Gene 24213 (Tetrahymena)
24213
Sequence
Protein domains of 24213.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24213.AA | C8 | 42-256 | 60 | 4.5e-120 | 405.22 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 42-256 Range on HMM: 1-226/226 Sequence Identity: 60% (136 aa) FKNFEYLSSGAYALVLKAQNIQQNRQVALKFLGSSNQNDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME |.||.|||.|||..||||.|...||...|||. ..|..|...|||..|||||.|.|.|..|.||.|||||.|.|...|. ..|..|||||.||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCENNLKQLFDILRKEQVPPPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCDLGFASAVSKSKS-FKSKK----GTDPYFAP |||.|||||.| .|..|....|.|||||||||..|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| . ||| ||. |||| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP EVDEG------QSRIQSDLFSLGLVL |. .. |.||||||||.|||| EIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 24213.AA | Ciliate-C8 | 51-256 | 56 | 7e-118 | 397.93 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 56% (134 aa)
GAYALVLKAQNIQQNRQVALKFLGSSNQNDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVK---SFFVMEMELCENN-
||...||||||..|||.|||||. ..|...||..|...|||||...|.|..|.|.||||||||||...|| ||||.||||..| ||||||||.|..|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC
-LKQLFDILRKEQVPPPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCD------LGFASAVSKSKS-FKSKK--GTDPY---
|||.|| .||.|..| .||||||||||....|.||..|||||||||.|||||....|...||||| .||||...|.|| . ||| ||| |
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM
--------FAPEVDEGQSRIQSDLFS-------LGLVL
||||| ..|||||||.|| .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
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| Kinase | 24213.AA | C2 | 51-269 | 41 | 6.5e-70 | 237.97 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 51-269 Range on HMM: 1-245/245 Sequence Identity: 41% (101 aa) GAYALVLKAQNIQQNRQVALKFLGSSNQNDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEE-KEDEDADGNDIIVQTEV--------KSFFVMEME || .||||| | .|||.|||| ..|| || ... |||....... . ....||..||| .. ||||| | ...... | |.|.|.|.| GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCENNLKQLFDILRKEQVPPPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCD----------LGFASAVSKSKS---FKSKK |. |||| |. .||.. | .|||.|.||||. . | || ..| ||||||.|||. ... ||||| . |||.....|| |. | FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GTDPY----FAPEVDEGQSRIQSDLFS-LGLVLLELDNLNTLNENW .| | |||||... . .||||| .|.||||||| .. . . WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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| Kinase | 24213.AA | Pkinase | 42-259 | 22 | 5.9e-30 | 107.0 | Pfam | 1-205 (293) | Show / Hide |
Range on Protein: 42-259 Range on HMM: 1-205/293 Sequence Identity: 22% (52 aa) FKNFEYLSSGAYALVLKAQNIQQNRQVALKFLGSSNQNDKNGIESLK-KEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEM .. . . ||... | |.... ...||.| . ...... .. .. | ...... .... | ||.|. |. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCENN--LKQLFDILR--KEQVP--PPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCDLGFASA--VSKSKSFKSKKGTDP |.||. . |||... .. . .... | .. |.|.||. .| ..|.|||.||.|.|. . . ..|.|| |.| .. ... || . EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW YFAPEV--DEGQSRIQSDLFSLGLVLLEL | |||| . .| .|.|..| |. YMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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| Kinase | 24213.AA | STE | 42-259 | 19 | 1.3e-26 | 91.03 | In-house | 1-261 (359) | Show / Hide |
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 19% (55 aa)
FKNFEYLSSGAYALVLKAQNI------QQNRQ---------VALKFLGSSNQN----------DKNG----IESLKKEYEMLQKFSQ-SEFLVNVYDCFY
... | . .||. | || |. . ... .| | . .|.| ..| .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
LMEEKEDEDADGNDIIVQTEVKSFFVMEMELCE-NNLKQLFDILRKEQVPPPKQM--------KEI--IAIQMLEG-LNNLHVKNIMHRDIKPQNFLVCP
.. .. .. . ||... | .. . . . | ... ..| |. | |.| |. || ..|.||||||.| |.
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--
SKEYGFSIKLCDLGFASAVSK-----------------SKSFKSKKGTDPYFAPEVDEG-QSR------IQSDLFSLGLVLLEL
.|||| |... ... .. .. || . |||| .. .. ...| |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
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| Kinase | 24213.AA | CMGC | 42-220 | 16 | 7.5e-26 | 81.14 | In-house | 1-256 (513) | Show / Hide |
Range on Protein: 42-220 Range on HMM: 1-256/513 Sequence Identity: 16% (43 aa) FKNFEYLSSGAYALVLKAQN--------------IQQNRQVALK--FLGSSNQND------KNGIE-SLKKEYEMLQKFS---------------QSEF- ... ... .|.|. | |... .. |..||.| .. .... |.|. . | ..|.... . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEMELCENNLKQLFDILR------KEQVPPPKQ------------MKEII-----AIQMLEGLN- .|. ||.|| ... .|. | . | . . . .|.....|.|. . . . . .. . | .. . |.|.||. IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL -NLHVKN--IMHRDIKPQNFLVCPSKEY----------------GFSIKLCDLGFASAVSK .| .. |.|||.||.| |... .|. . .|.|| |.| .... KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP |
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| Kinase | 24213.AA | CAMK | 47-256 | 15 | 8.2e-24 | 72.99 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 47-256 Range on HMM: 1-324/425 Sequence Identity: 15% (52 aa) YLSSGAYALVLKAQNIQQN------------RQVALKF------------------------LGSSNQN-DKNGIESLKKEYEMLQKFS------QSEFL | .|... | ...... . ..|| |. ...... . . .....|.|...| . . . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNVYDCFYL-----------MEEKEDEDADGNDIIVQTEVKSFFVMEM---ELCENN--LKQLFDILRKE-----------QVPPPKQMKEIIAI----Q .. |. . .| | . .....| | |.|.. . ||| ... | . ..| | | IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQ MLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFKSKKGTDPYFA ...... .| .||.|||.|| | |.. ... . ||..| ||| . ... .| || .| | ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA -PEVDEG-------------QSRI--QSDLFSLGLVL ||| .| . . ..| |.| .| APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL |
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| Kinase | 24213.AA | Ciliate-E1 | 48-250 | 22 | 9.5e-23 | 71.12 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 48-250
Range on HMM: 1-202/202
Sequence Identity: 22% (48 aa)
LSSGAYALVLKAQNIQQN-RQVALKFLGSSNQNDKNGIESLKKEYE-MLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME-LCE
...| ...|.|| ....| .|||.|. . ..| .....||| ... | . . .....|.... . . . ||...... . ... .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY-------ICIIIFECCCCSLKDYLQNH--
NNLKQLFDILRKEQVPPPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCDLGFAS-AVSKSKSFKSKKGTDPYFAPEVD----
| | .........| | |. |..|...||. || .||.|||||||| |.. ...| .. |.| .. ..... . .|| |..|.
NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP
----EGQ--SRIQSDLF
. . ..||..
EQEHNKNQKINYKSDIY
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| Kinase | 24213.AA | S_TKc | 42-323 | 21 | 7e-22 | 79.94 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-323 Range on HMM: 1-231/231 Sequence Identity: 21% (63 aa) FKNFEYLSSGAYALVLKAQNIQQNRQVALKFLGSSNQNDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME .. . . .||.. | |.... .|.||.| . |....| ..|.| . ...|. ||.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCENNLKQLFDILRKEQVP------PPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCDLGFASAVSKSKSFKSKKGTDPYFA .|...| |||...| . . |. . . ... |....|. .| ..|.|||.||.| |.. ||.|| |.| . .. || | | YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA PEVDEGQSRIQSDLFSLGLVLLELDNLNTLNENWIDFKTKNYLFKGEEIPKEIYQIDKNSNIYKIAQICLKPRYLERTTAGELLS--------QLI ||| | .. .| |.| .| |. .. . .... . . . . . ||. .| || |.| . . PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 24213.AA | Ciliate-E2 | 140-259 | 23 | 1.4e-21 | 70.78 | In-house | 113-289 (365) | Show / Hide |
Range on Protein: 140-259 Range on HMM: 113-289/365 Sequence Identity: 23% (45 aa) MELCENNLKQLFDILRKEQVPPPKQ--------MKEI--IAIQMLE---------------GLNNLHVKN-IMHRDIKPQNFLVCPSKEYGFSIKLCDLG ||.|. . |||.... . ... .||| | | |. .|. || || |.||||||.| |. ||..|.| MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG FASAVSKS----------KSFKSKK-----------------------GTDPYFAPEVDEGQSR----------IQSDLFSLGLVLLEL .. .... | .. | || .| |||. .|.. ..|..||| .| |. LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
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| Kinase | 24213.AA | Ciliate-E3 | 169-260 | 37 | 4.2e-21 | 62.78 | In-house | 108-202 (202) | Show / Hide |
Range on Protein: 169-260 Range on HMM: 108-202/202 Sequence Identity: 37% (36 aa) IAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYG-FSIKLCDLGFASAVSKSKSFKSKK--GTDPYFA-PEVDE-GQSRIQSDLFSLGLVLLELD |.||...|. .| ||| | ||||.|.|| .|... || ||.| . .| | .. . |. |..| ||... .| ||. |.| |...| ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | 24213.AA | TKL | 169-259 | 21 | 3e-18 | 62.33 | In-house | 137-282 (364) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 137-282/364 Sequence Identity: 21% (31 aa) IAIQMLEGLNNLHV--------KNIMHRDIKPQNFLVCPSKE----------YGFSIKLCDLGFASAVSKSKS--------------------FKSKKGT .|... |.| || ..| |||.|..| || . . .|.||.|.. .|.|.. .. || WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT DPYFAPEV-----------------DEGQSRIQSDLFSLGLVLLEL . |||| ... ..| .| |.|| |. PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI |
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| Kinase | 24213.AA | TyrKc | 42-322 | 18 | 7.5e-10 | -63.41 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 42-322
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)
FKNFEYLSSGAYALVLKAQNIQQNRQVALKFLGSSNQNDKNGIESLKKEYEMLQKF-SQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEM
. . | .||. | |.. . .||| | | .. .| . .| ... |. . . .|. | . ... ... .. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------------FMYIEPLMIV-M
ELCENNLKQLFDILRKEQVPPPKQMKEIIAIQMLEGLNNLHVKNIMHRDIKPQNFLVCPSKEYGFSIKLCDLGFASAVSKS-------KSFKSKK--GTD
|.... | | ||| . . . . ...| .| . || ||. |||. | || . .| .| | . .. . ..|. |..
EYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK
P-----YFAPEV-DEGQSRIQSDLFSLGLVLLELDNL-NTLNEN-----WIDFKTKNYLFKGEEIPKEIY-----QIDKNSNIYKIAQICLKPRYLERTT
|||. ..| ..|| .| | .. |. . . .. .. .|. .|. |. . . .|.| . | . .| |
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT
AGELLSQL
|. ...
FSEIHECF
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| Kinase | 24213.AA | Ciliate-E2 | 42-116 | 14 | 1.5e-07 | 21.96 | In-house | 1-107 (365) | Show / Hide |
Range on Protein: 42-116 Range on HMM: 1-107/365 Sequence Identity: 14% (16 aa) FKNFEYLSSGAYALVLKAQNIQQNRQVALK-----------------FLGSSNQNDKNGIESLKKEYEMLQ---------------KFSQSEFLVNVYDC .| . . .|... | |........|.|.| .. ... ||.||..|.| ... .. .. .... |.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FYLMEEK |. . .. FQEKDDN |
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| Kinase | 24213.AA | Ciliate-E3 | 42-116 | 24 | 0.001393 | 7.38 | In-house | 1-77 (202) | Show / Hide |
Range on Protein: 42-116 Range on HMM: 1-77/202 Sequence Identity: 24% (19 aa) FKNFEYLSSGAYALVLKAQNIQQNRQVALKFLGSSNQND---KNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEK . | | . .| || . |.|..|| | . .||.. . .| . |.. |...| ..| .| . | YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNK |
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| Kinase | 24213.AA | TKL | 48-107 | 15 | 0.12298 | 1.68 | In-house | 1-91 (364) | Show / Hide |
Range on Protein: 48-107 Range on HMM: 1-91/364 Sequence Identity: 15% (14 aa) LSSGAYALVLKAQNIQQN--------RQVALKFLGS--SNQNDKNGIES--------------------LKKEYEMLQKFSQ-SEFLVNVY . ||... | |.. ... . || | . | .. ..|| | ..|.|.... . . .| . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM |
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| Kinase | 24213.AA | Ciliate-C8 | 350-542 | 41 | 9.80000000001e-101 | 340.96 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 350-542 Range on HMM: 1-238/238 Sequence Identity: 41% (98 aa) GSFGMVLAT------KKVKLDNKEIVLKIQKIEDESQIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDR-----------------YSVFELEKCS--C |.|||||.. .||.|...|.|.||||...|..|.....|||....|.|||.||........ ... ..|.|.|||. | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC SLDEYLDR-QNKDGQLSEDDKFQIAIQIIDSVNYIHSFNIIHRDIKPDNFLVYLD-GKQPEIKLCD------FGLSAQISDNKE---------SIQTIEH .|..|.|| ..|....|...|..||||.||||||.| |||.||||||.||||..| ..||.||||| ||...|...||. ..|.||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --IGNFGYSAPEILNK-KDNEFKFYTKKSDSYSVGLLL .||.||.|||...| .... ....||||||||||.| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 24213.AA | C8 | 349-542 | 47 | 8e-96 | 324.65 | In-house | 9-226 (226) | Show / Hide |
Range on Protein: 349-542 Range on HMM: 9-226/226 Sequence Identity: 47% (105 aa) FGSFGMVLATKKVKLDNKEIVLKIQKIEDESQIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCS-----------CSLDE--------- ||..||||..|.|| ||.|||||.||......|||..|||.....|.|.|.||.|..|.......|.|||.|||| |...| FGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLK --YLDRQNKDGQLSEDDKFQIAIQIIDSVNYIHSFNIIHRDIKPDNFLVYLDGKQP-EIKLCDFGLSAQISDNKESIQTIEH--IGNFGYSAPEILNKKD |..|.||..|.|...|..||||.||.|||||..||.||||||.||||.||.... ||||||||...|.|.||..||.... .|...|.||||..|.| QLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQD NEFKFYTKKSDSYSVGLLL |..|.|...||..||||.| NQYKQYRIQSDLFSVGLVL |
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| Kinase | 24213.AA | C2 | 350-555 | 28 | 1.8e-45 | 153.3 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 350-555 Range on HMM: 1-245/245 Sequence Identity: 28% (73 aa) GSFGMVLATKKVKLDNKEIVLKIQKIED-----ESQIQNEISIMQKLK-EPLVVQLYDSYIIENKIGPD-------------R----------YSVFELE |.||.|| . | .|....||||.... ....|.|..||.... |.....|... . | . |.|.| GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE KCSCSLDEYLDRQNKDG-QLSEDDKFQIAIQIIDSVNYIHSFNIIHRDIKPDNFLVYLDGKQ-PEIKLCD----------FGLSAQISDNKESIQTIEHI .|.. | |..|. |. ..... | ..|||..||.||.| |.|.||||||.|||. .| .. | ||||| | . .. ||. | . . FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GNFGY----SAPEILNKKDNEFKFYTKKSDSYS-VGLLLALLDNYQVLKKNA . | .|||. . . | |.|| .| ||. | ||| | . WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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| Kinase | 24213.AA | CAMK | 350-542 | 19 | 2.9e-32 | 100.71 | In-house | 5-324 (425) | Show / Hide |
Range on Protein: 350-542
Range on HMM: 5-324/425
Sequence Identity: 19% (62 aa)
GSFGMVLATKKVKLDN-----------KEIVLKI---QKIE----------------------------DESQIQNEISIMQK-------LKEPLVVQLY
|||| | . . . .. || .|. |. ....||.||.| |. | ...||
GSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLY
DSYI------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQLSEDDKFQIAIQIIDSVNYIHSFNIIH
. | .| . |.. .. . | || | .|. .. . .| ..|.. .. ||.. |.|.|| ||.|
EVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVH
RDIKPDNFLVYLDGKQPE--------------IKLCDFGLSAQISDNKESI---------------------QTIEHIGNFGYSA-PEILNK--KDNEF-
||.||.| |. ... . ||..|||..... ..... . | .| | ||.||. ..| .
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN
------KFYTKKSDSYSVGLLL
. |..|.| |.| .|
ATDEEKPYYGPKCDMWSCGVIL
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| S_TKc | 24213.AA | S_TKc | 341-614 | 23 | 4.5e-29 | 103.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 341-614
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)
EQIPKQAHFGSFGMVLATKKVKLDNKEIVLKIQKIEDESQIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG
.| .. |.|| | ...| .... .|| | .|..||.|..| . | .|.|||.. . . .| |. .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG
Q---LSEDDKFQIAIQIIDSVNYIHSFNIIHRDIKPDNFLVYLDGKQPEIKLCDFGLSAQISDNKESIQTIEHIGNFGYSAPEILNKKDNEFKFYTK-KS
..| . .. ||.. ..|.|| .|||||.||.| |. .||.|||||..|. .| | |||.| |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC
DSYSVGLLLA-LLDNYQVLKKNAALTFAQMTQKQLDKPFEKSNININKNSQIYKFINHLVVSDSGKRASLYDIVE----QNDIKFV
| .|.| .|. .| | . ...| .. .. ||... . | || . .. . . ..
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 24213.AA | Pkinase | 362-543 | 28 | 8.4e-27 | 95.85 | Pfam | 21-203 (293) | Show / Hide |
Range on Protein: 362-543 Range on HMM: 21-203/293 Sequence Identity: 28% (57 aa) KLDNKEIVLKIQKIEDESQIQN-------EISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC-----SLDEYLDRQNKDGQL--SEDDKFQI | ..|. ..|| | ..|. .. ||.||..|. | .|.|||.. ... . .| | . .| .|. . ..| . ||.. . KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFY AIQIIDSVNYIHSFNIIHRDIKPDNFLVYLDGKQPEI----KLCDFGLSAQISDNKESIQTIEHIGNFGYSAPEILNKKDNEFKFYTKKSDSYSVGLLLA . ||. ..|.|| .|||||.||.|.| .| ....| |.|||||..|.. . . . | .| |||... . . |..|.| .|.|..|. MYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILY |
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| Kinase | 24213.AA | Ciliate-E1 | 350-536 | 26 | 3.1e-26 | 82.59 | In-house | 4-202 (202) | Show / Hide |
Range on Protein: 350-536 Range on HMM: 4-202/202 Sequence Identity: 26% (56 aa) GSFGMVLATKKVKLDNKEIVLKIQKIEDE-S------QIQNEISIMQKLKEPL-VVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLD---------- |||..|. |. . .... .||..... . .|.....||. .|. ..|..| ..|.. .. ... .|.|.||| .||. GSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEYWQQ RQNKDGQLSEDDKFQIAIQIIDSVNYIHSFNIIHRDIKPDNFLVYLDGKQPEIKLCDFGLSAQISDNKESIQTIEHIGNFGYSAPEILNK---KDNEFKF |....|.... | ||..|.|| ....|..|||||||||.| |.. . .. ..||||.| .. |... . ... . |. || .| . |. . CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHY-YYPPEQYNCPEQEHNKNQK YTKKSDSY ...||| | INYKSDIY |
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| Kinase | 24213.AA | Ciliate-E2 | 349-542 | 23 | 5.9e-26 | 86.07 | In-house | 9-286 (365) | Show / Hide |
Range on Protein: 349-542 Range on HMM: 9-286/365 Sequence Identity: 23% (68 aa) FGSFG-----MVLATKKV-----------------KLDNKEIVLKIQKIEDESQIQNEISIMQ----------------KLKEPLVVQLYDSYI--IENK .|.|| | ..| | ..|.. .||.| . || .||.||. .|. | ....|.... .|. QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN IGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQLSEDDKFQIAIQIID---------------SVNYIHSFN-IIHRDIKPDNFLVYLDGKQP | . .| |. .| .|. ... . ....| .| ||.. ..|.|| | ||||||||.| |. I------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------- EIKLCDFGLSAQISDNKE--------SIQTIEH----------------------IGNFGYSAPEILNKKDNE----FKFYTKKSDSYSVGLLL ||..||||| ...|. . . . . .|. || ||||||.|... .| |..|.| .|.| .| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | 24213.AA | STE | 353-542 | 26 | 1.1e-25 | 87.72 | In-house | 39-258 (359) | Show / Hide |
Range on Protein: 353-542
Range on HMM: 39-258/359
Sequence Identity: 26% (60 aa)
GMVLATKKVKLDNKEIV--------LKIQKIEDESQIQNEISIMQKLK--EPLVVQLYDSYIIENKI--GPDRYSVFELEKCSC-SLDEYLDRQNKDGQ-
| . | |...|.|.. |.. .|.. ||..||.||.|.. | .|. |..|. |.. | .. .| .. |||. ... . |.
GEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKP
----------LSEDDKFQIAIQIIDS-VNYIHSFNIIHRDIKPDNFLVYLDGKQPEIKLCDFGLSAQISDN--------------KESIQTIEHIGNFGY
..|. |. ||. .|.|| .||||||||.| |. .||||||...|..|. . .. .| .
LNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-W
SAPEILNKKDNE-FKFYTKKSDSYSVGLLL
|||.... .. | |. |.| .|.|...
MAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
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| Kinase | 24213.AA | CMGC | 350-492 | 17 | 8.1e-25 | 77.69 | In-house | 10-251 (513) | Show / Hide |
Range on Protein: 350-492 Range on HMM: 10-251/513 Sequence Identity: 17% (43 aa) GSFGMVLATKK-------------VKLDNKEIVLKIQKIEDESQIQ---------------NEISIMQKLK-----------------EPLVVQLYDSYI |..|.| . . .|... .|. | . ..| ||.|...|. .. .|.|||.. GTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFY IEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QLSEDD------------KFQIA------IQIIDSVN--YIHSFN--IIH .| . .. ... . | . ..| .|..... . | ||| . . ||. ... |.|| . ||| HKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIH RDIKPDNFLVYLDGKQ-----------------PEIKLCDFGLS ||.|| | |. ... ..|.|||||. RDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | 24213.AA | TKL | 425-542 | 25 | 4.4e-23 | 79.98 | In-house | 124-279 (364) | Show / Hide |
Range on Protein: 425-542 Range on HMM: 124-279/364 Sequence Identity: 25% (42 aa) SLDEYLDRQNKDGQLSEDDKFQIAIQIIDSVNYIHSFN--------IIHRDIKPDNFLVYLDGKQPE-----------IKLCDFGLSAQISDNKESIQTI || .|| . ....|..| .|| || | |||||.|..| || ... .|.|||||| .| .... | SLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM EH-----------------IGNFGYSAPEILNKKDN-----------EFKFYTKKSDSYSVGLLL . .|.... |||.|....| ... |..|.| || |..| TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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| Kinase | 24213.AA | Ciliate-E3 | 420-546 | 38 | 7.1e-17 | 49.41 | In-house | 84-202 (202) | Show / Hide |
Range on Protein: 420-546 Range on HMM: 84-202/202 Sequence Identity: 38% (49 aa) EKCSC-SLDEYLDRQNKDGQLSEDDKFQIAIQIIDSVNYIHSFNIIHRDIKPDNFLVYLDGKQPEIKLCDFGLSAQISDNKESIQTIEHIGNFGYSAPEI | || .| .|. || ... .|.|||| .. ||. |||| ||||||.|| | || ||||.| | . || ..| |.|||. EYCSNGDLYHYIKQQN----KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ LNKKDNEFKFYTKKSDSYSVGLLLALLD . . . ... || |||| . .| NDQ--QQISK---ESDYYSVGAVFCQLC |
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| LRR_RI | 24213.AA | LRR_RI | 671-698 | 39 | 0.008905 | 13.01 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 671-698 Range on HMM: 1-28/28 Sequence Identity: 39% (11 aa) NITSLTLDLSYNSIGDEGAYDLGIGIAQ | . ..|.||.| .||||. | |... NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 24213.AA | LRR_RI | 731-758 | 42 | 0.00443 | 15.15 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 731-758 Range on HMM: 1-28/28 Sequence Identity: 42% (12 aa) NITSLTLDLINNSIGDEGARYLGTGIAQ | . ..|.| || .||||.| | |... NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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