Gene 25202 (Tetrahymena)

25202

Species: Tetrahymena
Alias: TTHERM_01356330, 25202, 344.m00014, PreTt25202, 723
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
25202.NA RNA None 3753 None Fasta, JSON
25202.AA Protein None 1250 None Fasta, JSON
25202.kin_dom Protein Kinase Domain None 180 None Fasta, JSON
25202.kin_dom2 Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of 25202.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25202.AA C8 173-406 57 1.3e-120 406.95 In-house 1-226 (226) Show / Hide 
Range on Protein: 173-406
Range on HMM: 1-226/226
Sequence Identity: 57% (142 aa)

FQNFEYLSSGAYALVLKAKNVKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDGNEKPIITKEKSFFVMEME
|.||.|||.|||..||||||||.||...|||..|..|.  ..|||..||||..|.|.|.||.||.|||||.|.|..| .|..||| ..|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDYLRNTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKICKKFRFLQNLSIQKIIDNQGDLGFASAVTKSK
|||||||||.|..||.|.. |.|.||||||||..|.|..|.||||||||||.|||||..|.|||.||.|                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYLSKQ----GTDTYFAPEVEKG------QSRIQSDLFSLGLVL
||..||.    ||..|||||.||.      |.||||||||.||||
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25202.AA Ciliate-C8 182-406 52 1.9e-118 399.81 In-house 1-238 (238) Show / Hide 
Range on Protein: 182-406
Range on HMM: 1-238/238
Sequence Identity: 52% (133 aa)

GAYALVLKAKNVKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDGNEKPIITKEK---SFFVMEMELCEQN-
||...||||.| |.||.|||||..|..|.  ...|...||||....|.|..|.|.||||||||||... |.|||.| . |.||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRNTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKICKKFRFLQNLSIQKIIDNQGDLGFASAVTKSKSHYL
 |||.||..|..|.. ||..||||||||....|.||..|||||||||.|||||..|.|..|||.|. |     . .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKQ--GTDTY-----------FAPEVEKGQSRIQSDLFS-------LGLVL
||.  |||.|           |||||||.|||||||.||       .||||
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25202.AA C2 182-419 36 2.1e-66 225.83 In-house 1-245 (245) Show / Hide 
Range on Protein: 182-419
Range on HMM: 1-245/245
Sequence Identity: 36% (93 aa)

GAYALVLKAKNVKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDGNEKPIITKEK---------SFFVMEME
|| .||||| | |.|| ||||   | | . ..| ... |||....... . ....||..||| ... | .   |.  . ..|.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDYLRNTQ-LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKIC-KKFRFLQNLSIQKIIDNQGDLGFASAVTKS
 |. |||| |. .|. .  |.|..|.|.||||. . | ||...| ||||||.|||.  .|    |||.|    .. |.          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KSHYLSKQ--GTDTY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLNVLNQNW
||    ..  .| .|    |||||...  . .||||| .|.||||||| .  . . 
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25202.AA CMGC 173-340 15 3.7e-24 75.47 In-house 1-246 (513) Show / Hide 
Range on Protein: 173-340
Range on HMM: 1-246/513
Sequence Identity: 15% (40 aa)

FQNFEYLSSGAYALVLKAKN--------------VKSNRMVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
... ... .|.|. | |...               ..|..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEDVEVDKDGNEKPIITKEKSFFVMEMELCEQNLKQLFDYLR-------NTQLPSQE------------IKEII-----AIQMLEGLN-
.|. ||.||  ..| . ..| ..  |   .   . . .|.....|.|. .  .       .  |.  .            || ..     . |.|.||. 
IVKLYDIFYHKNSDGNEYEDKHI--ISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-TLHIKN--IMHRDIKPNNFLVCPSQTY----------------GFTIKIC
  .| ..  |.|||.|| | |...  ..                 ...|||
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 25202.AA Pkinase 173-340 23 2.5e-23 83.54 Pfam 1-154 (293) Show / Hide 
Range on Protein: 173-340
Range on HMM: 1-154/293
Sequence Identity: 23% (41 aa)

FQNFEYLSSGAYALVLKAKNVKSNRMVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDGNEKPIITKEKSFFVMEM
..  . . ||... | |.........||.| .   ...  | .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEQN--LKQLFDYLR---NTQL--PSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKIC
|.||    .  ||||..   .. .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|||
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 25202.AA CAMK 178-340 13 9.7e-19 56.35 In-house 1-238 (425) Show / Hide 
Range on Protein: 178-340
Range on HMM: 1-238/425
Sequence Identity: 13% (34 aa)

YLSSGAYALVLKAKNVKSN------------RMVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | .... ...            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEEDVEVDKDGNEKPIITKEKSFFVMEM---ELCEQN--LKQLFDYLR-NTQ---------------LPSQEIKEIIAIQ
.. |. .               ...          .. . .....| |   |.|.    .  ||||.. ...               .. .| . ..  |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-Q

MLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYG-------------FTIKIC
...... .| .||.|||.|| | |.. . .               ..|||.
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 25202.AA Ciliate-A1 262-409 29 2e-16 52.37 In-house 73-221 (301) Show / Hide 
Range on Protein: 262-409
Range on HMM: 73-221/301
Sequence Identity: 29% (47 aa)

KEKSFFVMEMELCEQNLKQLFDYLRNTQ-LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVC-PSQTYGFTIKICKKFRFLQNLSIQK-IIDNQ
||  |..||   |. ..  ||.|  .   .   || ||   |. ||.  .| .||.|||.|| | |.    .     .|||  .   . |  ..   |. 
KECMFIIMEY--CQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILIHFDDK-----WKIC-DLGMSKQLEQNQDCCDDV

GDLGFASAVTKSKSHYLSKQGTDTYFAPEV----------EKGQSRIQSDLFSLGLVLLEL
    |.  | |  .|  .| |.  | .||            ..    |||..|||.....|
NGCSFSKQVNK-HYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL
Kinase 25202.AA STE 173-340 19 8.5e-16 52.36 In-house 1-189 (359) Show / Hide 
Range on Protein: 173-340
Range on HMM: 1-189/359
Sequence Identity: 19% (41 aa)

FQNFEYLSSGAYALVLKAKNVK---------------SNRMVALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYDCF
... | . .||.  | ||.|.|               .....| | .    |..|.              . .....|| ....|... ... |. |.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YLMEEDVEVDKDGNEKPIITKEKSFFVMEMELCE-QNLKQLFDYLRNTQLPS-----------QEIKEIIAIQMLEG-LNTLHIKNIMHRDIKPNNFLVC
.   ..             .|...   . ||...   | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |. 
FKEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-

PSQTYGFTIKIC
        .|.|
--------VKLC
Kinase 25202.AA S_TKc 173-472 19 8.9e-16 54.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 173-472
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

FQNFEYLSSGAYALVLKAKNVKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEEDVEVDKDGNEKPIITKEKSFFVMEME
..  . . .||.. | |....|..| ||.| .           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEQNLKQLFDYLRNTQ-------LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFTIKIC-----KKFRFLQNLSIQKIIDNQGD
.|...|  ||||... .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||||     ...                 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------

LGFASAVTKSKSHYLSKQGTDTYFAPEVEKGQSRIQSDLFSLGLVLLELDNLNVLNQNWIDFDIKGELYQGKGIASQYQIDRNSNIYKIAEICLKSNYLE
               .  ||  | ||||  | ..  .|  |.| .| |.     . .         ....  |          .    . . ||. .  .
--------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEK

RTTSGDLLS--------ELI
| |  ..|         . .
RPTA-EALQDEWDIKCHPWF
Kinase 25202.AA Ciliate-E2 271-409 22 3.1e-15 48.72 In-house 113-289 (365) Show / Hide 
Range on Protein: 271-409
Range on HMM: 113-289/365
Sequence Identity: 22% (46 aa)

MELCEQNLKQLFDYLRNTQLPSQEI---------KEI--IAIQMLE---------------GLNTLHIKN-IMHRDIKPNNFLVCPSQTYGFTIKICKKF
||.|..  . ||||..| .. ....         |||  |  | |.               .|. || || |.||||||.| |.         |||.   
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

----------RFLQNLSIQKIIDNQG--------DLGFASAVTKSKSHYLSKQ-----------GTDTYFAPEVEKGQSR----------IQSDLFSLGL
          . .. ....|.. . .        ...               |           ||  | |||. .|..            ..|..||| 
LSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD---------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

VLLEL
.| |.
ILYEM
Kinase 25202.AA Ciliate-E1 259-353 27 2.1e-13 40.39 In-house 64-169 (202) Show / Hide 
Range on Protein: 259-353
Range on HMM: 64-169/202
Sequence Identity: 27% (29 aa)

IITKEKSFFVMEMELCEQNLKQLFD----------YLRNTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPNNFLVCPSQTYGFT-IKICKKFRFLQ
|. ..  ...  .|.|...||. ..          . .| .  ... |. |..|...||. ||..||.|||||| | |.. .  | .. . |.|..   |
IKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQ

NLSIQK
| ..|.
NQQCQY
Kinase 25202.AA TKL 299-340 28 6e-08 24.72 In-house 137-196 (364) Show / Hide 
Range on Protein: 299-340
Range on HMM: 137-196/364
Sequence Identity: 28% (17 aa)

IAIQMLEGLNTLHI--------KNIMHRDIKPNNFLVCPSQT----------YGFTIKIC
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC
Kinase 25202.AA Ciliate-E1 179-243 22 7.8e-08 22.07 In-house 1-66 (202) Show / Hide 
Range on Protein: 179-243
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

LSSGAYALVLKAKNVKSN-RMVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFYL
...| ...|.|||. ..| . ||.|.  |  ..    .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 25202.AA Ciliate-E2 173-247 12 2e-05 14.54 In-house 1-107 (365) Show / Hide 
Range on Protein: 173-247
Range on HMM: 1-107/365
Sequence Identity: 12% (14 aa)

FQNFEYLSSGAYALVLKAKNVKSNRMVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
.   . . .|... | |.|. | ....|.|. . .                 .. .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEED
||. . ..
CFQEKDDN
Kinase 25202.AA TKL 359-409 17 0.000487 10.45 In-house 196-282 (364) Show / Hide 
Range on Protein: 359-409
Range on HMM: 196-282/364
Sequence Identity: 17% (15 aa)

GDLGFASAVTKSKS-------------------HYLSKQGTDTYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
.|.|..  ...|..                   .  .. ||  . ||||                 ....   ..| .| |.|| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 25202.AA Ciliate-A1 173-213 19 0.001392 7.99 In-house 1-42 (301) Show / Hide 
Range on Protein: 173-213
Range on HMM: 1-42/301
Sequence Identity: 19% (8 aa)

FQNFEYLSSGAYALVLKAKNVKSNR-MVALKFLTCTSKEGLK
.     . .| .  |..| ..  ..  ...| . || .| .|
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYK
Kinase 25202.AA STE 360-409 20 0.006341 6.31 In-house 190-261 (359) Show / Hide 
Range on Protein: 360-409
Range on HMM: 190-261/359
Sequence Identity: 20% (15 aa)

DLGFASAVTKS----------------KSHYLSKQGTDTYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|  |||....|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 25202.AA Pkinase 359-409 29 0.013077 10.31 Pfam 154-205 (293) Show / Hide 
Range on Protein: 359-409
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASAV-TKSKSHYLSKQGTDTYFAPEV--EKGQSRIQSDLFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  .       .| .|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 25202.AA C8 564-776 49 5.5e-103 348.44 In-house 1-226 (226) Show / Hide 
Range on Protein: 564-776
Range on HMM: 1-226/226
Sequence Identity: 49% (113 aa)

INNFQILNFGSFGMILSTKKVEFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCSSYQAKLIISYSFIVEE-
.||||.|.||..||.|..|.|. .|.|||||.||..|.|.|||...||.....|.|.|.||.|..|.....|.|.|||.||||  .  .    |. |.| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQL-EIKLCDFGLSTQLEKNCEQIEILDM--VGNWAYMA
          |.||. |...||.|.|..||||.||.||||||.||.||||||.|||||| .|.. ||||||||...|..||...|.. .|  .|.|||.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILTKNNDQNKIYSKKSDSYSVGLLL
|||..|...|.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25202.AA Ciliate-C8 573-776 39 1.3e-93 317.29 In-house 1-238 (238) Show / Hide 
Range on Protein: 573-776
Range on HMM: 1-238/238
Sequence Identity: 39% (97 aa)

GSFGMILST------KKVEFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEK-----------------YVVFELEKCSSYQ
|.|||.|..      .||.....|.|.||||...|.||.....|||....|.|||.||..........|.                 ..|.|.|||..  
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQN-

AKLIISYSFIVEEYLER-QGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLY-GNQLEIKLCD------FGLSTQLEKNCE-------
           ..|..| . |....|...|..||||.||||||.|||||.||||||.|||||.  ..|..|||||      ||...||.||..       
--------CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKF

--QIEILDM--VGNWAYMAPEILTK-NNDQNKIYSKKSDSYSVGLLL
  ......|  .|||.|.|||...| . .|..|.|||||||||||.|
KGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25202.AA C2 573-776 27 2.2e-40 135.73 In-house 1-232 (245) Show / Hide 
Range on Protein: 573-776
Range on HMM: 1-232/245
Sequence Identity: 27% (69 aa)

GSFGMILSTKKVEFNNKEIVLKIQKIVN-----EQEIQNEIRIMQQLK-TPLVVQLYD-------NYII------EKATAPEK----------YVVFELE
|.||..| .   .  |....||||..       ..|.|.|..||.|..  |.....|.       . ..      |.    |.           ||.|.|
GAFGLVLKAFNKK-QNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSSYQAKLIISYSFIVEEYLERQGKEG-EFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQL-EIKLCD----------FGLSTQLEK
.|..             . |..|. |.  ......|  .|||..||.||.|.|.|.||||||.|||. .  ...  |||||          |  .  |..
FCQGN-----------LKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKY

NCEQIEILDMVGNWAY----MAPEILTKNNDQNKIYSKKSDSYS-VGLLL
| ..| .  ...  .|    .|||.      . .|| |.|| .| ||. |
NKSRIHFSKFKWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVL
Kinase 25202.AA CAMK 569-776 16 1.6e-26 81.86 In-house 1-324 (425) Show / Hide 
Range on Protein: 569-776
Range on HMM: 1-324/425
Sequence Identity: 16% (57 aa)

ILNFGSFGMILSTKKVEFNN-----------KEIVLKI---QKIV----------------------------NEQEIQNEIRIMQQ-------LKTPLV
.|  ||||     .  . ..           ..   ||   .|.                             .......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYI----------------IEKATAPEKYVVFELEKCSSYQAKLIISYSFIVEEYLERQ------------GKE-------------GEFSDEEK
..||. |                 .   .  . | |.|                  . || .               .              | |. .| 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVME------------------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA

LNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYG--------------NQLEIKLCDFGLSTQLEKNCEQI---------------------EILDMVG
  .  |... |.|.|  ||.|||.||.| |..  .              |.  ||..|||........ ..                         ...|
RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG

NWAYMA-PEILTKNN---------DQNKIYSKKSDSYSVGLLL
  .||| ||.| ..          .... |..|.|  |.| .|
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 25202.AA TKL 678-776 23 1.7e-24 85.12 In-house 134-279 (364) Show / Hide 
Range on Protein: 678-776
Range on HMM: 134-279/364
Sequence Identity: 23% (35 aa)

KLNIAIQVIDSVNYIHCFN--------IIHRDIKPDNFLVCLYGN-----------QLEIKLCDFGLSTQLEKNCEQIEILDM-----------------
....|...   .|| |  |        |||||.|..| ||   ..           .  .|.||||||. .... ..  .  .                 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

VGNWAYMAPEILTKNNDQNK-----------IYSKKSDSYSVGLLL
.|. ..||||.| .... ..            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 25202.AA STE 681-776 32 6.6e-23 77.8 In-house 156-258 (359) Show / Hide 
Range on Protein: 681-776
Range on HMM: 156-258/359
Sequence Identity: 32% (36 aa)

IAIQVIDS-VNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKNCE--------------QIEILDMVGNWAYMAPEILTKNNDQ-NKIYS
|. |..    .|.|  .||||||||.| |.        .||||||...||....               | .   .||   .||||....|.   .| |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLL
 |.| .|.|...
TKCDIWSLGCTI
Kinase 25202.AA Ciliate-E2 667-776 25 2.2e-22 73.66 In-house 138-286 (365) Show / Hide 
Range on Protein: 667-776
Range on HMM: 138-286/365
Sequence Identity: 25% (41 aa)

QGKEGEFSDEEKLNIAIQVID---------------SVNYIHCFN-IIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKN---------CEQIEILD-
. . . |...| ..|  |...                ..|.|  | ||||||||.| |.        ||..|||||... ..         |. .     
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KN

--------------------MVGNWAYMAPEILTKNNDQN----KIYSKKSDSYSVGLLL
                     .|.  ||||||| . ...|    | |..|.| .|.| .|
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 25202.AA Pkinase 564-776 25 4e-22 79.3 Pfam 1-202 (293) Show / Hide 
Range on Protein: 564-776
Range on HMM: 1-202/293
Sequence Identity: 25% (57 aa)

INNFQILNFGSFGMILSTKKVEFNNKEIVLKIQKIVNEQEIQN-------EIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCS----SYQAKL
.   ...  ||||     ...  ..|. ..|| | ..| . ..       ||.||. |. | .|.||| .       .. |.|.|.  .     .  . .
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYI

IISYSFIVEEYLERQGKEGEF--SDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQL--EIKLCDFGLSTQLEKNCEQIEILDMVGNWAYM
                ..| |  |..|  ... |..  ..|.|  .|||||.||.|.|.    ...   .|.|||||. |.. .  .    . .|   ||
ST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYM

APEILTKNNDQNKIYSKKSDSYSVGLLL
|||..      .. |..|.| .|.|..|
APEVIR----GGQYYGPKVDMWSCGCIL
Kinase 25202.AA Ciliate-E1 570-770 23 3.3e-20 62.77 In-house 1-202 (202) Show / Hide 
Range on Protein: 570-770
Range on HMM: 1-202/202
Sequence Identity: 23% (51 aa)

LNFGSFGMILSTKKVEFNNKEIVLKIQKIV---N----EQEIQNEIRIMQQLKTPL-VVQLYDNYIIEKATAPEKYVVFELEKCSSYQAKL----IISYS
.  |||....  |. . |.... .||...    |    ..||.... ||. .|.   ..|..| ..|...    .. .||. .|| ..       .  |.
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY--ICIIIFECCCCSLKDYLQNHNRL-EYW

FIVEEYLERQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLST--QLEKNCEQ---IEILDMVGNWAYMAPEI
.. ..      ....|....|..|..| || ....| .|||||||||.| |.. . ... .   |||.|   ....| ..    ..  .  .. |. |  
QQCQQ------NQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP--

LTKNNDQNKIYSKKSDSY
.  . ..|.....||| |
EQ-EHNKNQKINYKSDIY
Kinase 25202.AA S_TKc 567-848 22 5.5e-18 66.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 567-848
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FQILNF---GSFGMILSTKKVEFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKC---SSYQAKLIISYSFIV
..||.    |.||     ....  ...  .|| |    . |..||.|... . | .|.||| .        . |.|.|.      .             .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGD-------------L

EEYLERQGKEGE---FSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKNCEQIEILDMVGNWAYMAPEILTKNN
 .|....|..|    |.  .   .. |... ..|.|  .|||||.||.| |..      .||.|||||..||           ..|   |||||.|    
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL----

DQNKIYSK-KSDSYSVG-LLLSLLDNYLILKELTGTTFMNMTQNQYEEPFKKQKIKIKQDTEIFKFIQQLVVWERVNRASLSIIVE----QNSNKFK
     |.| |.| .|.| .|  .|  |        ..| ..                  . |   ||... ...  .| .   . .     ..  . 
----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25202.AA CMGC 564-732 15 9.9e-16 47.28 In-house 1-257 (513) Show / Hide 
Range on Protein: 564-732
Range on HMM: 1-257/513
Sequence Identity: 15% (40 aa)

INNFQILNFGSFGMILSTKKVE-------------FNNKEIVLKIQKIVNEQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.  . .  .              .|... .|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYIIEKATAPEK-----------YVVFELEKCSSYQAKLIISYSF-----IVEEYLERQ-GKEGE----------FSDEEKLNIAIQVIDSVN-
.|.||| .  .. . .|.           .. .  | .    ...| ...|     .  .  | . .|. .          |.      .. |.. ... 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKH-PHRRPPHNIKYFMI-HIR-YMYQILRGLKL

-YIHCFN--IIHRDIKPDNFLVCLYGNQ-----------------LEIKLCDFGLSTQLEKN
 |.|  .  |||||.|| | |..  .                    ..|.|||||.......
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 25202.AA Ciliate-A1 674-776 33 2e-14 45.43 In-house 99-218 (301) Show / Hide 
Range on Protein: 674-776
Range on HMM: 99-218/301
Sequence Identity: 33% (41 aa)

SDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKNC----------------EQIEILDMVGNWAYMAPEI----L
. ||   |  | |  .  ||  ||.|||.||.| |.   ..   .|.||.|.|.||| |                    .     ||  ||.||     .
KKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILI---HFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHY

-TKNNDQNKIYSKKSDSYSVGLLL
  .    |||| |.|| ||.|. .
RDQMFIENKIY-KQSDMYSLGCII
Kinase 25202.AA TyrKc 564-843 17 8.8e-10 -64.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 564-843
Range on HMM: 1-280/280
Sequence Identity: 17% (59 aa)

INNFQILNFGSFGMILSTKKVEFNNKEIVL--KIQKIVNEQEIQNEIRIMQQL--KTPLVVQLYDNYIIEKA-----TAPEKYVVFE----------LEK
|   ..|  | || .   .       . |   ....   .... .|.||| .|  . | .|.||   .. .       ..  ..|.|          | |
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CSSYQAKLIISYSFIVEEYLERQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLYGNQLEIKLCDFGLSTQLEKN------CEQIEI
.                           .. ...|....|. .  .|.|  |.||||.   |   ||.|... .| .|||||  ..         . .  
HRPK------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN---CLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

-----LDMVGNWAYMAPEILTKNNDQNKIYSKKSDSYSVGLLL-----------SL-----LDNYLILKELTGTTFMNMTQNQYEEP--FKKQKIKIKQD
      ...     |||| .     . .... ||| .| | ..           .      ..|. ... .     |   .| |  |  |          
KEHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF------VCCP

TEIFKFIQQLVVWERVNRASLSIIVEQN
.|... ..|    .  .| . | |.|. 
DEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 25202.AA Ciliate-E2 564-627 18 0.000476 9.77 In-house 1-102 (365) Show / Hide 
Range on Protein: 564-627
Range on HMM: 1-102/365
Sequence Identity: 18% (19 aa)

INNFQILNFGSFG--MILSTKKV--------------------EFNNKEIVLKIQK------IVNEQEIQNEIR----------IMQQLKTPLVVQLYDN
..  ... .|.||     . .||                    ....|.. .||.|      | .|. | .||.          |..||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI
..
FQ
Kinase 25202.AA STE 564-627 15 0.050375 3.09 In-house 1-100 (359) Show / Hide 
Range on Protein: 564-627
Range on HMM: 1-100/359
Sequence Identity: 15% (15 aa)

INNFQILNFGSFG-MILSTKKVE----FNNKE---------IVLKIQKIVN--------------------EQEIQNEIRIMQQLK--TPLVVQLYDNYI
  . ...  |.||   .  ..       ....         .  |. .. |                    .|.|..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase 25202.AA Ciliate-A1 564-624 21 0.120856 1.29 In-house 1-64 (301) Show / Hide 
Range on Protein: 564-624
Range on HMM: 1-64/301
Sequence Identity: 21% (14 aa)

INNFQILNFGSFGMILSTKKVEFNNKEIVLKIQKIVNEQEIQ---NEIRIMQQLKTPLVVQLYD
    | .  |||| ..    .. . | . .|| .. |    .   .| |...|.  . |.  |.
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQ