFKKASDMFSFGLVLLEL
..|. ||  ..||||                  .. . ...|..|||.|| |.
TMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 12230.AA C2 31-58 44 5.7e-05 13.05 In-house 166-201 (245) Show / Hide 
Range on Protein: 31-58
Range on HMM: 166-201/245
Sequence Identity: 44% (16 aa)

KLII--------GDLAFASALQNNKSRISFSKFVFK
|| .        .|..|||.|..|||||.||||...
KLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWT
Kinase 12230.AA Ciliate-E2-Unclassified 71-105 34 0.00072 9.33 In-house 220-263 (352) Show / Hide 
Range on Protein: 71-105
Range on HMM: 220-263/352
Sequence Identity: 34% (15 aa)

YTKKGTQSYC----APEVDQG-IFK----KASDMFSFGLVLLEL
.|. || .|     |||| ||        ...|..|.| .| |.
WTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase 12230.AA Ciliate-E2 75-157 19 0.023384 3.88 In-house 249-353 (365) Show / Hide 
Range on Protein: 75-157
Range on HMM: 249-353/365
Sequence Identity: 19% (22 aa)

GTQSYCAPEVDQGIFK----------KASDMFSFGLVLLELDNIQT-FDFTKTTNQEKLEIQFGNIFTSFQ---------------INRLSQI-YRIAKQ
||  | |||. .|             ...|..|.| .| |.   .. |           .|. ..|  ...                . .||    . |.
GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----CLEFDPKNRL
    .|. ||..|.
FGKRMLQKDPEKRI
Kinase 12230.AA TKL 140-166 18 0.090856 2.16 In-house 338-364 (364) Show / Hide 
Range on Protein: 140-166
Range on HMM: 338-364/364
Sequence Identity: 18% (5 aa)

QIYRIAKQCLEFDPKNRLPPVDLLIQF
.. .....| . ||..|.   ..| ..
SMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 12230.AA Pkinase 75-105 39 0.248223 5.79 Pfam 173-205 (293) Show / Hide 
Range on Protein: 75-105
Range on HMM: 173-205/293
Sequence Identity: 39% (13 aa)

GTQSYCAPEV--DQGIFKKASDMFSFGLVLLEL
||  |.||||  ..    ...||.|.|..| |.
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 12230.AA C2 267-455 40 7.69999999999e-103 347.96 In-house 1-245 (245) Show / Hide 
Range on Protein: 267-455
Range on HMM: 1-245/245
Sequence Identity: 40% (99 aa)

GATGLILGAYNKSLNRHSALKIQRVPS-----KHEIVREIGIIKDCQ-MPLVINFYGFFYLDVTKKED------------------------FVVYEIEK
||.||.|.|.||. |||.|||||.. |     .||...|.||...|| ||..|..|..|||.|.||||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYFNRLKKENIQLNDEEKMQIAIQVIDVINYLHQNDIVHRDIKLENILYIDDNQSQIPIIKLTD----------FDQARKMYYNWIRING-NLV
|.|||||||||..|.|.......||..|||..|.|||||..||||||||..|.||..| |..||.|||.|          ||.|.|. ||..||.. ...
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFD-QQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

KDYKPIKG----------------TCGTLGYISPEIFNTQLFTFQS
... ....                 ..|.||...|..|.|..|...
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 12230.AA Ciliate-C8 267-464 33 1.3e-86 294.04 In-house 1-238 (238) Show / Hide 
Range on Protein: 267-464
Range on HMM: 1-238/238
Sequence Identity: 33% (80 aa)

GATGLILG-------AYNKSLNRHSALKIQRVPSKHEIVREIGIIKDCQMPLVINFYGFFYLD-VTKKED-----------------FVVYEIEKCS--G
||.|..|.       ..... .|....|||.. ..|||.....| ..||||.|...|..|||. ..||||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYFNRLKKENIQLNDEEKMQIAIQVIDVINYLHQNDIVHRDIKLENILYIDDNQSQIPIIKLTD------FDQARKMYYNWI-RINGNLVKDYKPIK
||||||.|..|.........|..||||.||..||||...|.|||||..|.|...| |...|.||| |      |..|... .|.   .  . .. . .|.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFD-QQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIE

GT-CGTLGYISPEIFNT------QLFTFQSEIFSLGVCL
.  ||..||. ||. .       ..|...|...|.|..|
MYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12230.AA C8 259-464 32 9.2e-50 170.87 In-house 2-226 (226) Show / Hide 
Range on Protein: 259-464
Range on HMM: 2-226/226
Sequence Identity: 32% (76 aa)

SNFEFISVGATGLILGAYNKSLNRHSALKIQRVPSKHEIVREIGIIKDCQMPLVINFYGFFYLD-VTKKEDFVVYEIEKCS-------------------
.||...| || |..| |.|   ||. .||.| . .|..|  .. | | ..||.|.  | |.... ....|...|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYFNRLKKENIQLNDEEKMQIAIQVIDVINYLHQNDIVHRDIKLENILYIDDNQSQIPIIKLTDFDQARKMYYNWIRINGNLVKDYKPIKGTCG
   ||||..  ..... |...|.| .||||.|| .||.|.  |.|||||..|.|   |.. ....||| ||. | .   |   |    ..        ||
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQN-YGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CG

TLGYISPEIFNT-----QLFTFQSEIFSLGVCL
|..|. ||| .      . .. || .||.|. |
TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12230.AA CAMK 263-462 17 1.4e-25 78.78 In-house 1-322 (425) Show / Hide 
Range on Protein: 263-462
Range on HMM: 1-322/425
Sequence Identity: 17% (57 aa)

FISVGATGLILGAYNKSLN------------RHSALKI---QRVP----------------------------SKHEIVREIGIIKDCQ-------MPLV
 .  |. |    ...|. .            .. | ||   ....                            ..... ||| | | .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

INFYGFFY----------------LDVTKKEDFVVYE--IEKCSG-NLKQY-FNRLKKE--------------NIQLNDEEKMQIAIQVIDVINYLHQND
|..| ..                    ||.....      | |||  | .. |.....               .  .. .|  ..  |... ..|.|...
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKLENILYIDDNQSQIP------------IIKLTDFDQARKM-------YYNWIRINGNLVKD-------YKPIKGTCGTLGYIS-PEIFNT---
|||||.|.||||. |.| .. |             ||..||  |.|.       . . .  .  . ..        .. |  |||..|.. ||..|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------QLF-TFQSEIFSLGV
          .   .... . |.||
CNMQNATDEEKPYYGPKCDMWSCGV
Kinase 12230.AA Ciliate-E2 285-464 22 6.8e-25 82.37 In-house 51-286 (365) Show / Hide 
Range on Protein: 285-464
Range on HMM: 51-286/365
Sequence Identity: 22% (57 aa)

ALKIQRVPSKHEIVREIGIIK----------------DCQMPLVINFYGFFYLDVTKKEDFVVYEIEKCSG-NLKQYFN--RLKKENI-----QLNDEEK
|.||..   . .| .|| |..                  . | .|..| .|.   .|... . .  | |.| .|..| .  ..|. ..     .....| 
AMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI

MQIAIQVID---------------VINYLHQND-IVHRDIKLENILYIDDNQSQIPIIKLTDFDQARKMY--YNWIRINGNLVKDYKPIKG---------
 .|  |...                ..|||..  |.|||||.||||.          ||..||  ..|    .. ... ... | |.  |.         
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYM

-----------TCGTLGYISPEIFNTQL---------FTFQSEIFSLGVCL
           .|||.|| .|||.| .           .... |.||||.|
DQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 12230.AA AGC 366-464 23 1.4e-22 53.78 In-house 161-295 (395) Show / Hide 
Range on Protein: 366-464
Range on HMM: 161-295/395
Sequence Identity: 23% (34 aa)

QVIDVINYLHQ-NDIVHRD-IKLENILYIDDNQSQIPIIKLTDFDQARK--MYY--------------------------------NWIRIN------GN
...  . |||. ..|.||| .|.||||  .|       ||||||  . .  ...                                || | |       .
CIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTT

LVKDYKPIKGTCG--TLGYISPEIFNTQLFTFQSEIFS--LGVCL
  |. .  .  ||  |  |..|||.     ...  . |  ||...
R-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM
Kinase 12230.AA Ciliate-E2a 345-462 26 3e-20 56.32 In-house 87-204 (275) Show / Hide 
Range on Protein: 345-462
Range on HMM: 87-204/275
Sequence Identity: 26% (35 aa)

FNRLKKEN-IQLNDEEKMQIAIQVI-DVINYLHQNDIVHRDIKLENILYID-DNQS-QIPIIKLTDFDQARKM--YYNWIRINGNLVKDYKPIKGTCGTL
....|.   .. ...| ..|  | . . ..|.||. |.|||.|.||||. . . .| |   ||. ||  |..   .            ..| ..  ||| 
YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD------------EKKYMFQKCGTP

GYISPEIFNTQL------FTFQSEIFSLGV
||. ||..|          . .  ..|.||
GYVAPEVLNNKEVLKHKQYDTKCDMWSCGV
Kinase 12230.AA Ciliate-E2-Unclassified 339-464 25 3.1e-19 63.41 In-house 106-260 (352) Show / Hide 
Range on Protein: 339-464
Range on HMM: 106-260/352
Sequence Identity: 25% (41 aa)

GNLKQYFNRLKK------------ENIQLNDEEKMQ------IAIQVIDVINYLHQND-IVHRDIKLENILYIDDNQSQIPIIKLTDFDQARKMYYNWIR
|.|.|| .  ||            .. .  .|....      .. |... ..|||..  |.|||||.||||. ....     ||..||  ..|  .|   
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNC

INGNL-----VKDYKPIKGTCGTLGYI----SPEIFNTQLFT----FQSEIFSLGVCL
  .|      . ... .. .|||..|.    .||..  |       ... |.||||.|
D-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase 12230.AA Ciliate-E1 264-409 23 3.5e-19 59.39 In-house 1-160 (202) Show / Hide 
Range on Protein: 264-409
Range on HMM: 1-160/202
Sequence Identity: 23% (38 aa)

ISVGATGLILGAYNKSLN-RHSALKIQRVP---SKHEIVREIGIIKDCQMPLVINFYGFFYLDVTKKED--FVVYEIEKCSGNLKQYFN---------RL
|. |  .... |.... | .. |.||. .    .. ..  ||  ..  .. .  ..| . ..|. |...  . .  .|.|. .||.|..          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KKENIQLNDEEKMQIAIQVIDVINYLHQNDIVHRDIKLENILYIDDNQSQIPIIKLTDFDQ
.....|.....||||..| || ...|||. | ||||| .|||. .... ..  . . .| .
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLK
S_TKc 12230.AA S_TKc 258-553 19 3.4e-16 60.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 258-553
Range on HMM: 1-231/231
Sequence Identity: 19% (60 aa)

DSNFEFISVGATGLILGAYNKSLNRHSALKIQRVPSKHEIVREIGIIKDCQMPLVINFYGFFYLDVTKKEDFVVYEIEKCSG---NLKQYFNRLKKEN--
    . |  || |    ...|. .|. |.|| .      | ||| | |  . | ....|..|.       |..    | |.|   .|..|  . ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IQLNDEEKMQIAIQVIDVINYLHQNDIVHRDIKLENILYIDDNQSQIPIIKLTDFDQARKMYYNWIRINGNLVKDYKPIKGTCGTLGYISPEIFNTQLFT
 ...  .   .. |... ..|.|.. |.|||.| ||||  .        ||..||  ||..                  .  |||. |..||..    ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYG

F-QSEIFSLGVCLAVIDNFETLEPFLKQKNLDYLHGFKIPFEPSYLIKNESNNIGPGGAKAVASEIAKCPTLSALRLLLGSNNIGPD---GAKAIAS---
.  . . |.|..|.    .    ||      ..   ||.                               . .|. .. .  .  |.   .|  .     
KCKCDWWSCGCILYEM--LCGYPPFP-----QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

EIAKCPTL
.|.. | .
DIKCHPWF
Kinase 12230.AA Pkinase 285-462 23 1.3e-15 56.23 Pfam 28-200 (293) Show / Hide 
Range on Protein: 285-462
Range on HMM: 28-200/293
Sequence Identity: 23% (45 aa)

ALKIQRVPSKHEIVR-------EIGIIKDCQMPLVINFYGFFYLDVTKKEDFVVYEIEKCSGN--LKQYFNRLK-KENIQL--NDEEKMQIAIQVIDVIN
|.|| ....... ..       || | | .. | .. .|..|.      .| .    | | |   .   | ... ...  .   ..|   .. |..  ..
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

YLHQNDIVHRDIKLENILYIDDNQSQI-PIIKLTDFDQARKMYYNWIRINGNLVKDYKPIKGTCGTLGYISPEIFN-TQLFTFQSEIFSLGV
|.|.. |.|||.|.|||| || |. .| ...|..||  |....             .   .. |||..|..||. .  |  .  . ..|.|.
YCHSMGIIHRDLKPENIL-ID-NNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC
Kinase 12230.AA TKL 360-464 16 2.9e-14 47.8 In-house 134-279 (364) Show / Hide 
Range on Protein: 360-464
Range on HMM: 134-279/364
Sequence Identity: 16% (26 aa)

KMQIAIQVIDVINYLHQND--------IVHRDIKLENILYIDDNQSQ--------IPI-IKLTDFDQARKM----------------YYNWIRINGNLVK
....|...   .||||...        |.|||.| .|||  .... .        ... .|..||  .| |                       .  .  
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA------E--HQ-

DYKPIKGTCG-TLGYISPEIFNTQ----------------LFTFQSEIFSLGVCL
...  ..|.. |... .||... |                 .. .. ..| |..|
NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
TyrKc 12230.AA TyrKc 258-530 17 1.6e-08 -84.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 258-530
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

DSNFEFISVGATGLILGAYN------KSLNRHSALKIQRVPSKHEIVREIGIIKDC--QMPLVINFYGFFYLD----VTKKEDFVVYEIEKCSGNLKQYF
 .  . .  || | .  .        |.|. ..         . .. ||. | .    . | ....||    .    .  .  ..| |  .  |.||.| 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYL

NRLKKENIQLNDEEKMQIAIQVIDVINYLHQNDIVHRDIKLENILYIDDNQSQIPIIKLTDFDQARKMYYN-WIRINGNLVKDYKPIK---GTC--GTLG
 . ...   |. ... ....|. .  .|||.. ..|||.   |.|. ...     ..| .||  .|. |   .        |||.  |   |.     . 
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIR

YISPEIFNTQLFTFQS----------EIFSLGVCLAVI-----DNFETLEPFLKQKNLDYLHGFKIPFEPSYLIKNE--SNNIGPGGAKAVASEIAKC--
  .|| .|.  ||..|          |||..|            . . .  ..||       |.  |  |...   .  .    ..  ... . . .|  
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-------GYRMPQPPNDY---PMSF----VCCPDEMYQIMKQCWH

------PTLSALRLLL
      || |... ..
EDPEDRPTFSEIHECF