Gene 24005 (Tetrahymena)

24005

Species: Tetrahymena
Alias: PreTt24005, 257.m00030, 781, 24005, TTHERM_01155690
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
24005.AA Protein None 1124 None Fasta, JSON
24005.kin_dom Protein Kinase Domain None 222 None Fasta, JSON
24005.kin_dom2 Protein Kinase Domain None 209 None Fasta, JSON
24005.NA RNA None 3375 None Fasta, JSON

Protein domain

Protein domains of 24005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24005.AA C2 48-270 49 1e-133 450.53 In-house 1-245 (245) Show / Hide 
Range on Protein: 48-270
Range on HMM: 1-245/245
Sequence Identity: 49% (122 aa)

GSFALVLKAINKNTGQTVALKVVECDESDLKGMEVIQEEYKMLQIFSGCKYIIKVFNSFYLTESIDSDEDEDDNQIPVDQSN--NQSSLLRIFYVMEQEF
|.|.|||||.||.....||||..||...|..||. .|.||.... .....|||||.|.||||.. ..|||||.......|.|  .|.....||.|.||||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CQTTLESFIDTCRKKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD----------LAFASALQNNETILSISTFKG
||..|......|||.||||.||||.||.||..||...|||||.|||||||||||..|||.|.||.||||          ..|||.|..|.. ...|.||.
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

SQAY----TAPEVYE-----KSDLFS-VGIVLLELDNIATFDINK
.|.|    .|||||.     .||||| ||.|||||||.....|..
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 24005.AA Ciliate-C8 48-257 40 1.3e-98 333.91 In-house 1-238 (238) Show / Hide 
Range on Protein: 48-257
Range on HMM: 1-238/238
Sequence Identity: 40% (99 aa)

GSFALVLKAINKNTGQTVALKVVEC-DESDLKGMEVIQEEYKMLQIFSGCKYIIKVFNSFYLTESIDSDEDEDDNQIPVDQSN--NQSSLLRIFYVMEQE
|.|..||||.||.....||||..|| .. . ..|| ...||.|.. |. ......|...|||.| .....|.....|...| .  .      .|.|||.|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK------SFFVMEME

FCQTT--LESFIDTCRKKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCD------LAFASALQNNETILSISTFKGS
.||..  |....|.||||.||||||||||..||..|||..||.|...||||||.|||..|||...|| ||||      ..|||.|..|........|||.
KCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGT

QAY-----------TAPEVYEK-----SDLFS-------VGIVL
..|           .||||..|     ||.||       ||.||
DQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 24005.AA C8 36-257 34 4.6e-55 189.24 In-house 1-226 (226) Show / Hide 
Range on Protein: 36-257
Range on HMM: 1-226/226
Sequence Identity: 34% (82 aa)

QKHYQILEFAGNGSFALVLKAINKNTGQTVALKVVEC-DESDLKGMEVIQEEYKMLQIFSGCKYIIKVFNSFYLTESIDSDEDEDDNQIPVDQSNNQSSL
 . .|.| |   |....|||| | .  ....||. .| ...| ...| |. ||.|.|.|.  . .. . . ||. .. . .|....|.. |   .     
FNNFQYLSF---GAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYE-VFEEEKCSNEKIVQTEE-----

LRIFYVMEQEFCQTTLESFIDTCRKKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALQNNET-ILSISTF
 . . ||| | |.  |. . | .|.|. ..|..||||..||..|.| ..| . ..||||||.|||. .||| ... ||||..|||... |.  |.|.  .
-KSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMN

K-GSQAYTAPEVYEK-----------SDLFSVGIVL
. | .|| |||. .|           |||||||.||
TCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 24005.AA CMGC 39-224 15 8.5e-31 97.7 In-house 1-257 (513) Show / Hide 
Range on Protein: 39-224
Range on HMM: 1-257/513
Sequence Identity: 15% (44 aa)

YQILEFAGNGSFALVLKAIN--------------KNTGQTVALKVVECDESDLKGME----------VIQEEYKMLQIFS----------------GCKY
|.|..  | |... | |...              ..|.. ||.| .  .. .  ..            .. | |.|. ..                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKVFNSFYLTES----------IDSDEDEDDNQIPVDQSNNQSSLLRIFYVMEQEFCQTTLESFIDTCRK-----KNSYPSQQM------------KEI
|.| ...||  .|          | |                | ..  .. |.  |.....|  .|. ...     .. . |.              .  
IVKLYDIFYHKNSDGNEYEDKHII-S----------------Q-HFNHLYLVF--EYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKY

MT------IQILDSVA--FLHRFD--VVHRDIKPSNFLLNFDQNG----------------NPTLKLCDLAFASALQNN
..       ||| ...  ..|. .  ..|||.||.| |.| .                   | .||.||  .| .. ..
FMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 24005.AA Pkinase 39-260 22 2.9e-29 104.56 Pfam 1-205 (293) Show / Hide 
Range on Protein: 39-260
Range on HMM: 1-205/293
Sequence Identity: 22% (55 aa)

YQILEFAGNGSFALVLKAINKNTGQTVALKVVECDESDLKGMEVIQE---EYKMLQIFSGCKYIIKVFNSFYLTESIDSDEDEDDNQIPVDQSNNQSSLL
|.|..  | |||. | |...|.||..||.|... . .. ......     | .... . ....|.. . .|.                            
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---------------------------

RIFYVMEQEFCQTTLESFIDTC-----RKKNSY--PSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP--TLKLCDLAFASALQNNET
.  . | .|.|. .|.  .| .     ......  . .. | .|. |||  ....|.  ..|||.||.|.|..  .||..  ..|.||  .|  .. .  
KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-Y-N

ILSISTFKGSQAYTAPEVYE-------KSDLFSVGIVLLEL
    .|| |.  | ||||         |.| .|.|..| |.
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 24005.AA S_TKc 39-322 22 1.7e-25 91.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-322
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

YQILEFAGNGSFALVLKAINKNTGQTVALKVVECDESDLKGMEVIQEEYKMLQIFSGCKYIIKVFNSFYLTESIDSDEDEDDNQIPVDQSNNQSSLLRIF
|.||.  | |.|. | |...|.||. ||.|..          | |. | ..|.   ....|.| . .|.                              .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD----------------------------DH

YVMEQEFCQT---TLESFIDTCRKKNS---YPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALQNNETILSIST
. |  |.| .   .| ..|. ....     .|  . . .|  ||.. ....|.  ..|||.||.| ||.       ..|.||  .|  |         .|
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TT

FKGSQAYTAPEVY---E-KSDLFSVGIVLLELDN-IATFDINKTKLQEKFETQNGSIFTNFNLDRQSHIYKIAVQCLNYDVNQRKPAVELLI--------
| |.  | ||||      |.|  |.|..| |.      |. .  .. .|                 .    .  .||..| ..|  | |.|         
FCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

QFI
...
PWF
Kinase 24005.AA Ciliate-E1 45-251 19 4.3e-20 62.38 In-house 1-202 (202) Show / Hide 
Range on Protein: 45-251
Range on HMM: 1-202/202
Sequence Identity: 19% (44 aa)

AGNGSFALVLKAINKNTG-QTVALKVVECD--ESDLKGMEVIQEEYKMLQIFSGCKYIIKVFNSFYLTES------IDSDEDEDDNQIPVDQSNNQSSLL
 |||||..|.||...|.  . ||.|...|   ... .  ..|.|.||... | . .|||.... ... ..      ... .... ... .          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

RIFYVMEQEFCQTTLESFIDTCRKKNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNPT-LKLCDLAFASALQNNETILSISTFK
           .  |   .. |.... . ..| |. ...|..| .. || . . ||||||.| | | . |.. . . ....   . .|.      .. ..
-----------N-RL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYY

GSQAYT--------APEVYEKSDLF
 .. |.          ..  |||..
PPEQYNCPEQEHNKNQKINYKSDIY
Kinase 24005.AA CAMK 175-257 22 1.8e-19 58.73 In-house 187-324 (425) Show / Hide 
Range on Protein: 175-257
Range on HMM: 187-324/425
Sequence Identity: 22% (31 aa)

QILDSVAFLHRFDVVHRDIKPSNFLLNFDQNGNP-------------TLKLCDLAFASALQNNE-----------------TIL----SISTFKGSQAYT
||.. |...|  ..||||.|| | ||. . ....             ..|..|  ||  .. .|                 |.       .|| |. .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVYEK--------------------SDLFSVGIVL
| ||| ..                    .|  |.|..|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 24005.AA STE 171-260 28 1.3e-18 62.38 In-house 155-261 (359) Show / Hide 
Range on Protein: 171-260
Range on HMM: 155-261/359
Sequence Identity: 28% (33 aa)

IMTIQILDS-VAFLHRFDVVHRDIKPSNFLLNFDQNGNPTLKLCDLAFASALQNN-------------ETILSIS-TFKGSQAYTAPEVYE---------
... |||    ..||.  ..||||||.| ||          ||||  ... |...             ||. . . || |.. . |||| .         
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

---KSDLFSVGIVLLEL
   |.|  |.|....|.
YDTKCDIWSLGCTIIEM
Kinase 24005.AA ULK 138-257 23 1.3e-16 54.54 In-house 92-246 (329) Show / Hide 
Range on Protein: 138-257
Range on HMM: 92-246/329
Sequence Identity: 23% (36 aa)

F--YVMEQEFCQT-TLESFIDTCRK-------KNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFAS
.  . . .|.|.  .||..| . .|       |.  . |. .... .|||    .||   ..||||||.| |.. .| .        |..||..|  || 
HNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFF-KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

ALQNN----ETILSIS---TFKGSQAYTAPEVYE----------K-SDLFSVGIVL
 ..|.    . ... .    ..|.  | ||.. .          . .|..|.|...
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 24005.AA ULK 143-257 25 1.4e-15 51.77 In-house 96-242 (324) Show / Hide 
Range on Protein: 143-257
Range on HMM: 96-242/324
Sequence Identity: 25% (37 aa)

QEFCQT-TLESFIDTCRK------KNSYPSQQMKEIMTIQILDSVAFLHRFDVVHRDIKPSNFLLNFDQNG--------NPTLKLCDLAFASALQNN-ET
.|.|.  .||..| . .|      |.  . |. .... .||.    .||   ..||||||.| |.. .| .        |..||..|  ||  ..|| . 
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFF-KQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

ILSISTFK------GSQAYTAPEVYE----------K-SDLFSVGIVL
   . |..      |.  | ||.. .          . .|..|.|...
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 24005.AA Ciliate-E2 144-260 18 3.9e-14 44.91 In-house 114-289 (365) Show / Hide 
Range on Protein: 144-260
Range on HMM: 114-289/365
Sequence Identity: 18% (34 aa)

EFCQT-TLESFI---DTCRKKN----SYPSQQMKEIMTIQILD---------------SVAFLHRFD-VVHRDIKPSNFLLNFDQNGNPTLKLCDLAFAS
|.||  .|...|   ...|...     |.. .    .. |||.                . .||    ..||||||.| |.         .|..|. .. 
EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSK

ALQNN-------------------ETILS----------ISTFKGSQAYTAPEVYE---------------KSDLFSVGIVLLEL
 ....                   ..  .          . |. |.  | |||...               |.|..|.|..| |.
KYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 24005.AA STE 39-107 18 1.8e-11 36.91 In-house 1-100 (359) Show / Hide 
Range on Protein: 39-107
Range on HMM: 1-100/359
Sequence Identity: 18% (18 aa)

YQILEFAGNGSFALVLKAINKN---------------TGQTVALKVVECDESD---------------LKGMEVIQEEYKMLQIFSG-CKYIIKVFNSFY
....|. |.|.|  | ||.|..               ||. .| |... ....                . |. |..| |... ..  ...|.| . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase 24005.AA CAMK 46-103 18 2.9e-07 18.69 In-house 3-104 (425) Show / Hide 
Range on Protein: 46-103
Range on HMM: 3-104/425
Sequence Identity: 18% (19 aa)

GNGSFALVLKAINKNTG------------QTVALKVVECDESD--------------------------LKGMEVIQEEYKMLQIFSG------CKYIIK
| |||. | ..|.|||.            | || |... .  .                           | .. .. |.....  .|       . |||
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VF
 .
LY
Kinase 24005.AA ULK 39-103 20 1e-06 19.48 In-house 1-81 (324) Show / Hide 
Range on Protein: 39-103
Range on HMM: 1-81/324
Sequence Identity: 20% (17 aa)

YQILEFAGNGSFA-LVLKAINKNT---GQTVALKVVE----CDESDLKG----MEVIQEEYKMLQIFS--GCKY--IIKVF
|.. .  | |||.  | |..||.|   .| || |...     . . .      .. .. | . ....    ...  |.| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY
Kinase 24005.AA ULK 39-107 22 9.8e-05 12.56 In-house 1-88 (329) Show / Hide 
Range on Protein: 39-107
Range on HMM: 1-88/329
Sequence Identity: 22% (20 aa)

YQILEFAGNGSFALVLKAINKNT----GQTVALKVVECDESDLKG--------MEVIQEEYKMLQIFS---GCKY----IIKVFNSFY
|.. .  | |||. | |..||.|    .. || |... .. . |         .. .. | | ..      ..|.    |.| .  |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFE
Kinase 24005.AA Ciliate-E2 39-107 14 0.002122 7.51 In-house 1-102 (365) Show / Hide 
Range on Protein: 39-107
Range on HMM: 1-102/365
Sequence Identity: 14% (15 aa)

YQILEFAGNGSFALVLKAINKNTGQ------------------TVALKVVECDESDLKGMEVIQEEYKMLQ---------I------FSGCKYIIKVFNS
| ...  |.|.|. | |. ......                   |. | ..      .. | |  | ....         .      .  ...||| . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY
|.
FQ
Kinase 24005.AA STE 302-322 41 0.002746 7.61 In-house 336-359 (359) Show / Hide 
Range on Protein: 302-322
Range on HMM: 336-359/359
Sequence Identity: 41% (10 aa)

QCLNYDVNQRKPAVELLI---QFI
.||..| |.|  | .||     ||
KCLQKDPNKRPTASQLLKSEHPFI
Kinase 24005.AA C2 428-614 38 3.8e-101 342.34 In-house 1-245 (245) Show / Hide 
Range on Protein: 428-614
Range on HMM: 1-245/245
Sequence Identity: 38% (95 aa)

GAAGLVLGVFNKSQNRHSALKIQRAK------KYEVVREVGIMRVCQ-MPLVVKLYDYFYLNVNTQED------------------------FVVYELEK
|| ||||..|||.||||.|||||...      . ||..|.|||| || ||...|.|.||||.||..||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSGNLKQFLNNLKKQNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPEIPTIKLAD----------FDQARKIPKNDN-LDFGEIVS
|.|||||..|...|||.......|...|||.||.|||||...|||||||..|.||......||||||.|          ||.|.|...|.. . | ....
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

EYFTIEG----------------ACGTIGYCPPELVKTFLYSLKS
.. ....                ...|.||...||.....|....
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 24005.AA Ciliate-C8 428-623 34 1.2e-88 300.78 In-house 1-238 (238) Show / Hide 
Range on Protein: 428-623
Range on HMM: 1-238/238
Sequence Identity: 34% (83 aa)

GAAGLVLG-------VFNKSQNRHSALKIQRAK-KYEVVREVGIMRVCQMPLVVKLYDYFYLN-VNTQED-----------------FVVYELEKCS--G
|| |.||.        ......|....|||... . |......||. ||||.||..||.|||. .| .||                 |.|.|.|||.  .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQFLNNLKKQNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPEIPTIKLAD------FDQARKIPKNDN-LDFGEIVSEYFTIEG
||||......|.........|..||||..| .||||...|.|||||..|.|..... ..|||||.|      |..|...||| . . . ... .. .||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

A-CGTIGYCPPELVKT------FLYSLKSDIFSVGVCL
. ||..||..||..|        ..|.|||..|||..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 24005.AA C8 421-623 31 4.9e-49 168.3 In-house 3-226 (226) Show / Hide 
Range on Protein: 421-623
Range on HMM: 3-226/226
Sequence Identity: 31% (72 aa)

NFEFISVGAAGLVLGVFNKSQNRHSALKIQRAKKY-EVVREVGIMRVCQMPLVVKLYDYFYLN-VNTQEDFVVYELEKCS--------------------
||...| || |.||   |  .||. .||.|  .   .   .  ||. ..||.|...|| .... .  .|...|.|.||||                    
NFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC

-GNLKQFLNNLKKQNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPEIPTIKLADFDQARKIPKNDNLDFGEIVSEYFTIEGACGTI
  ||||.   ............| .||||..| .||.|...|.|||||..|.|   .  ....|||.||. | ...|| . .    . .       ||| 
EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT-------CGTW

GYCPPELVKT-----FLYSLKSDIFSVGVCL
.|  ||  |        |. .||.||||. |
AYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 24005.AA CAMK 424-621 18 2.4e-36 114.1 In-house 1-322 (425) Show / Hide 
Range on Protein: 424-621
Range on HMM: 1-322/425
Sequence Identity: 18% (59 aa)

FISVGAAGLVLGVFNKSQN------------RHSALKI--------------------------------QRAKKYEVVREVGIMRVCQ-------MPLV
 .  |. | |  ...|. .            .. | ||                                .  .. .| ||. ||. .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYDYFYL-----------NVNTQ----EDFVVYEL---EKCSGN------LKQFLNN-----------LKKQNKELDEDQKIKIAIQIMDAINYLHIH
.|||...             . ..|    .....  .   | |||       .     .           .  ... ..|..  ..  || .|..|.| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

EIVHRDIKLENLLYIDQDPEIP-------------TIKLADFDQARKIPKNDNLDFG------------EIVSEYFTIEGACGTIGYCP-PELVKTFL--
 |||||.|.||.|. | ... .             .||..||  |.|.....|. .              .. |    .  ||| .|.. ||...     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YSLKSDIFSVGV
            |. |.|. |.||
NMQNATDEEKPYYGPKCDMWSCGV
S_TKc 24005.AA S_TKc 419-694 21 6.8e-26 93.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 419-694
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

DPNFEFISVGAAGLVLGVFNKSQNRHSALKIQRAKKYEVVREVGIMRVCQMPLVVKLYDYFYLNVNTQEDFVVYELEKCSG---NLKQFLNNLKKQNKE-
    . |  || | |  . .|. .|. |.|| .     . ||. |..  . | .|||||.|.       |..   .| |.|   .|.... . ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPEIPTIKLADFDQARKIPKNDNLDFGEIVSEYFTIEGACGTIGYCPPELVKTFLYSL-
 ..| .  ... || .|..|.| | |.|||.| ||.|  .      .||..||  ||..                     |||  |..||..    |.  
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYGKC

KSDIFSVGVCLALIDN----FETLEPVLLNKSLDYYNGFQIPFEAKYGDQQEVVKRNTKIYDILLQTVVFRQDKRTNLSLILD--------GFL
|.|. |.|..|.        |.  . ....| .                            |.. .  ..  .||     .|          ..
KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24005.AA Ciliate-E2 439-623 22 1.3e-25 84.83 In-house 44-286 (365) Show / Hide 
Range on Protein: 439-623
Range on HMM: 44-286/365
Sequence Identity: 22% (59 aa)

KSQNRHSALKIQRAKKYEVV-REVGIMR----------------VCQMPLVVKLYDYFYLNVNTQEDFVVYELEKCSG-NLKQFLNNL-KKQNKE-----
| ..   |.||.. .. | . .|  |||                  . | ..|.|..|.   ..... . . .| |.| .|.....|  ||.|.|     
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ---EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDK

-LDEDQKIKIAIQIMD---------------AINYLHIHE-IVHRDIKLENLLYIDQDPEIPTIKLADFDQARKIPKNDNLDFGEIVSEYFTIEGA----
 ..| . ..|  || .               |..|||    |.|||||.||.|.         ||..||  ..|. .. .  ..  .  .  ..      
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTS

------------------CGTIGYCPPELVK---------TFLYSLKSDIFSVGVCL
                  ||| || .|| ..            |. |.||.|.||.|
RTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 24005.AA Pkinase 453-621 26 3.3e-24 86.67 Pfam 41-200 (293) Show / Hide 
Range on Protein: 453-621
Range on HMM: 41-200/293
Sequence Identity: 26% (48 aa)

KKYEVVR--EVGIMRVCQMPLVVKLYDYFYLNVNTQEDFVVYELEKCSG-----NLKQFLNNLKKQNKEL--DEDQKIKIAIQIMDAINYLHIHEIVHRD
|... .|  |. ||. .. | .|.|||.|.      .| .   .| | |      |. ..    .... .  .|.. .... ||  ...|.| . |.|||
KDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRD

IKLENLLYIDQDPEI-PTIKLADFDQARKIPKNDNLDFGEIVSEYFTIEGACGTIGYCPPELVK-TFLYSLKSDIFSVGV
.|.||.| ||....| ...|..||  |...         .  .. .|  . |||..|..||...    |. |.|..|.|.
LKPENIL-IDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MT--TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC
Kinase 24005.AA ULK 499-623 26 3.2e-17 57.69 In-house 102-242 (324) Show / Hide 
Range on Protein: 499-623
Range on HMM: 102-242/324
Sequence Identity: 26% (40 aa)

GNLKQFLNNLKK-----QNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPE--------IPTIKLADFDQARKIPKN-DNLDFG---
|.|.|.... ||      .| | |.. |.. .||. .  .|| | |.|||||..|.|  . .|         ....|.|||  |... .|  . .     
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTC

--EIVSEYFTIEGAC---GTIGYCPPELVK----TFLYS-LKSDIFSVGVCL
  |               ||  |  |....       |.  |.||.|.|. .
VNE-----------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 24005.AA Ciliate-E1 425-617 19 3.6e-17 52.77 In-house 1-202 (202) Show / Hide 
Range on Protein: 425-617
Range on HMM: 1-202/202
Sequence Identity: 19% (43 aa)

ISVGAAGLVLGVFNKSQN-RHSALKIQRAKKY-EVVREVGIMRVCQMPLVVKLYDYFYLNVNTQE-DFV---VYELEKCSGNLKQFLN---------NLK
|. |  ..|.  .....| .. |.||.  .   . . .  . . .. .. .| ..| .  ..... |.    .  .|.|. .||. |.          ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KQNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPEIPTIKLADFDQARKIPKNDNLDFGEIV----SEYFTIEGACGTIGYCPPELV
.........||..|..|. |....||.. | ||||| .|.|. .|.  . .                  |||       ... ..   . |  |.||| .
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC------------------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQY

K--------TFLYSLKSDIF
.        .  .. ||||.
NCPEQEHNKNQKINYKSDIY
Kinase 24005.AA CMGC 438-566 18 8.8e-16 47.44 In-house 34-248 (513) Show / Hide 
Range on Protein: 438-566
Range on HMM: 34-248/513
Sequence Identity: 18% (40 aa)

NKSQNRHSALKIQR-AKKYEVV---------------REVGIMRVCQ-----------------MPLVVKLYDYFY-LNVNTQED-----------FVVY
..  |.. |.|. . .. ||                 ||. |..  .                  . .|||||.||  | ...|.            .  
HHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYL

ELEKCSGNLKQFLNNLKK-----QNKELDEDQ------------KIKIA------IQIMDAIN--YLHIHE--IVHRDIKLENLLYIDQDPEI-------
  | .  .|.|.. | ..     ....|.| .            . ..        ||  ...  |.| |   |.|||.| ||.|  ..   |       
VFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS

---------PTIKLADF
          ..|..||
EDWNPCQKNGRLKICDF
Kinase 24005.AA ULK 499-566 32 5.9e-14 45.19 In-house 105-186 (329) Show / Hide 
Range on Protein: 499-566
Range on HMM: 105-186/329
Sequence Identity: 32% (27 aa)

GNLKQFLNNLKK------QNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPE--------IPTIKLADF
|.|.|.... ||       .| | |.. |.. .||. .  .|| | |.|||||..| |  . .|         ....|.|||
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF
Kinase 24005.AA STE 456-566 26 2.1e-12 40.19 In-house 74-191 (359) Show / Hide 
Range on Protein: 456-566
Range on HMM: 74-191/359
Sequence Identity: 26% (34 aa)

EVVREVGIMRVCQ--MPLVVKLYDYFYLN---VNTQEDFVVYELEKCS-GNLKQFLNNLKKQNKELD----------EDQKIKIAIQIMDA-INYLHIHE
.. .|. ||. |.   | .|| |.... .    .  ..  .. .| .. | | ..... .. .|.|.          |.| ..|. ||  .  .||| | 
QILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH

IVHRDIKLENLLYIDQDPEIPTIKLADF
|.|||||  | |          .||.||
IIHRDIKPANILL---------VKLCDF
TyrKc 24005.AA TyrKc 389-693 18 1.2e-09 -66.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 389-693
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

MSKFQQLETQPFKEQEYYIILNNLQNMNKFDPNFEFISVGAAGLVLGVFNKSQNRHSALKIQRAKKYEVVREVGIMRVC--QMPLVVKLYDYFYLN----
 .. ..|    | |    .                          . |  |. . ..        . .  ||  ||.    . | .|.|| .        
ITLGKKLGEGAFGEVYKGTWK------------------------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNF

VNTQEDFVVYELEKCSGNLKQFLNNLKKQNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDIKLENLLYIDQDPEIPTIKLADFDQARKIPKNDNLDFGE
.  .  ..| |. .  |.||..| . ...   |  ........|| .  .||| . ..|||.   | |. ..     |.| .||  .|.|   |.     
MYIEPLMIVMEYMPH-GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG---

IVSEYFTIE---GAC--GTIGYCPPELVKTFLYSLKSDIFSVGVCL-----------AL-----IDNFETLEPVLLNKSLDYYNG-----FQIPFEAKYG
  ..| .     |.     |  ..||  ..  .. |||..| |||.                  ..|.| .| |   . ..         |         
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---------

DQQEVVKRNTKIYDILLQTVVFRQDKRTNLSLILDGF
     |   ...|.| .|   .  ..| . | | . |
-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 24005.AA Pkinase_Tyr 497-544 22 0.006077 10.59 Pfam 90-137 (270) Show / Hide 
Range on Protein: 497-544
Range on HMM: 90-137/270
Sequence Identity: 22% (11 aa)

CSGNLKQFLNNLKKQNKELDEDQKIKIAIQIMDAINYLHIHEIVHRDI
. |.|. .| . . ... |.  .......|| .. .||. . ..|||.
PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 24005.AA ULK 594-623 31 0.022369 4.21 In-house 212-246 (329) Show / Hide 
Range on Protein: 594-623
Range on HMM: 212-246/329
Sequence Identity: 31% (11 aa)

CGTIGYCPPELVK----TFLYS-LKSDIFSVGVCL
|||  |  |....       |.  |.||.|.|. .
CGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 24005.AA STE 594-623 27 0.067297 2.64 In-house 224-258 (359) Show / Hide 
Range on Protein: 594-623
Range on HMM: 224-258/359
Sequence Identity: 27% (10 aa)

CGTIGYCPPELVK--TFL----YSLKSDIFSVGVCL
.||  .  || ..  .      |. |.|| |.| ..
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 24005.AA Pkinase_Tyr 600-623 33 0.397705 4.44 Pfam 181-204 (270) Show / Hide 
Range on Protein: 600-623
Range on HMM: 181-204/270
Sequence Identity: 33% (8 aa)

CPPELVKTFLYSLKSDIFSVGVCL
..||  ..  .. |||. | ||..
MAPECINYGKFTTKSDVWSFGVLM