Gene 2605 (Tetrahymena)

2605

Species: Tetrahymena
Alias: 2605, PreTt02605, TTHERM_01685280, 559.m00003, 1059
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
2605.AA Protein None 466 None Fasta, JSON
2605.kin_dom Protein Kinase Domain None 173 None Fasta, JSON
2605.kin_dom2 Protein Kinase Domain None 115 None Fasta, JSON
2605.NA RNA None 1401 None Fasta, JSON

Protein domain

Protein domains of 2605.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2605.AA C8 54-166 63 7.4e-65 221.79 In-house 103-226 (226) Show / Hide 
Range on Protein: 54-166
Range on HMM: 103-226/226
Sequence Identity: 63% (79 aa)

QDNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAPEV
..|||||.|..|..|....||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..|||    ||.||||||.
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEI

EAG------QSRIQSDLFSLGLIL
|..      |.||||||||.||.|
EKKQDNQYKQYRIQSDLFSVGLVL
Kinase 2605.AA Ciliate-C8 54-166 53 9.6e-64 218.09 In-house 97-238 (238) Show / Hide 
Range on Protein: 54-166
Range on HMM: 97-238/238
Sequence Identity: 53% (76 aa)

QDN--LKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDA
|.|  |||.||..||.|..| ..||||||||||...|.||..|||||||||.||||| ...|...|||||      .||||...|.|| ..|||  |||.
QQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQ

Y-----------FAPEVEAGQSRIQSDLFS-------LGLIL
|           ||||||..|||||||.||       .||.|
YIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2605.AA C2 54-179 43 2.4e-36 121.75 In-house 102-245 (245) Show / Hide 
Range on Protein: 54-179
Range on HMM: 102-245/245
Sequence Identity: 43% (62 aa)

QDNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD----------LGFASAVSKSKS--FMSK-KGT
| |||| |. .|||.  | ..||.|.||||. . | || ..| ||||||.|||.  ...    |||||          . |||.....||   .|| |.|
QGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWT

DAY----FAPEVEAGQSRIQSDLFS-LGLILLELDNLKTLNENW
 .|    |||||. .  . .||||| .|..|||||| .. . . 
QQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 2605.AA TKL 79-169 21 4.9e-20 68.83 In-house 137-282 (364) Show / Hide 
Range on Protein: 79-169
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCASKE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EAGQSRIQSDLFSLGLILLEL
 .. ||||                 . ..   ..| .| |..| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 2605.AA Ciliate-E3 79-170 36 1.3e-18 54.95 In-house 108-202 (202) Show / Hide 
Range on Protein: 79-170
Range on HMM: 108-202/202
Sequence Identity: 36% (35 aa)

IAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYG-FSIKLCDLGFASAVSKSK--SFMSKKGTDAYFA-PEVEA-GQSRIQSDLFSLGLILLELD
|.||.|.|.  .| ||| | ||||.|.||  .|...   || ||.| .   .| |  .     |.  ..| ||.   .|    ||. |.| ....| 
ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 2605.AA Ciliate-E2 1-169 22 1.9e-18 59.89 In-house 36-289 (365) Show / Hide 
Range on Protein: 1-169
Range on HMM: 36-289/365
Sequence Identity: 22% (59 aa)

MNKSH-----FKIFIFLSKFLKNKKYLQINQKKIIQKFRNKHF------------FNQNFNIKLIQFYNQQDN---------LKQ--LFDFLRKQQVPPP
. ..      .||.|.  | .|...  ||.|.. | .  |  |             | .. ||.. ..  .|.         ...  |||......   .
Q-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRN

KE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKS----------KSFMS
.|        .|||  |  | ..               .|. || || |.||||||.| |.         ||..|.|..  ....          | .| 
HEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF

KK-----------------------GTDAYFAPEVEAGQSR----------IQSDLFSLGLILLEL
 |                       ||  | |||.  |..            ..|..||| || |.
-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 2605.AA Pkinase 60-169 29 1.3e-17 63.36 Pfam 91-205 (293) Show / Hide 
Range on Protein: 60-169
Range on HMM: 91-205/293
Sequence Identity: 29% (35 aa)

LFDFLR--KQQVP--PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDAYFAPEV--EAG
|||...  .. .   ...| | ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  ...  ||  | ||||  .. 
LFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

QSRIQSDLFSLGLILLEL
     .| .|.|.|| |.
YYGPKVDMWSCGCILYEM
Kinase 2605.AA Ciliate-A1 79-169 28 1.7e-17 56.1 In-house 106-221 (301) Show / Hide 
Range on Protein: 79-169
Range on HMM: 106-221/301
Sequence Identity: 28% (34 aa)

IAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSK-------------------SFMSKKGTDAYFAPEV----------E
|  |.|||.  .| .||.|||.|||| |.   . .    |.||||       ..                      .| |.  | .||            
ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFI

AGQSRIQSDLFSLGLILLEL
 .    |||..|||.|...|
ENKIYKQSDMYSLGCIICFL
Kinase 2605.AA CAMK 82-166 21 1.7e-17 52.25 In-house 187-324 (425) Show / Hide 
Range on Protein: 82-166
Range on HMM: 187-324/425
Sequence Identity: 21% (30 aa)

QMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYF
|...... .| .||.|||.|| | |.. ...               . ||..| |||  . ...                         .    || .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVEAG-------------QSRI--QSDLFSLGLIL
| |||  |             .  .  ..|  |.| ||
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 2605.AA STE 78-169 26 2.6e-17 57.78 In-house 155-261 (359) Show / Hide 
Range on Protein: 78-169
Range on HMM: 155-261/359
Sequence Identity: 26% (31 aa)

IIAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEVEAG-QSR----
.|. | ..| |. || ..|.||||||.| |.         .|||| |... ...                 ..   .  ||  . ||||  . ..     
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

--IQSDLFSLGLILLEL
  ...|  |||. ..|.
YDTKCDIWSLGCTIIEM
Kinase 2605.AA Ciliate-E2-Unclassified 7-169 22 3.1e-16 52.81 In-house 34-263 (352) Show / Hide 
Range on Protein: 7-169
Range on HMM: 34-263/352
Sequence Identity: 22% (53 aa)

KIFIFLSKFLKNKKYLQINQKKIIQK-------------------------FRNKHFFNQNFNIKLIQFYNQQDNLKQ--------------LFDFLRKQ
|| |. .|  .||.   .|..|....                          .  . |.. .|| ..  | .. .|.|              ||. ....
KIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQR

QVPPPKEMK----EIIAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCASKEYGFSIKLCDLGFAS----------------AVSKSKSFMSKKGTDAYF--
.  . ...|    . .. | ..||. || || | ||||||.| |.  ...  . ||..|.|...                .. |.. . .. ||  |   
KIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ

--APEVEAG-QSR----IQSDLFSLGLILLEL
  ||||  | .      ...| .||| || |.
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase 2605.AA S_TKc 3-233 20 2.1e-10 -24.45 SMART 17-231 (231) Show / Hide 
Range on Protein: 3-233
Range on HMM: 17-231/231
Sequence Identity: 20% (54 aa)

KSHFKI--FIFLSKFLKNKKYLQINQKKIIQKFRNKHFFNQNFNIKLIQFYNQQDNL--------K---QLFDFLRKQQVP------PPKEMKEIIAIQM
| . |    |.  | .|      ..  .| .|       .  . .||. ..   |.|             |||...|.. .      |. . . ... |.
KCRHKKTGRIVAIKIIK---EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QI

IEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFAPEVEAGQSRIQSDLFSLGLILLELDNLKTLNENWIDTN
...|. .| ..|.|||.||.| |..        ||.|| |.|  .      ..  ||  | ||||  | ..  .|  |.| || |.   ... .   . .
CCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQ

IKYYLFKGEEIPKEKYQIDKNSNIYKIAKICLKPWYLDRTTAGELLS--------QLI
  . . .              .    . . ||.    .| || |.|         . .
MMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2605.AA TyrKc 10-232 17 2e-06 -118.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-232
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

IFLSKFL--------------------KNKKYLQINQKKIIQKFRN-KHFFNQN--FNIKLIQFY---NQQ-------DNLKQLF---------DFLRKQ
| | | |                    . |..        .. |..      .    .  ....|    ||       . |  ..         |.||| 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

QVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKS-------KSFMSKK--GTD-----AYFAPEVE-AGQ
.   . . .  ...|  .| . || ||. |||.   | || . .     .| .| | . ..          .  ..|.  |..        |||.   | 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

SRIQSDLFSLGLILLELDNL-KTLNEN-----WIDTNIKYYLFKGEEIPKEKY-----QIDKNSNIYKIAKICLKPWYLDRTTAGELLSQL
  ..|| .| |  . |.  . ..  ..       .. .  |. .|.  |. ..          . .|.| | | .    || |  |. ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 2605.AA C8 259-332 51 1.9e-37 127.52 In-house 150-226 (226) Show / Hide 
Range on Protein: 259-332
Range on HMM: 150-226/226
Sequence Identity: 51% (40 aa)

KPENFLVYLDGKQP-EIKLCDFGLSAQIPDNKDLIQTIES--IGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLL
||.||||.||.... ||||||||...|...||. ||....  .|...|.||||..||||..|.|...||..||||.|
KPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 2605.AA Ciliate-C8 259-332 47 2.3e-33 116.96 In-house 146-238 (238) Show / Hide 
Range on Protein: 259-332
Range on HMM: 146-238/238
Sequence Identity: 47% (44 aa)

KPENFLVYLD-GKQPEIKLCD------FGLSAQIPDNKD---------LIQTIES--IGNLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL
||.||||..| ..||.|||||      ||...|.|.||.          .|.||.  .||.||.|||...| ......|.|||||||||||.|
KPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2605.AA Ciliate-E2 259-332 26 5.3e-14 44.43 In-house 188-286 (365) Show / Hide 
Range on Protein: 259-332
Range on HMM: 188-286/365
Sequence Identity: 26% (29 aa)

KPENFLVYLDGKQPEIKLCDFGLSAQIPDNKD--------LIQTIES----------------------IGNLGYSAPEILNKQDNE----LKIYSKKSD
|||| |.        ||..||||| .. |. .         . .  .                      .|..|| ||||||.....     | |..|.|
KPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD

SYSVGLLL
 .|.| .|
IWSLGVIL
Kinase 2605.AA CAMK 259-332 21 1.8e-13 39.09 In-house 206-324 (425) Show / Hide 
Range on Protein: 259-332
Range on HMM: 206-324/425
Sequence Identity: 21% (25 aa)

KPENFLVYLDGKQPE--------------IKLCDFGLSAQIPDNKDLI---------------------QTIESIGNLGYSA-PEILNKQ---------D
|||| |.  ...  .              ||..|||...........                         .. | ..| | ||.||..         |
KPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATD

NELKIYSKKSDSYSVGLLL
.| . |..|.|  |.| .|
EEKPYYGPKCDMWSCGVIL
Kinase 2605.AA TKL 259-332 24 4.7e-11 36.06 In-house 167-279 (364) Show / Hide 
Range on Protein: 259-332
Range on HMM: 167-279/364
Sequence Identity: 24% (28 aa)

KPENFLVYLDGKQPE-----------IKLCDFGLSAQIP---DNKDLI--------------QTIESIGNLGYSAPEILNKQDN-----------ELKIY
|..| ||  ...              .|.||||||  .    ...|                .|.  .|.... |||.|..|.|           . . |
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

SKKSDSYSVGLLL
|.|.| || |..|
SEKCDVYSFGIVL
Kinase 2605.AA Ciliate-A1 259-340 32 1.7e-10 31.92 In-house 128-226 (301) Show / Hide 
Range on Protein: 259-340
Range on HMM: 128-226/301
Sequence Identity: 32% (33 aa)

KPENFLVYLDGKQPEIKLCDFGLSAQIPDNK----------------DLIQTIESIGNLGYSAPEI----L-NKQDNELKIYSKKSDSYSVGLLLAFLDN
||.| |.  | |   .|.||.|.| | . |.                   .|..  ||| | .||     .  ..  | ||| |.|| ||.|. . || .
KPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIY-KQSDMYSLGCIICFLCY

YQD
  |
KED
Kinase 2605.AA STE 259-332 24 8.6e-10 30.88 In-house 179-258 (359) Show / Hide 
Range on Protein: 259-332
Range on HMM: 179-258/359
Sequence Identity: 24% (22 aa)

KPENFLVYLDGKQPEIKLCDFGLSAQIPDNKD--------------LIQTIESIGNLGYSAPEILNKQDNE-LKIYSKKSDSYSVGLLL
|| | |.        .||||||...|. |. .                ..   .|   . |||.......   | |. |.| .|.|...
KPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 2605.AA Ciliate-E3 259-336 39 2.5e-07 19.24 In-house 130-202 (202) Show / Hide 
Range on Protein: 259-336
Range on HMM: 130-202/202
Sequence Identity: 39% (31 aa)

KPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDLIQTIESIGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLLAFLD
||.|.||     |  || ||||.| |   || ...|        |.|||.. .|       || || ||||  .  | 
KPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQ-----ISKESDYYSVGAVFCQLC
Kinase 2605.AA Ciliate-E2-Unclassified 259-332 28 8.8e-07 19.57 In-house 171-260 (352) Show / Hide 
Range on Protein: 259-332
Range on HMM: 171-260/352
Sequence Identity: 28% (26 aa)

KPENFLVYLDGKQPEIKLCDFGLSAQIPDN----------KDLIQTIES---IGNLGYS----APEILNKQDNELKIYSKKSDSYSVGLLL
|||| |.  .||  .||..|||.| .. .|          .. ..  ..   .|...|     |||.| .| .. .   .|.| .|.| .|
KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVIL
Kinase 2605.AA C2 259-345 32 6e-06 16.4 In-house 149-245 (245) Show / Hide 
Range on Protein: 259-345
Range on HMM: 149-245/245
Sequence Identity: 32% (33 aa)

KPENFLVYLDGKQ-PEIKLCD----------FGLSAQIPDNKDLIQTIESIGNLGY----SAPEILNKQDNELKIYSKKSDSYS-VGLLLAFLDNYQDLK
||.|||. .| .. | |||||          |  .  .. ||  | . .  .   |    .|||.      . .|| |.|| .| ||. |  ||| |   
KPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYT

KNA
 . 
ICC
Kinase 2605.AA Pkinase 259-333 33 1.8e-05 20.44 Pfam 135-203 (293) Show / Hide 
Range on Protein: 259-333
Range on HMM: 135-203/293
Sequence Identity: 33% (27 aa)

KPENFLVYLDGKQPEI----KLCDFGLSAQI-PDNKDLIQTIESIGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLLA
||||.|  .| ....|    |.|||||..|.   |.   .|.   | ..| |||...    . . |..|.| .|.|..|.
KPENIL--ID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTF--CGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILY