5060

Species: Tetrahymena
Alias: TTHERM_01461130, PreTt05060, 5060, 79, 401.m00007
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
5060.AA Protein None 1709 None Fasta, JSON
5060.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
5060.kin_dom2 Protein Kinase Domain None 202 None Fasta, JSON
5060.NA RNA None 5130 None Fasta, JSON

Protein domain

Protein domains of 5060.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5060.AA C8 42-256 58 8.9e-117 394.25 In-house 1-226 (226) Show / Hide
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 58% (133 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEME
|.||.|||.|||..||||.|.|..|...|||. ..|..|...|||..||||..|.|. ..|.||.|||||.|.|........|...||| .||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKSKS-FVSKK----GTDAYFAP
||| ||||| | .|..|....||.|||||||||.|.|..|.||||||||||.||||| .|.|||.|||||.||||..||.|| . |||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEQG------KSRIQSDLFSLGLVL
|.|..      ..||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 5060.AA Ciliate-C8 51-256 53 8.10000000001e-115 387.74 In-house 1-238 (238) Show / Hide
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 53% (128 aa)

GAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVK---SFFVMEMELCEYN-
||...||||.|.||.|.|||||. ..|....|..|...||||....|....|.|.||||||||||....|||||...||| .|   ||||||||.|. | 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCD------LGFASALSKSKS-FVSKK--GTDAY---
 |||..| .||.|..| ...|||||||||...|.||..|||||||||.||||| .|.|...|||||      .||||.|.|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEQGKSRIQSDLFS-------LGLVL
        ||||||...||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL

Kinase 5060.AA C2 51-269 40 4.6e-68 231.56 In-house 1-245 (245) Show / Hide
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 40% (99 aa)

GAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEE-QEDKDDDGNNIVVQTGV--------KSFFVMEME
|| .|||||.| ||.|.||||     .. | || ... |||....... . ....||..||| .. .|| | | ... ..           |.|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCD----------LGFASALSKSKS--FVSK-K
 |. |||| .. .|||.  | ...|.|.||||. . | || ..| ||||||.|||.  .|.    |||||          . |||.|...||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEQGKSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||.|.  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC

Kinase 5060.AA Pkinase 42-259 23 7.7e-29 103.05 Pfam 1-205 (293) Show / Hide
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 23% (53 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLK-KEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEM
..  . . ||... | |... .  ..||.| .  ..|...  .. ..  | ...... .. . |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEYNLKQLLDIL-----RKQQVP--PEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASA--LSKSKSFVSKKGTD
|.||  |. ..|       ... .   .|.|.| ..  |...||. .| ..|.|||.||.|.|. .  . . ..|.|| |.|    . ..  . .  || 
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

AYFAPEV--EQGKSRIQSDLFSLGLVLLEL
 | ||||  .. .    .| .|.|..| |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEM

Kinase 5060.AA STE 42-259 19 2.1e-27 93.85 In-house 1-261 (359) Show / Hide
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 19% (56 aa)

FQNFEYLSSGAYSLVLKAYNS------KQKRQ---------VALKFLGSSNEE----------DNNG----IESLKKEYELLQKFSK-SQFLVNVYDCFY
... | . .||.  | ||.|       | ...         .| | .  .|..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEQEDKDDDGNNIVVQTGVKSFFVMEMELCE-YNLKQLLD-ILRKQQVPP----------EKEIKEIIAIQMIEG-LNNLHVKNIMHRDIKPQNFLVC
   .              .. ..   . ||...   | ....    ...  .          |..|. .|. | ..| |. || ..|.||||||.| |. 
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIA-YICRQILKGLLYYLHSHHIIHRDIKPANILL-

SSQEYGFSIKLCDLGFASALSK-----------------SKSFVSKKGTDAYFAPEV-EQGKSR------IQSDLFSLGLVLLEL
        .|||| |... |..                 ..   .  ||  . |||| .|...       ...|  |||....|.
--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM

Kinase 5060.AA CMGC 42-220 15 3.9e-27 85.43 In-house 1-256 (513) Show / Hide
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 15% (41 aa)

FQNFEYLSSGAYSLVLKAYN--------------SKQKRQVALKFLGSSNEEDNNGI---------ESLKKEYELLQKFS---------------KSQF-
... ... .|.|. | |...               . ...||.| . .   ... .           .   | ..|....               |    
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEMELCEYNLKQLLDILR------KQQVPPEKE------------IKEII-----AIQMIEGLN-
.|. ||.||  ... . ..| . |  .      . . .|.....|.|...  .      ...  .| .            || ..     . |...||. 
IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPQNFLVCSSQEY----------------GFSIKLCDLGFASALSK
  .| ..  |.|||.||.| |...  |.                 . .|.|| |.| ....
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP

Kinase 5060.AA S_TKc 42-323 22 2.8e-24 87.9 SMART 1-231 (231) Show / Hide
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEME
..  . . .||.. | |... | .|.||.| .           |....| ..|.|  .  ..|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEYNLKQLLDILRKQQVP------PEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKSKSFVSKKGTDAYFA
.|. .|  |.|...|.. .      || ... ... |....|. .| ..|.|||.||.| |...       ||.|| |.|  |       .  ||  | |
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA

PEVEQGKSRIQSDLFSLGLVLLELDNLKTLNENWIDFETKKYLFDGQEIPNEKYEIDKKSNIYKIAQICLKHRYLDRTTAGELLS--------QLI
|||  | ..  .|  |.| .| |.   ... .   .... | .                .    . . ||.    .| || |.|         . .
PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 5060.AA Ciliate-E2 140-259 24 1.3e-23 77.89 In-house 113-289 (365) Show / Hide
Range on Protein: 140-259
Range on HMM: 113-289/365
Sequence Identity: 24% (46 aa)

MELCEY-NLKQLLDILRKQQ--------VPPEKEIKEI--------------IAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCSSQEYGFSIKLCDLGFA
||.|.. .|.... . .|..         . |||||.|              .. ..|..|. || || |.||||||.| |.         ||..|.|..
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLS

SALSKS----------KSFVSKK-----------------------GTDAYFAPEVEQGKSR----------IQSDLFSLGLVLLEL
  ....          | .   |                       ||  | |||. .||.            ..|..||| .| |.
KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

Kinase 5060.AA CAMK 47-256 14 2.4e-23 71.48 In-house 1-324 (425) Show / Hide
Range on Protein: 47-256
Range on HMM: 1-324/425
Sequence Identity: 14% (50 aa)

YLSSGAYSLVLKAYNSKQK------------RQVALKF-------------------------LGSSNEEDNNGIESLKKEYELLQKFSK------SQFL
 | .|... | .... . .            ..|| |.                          ....... .  .....|.|...| ..         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY------------LMEEQEDKDDDGNNIVVQTGVKSFFVMEM---ELCEYN--LKQLLDILRKQ---------------QVPPEKEIKEIIAI
.. |. .               . |           |    .....| |   |.|.    .  |.| ....                  .|.| . ..  
IKLYEVYEDPHYFKNTNDYET-SKQ-----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-

QMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYG-------------FSIKLCDLGFASALSKSK------------------------SFVSKKGTDAYF
|...... .| .||.|||.|| | |.... .               . ||..| |||  . ...                         .    || .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVEQG-------------KSRI--QSDLFSLGLVL
| ||| .|             |  .  ..|  |.| .|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL

Kinase 5060.AA Ciliate-A1 140-259 28 1.2e-20 67.03 In-house 80-221 (301) Show / Hide
Range on Protein: 140-259
Range on HMM: 80-221/301
Sequence Identity: 28% (43 aa)

MELCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKSK-----------------
|| |.|..  | .         . || ||   |.|||.  .| .||.|||.|||| |.     .    |.||||    |  ..                 
MEYCQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDVNGCSFSKQVNK

--SFVSKKGTDAYFAPEV----------EQGKSRIQSDLFSLGLVLLEL
    ..| |.  | .||             .|   |||..|||.....|
HYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL

Kinase 5060.AA Ciliate-E1 135-250 26 1.8e-19 60.38 In-house 71-202 (202) Show / Hide
Range on Protein: 135-250
Range on HMM: 71-202/202
Sequence Identity: 26% (36 aa)

FFVMEMELCEYNLKQLLD---------ILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFAS--ALSKSKS
...  .|.|...||. |.         .....|     . |. |..|.|.||. || .||.|||||||| |.... .| ..    |.| ..   ... ..
ICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQ

FVSKKGTDAYFAPEV---------EQGKSRIQSDLF
 . |  |. |  ||.         .. |  ..||..
CQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY

Kinase 5060.AA TKL 169-259 21 4.2e-19 65.44 In-house 137-282 (364) Show / Hide
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCSSQE----------YGFSIKLCDLGFASALSKSKS--------------------FVSKKGT
.|...  |.| ||         ..| |||.|..| || .  .          .   .|.||.|..  .|.|..                      .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EQGKSRIQSDLFSLGLVLLEL
 .. ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI

Kinase 5060.AA TyrKc 42-322 19 5.5e-10 -61.2 SMART 1-280 (280) Show / Hide
Range on Protein: 42-322
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKF-SKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSF-----
 .  . | .||.  | |.  .   .||| | | ..       .| . .| ... |.  . . .|. | .    ...                  |     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------------------FMYIEP

FVMEMELCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKS-------KSFVSKK
  . ||....    |.| ||| .     . .  ...|  .| . || ||. |||.   | || . .     .| .| | . ..          .  ..|.
LMIVMEYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKE

--GTD-----AYFAPEVE-QGKSRIQSDLFSLGLVLLELDNL-KTLNEN-----WIDFETKKYLFDGQEIPNEKY--EI---DKKSNIYKIAQICLKHRY
  |..        |||.   ||  ..|| .| | .. |.  . ..  ..       ..|  .|. .|   |  ..  ..      . .|.| . | ..  
HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

LDRTTAGELLSQL
 || |  |. ...
EDRPTFSEIHECF

Kinase 5060.AA Ciliate-E1 48-112 23 1.8e-08 24.18 In-house 1-66 (202) Show / Hide
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 23% (16 aa)

LSSGAYSLVLKAYNSKQK-RQVALKFLGSSNEEDNNGIESLKKEYE-LLQKFSKSQFLVNVYDCFYL
...| .|.|.||.. ... .|||.|.      .. | .....|||  ... | | . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI

Kinase 5060.AA Ciliate-E2 42-116 14 4.1e-05 13.48 In-house 1-107 (365) Show / Hide
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (15 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALK-----------------FLGSSNEEDNNGIESLKKEYELLQ---------------KFSKSQFLVNVYDC
.   . . .|... | |. . |...|.|.|                 ..   .   .|.||..|.|  ...               .. .. .... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYLMEEQ
|. . ..
FQEKDDN

Kinase 5060.AA Ciliate-A1 42-79 23 0.002536 7.09 In-house 1-39 (301) Show / Hide
Range on Protein: 42-79
Range on HMM: 1-39/301
Sequence Identity: 23% (9 aa)

FQNFEYLSSGAYSLVLKAYNSK-QKRQVALKFLGSSNEE
.     . .| .. |..||..  ||. ...| .  .| |
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE

Kinase 5060.AA Ciliate-E1 261-298 20 0.00902 5.41 In-house 160-202 (202) Show / Hide
Range on Protein: 261-298
Range on HMM: 160-202/202
Sequence Identity: 20% (9 aa)

NLKTLNENWIDFETKKYLFDGQEI-----PNEKYEIDKKSNIY
.......  .. .|..|    |       .|....|..||.||
KNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY

Kinase 5060.AA C8 403-603 46 3.7e-98 332.41 In-house 1-226 (226) Show / Hide
Range on Protein: 403-603
Range on HMM: 1-226/226
Sequence Identity: 46% (106 aa)

QNDFQILSFGNYGMVLATKKAMLNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGPDRYSVFELEKCS-----------CSLDE--
 |.||.||||.|||||..|..  |.|||||.||....| |||..|||.....|.|.|.||.|..|. .....|.|||.||||           |...|  
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

---------YLERSNKDGQINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQA-EIKLCDFGLSAQIPDNSDSIQTIEP--IGNFGYSAP
         |.|| ||..|........||||.||.|||||..||.||||||.||||.||...  ||||||||...|...| ..||...   .|...|.||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EILNKKDNELKIYTKKSDSYSVGLLL
||..|.||..|.|...||..||||.|
EIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 5060.AA Ciliate-C8 412-603 39 1.6e-91 310.34 In-house 1-238 (238) Show / Hide
Range on Protein: 412-603
Range on HMM: 1-238/238
Sequence Identity: 39% (93 aa)

GNYGMVLAT------KKAMLN-KEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGPDR-----------------YSVFELEKCS--C
|..||||..      .|  |. .|.|.||||...|..|.....|||....|.|||.||......   ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-SNKDGQINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQAEIKLCD------FGLSAQIPDNSD---------SIQTIEP
.|..|..|  .|... .... ..||||.||||||.| |||.||||||.||||..| ..| .|||||      ||...|.|.| .         ..|.|| 
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNFGYSAPEILNK-KDNELKIYTKKSDSYSVGLLL
  .||.||.|||...| ......|..||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL

Kinase 5060.AA C2 412-616 27 4.2e-41 138.2 In-house 1-245 (245) Show / Hide
Range on Protein: 412-616
Range on HMM: 1-245/245
Sequence Identity: 27% (69 aa)

GNYGMVLATKKAMLNKEIVLKIQKIED-----EQLIQNEISIMQKLK-EPLVVQLYDSYIIENTLGPD-------------R----------YSVFELEK
|  |.|| .     |....||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSCSLDEYLERSNKDG-QINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQA-EIKLCD----------FGLSAQIPDNSDSIQTIEPIG
|.. |  |..|  |.  . ...   ..|||..||.||.| |.|.||||||.|||. .| ..   |||||          |  .  .. |   | . .  .
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

NFGY----SAPEILNKKDNELKIYTKKSDSYS-VGLLLALLDNYQVLKTNT
   |    .|||.      . .|| |.|| .| ||. |  ||| |    . 
TQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC

Kinase 5060.AA CAMK 408-603 19 4e-36 113.38 In-house 1-324 (425) Show / Hide
Range on Protein: 408-603
Range on HMM: 1-324/425
Sequence Identity: 19% (64 aa)

ILSFGNYGMVLATKKAMLN------------KEIVLKI---QKIE----------------------------DEQLIQNEISIMQK-------LKEPLV
.|  |..| |   .    .            ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYIIEN---------TLGP-----DRYSVFEL---EKCSC-----SLDEYLERSNK------------DGQINEDDRFQIAIQIIDSVNYIHSFN
..||. |  ..         |        |.. .. .   | ||       | .|. .  .            .| ..|..  ..  ||.. |.|.|| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVYLDG--------------KQAEIKLCDFGLSAQIPDNSDSI---------------------QTIEPIGNFGYSA-PEILNKK----
|.|||.|||| |.  ..              ... ||..|||...........                         .. |  .| | ||.||.|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DNELKIYTKKSDSYSVGLLL
     |.| . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL

Kinase 5060.AA S_TKc 403-674 23 9.1e-31 109.45 SMART 1-231 (231) Show / Hide
Range on Protein: 403-674
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

QNDFQILSFGNYGMVLATKKAMLNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGPDRYSVFELEKCSC---SLDEYLERSNKDGQ
    ...  | .| |   ..   ...  .|| |    . |..||.|..| . | .|.|||..          .  . .| |.    .| .|... .. | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---INEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNSDSIQTIEPIGNFGYSAPEILNKKDNELKIYTK-KSD
   ..| .   .. ||.. ..|.|| .|||||.|||| |.       .||.|||||..|.            .|   | |||.|         |.| |.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCD

SYSVGLLLA-LLDNYQVLKTNTSLNFALMTQKQLDQPFEKSNILINKNSQIYKFINLLVVSDSYQRASLYDIVE-----KSDITF
 .|.| .|. .|  |         . ..| .| .              ..   ||. . . |  .| .  .. .     |..  |
WWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 5060.AA STE 403-603 23 9.6e-30 102.25 In-house 1-258 (359) Show / Hide
Range on Protein: 403-603
Range on HMM: 1-258/359
Sequence Identity: 23% (62 aa)

QNDFQILSFGNYG-MVLA-------------------TKKAMLNKEIVLKIQK---------------IEDEQLIQNEISIMQKLK--EPLVVQLYDSYI
. . ...  |..|  ..|                   |.. |  |.. |. ..               .|..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEN--TLGPDRYSVFELEKCSC-SLDEYLERSNKDGQ-----------INEDDRFQIAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDF
 |.  .   |   .. .| ..  |||. ...  . |.           ..|.    |. ||.    .|.|| .|||||||| | |.        .|||||
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDF

GLSAQIPDNSDSI--------------QTIEPIGNFGYSAPEILNKKDNE-LKIYTKKSDSYSVGLLL
|...|. |....|              ..   .|   . |||.... ..   | |. |.| .|.|...
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI

Kinase 5060.AA Ciliate-E1 409-597 25 2.3e-26 83.04 In-house 1-202 (202) Show / Hide
Range on Protein: 409-597
Range on HMM: 1-202/202
Sequence Identity: 25% (53 aa)

LSFGNYGMVLATKKAMLN-KEIVLKIQKIEDEQ-------LIQNEISIMQKLKEPL-VVQLYDSYIIENTLGPDRYSVFELEKCSCSLDEYLE-------
.. | ...|.  |.   | ... .||..... .       .|.....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RSNKDGQINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNSDSIQTIEPIGNFGYSAPEILNK---KDNE
    .....| ...   ||..|.|| ....|..|||||||||.| |.. . ..   ..||||.| ..  |... . ..      |. || .|    . |.
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYK-GYTHYYYPPEQYNCPEQEHNK

LKIYTKKSDSY
 .....||| |
NQKINYKSDIY

Kinase 5060.AA Pkinase 430-604 27 1e-25 92.0 Pfam 31-203 (293) Show / Hide
Range on Protein: 430-604
Range on HMM: 31-203/293
Sequence Identity: 27% (52 aa)

VLKIQKIEDEQLIQN----EISIMQKLKEPLVVQLYDSYIIENTLGPDRYSVFELEKCSC-----SLDEYLERSNKDGQI--NEDDRFQIAIQIIDSVNY
..| ...........    ||.||..|. | .|.|||..        ...  . .| | .     .| .|...  ..| .   |..   .. ||.  ..|
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEY

IHSFNIIHRDIKPENFLVYLDGKQAEI----KLCDFGLSAQIPDNSDSIQTIEPIGNFGYSAPEILNKKDNELKIYTKKSDSYSVGLLLA
.|| .|||||.||||.|  .| .. .|    |.|||||..|.  .  .  .  . |  .| |||...    . . |..|.| .|.|..|.
CHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILY

Kinase 5060.AA TKL 486-603 24 2.7e-24 84.37 In-house 124-279 (364) Show / Hide
Range on Protein: 486-603
Range on HMM: 124-279/364
Sequence Identity: 24% (41 aa)

S-LDEYLERSNKDGQINEDDRFQIAIQIIDSVNYIHSFN--------IIHRDIKPENFLVYLDGK-----------QAEIKLCDFGLSA------QIPDN
| |. ..           . |...|..|   .|| || |        |||||.|..| ||  ...           .  .|.||||||       .  |.
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

SDSIQ-----------TIEPIGNFGYSAPEILNKKDN-----------ELKIYTKKSDSYSVGLLL
. ...           |. ..|.... |||.|....|           . . |..|.| || |..|
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

Kinase 5060.AA CMGC 406-553 17 8.3e-24 74.31 In-house 1-251 (513) Show / Hide
Range on Protein: 406-553
Range on HMM: 1-251/513
Sequence Identity: 17% (45 aa)

FQILS---FGNYGMVLATKK--------------AMLNKEIVLKIQKIEDEQLIQ---------------NEISIMQKLK-----------------EPL
..|..    | ||.|   .                  |... .|. | .    .|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIENTLGP-----------DRYSVFELEKCSCSLDEYLERSNKD-----GQINEDDR---------------FQ----IAIQIIDSVN--YI
.|.|||..  .|. |.           ...  .  | . ..| .|... ..|     ..  ..                 |     .. ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFN--IIHRDIKPENFLVYLDGKQ-----------------AEIKLCDFGLS
|| .  |||||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA

Kinase 5060.AA Ciliate-E2 407-603 22 5.8e-23 75.64 In-house 5-286 (365) Show / Hide
Range on Protein: 407-603
Range on HMM: 5-286/365
Sequence Identity: 22% (66 aa)

QILSFGNYG-----MVLATKKAML------------------NKEIVLKIQKIEDEQLIQNEISIMQ----------------KLKEPLVVQLYDSYI--
... .||.|      |  ..|                     .|.. .||.|  . . | .||.||.                .|. | ....|....  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

IENTLGPDRYSVFELEKCSC-SLDEYLE--RSN-------KDGQINEDDRFQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFLVYLD
 .|..       . .| |.  .| .|..  . .       . ....|  . .|  ||..                ..|.|| | |||||||||| |.   
DDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

GKQAEIKLCDFGLSAQIPDNSD--------SIQTIEP----------------------IGNFGYSAPEILNKKDNE----LKIYTKKSDSYSVGLLL
     ||..||||| .. |...         . .                         .|. || ||||||.|...     | |..|.| .|.| .|
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

Kinase 5060.AA Ciliate-A1 500-606 32 2.5e-17 55.5 In-house 98-221 (301) Show / Hide
Range on Protein: 500-606
Range on HMM: 98-221/301
Sequence Identity: 32% (41 aa)

INEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNS----------------DSIQTIEPIGNFGYSAPEI----
. ...   |  |||  .  ||. ||.|||.||.| |.  | |   .|.||.|.| | . |                    .|..  ||  | .||     
MKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMH

L-NKKDNELKIYTKKSDSYSVGLLLALL
.  ..  | ||| |.|| ||.|. .  |
YRDQMFIENKIY-KQSDMYSLGCIICFL