Gene 25205 (Tetrahymena)

25205

Species: Tetrahymena
Alias: PreTt25205, 25205, TTHERM_01356360, 722, 344.m00017
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
25205.AA Protein None 803 None Fasta, JSON
25205.kin_dom Protein Kinase Domain None 169 None Fasta, JSON
25205.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
25205.NA RNA None 2412 None Fasta, JSON

Protein domain

Protein domains of 25205.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25205.AA C8 90-314 54 3.7e-112 378.92 In-house 1-226 (226) Show / Hide 
Range on Protein: 90-314
Range on HMM: 1-226/226
Sequence Identity: 54% (134 aa)

FQNLEYLSSGAYALVLKAKNINSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDE---------KSFFVMEME
|.| .|||.|||..||||||...||...|||..|..|.  ..|||..||||..|.|.|.||.||.|||||.|.|..| .|..         ||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDFFRNTQLP-SQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKICKIFRFLQNISIQKIIDNQGDLGFASAVTKSK
|||||||||.|..||.|.. |...||||||||..|.|..|.||||||||||.|||||..|.|||.||.|                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYLSKK----GTDTYFAPEVEKG------QSRIQSDLFSLGLVL
||..|||    ||..|||||.||.      |.||||||||.||||
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25205.AA Ciliate-C8 99-314 51 1.6e-111 376.84 In-house 1-238 (238) Show / Hide 
Range on Protein: 99-314
Range on HMM: 1-238/238
Sequence Identity: 51% (129 aa)

GAYALVLKAKNINSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVD---------KDEK---SFFVMEMELCEQN-
||...||||.|...||.|||||..|..|.  ...|...||||....|.|..|.|.||||||||||... |          .||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFFRNTQLP-SQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKICKIFRFLQNISIQKIIDNQGDLGFASAVTKSKSHYL
 |||.||..|..|.. |||.||||||||....|.||..|||||||||.|||||..|.|..|||.|. |       .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTDTY-----------FAPEVEKGQSRIQSDLFS-------LGLVL
|||  |||.|           |||||||.|||||||.||       .||||
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25205.AA C2 99-327 37 4.4e-64 217.79 In-house 1-245 (245) Show / Hide 
Range on Protein: 99-327
Range on HMM: 1-245/245
Sequence Identity: 37% (95 aa)

GAYALVLKAKNINSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEV------------------DKDEKSFFVMEME
|| .||||| | ..|| ||||   | | . ..| ... |||....... . ....||..||| ... |                    .  |.|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDFFRNTQ-LPSQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKIC-KIFRFLQNISIQKIIDNQGDLGFASAVTKS
 |. |||| |.  |. .  |.||.|.|.||||. . | ||...| ||||||.|||.  .|    |||.|    .. |.          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KS-HYLSK-KGTDTY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLNVLNQNW
||  . || |.| .|    |||||...  . .||||| .|.||||||| .  . . 
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25205.AA CMGC 90-248 15 1.1e-27 87.28 In-house 1-246 (513) Show / Hide 
Range on Protein: 90-248
Range on HMM: 1-246/513
Sequence Identity: 15% (39 aa)

FQNLEYLSSGAYALVLKAKN--------------INSNRMVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
....... .|.|. | |...              ...|..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEDVEVDKDEKS------FFVMEMELCEQNLKQLFDFFR-------NTQLPSQQ------------IKEII-----AIQMLEGLN--TL
.|. ||.||  ..| . ..|  .       . . .|.....|.|. .  .       .  |.  .            || ..     . |.|.||.   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HIKN--IMHRDIKPNNFLVCPSQTY----------------GFTIKIC
| ..  |.|||.|| | |...  ..                 ...|||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 25205.AA Pkinase 90-248 23 8.7e-26 92.26 Pfam 1-154 (293) Show / Hide 
Range on Protein: 90-248
Range on HMM: 1-154/293
Sequence Identity: 23% (40 aa)

FQNLEYLSSGAYALVLKAKNINSNRMVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDEKSFFVMEMELCEQNLKQ
.. .. . ||... | |.........||.| .   ...  | .. ..  | ...... .... |  ||.|.            |.   | ||.||  |. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-----------KDHIYMVMEYCEGGLY-

LFDFF------RNTQL--PSQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKIC
..| |      |.. .  . ...| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|||
VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 25205.AA CDK 90-235 27 9.3e-24 72.74 In-house 1-141 (284) Show / Hide 
Range on Protein: 90-235
Range on HMM: 1-141/284
Sequence Identity: 27% (43 aa)

FQNLEYLSSGAYALVLKAKNINSN-----RMVALKFLTCTS------KEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDE-KSFFVM
.. || .  |.|. | ||.. ...     ..|||| .   .      |||.    .   |  ||..    .  |...|... .. | .  ||  .. ..|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFP--ITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNN-KDKHENKLYM

EMELCEQNLKQLFDFFRNTQLPSQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLV
 .| ... ||.. |           || ..  |.|.||. .| ..|||||.||.| |.
VFEYMDHDLKKYMD-----------IKCYM-WQLLRGLHYCHSNWIMHRDLKPQNILI
Kinase 25205.AA Ciliate-E1 96-261 25 9e-22 67.91 In-house 1-169 (202) Show / Hide 
Range on Protein: 96-261
Range on HMM: 1-169/202
Sequence Identity: 25% (46 aa)

LSSGAYALVLKAKNINSN-RMVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFYLMEEDVEVDKDEKSFFVMEMELCEQNLKQLFD--
...| ...|.|||..|.| . ||.|.  |  ..    .....|||  ... | . . .....|....         |.  ...  .|.|...||. ..  
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI---------DQNYICIIIFECCCCSLKDYLQNH

--------FFRNTQLPSQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFT-IKICKIFRFLQNISIQK
        . .| .  ..| |. |..|...||. ||..||.|||||| | |.. .  | .. . |.|..   || ..|.
NRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY
Kinase 25205.AA CAMK 95-248 15 9.1e-20 59.71 In-house 1-238 (425) Show / Hide 
Range on Protein: 95-248
Range on HMM: 1-238/425
Sequence Identity: 15% (37 aa)

YLSSGAYALVLKAKNINSN------------RMVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | .....|..            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEED-VEVDKDEKSFFVM-EMELCEQN--LKQLFDFFR-NTQ---------------LPSQQIKEIIAIQMLEGLNTLHI
.. |. .               .. |  .||.. ..||  ||.|.    .  |||. . ...               .. .. . ..  |...... .| 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QICSAVHYCHS

KNIMHRDIKPNNFLVCPSQTYG-------------FTIKIC
.||.|||.|| | |.. . .               ..|||.
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 25205.AA S_TKc 90-380 19 5.8e-17 63.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 90-380
Range on HMM: 1-231/231
Sequence Identity: 19% (60 aa)

FQNLEYLSSGAYALVLKAKNINSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDEKSFFVMEMELCEQNLKQL
.. |. . .||.. | |.......| ||.| .           |....| ..|.|  . ...|. ||.|.             ... | ||.|...|  |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDL

FDFFRNTQ-------LPSQQIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKIC-----KIFRFLQNISIQKIIDNQGDLGFASAVTK
||. .. .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||||     ...                          
FDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL--------------------------

SKSHYLSKKGTDTYFAPEVEKGQSRIQSDLFSLGLVLLELDNLNVLNQNWIDFDIKGEIYQGKGIASQYQIDRNSNIYKIAEICLKPNYLERTTSGDLLS
      .  ||  | ||||  | ..  .|  |.| .| |.     . .         ....  |          .    . . ||. .  .| |  ..| 
-----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ

--------ELI
        . .
DEWDIKCHPWF
Kinase 25205.AA Ciliate-E2 90-317 16 3.3e-16 52.12 In-house 1-289 (365) Show / Hide 
Range on Protein: 90-317
Range on HMM: 1-289/365
Sequence Identity: 16% (53 aa)

FQNLEYLSSGAYALVLKAKNINSNRMVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
.  .. . .|... | |.|... ....|.|. . .                 .. .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEDVEVDKDEKSFFVMEMELCEQ-NLKQ---LFDFFRNTQLP-----SQQIKEIIAIQMLE---------------GLNTLHIKN-IMHRDIKPN
||. .          .. . . ||.|.. .|..    .. .|| ...     . .    |  | |.               .|. || || |.||||||.
CFQEK---------DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE

NFLVCPSQTYGFTIKIC--KIFRFLQNI-------SIQKIIDNQG--------DLGFASAVTKSKSHYLSKK-----------GTDTYFAPEVEKGQSR-
| |.         |||.   . .....        ...|.. . .        ...                           ||  | |||. .|..  
NILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD---------------QIIQQNMFNTICGTPGYMAPEILNGKKYD

---------IQSDLFSLGLVLLEL
          ..|..||| .| |.
NQQKQKGYDYKCDIWSLGVILYEM
Kinase 25205.AA STE 90-248 19 5.6e-16 53.01 In-house 1-189 (359) Show / Hide 
Range on Protein: 90-248
Range on HMM: 1-189/359
Sequence Identity: 19% (39 aa)

FQNLEYLSSGAYALVLKAKNIN---------------SNRMVALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYDCF
....| . .||.  | ||.|..               .....| | .    |..|.              . .....|| ....|... ... |. |.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YLMEEDVEVDKDEKSFFVMEMELCE-QNLKQLFDFFRNTQLPS-----------QQIKEIIAIQMLEG-LNTLHIKNIMHRDIKPNNFLVCPSQTYGFTI
.   ..    .....   . ||...   | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |.         .
FKEGHN----HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------V

KIC
|.|
KLC
Kinase 25205.AA TKL 207-317 20 3.3e-12 40.27 In-house 137-282 (364) Show / Hide 
Range on Protein: 207-317
Range on HMM: 137-282/364
Sequence Identity: 20% (31 aa)

IAIQMLEGLNTLHI--------KNIMHRDIKPNNFLVCPSQT----------YGFTIKIC--KIFRFLQNISIQKIID-------NQGDLGFASAVTKSK
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|||   . ||... . .. .        .        .  ...
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE--------HQ-NNR

SHYLSKKGTDTYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
..  .. ||  . ||||                 ....   ..| .| |.|| |.
KTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 25205.AA STE 268-317 20 0.008692 5.82 In-house 190-261 (359) Show / Hide 
Range on Protein: 268-317
Range on HMM: 190-261/359
Sequence Identity: 20% (15 aa)

DLGFASAVTKS----------------KSHYLSKKGTDTYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|  |||....|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 25205.AA Pkinase 267-317 29 0.017529 9.86 Pfam 154-205 (293) Show / Hide 
Range on Protein: 267-317
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASAV-TKSKSHYLSKKGTDTYFAPEV--EKGQSRIQSDLFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  .       .| .|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 25205.AA C8 445-646 49 1.2e-103 350.64 In-house 1-226 (226) Show / Hide 
Range on Protein: 445-646
Range on HMM: 1-226/226
Sequence Identity: 49% (112 aa)

ANNFQILNFGSFGMILSTKKVEFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLIVQLYDNYIIEKATAPEKYVVFELEKCS-----------CSLKE-
 ||||.|.||..||.|..|.|. .|.|||||.||..|.|.|||...||.....|...|.||.|..|.....|.|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQGREREFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCDFGLSAQLEKNCEQIEILDM--LGNYAYMA
          |.||. .. .||.|.|..||||.||.||||||.||.||||||.|||||||.|.. ||||||||...|..||...|.. .|  .|. ||.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILAKNDNQNKIYSKKSDSYSVGLLL
|||..|.|||.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25205.AA Ciliate-C8 454-646 41 3.6e-100 339.09 In-house 1-238 (238) Show / Hide 
Range on Protein: 454-646
Range on HMM: 1-238/238
Sequence Identity: 41% (98 aa)

GSFGMILST------KKVEFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLIVQLYDNYIIEKATAPEK-----------------YVVFELEKCS--C
|.|||.|..      .||.....|.|.||||...|.||.....|||....|..||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLKEYLER-QGREREFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLEIKLCD------FGLSAQLEKNCE---------QIEILDM
.||.|..| .  . ..|...|..||||.||||||.|||||.||||||.|||||.| ..|..|||||      ||...||.||..         ......|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--LGNYAYMAPEILAK-NDNQNKIYSKKSDSYSVGLLL
  .||..|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25205.AA C2 454-659 29 1.8e-46 156.8 In-house 1-245 (245) Show / Hide 
Range on Protein: 454-659
Range on HMM: 1-245/245
Sequence Identity: 29% (75 aa)

GSFGMILSTKKVEFNNKEIVLKIQKIVN-----EQEIQNEIRIMQQLK-TPLIVQLYD-------NYII------EKATAPEK----------YVVFELE
|.||..| .   .  |....||||..       ..|.|.|..||.|..  |.|...|.       . ..      |.    |.           ||.|.|
GAFGLVLKAFNKK-QNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLKEYLERQGRER-EFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCD----------FGLSAQLEKNCEQIEILDML
.|.. || |..|.  .  ......|  .|||..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  |..| ..| .  . 
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNYAY----MAPEILAKNDNQNKIYSKKSDSYS-VGLLLSLLDNYLILKEKA
. ..|    .|||.      . .|| |.|| .| ||. |  |||  .   . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25205.AA CAMK 450-646 18 1.4e-32 101.79 In-house 1-324 (425) Show / Hide 
Range on Protein: 450-646
Range on HMM: 1-324/425
Sequence Identity: 18% (61 aa)

ILNFGSFGMILSTKKVEFNN-----------KEIVLKI---QKIV----------------------------NEQEIQNEIRIMQQ-------LKTPLI
.|  ||||     .  . ..           ..   ||   .|.                             .......||.||..       |. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYIIEKA--------TAP------EKYVVFEL---EKCSC-----SLKEYLERQGR------------EREFSDEEKLNIAIQVIDSVNYIHCFN
..||. |  ..         |        .|.... .   | ||       | .|. ..|.            .. |. .|   .  |... |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNFLVCLDG--------------NQLEIKLCDFGLSAQLEKNCEQI---------------------EILDMLGNYAYMA-PEILAKN----
|.|||.||.| |.. ..              |.  ||..|||........ ..                         .. |  .||| ||.| ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DNQNKIYSKKSDSYSVGLLL
     |.... |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 25205.AA S_TKc 448-718 23 3.5e-30 107.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 448-718
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

FQILNF---GSFGMILSTKKVEFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLIVQLYDNYIIEKATAPEKYVVFELEKCSC---SLKEYLERQGRER
..||.    |.||     ....  ...  .|| |    . |..||.|... . | ||.||| .         ... . .| |.    .|..|....||..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKNCEQIEILDMLGNYAYMAPEILAKNDNQNKIYSK-KS
    |.  .   .. |... ..|.|  .|||||.||.| |..      .||.|||||..||           . |   |||||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILKEKAGVIFANMTLNQYEEPFKKQKINIKRDTEIFKFIQQLVVWERVNRASLSIIVE----QNSKKFK
| .|.| .|  .|  |        ..| ..                  . |   ||... ...  .| .   . .     ..  . 
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25205.AA Pkinase 473-646 27 6.3e-28 99.83 Pfam 31-202 (293) Show / Hide 
Range on Protein: 473-646
Range on HMM: 31-202/293
Sequence Identity: 27% (51 aa)

VLKIQKIVNEQEIQN----EIRIMQQLKTPLIVQLYDNYIIEKATAPEKYVVFELEKCSC-----SLKEYLERQGREREF--SDEEKLNIAIQVIDSVNY
..| ...  ......    ||.||. |. | ||.||| .        .... . .| | .     .|..|...  |.. |  |..|  ... |..  ..|
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEY

IHCFNIIHRDIKPDNFLVCLDGNQL--EIKLCDFGLSAQLEKNCEQIEILDMLGNYAYMAPEILAKNDNQNKIYSKKSDSYSVGLLL
.|  .|||||.||.|.|.  . ...   .|.|||||..|.. .  .    .  | . |||||..      .. |..|.| .|.|..|
CHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCIL
Kinase 25205.AA Ciliate-E1 451-640 26 8.5e-27 84.44 In-house 1-202 (202) Show / Hide 
Range on Protein: 451-640
Range on HMM: 1-202/202
Sequence Identity: 26% (56 aa)

LNFGSFGMILSTKKVEFNNKEIVLKIQKIV---N----EQEIQNEIRIMQQLKTPL-IVQLYDNYIIEKATAPEKYVVFELEKCSCSLKEYLE-------
.  |||....  |. . |.... .||...    |    ..||.... ||. .|.   |.|..| ..|...    .  .. .|.|.||||.||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQGREREFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSA-QLEKNCEQIEILDMLGNYA-YMAP-EILAKNDNQ
    |  . .|....|..|..| || ....| .|||||||||.| |.. . ... .   |||.|  . ... .|. .  .. .|. ..   ...  . |.
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

NKIYSKKSDSY
|.....||| |
NQKINYKSDIY
Kinase 25205.AA TKL 548-646 24 3.2e-25 87.79 In-house 134-279 (364) Show / Hide 
Range on Protein: 548-646
Range on HMM: 134-279/364
Sequence Identity: 24% (36 aa)

KLNIAIQVIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLEIKLCDFGLSAQLEKNCEQIEILDM-----------------
....|...   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  .... ..  .  .                 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

LGNYAYMAPEILAKNDNQNK-----------IYSKKSDSYSVGLLL
 |....||||.| ...| ..            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 25205.AA STE 468-646 22 1.7e-24 83.47 In-house 29-258 (359) Show / Hide 
Range on Protein: 468-646
Range on HMM: 29-258/359
Sequence Identity: 22% (54 aa)

NNKE---------IVLKIQKIVN--------------------EQEIQNEIRIMQQLK--TPLIVQLYDNYIIE---KATAPEKYVVFELEKCSC-SLKE
....         .  |. .. |                    .|.|..||.||....   | ||. |. |. |   .    | ... |.  ..  || .
TGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEY--MDGGSLDD

YLE-RQGREREFS----------DEEKLNIAIQVIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKNCE--------------QI
 .. . |. ....           ..   |. |..    .|.|  .||||||||.| |.        .||||||...||....               | 
IIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQ

EILDMLGNYAYMAPEILAKNDNQ-NKIYSKKSDSYSVGLLL
.   . |   .||||.. .|..  .| |. |.| .|.|...
KRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 25205.AA Ciliate-E2 445-646 21 2e-24 80.76 In-house 1-286 (365) Show / Hide 
Range on Protein: 445-646
Range on HMM: 1-286/365
Sequence Identity: 21% (65 aa)

ANNFQILNFGSFG--MILSTKKV--------------------EFNNKEIVLKIQK------IVNEQEIQNEIR----------IMQQLKTPLIVQLYDN
 .  ... .|.||     . .||                    ....|.. .||.|      | .|. | .||.          |..||. | |...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YIIEKATAPEKYVVFELEKCSC-SLKEYLERQGRER--------EFSDEEKLNIAIQVID---------------SVNYIHCFN-IIHRDIKPDNFLVCL
.. ..    .... . .| |.  .|..|.. .   |         |...| ..|  |...                ..|.|  | ||||||||.| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEIKLCDFGLSAQL-EKNCEQI------EILDML-----------------------GNYAYMAPEILAKND----NQNKIYSKKSDSYSVGLLL
      ||..||||| .. ..|....      ....                         |.. ||||||| . .    .. | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 25205.AA CMGC 448-596 16 5.6e-24 74.87 In-house 1-251 (513) Show / Hide 
Range on Protein: 448-596
Range on HMM: 1-251/513
Sequence Identity: 16% (41 aa)

FQILN---FGSFGMILSTKKVE-------------FNNKEIVLKIQKIVNEQEIQ---------------NEIRIMQQLK-----------------TPL
..|..    |..|.  . .  .              .|... .|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQLYDNYIIEKATAPEK-----------YVVFELEKCSCSLKEYLERQG------REREFSDEE------------KLNIA------IQVIDSVN--YI
||.||| .  .. . .|.           .. .  | . ..|..|....       | ...|. .            . ..        |.. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LEIKLCDFGLS
|  .  |||||.|| | |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 25205.AA CDK 488-596 27 1.8e-13 39.27 In-house 58-160 (284) Show / Hide 
Range on Protein: 488-596
Range on HMM: 58-160/284
Sequence Identity: 27% (33 aa)

EIRIMQQLKTPLIVQLYDNYIIE---KATAPEK-----YVVFELEKCSCSLKEYLERQGREREFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLV
|| ....|  | ||.|.| .. .   ..    |     | |||   .   ||.|..              ..  | .. ..|.|  .|.|||.|| | |.
EISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEY--MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI

CLDGN--QLEIKLCDFGLS
  .|.     .|. ||||.
NNNGEVKCGRLKIADFGLA
Kinase 25205.AA TyrKc 451-713 18 7e-11 -46.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 451-713
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

LNF------GSFGMILSTKKVEFNNKEIVL--KIQKIVNEQEIQNEIRIMQQL--KTPLIVQLYDNYIIEKA-----TAPEKYVVFELEKCSCSLKEYLE
. .      | || .   .       . |   ....   .... .|.||| .|  . | ||.||   .. .       ..  ..|.|. .   .||.|| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

RQGREREFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKN------CEQIEI-----LDMLGNYAYMAPEILA
. ...  .. ...|....|. .  .|.|  |.||||.   | ||  ..    .| .|||||  ..         . .        ...  .  |||| . 
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KNDNQNKIYSKKSDSYSVGLLL-------SLLDNY-----LILKEKAGVIFANMTLNQYEE----PFKKQKINIKRDTEIFKFIQQLVVWERVNRASLSI
    . .... ||| .| | ..                  .  .|    . . . . | ..     |          .|... ..|    .  .| . | 
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSE

IVEQN
|.|. 
IHECF