Gene 28067 (Tetrahymena)

28067

Species: Tetrahymena
Alias: TTHERM_01410020, 373.m00012, 28067, PreTt28067, 338
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
28067.AA Protein None 497 None Fasta, JSON
28067.kin_dom2 Protein Kinase Domain None 192 None Fasta, JSON
28067.NA RNA None 1494 None Fasta, JSON
28067.kin_dom Protein Kinase Domain None 192 None Fasta, JSON

Protein domain

Protein domains of 28067.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 28067.AA Pkinase 37-59 32 6.695656 0.73 Pfam 269-293 (293) Show / Hide 
Range on Protein: 37-59
Range on HMM: 269-293/293
Sequence Identity: 32% (8 aa)

IVKQCLEFNPQNRTSAVDLLIQ--F
..| ||...|. | .| ..|    |
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase 28067.AA C2 160-348 38 9.2e-98 331.09 In-house 1-245 (245) Show / Hide 
Range on Protein: 160-348
Range on HMM: 1-245/245
Sequence Identity: 38% (94 aa)

GATGLILGVYNISQKRHSALKIQRVSS-----KHEIVREIGIIRDCQ-MPLVIKFYGFFYLDVTKKED------------------------FVVYEIEK
||.||.|...| .|.||.|||||.. |     .||...|.||.|.|| ||..||.|..|||.|.||||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTD----------FDQARKMYYNLINDNGNY-V
|.|||||||||..|.........||..|||..|.|||||..|||||||| .|.||...... .|.|||.|          ||.|.|. || .. ...  .
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQG-IPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

KDYKPIKG----------------ACGTLGYISPEIFNTQLYTFQS
... ....                ...|.||...|..|.|.||...
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 28067.AA Ciliate-C8 160-351 31 6.6e-76 258.48 In-house 1-232 (238) Show / Hide 
Range on Protein: 160-351
Range on HMM: 1-232/238
Sequence Identity: 31% (74 aa)

GATGLILG-------VYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKED-----------------FVVYEIEKCS--G
||.|..|.        .. ...|....|||.. ..|||.....| ..||||.|...|..|||. ..||||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTD------FDQARKMYYNLI-NDNGNYVKDYKPIK
||||||.|..|.........|..||||.||..||||...|.||||| .|.|.... ....|.||| |      |..|... .|       .... . .|.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFD-QQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIE

GA-CGTLGYISPEIFNT------QLYTFQSEIF
.. ||..||. ||. .       ......|...
MYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSY
Kinase 28067.AA C8 152-351 30 1.6e-42 145.42 In-house 2-220 (226) Show / Hide 
Range on Protein: 152-351
Range on HMM: 2-220/226
Sequence Identity: 30% (69 aa)

SNFEFISVGATGLILGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLD-VTKKEDFVVYEIEKCS-------------------
.||...| || |..|  .|. ..|. .||.| ...|..|  .. | . ..||.|.. | |.... ....|...|.| ||||                   
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQYFNRLKKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMYYNLINDNGNYVKDYKPIKGACG
   ||||..  ... . |...|.| .||||.|| .||.|   |.||||| .|.|   ... ....||| ||. | .   |   .    ..        ||
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQN-YGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CG

TLGYISPEIFNT-----QLYTFQSEIF
|..|. ||| .      . |. || .|
TWAYFAPEIEKKQDNQYKQYRIQSDLF
Kinase 28067.AA CAMK 156-344 18 7.3e-25 76.43 In-house 1-310 (425) Show / Hide 
Range on Protein: 156-344
Range on HMM: 1-310/425
Sequence Identity: 18% (57 aa)

FISVGATGLILGVYNISQK------------RHSALKI-------------------------------QRVSSKHEIVREIGIIRDCQ-------MPLV
 .  |. |    ..... .            .. | ||                               .| ...... ||| | . .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYGFFY----------------LDVTKKEDFVVYE--IEKCSG-NLKQY-FNRLKKD--------------KIQLNEEEKMQIAIQVIDVINYLHYND
||.| ..                    ||.....      | |||  | .. |.....               .  ..|.|  ..  |... ..|.| ..
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKIENILYIDSNKSKVP------------IIKLTDFDQARKM------YYNLINDNGNYVKD--------YKPIKGACGTLGYIS-PEIFNT---
|||||.| ||||. |.|... |             ||..||  |.|.      ...  ...|. . .         .. |  |||..|.. ||..|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------QLY
          . |
CNMQNATDEEKPY
Kinase 28067.AA Ciliate-E2 178-351 22 1.3e-21 70.98 In-house 51-280 (365) Show / Hide 
Range on Protein: 178-351
Range on HMM: 51-280/365
Sequence Identity: 22% (57 aa)

ALKIQRVSSKHEIVREIGIIR----------------DCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG-NLKQYFN--RLKKDKI-----QLNEEEK
|.||.. . . .| .|| |.|                  . | .||.| .|.   .|... . .  | |.| .|..| .  ..|....     ...|.| 
AMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI

MQIAIQVID---------------VINYLHYND-IVHRDIKIENILYIDSNKSKVPIIKLTDFD---------------QARKMYYNLINDNGNYVKDYK
 .|  |...                ..||| .  |.||||| ||||.          ||..||                | .|.| .  ||.     ...
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD

PIKGA----------CGTLGYISPEIFNTQL---------YTFQSEIF
               |||.|| .|||.| .          |.... |.
----QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW
Kinase 28067.AA Ciliate-E1 157-344 18 5.2e-18 55.54 In-house 1-202 (202) Show / Hide 
Range on Protein: 157-344
Range on HMM: 1-202/202
Sequence Identity: 18% (38 aa)

ISVGATGLILGVYNISQK-RHSALKIQRVS---SKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKED--FVVYEIEKCSGNLKQYFN---------RL
|. |  ....  ...... .. |.||. .    .. ..  ||  .   .. .  ..| . ..|. |...  . .  .|.|. .||.|..          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KKDKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMYYNLINDNGNYVKDYKPIKGACGTLGYISPEI-FN
.....|.....||||..| || ...||.. | ||||| .|||. .... .   . . .| .  . ..  ..   .|.. .  ..       . . .| ..
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYK

TQLY
. .|
SDIY
Kinase 28067.AA CAMK-Unique 238-344 26 1.2e-16 51.32 In-house 142-266 (363) Show / Hide 
Range on Protein: 238-344
Range on HMM: 142-266/363
Sequence Identity: 26% (35 aa)

FNRLKKDKIQLNE--EEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDS-----------NKSKVPIIKLTDFDQARKMYYNLINDNGNYVKDYKPI
|| ||. .....|   .  .|  ..  ...|.| .||||||.| |||..  |           .. .   |||.||. ...          | .| .  .
FNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHY---------NHNKMCHMM

KGACGTLGYISP--------------EIFNTQLY
.  |||. |..|              |. | | |
QTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCY
Kinase 28067.AA Ciliate-E2a 238-340 29 1.5e-16 45.26 In-house 87-183 (275) Show / Hide 
Range on Protein: 238-340
Range on HMM: 87-183/275
Sequence Identity: 29% (32 aa)

FNRLKKDKIQLNE-EEKMQIAIQVI-DVINYLHYNDIVHRDIKIENILYI--DSNKSKVPIIKLTDFDQARKM--YYNLINDNGNYVKDYKPIKGACGTL
....|..| .  | .| ..|  | . . ..|.| . |.|||.| ||||.   ..|..    ||. ||  |..   .            ..| ..  ||| 
YDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD------------EKKYMFQKCGTP

GYISPEIFN
||. ||..|
GYVAPEVLN
Kinase 28067.AA CAMKL 259-344 31 8.2e-15 43.55 In-house 135-212 (297) Show / Hide 
Range on Protein: 259-344
Range on HMM: 135-212/297
Sequence Identity: 31% (28 aa)

QVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMY-YNLINDNGNYVKDYKPIKGACGTLGYISPEIFNT--QLY
|... .||.| ..||||||| ||||  .....    ||..||  . ..  .         ... .  |  ||.. | .||||.   . |
QIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPC--------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPY
S_TKc 28067.AA S_TKc 151-431 17 3e-14 32.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 151-431
Range on HMM: 1-231/231
Sequence Identity: 17% (55 aa)

DSNFEFISVGATGLILGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSG---NLKQYFNRLKKDK--
    . |  || |    ..... .|. |.|| .      | ||| | .  . | ..|.|..|.       |..    | |.|   .|..|  . .. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMYYNLINDNGNYVKDYKPIKGACGTLGYISPEIFNTQLYT
 ...| .   .. |... ..|.| . |.|||.| ||||  .        ||..||  ||..                  .  |||. |..||..    |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYG

F-----------------QSEIFFTXXNKQLKKSKNKRIFIYLSPDGAKAVASEIAKCPTLSTLSLYLQPRWGESSSFRNSQMSYSLHFKPL---PLAQM
.                     |    .. .|| .                                       |.....  ..  |.. |       . 
KCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EA

GR-------KQQL
 .        . .
LQDEWDIKCHPWF
Kinase 28067.AA Ciliate-E2-Unclassified 232-351 25 5.5e-14 44.93 In-house 106-254 (352) Show / Hide 
Range on Protein: 232-351
Range on HMM: 106-254/352
Sequence Identity: 25% (38 aa)

GNLKQYFN-------------RLKKDKIQLNEEEKM-----QIAIQVIDVINYLHYND-IVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMYYNLIN
|.|.|| .             . .| . .. |..       ... |... ..|||..  |.||||| ||||. ...|     ||..||  ..|  .|  .
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNC

DNGNY-----VKDYKPIKGACGTLGYI----SPEIFNTQLYT----FQSEIF
| .|      . ... ..  |||..|.    .||..  | |     ... |.
D-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIW
Kinase 28067.AA Pkinase 178-348 23 2e-13 48.57 Pfam 28-193 (293) Show / Hide 
Range on Protein: 178-348
Range on HMM: 28-193/293
Sequence Identity: 23% (43 aa)

ALKIQRVSSKHEIVR-------EIGIIRDCQMPLVIKFYGFFYLDVTKKEDFVVYEIEKCSGN--LKQYFNRLK-KDKIQL--NEEEKMQIAIQVIDVIN
|.|| ....... ..       || | . .. | ....|..|.      .| .    | | |   .   | ... ...  .   |.|   .. |..  ..
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

YLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMYYNLINDNGNYVKDYKPIKGACGTLGYISPEIFN-TQLYTFQS
|.| . |.|||.| |||| ||.|    ...|..||  |....             .   .. |||..|..||. .  | |.  .
YCHSMGIIHRDLKPENIL-IDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV
TyrKc 28067.AA TyrKc 151-396 17 6.8e-07 -111.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 151-396
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

DSNFEFISVGATGLI-LGVYNISQKRHSALKIQRVSSKHEIVREIGIIRDC--QMPLVIKFYGFFYLD----VTKKEDFVVYEIEKCSGNLKQYFNRLKK
 .  . .  || | . .|...    .  | |  . ... .. ||. | .    . | ....||    .    .  .  ..| |  .  |.||.|  . ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRP

DKIQLNEEEKMQIAIQVIDVINYLHYNDIVHRDIKIENILYIDSNKSKVPIIKLTDFDQARKMYYN-LINDNGNYVKDYKPIK---GAC--GTLGYISPE
.   |. ... ....|. .  .||| . ..|||.   |.|. . .     ..| .||  .|. |            |||.  |   |.     .   .||
K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPE

IFNTQLYTFQS----------EIF-------FT-----XXNKQLKKSKNKRIFIYLSPD--------GAKAVASEIAKC--------PTLSTLSLYL
 .|.  .|..|          |||                |... .   ..      |.          ... . . .|        || |..  ..
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF