Gene 12233 (Tetrahymena)

12233

Species: Tetrahymena
Alias: 753, 299.m00018, TTHERM_01263990, 12233, PreTt12233
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
12233.AA Protein None 1031 None Fasta, JSON
12233.kin_dom2 Protein Kinase Domain None 124 None Fasta, JSON
12233.NA RNA None 3096 None Fasta, JSON
12233.kin_dom Protein Kinase Domain None 124 None Fasta, JSON

Protein domain

Protein domains of 12233.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12233.AA C2 285-321 48 1.3e-10 32.56 In-house 199-245 (245) Show / Hide 
Range on Protein: 285-321
Range on HMM: 199-245/245
Sequence Identity: 48% (23 aa)

KGTQSY----CAPEVDS-----GSDIFS-VGLVLLELDNMQSFDFTK
|.||.|     ||||.       ||.|| ||.||||||||| ... .
KWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 12233.AA PEK 286-374 23 1e-09 29.26 In-house 551-655 (655) Show / Hide 
Range on Protein: 286-374
Range on HMM: 551-655/655
Sequence Identity: 23% (25 aa)

GTQSYCAPEVDSGS-----------DIFSVGLVLLELDNM---QSFDFTKTTNQQK-LEIQFGNIFS--SFQINRQSQIYRIVKQCLEFNPQNRTPAVDL
||..|..||. ||.           |..| |....|.      ......|| .. .   ||| ..|.  .|. |.. . . .....|  .||.|  | ..
GTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFD-NKYPKQADFIQWMLSHDPQQRPSAQQI

LIQFIV
| .  .
LQHEFF
Kinase 12233.AA Ciliate-C8 286-308 45 9.5e-08 24.19 In-house 204-238 (238) Show / Hide 
Range on Protein: 286-308
Range on HMM: 204-238/238
Sequence Identity: 45% (16 aa)

GTQSYCAPEVDSG-----SDIFS-------VGLVL
|.  |.||||  .     |||||       |||||
GNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12233.AA C8 282-308 42 3.1e-07 21.3 In-house 185-226 (226) Show / Hide 
Range on Protein: 282-308
Range on HMM: 185-226/226
Sequence Identity: 42% (18 aa)

QFKK----GTQSYCAPEVDSG-----------SDIFSVGLVL
| ||    ||. | |||. ..           ||.|||||||
QSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12233.AA Pkinase 286-311 36 2.638971 2.16 Pfam 173-205 (293) Show / Hide 
Range on Protein: 286-311
Range on HMM: 173-205/293
Sequence Identity: 36% (12 aa)

GTQSYCAPEV-------DSGSDIFSVGLVLLEL
||  |.||||       .. .|..|.|..| |.
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 12233.AA C2 473-610 47 1.6e-81 277.13 In-house 1-167 (245) Show / Hide 
Range on Protein: 473-610
Range on HMM: 1-167/245
Sequence Identity: 47% (79 aa)

GATGLILGVYNISQKRHSALKIQRVSS-----KHEIVREIGIIRDCQ-MPLVIKFYGFFYLDVTKKED------------------------FVVYEIEK
||.||.|...| .|.||.|||||.. |     .||...|.||.|.|| ||..||.|..|||.|.||||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL
|.|||||||||..|.........||..|||..|.|||||..|||||||| .|.||...... .|.|||
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQG-IPTIKL
Kinase 12233.AA Ciliate-C8 473-610 37 3.4e-62 212.93 In-house 1-164 (238) Show / Hide 
Range on Protein: 473-610
Range on HMM: 1-164/238
Sequence Identity: 37% (62 aa)

GATGLILG-------VYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKED-----------------FVVYEIEKCS--G
||.|..|.        .. ...|....|||.. ..|||.....| ..||||.|...|..|||. ..||||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL
||||||.|..|.........|..||||.||..||||...|.||||| .|.|.... ....|.|||
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFD-QQYQPTIKL
Kinase 12233.AA C8 465-610 32 1e-36 124.95 In-house 2-168 (226) Show / Hide 
Range on Protein: 465-610
Range on HMM: 2-168/226
Sequence Identity: 32% (54 aa)

SNFEFISVGATGLILGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKEDFVVYEIEKCS-------------------
.||...| || |..|  .|. ..|. .||.| ...|..|  .. | . ..||.|.. | |.... ....|...|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL
   ||||..  ... . |...|.| .||||.|| .||.|   |.||||| .|.|   ... ....|||
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQN-YGFEIKL
Kinase 12233.AA Ciliate-E1 470-604 22 6.4e-18 55.24 In-house 1-149 (202) Show / Hide 
Range on Protein: 470-604
Range on HMM: 1-149/202
Sequence Identity: 22% (34 aa)

ISVGATGLILGVYNISQK-RHSALKIQRVS---SKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKED--FVVYEIEKCSGNLKQYFN---------RL
|. |  ....  ...... .. |.||. .    .. ..  ||  .   .. .  ..| . ..|. |...  . .  .|.|. .||.|..          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSK
.....|.....||||..| || ...||.. | ||||| .|||. .... .
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYV
Kinase 12233.AA CAMK-Unique 551-597 36 5.9e-14 42.25 In-house 142-190 (363) Show / Hide 
Range on Protein: 551-597
Range on HMM: 142-190/363
Sequence Identity: 36% (18 aa)

FNRLKKDKIQLNE--EEKMQIAIQVIDVINYLHYNDIVHRDIKIENILY
|| ||. .....|   .  .|  ..  ...|.| .||||||.| |||..
FNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMV
Kinase 12233.AA CAMK 469-610 18 3.5e-13 38.12 In-house 1-237 (425) Show / Hide 
Range on Protein: 469-610
Range on HMM: 1-237/425
Sequence Identity: 18% (43 aa)

FISVGATGLILGVYNISQK------------RHSALKI-------------------------------QRVSSKHEIVREIGIIRDCQ-------MPLV
 .  |. |    ..... .            .. | ||                               .| ...... ||| | . .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYGFFY----------------LDVTKKEDFVVYE--IEKCSG-NLKQY-FNRLKKD--------------KIQLNEEEKMQIAIQVIDVINYLHYND
||.| ..                    ||.....      | |||  | .. |.....               .  ..|.|  ..  |... ..|.| ..
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKIENILYIDSNKSKVP------------IIKL
|||||.| ||||. |.|... |             ||.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase 12233.AA Ciliate-E2 491-610 24 8.6e-13 40.23 In-house 51-197 (365) Show / Hide 
Range on Protein: 491-610
Range on HMM: 51-197/365
Sequence Identity: 24% (39 aa)

ALKIQRVSSKHEIVREIGIIR----------------DCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG-NLKQYFN--RLKKDKI-----QLNEEEK
|.||.. . . .| .|| |.|                  . | .||.| .|.   .|... . .  | |.| .|..| .  ..|....     ...|.| 
AMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI

MQIAIQVID---------------VINYLHYND-IVHRDIKIENILYIDSNKSKVPIIKL
 .|  |...                ..||| .  |.||||| ||||.          ||.
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKI
Kinase 12233.AA Ciliate-E2a 551-608 32 6.2e-12 31.43 In-house 87-151 (275) Show / Hide 
Range on Protein: 551-608
Range on HMM: 87-151/275
Sequence Identity: 32% (21 aa)

FNRLKKDKIQLNE-EEKMQIAIQVI-DVINYLHYNDIVHRDIKIENILYI--DSNK---SKVPII
....|..| .  | .| ..|  | . . ..|.| . |.|||.| ||||.   ..|.   |.. ||
YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKII
Kinase 12233.AA CAMK1 572-605 45 1.1e-11 30.15 In-house 116-150 (276) Show / Hide 
Range on Protein: 572-605
Range on HMM: 116-150/276
Sequence Identity: 45% (16 aa)

QVIDVINYLHYNDIVHRDIKIENILYIDS-NKSKV
|... ..|.|...|||||.| ||.|| |  . ||.
QILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKI
S_TKc 12233.AA S_TKc 464-688 19 2.6e-10 -25.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 464-688
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

DSNFEFISVGATGLILGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG---NLKQYFNRLKKDK--
    . |  || |    ..... .|. |.|| .      | ||| | .  . | ..|.|..|.       |..    | |.|   .|..|  . .. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKL------RVCLAVIDNF---------ETLEPSLKQKNLDC---------
 ...| .   .. |... ..|.| . |.|||.| ||||  .        ||.      |.     . |         | |         ..         
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

-----LHGFKIPFEPSYLVKNELIKRNTKIYDIILKTVAFNQEKRKNLSSIIA-----DLHQKY
     .   . ||.  . .  ..|.      |.| |   .. |||     . .      .|.  
CILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12233.AA Pkinase 491-597 23 2.4e-05 19.96 Pfam 28-141 (293) Show / Hide 
Range on Protein: 491-597
Range on HMM: 28-141/293
Sequence Identity: 23% (28 aa)

ALKIQRVSSKHEIVR-------EIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSGN--LKQYFNRLK-KDKIQL--NEEEKMQIAIQVIDVIN
|.|| ....... ..       || | . .. | ....|..|.      .| .    | | |   .   | ... ...  .   |.|   .. |..  ..
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

YLHYNDIVHRDIKIENILY
|.| . |.|||.| ||||.
YCHSMGIIHRDLKPENILI
TyrKc 12233.AA TyrKc 464-684 14 0.000211 -151.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 464-684
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

DSNFEFISVGATGLI-LGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDC--QMPLVIKFYGFFYLD----VTKKEDFVVYEIEKCSGNLKQYFNRLKK
 .  . .  || | . .|...    .  | |  . ... .. ||. | .    . | ....||    .    .  .  ..| |  .  |.||.|  . ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP

DKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSN--------------------------------KSK--VPI-------IKLR----
.   |. ... ....|. .  .||| . ..|||.   |.|. . .                                 .|  .||       |. .    
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

--------VCL-----------AV-----IDNFETLEPSLKQKNLDCLHG-----FKIPFEPSYLVKNELIKRNTKIYDIILKTVAFNQEKRKNLSSIIA
        ||.                  ..|.| .|   . . ... .      |                  ...|.|...  ... |.| . | |. 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--------------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

DL
..
CF
Kinase 12233.AA PEK 543-596 13 0.00122 7.69 In-house 365-459 (655) Show / Hide 
Range on Protein: 543-596
Range on HMM: 365-459/655
Sequence Identity: 13% (13 aa)

CS-GNLKQYFNRLK----------------------------------------KDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENIL
|. ..|... .. .                                        ..  ......  .|. |...  ||.| . ..|||.|  ||.
CEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIF