Gene 12085 (Tetrahymena)

12085

Species: Tetrahymena
Alias: PreTt12085, 12085, 547.m00004, TTHERM_01670170, 1196
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
12085.AA Protein None 361 None Fasta, JSON
12085.kin_dom2 Protein Kinase Domain None 155 None Fasta, JSON
12085.NA RNA None 1110 None Fasta, JSON
12085.kin_dom Protein Kinase Domain None 182 None Fasta, JSON

Protein domain

Protein domains of 12085.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12085.AA C8 1-193 44 2.2e-91 309.93 In-house 1-226 (226) Show / Hide 
Range on Protein: 1-193
Range on HMM: 1-226/226
Sequence Identity: 44% (102 aa)

TNNFQILSFGSFGIVLATKKVKLDNKEIVLKIQKIVGE---------MQKLKEPLVVQLYDSYIIENKLGPDRYSVLELEKCS-----------CSLDE-
.||||.||||..|.||..|.|| ||.|||||.||.. .         |.....|.|.|.||.|..|.......|.| |.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERSNKDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQP-EIKLCDFGLSAQIPDNVDSIQTIEH--IGNLGYSA
          |.|| ||..||....|..||||.||.|||||..||.||||||.||||.|..... ||||||||...|...| ..||....  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKNDNELKFYTKKSDSYSVGLLL
|||..|.||..|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12085.AA Ciliate-C8 10-193 38 7.3e-87 294.89 In-house 1-238 (238) Show / Hide 
Range on Protein: 10-193
Range on HMM: 1-238/238
Sequence Identity: 38% (92 aa)

GSFGIVLAT------KKVKLDNKEIVLKIQKIVGE---------MQKLKEPLVVQLYDSYIIENKLGPDR-----------------YSVLELEKCS--C
|.||.||..      .||.|...|.|.||||.. |         ||....|.|||.||.......  ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-SNKDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLE-GKQPEIKLCD------FGLSAQIPDNVD---------SIQTIEH
.|..|..|  .|........|..||||.||||||.| |||.||||||.||||... ..||.|||||      ||...|.|.| .         ..|.||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-NDNELKFYTKKSDSYSVGLLL
  .||.||.|||...| .........||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12085.AA C2 10-206 26 1.8e-34 115.19 In-house 1-245 (245) Show / Hide 
Range on Protein: 10-206
Range on HMM: 1-245/245
Sequence Identity: 26% (68 aa)

GSFGIVLATKKVKLDNKEIVLKIQKIVG---------E-----MQKLK-EPLVVQLYDSYIIENKLGPD-------------R----------YSVLELE
|.||.|| .   | .|....||||..           .     |....  |.....|...    .   |             .            |.|.|
GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLERSNKDG-QFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQ-PEIKLCD----------FGLSAQIPDNVDSIQTIEHI
.|.. |  |..|  |.  ..... | ..|||..||.||.| |.|.||||||.|||. .  .. | |||||          |  .  .. |   | . .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKNDNELKFYTKKSDSYS-VGLLLALLDNYQDLKTNT
.   |    .|||.      . . | |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 12085.AA CAMK 6-193 18 4.9e-28 86.84 In-house 1-324 (425) Show / Hide 
Range on Protein: 6-193
Range on HMM: 1-324/425
Sequence Identity: 18% (59 aa)

ILSFGSFGIVLATKKVKLDN-----------KEIVLKI-------------------------------------QKIVGEMQKLKE----------PLV
.|  ||||.|   .  .  .           ..   ||                                     ...  |.. .|           | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYIIEN--------------KLGPDRYSVLEL---EKCSC-----SLDEYLERSNK------------DGQFNEDDKFQIAIQIIDSVNYIHSFN
..||. |  ..                 .|.. .. .   | ||       | .|. .  .            .| |.|..  ..  ||.. |.|.|| |
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKPENFLVYLEGKQPE--------------IKLCDFGLSAQIPDNVDSI---------------------QTIEHIGNLGYSA-PEILNKN----
| |||.|||| |.   ..  .              ||..|||........ ..                         .  | ..| | ||.||..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DNELKFYTKKSDSYSVGLLL
     |.| . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 12085.AA CAMK1 88-190 39 9.1e-24 65.91 In-house 103-203 (276) Show / Hide 
Range on Protein: 88-190
Range on HMM: 103-203/276
Sequence Identity: 39% (42 aa)

GQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIK--LCDFGLSAQIPDNVDSIQTIEHIGNLGYSAPEILN-KNDNELKFYTKKS
|...|.|   |  ||.. |.|.|| .| |||.|||| | | .  . .||  ..||||| .. ....  .|    | .|| |||.|. |     |.| |. 
GNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTA--CGTPGYVAPEVLECKK---DKPYDKAC

DSYSVG
|  |.|
DMWSIG
Kinase 12085.AA Ciliate-E2 1-193 20 4.1e-23 76.18 In-house 1-286 (365) Show / Hide 
Range on Protein: 1-193
Range on HMM: 1-286/365
Sequence Identity: 20% (62 aa)

TNNFQILSFGSFG-----IVLATKKV-----------------KLDNKEIVLKIQ---------KIVGEMQ----------------KLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.         ..  .|.                .|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKLGPDRYSVLELEKCSC-SLDEYLE--RSN-------KDGQFNEDDKFQIAIQIID---------------SVNYIHSFN-ILHRDIKPENFL
..   .|..       | .| |.  .| .|..  . .       . ..|.|    .|  ||..                ..|.|| | |.|||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLEGKQPEIKLCDFGLSAQIPDNVD--------SIQTIEH----------------------IGNLGYSAPEILNKNDNE----LKFYTKKSDSYSVGL
.        ||..||||| .. |. .         . .  .                      .|..|| ||||||. ...     | |..|.| .|.| 
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 12085.AA Ciliate-E1 7-187 25 2.1e-22 70.0 In-house 1-202 (202) Show / Hide 
Range on Protein: 7-187
Range on HMM: 1-202/202
Sequence Identity: 25% (54 aa)

LSFGSFGIVLATKKVKLDNKEIVLKIQKIVGE---------------MQKLKEPL-VVQLYDSYIIENKLGPDRYSVLELEKCSCSLDEYLE--------
.. |||.||.  |. .  .... .||... .                ..|.|.   ..|..| ..|.. ..    ... .|.|.||| .||.        
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEYW

--RSNKDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSA-QIPDNVDSIQTIEHIGNLGYSAPEILNK---NDNE
   .....||... | ||..|.|| ....|..||.||||||.| |.. . ..   ..||||.|  ..  . ...|   .. .  |. || .|    . |.
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHY--YYPPEQYNCPEQEHNK

LKFYTKKSDSY
 . ...||| |
NQKINYKSDIY
Kinase 12085.AA STE 13-193 25 2.1e-22 76.0 In-house 39-258 (359) Show / Hide 
Range on Protein: 13-193
Range on HMM: 39-258/359
Sequence Identity: 25% (58 aa)

GIVLATKKVKLDNK-----------------EIVLKIQKIVGEMQKLK--EPLVVQLYDSYIIE---NKLGPDRYSVLELEKCSC-SLDEYLERSNKDGQ
| . | |...|.|.                 |.. .|.| .  |.|..   | .|. |..|. |   .| . . . ..|.  ..  |||. ...  . |.
GEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGK

-----------FNEDDKFQIAIQIIDS-VNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDNVDSI--------------QTIEHIGNLG
           |.|.    |. ||.    .|.|| .| |||||| | |.        .||||||...|. |....|              ..   .|   
PLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-

YSAPEILNKNDNE-LKFYTKKSDSYSVGLLL
. |||....|..   | |. |.| .|.|...
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 12085.AA Pkinase 39-194 28 7.9e-21 74.73 Pfam 54-203 (293) Show / Hide 
Range on Protein: 39-194
Range on HMM: 54-203/293
Sequence Identity: 28% (47 aa)

MQKLKEPLVVQLYDSYIIENKLGPDRYSVLELEKCSC-----SLDEYLERSNKDGQF--NEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGK
|..|. | .|.|||..        ...  . .| | .     .| .|...  ..| |   |..   .. ||.  ..|.|| .|.|||.||||.|  .  .
MKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-N

QPEI----KLCDFGLSAQIPDNVDSIQTIEHIGNLGYSAPEILNKNDNELKFYTKKSDSYSVGLLLA
...|    |.|||||..|.  .  .  .    | ..| |||...    . . |..|.| .|.|..|.
NGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILY
Kinase 12085.AA TKL 76-193 23 1.3e-20 70.96 In-house 124-279 (364) Show / Hide 
Range on Protein: 76-193
Range on HMM: 124-279/364
Sequence Identity: 23% (39 aa)

S-LDEYLERSNKDGQFNEDDKFQIAIQIIDSVNYIHSFN--------ILHRDIKPENFLVYLEGKQPE-----------IKLCDFGLSAQIP---DNVDS
| |. ..           . ....|..|   .|| || |        |.|||.|..| ||   ..              .|.||||||  .    .. |.
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

I--------------QTIEHIGNLGYSAPEILNKNDNELKF-----------YTKKSDSYSVGLLL
               .|.  .|.... |||.|....|  .            |..|.| || |..|
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 12085.AA S_TKc 1-265 23 8.6e-20 73.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-265
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

TNNFQILSFGSFGIVLATKKVKLDNKEIVLKI--QKIVGEMQKLK--EPLVVQLYDSYIIENKLGPDRYSVLELEKCSC---SLDEYLERSNKDGQ---F
    ...  |.|| |   ...| ....  .||  ..|  |.| ||   | .|.|||..          .  . .| |.    .| .|... .. |    |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDNVDSIQTIEHIGNLGYSAPEILNKNDNELKFYTK-KSDSYSV
.| .   .. ||.. ..|.|| .|.|||.|||| |.       .||.|||||..|.            .| . | |||.|         |.| |.| .|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GLLLALLDN----YQDLKTNTTSNFALMTQKQLDKPFEKSNIQINKNSQIYKFINLLVLSDSSQRASLYDIVE-QSD---IKFL
| .|. .      ..        . ..| .| .              ..   ||. .   | ..| .  .. . ..|     ..
GCILYEMLCGYPPFP--------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12085.AA CK1 10-143 17 6.2e-19 62.73 In-house 10-195 (339) Show / Hide 
Range on Protein: 10-143
Range on HMM: 10-195/339
Sequence Identity: 17% (32 aa)

GSFG--IVLATK---KVKLDN-----KEIVLKIQKIVGE---MQKLKEPLVVQLYDSY-------------------------IIENKLGPDRYSVLELE
|.||  | ...|   | . .|     .| ..|. ..  .   .|...| .....                             ..  . ..|.| .. ..
GGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMT

KCSCSLDEYLE-RSNKDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYL-------------EGKQPEIKLCDFGLS
 .  .|..... . . .. |.    ..||||..... |.|. ...||||||.||.. .             ...   . . |||..
LLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMA
Kinase 12085.AA TyrKc 1-260 19 2.7e-08 -88.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-260
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

TNNFQILSFGSFGIVL--------ATKKVKLDNKEIVLKIQKIVGE---MQKL--KEPLVVQLYDSYIIENKLG-----PDRYSVLELEKCSCSLDEYLE
    ..|  | ||.|         | |..| |       .. .  |   | ||  . | .|.||   ..  . .     .  . |.|. .   .|..|| 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

RSNKDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDN--------VDSIQT-IEHI--GNLGYSAPEILN
.. ..  .. .|. ....|| .  .|.|| |. |||.   | ||  ..    .| .|||||  | |         . . ..         .   ||| . 
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KNDNELKFYTKKSDSYSVGLLL----ALLDNYQDL-----KTNTTSNFALMTQKQLDKPFE----KSNIQINKNSQIYKFINLLVLSDSSQRASLYDIVE
      . .| ||| .| | ..     . .          ..|.     ... . ...| .     .       . .|. .      | ..| .  .|.|
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

QS
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CF