Gene 14779 (Tetrahymena)

14779

Species: Tetrahymena
Alias: PreTt14779, 242.m00026, 790, TTHERM_01119390, 14779
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
14779.AA Protein None 721 None Fasta, JSON
14779.kin_dom Protein Kinase Domain None 281 None Fasta, JSON
14779.kin_dom2 Protein Kinase Domain None 177 None Fasta, JSON
14779.NA RNA None 2166 None Fasta, JSON

Protein domain

Protein domains of 14779.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14779.AA C8 42-256 59 7.29999999999e-120 404.51 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 59% (135 aa)

FKNFEYLSNGAYALILKADNSQQNRKVALKFLGSSNQKDQNGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKEDEDDDGNDIIVQTEAKSYFVMEME
|.||.|||.|||...||| |...||...|||. ..|..|...|||..|||||.|.|.|....||.|||||.|.|...|....|..||||| ||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCENNLKQFFDILRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCDLGFASAVSRSKS-FVSKK----GTDAYFAP
|||.||||..| .|..|....||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|| .|| . |||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEAG------QSRIQSDLFSLGLIL
|.|..      |.||||||||.||.|
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 14779.AA Ciliate-C8 51-256 54 1.3e-118 400.34 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 54% (130 aa)

GAYALILKADNSQQNRKVALKFLGSSNQKDQNGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKEDEDDDGNDIIVQTEAK---SYFVMEMELCENN-
||....||| |..|||||||||. ..|....|..|...|||||...|.|....|.||||||||||...|||||||.||||. |   |.||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQFFDILRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCD------LGFASAVSRSKS-FVSKK--GTDAY---
 |||.|| .||.|..| ..||||||||||...|.||..|||||||||.|||||....|...|||||      .||||... .|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEAGQSRIQSDLFS-------LGLIL
        ||||||..|||||||.||       .||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 14779.AA C2 51-269 39 4.9e-67 228.0 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 39% (98 aa)

GAYALILKADNSQQNRKVALKFLGSSNQKDQNGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEE-KEDEDDDGNDIIVQTEA--------KSYFVMEME
|| .|.||| | .|||.||||     .. | || ... |||....... .  ...||..||| .. ||||| | ...... |         |. .|.|.|
GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCENNLKQFFDILRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCD----------LGFASAVSRSKS--FVSK-K
 |. ||||.|. .|||.  | ..||.|.||||. . | || ..| ||||||.|||.  ...    |||||          . |||... .||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEAGQSRIQSDLFS-LGLILLELDNLKALNENW
.| .|    |||||. .  . .||||| .|..|||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 14779.AA Pkinase 42-259 22 2.9e-25 90.39 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 22% (51 aa)

FKNFEYLSNGAYALILKADNSQQNRKVALKFLGSSNQKDQNGIESLK-KEYEMLQKFSQSECLVNVYDCFYLMEEKEDEDDDGNDIIVQTEAKSYFVMEM
..  . .  |...   |. .   ...||.| .  ...|..  .. ..  | ...... .... |  ||.|.                     |..  | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCENN--LKQFFDILR--KQQVP--PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCDLGFASA--VSRSKSFVSKKGTDA
|.||.   .   ||...  .. .   ...| | ..  |...||. .| ..|.|||.||.|.|.   .. . ..|.|| |.|      ..  . .  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EAGQSRIQSDLFSLGLILLEL
| ||||  ..      .| .|.|.|| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 14779.AA CMGC 42-219 14 4e-24 75.37 In-house 1-255 (513) Show / Hide 
Range on Protein: 42-219
Range on HMM: 1-255/513
Sequence Identity: 14% (39 aa)

FKNFEYLSNGAYALILKADN--------------SQQNRKVALKFLGSSNQKDQNGIE----------SLKKEYEMLQKFS---------------QSEC
... ...  |.|.   |. .               . |..||.| . .... ....            .   | ..|....               . . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKI-KNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-LVNVYDCFYLMEEKEDEDDDGNDIIVQTEAKSYFVMEMELCENNLKQFFDILR------KQQVPPPKE------------MKEII-----AIQMIEGLN
 .|. ||.||  ... .|..| . |  .     .. . .|.....|.|. .  .      ...  .. .             | ..     . |...||.
NIVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK

--NLHVKN--IMHRDIKPQNFLVCPSNEY----------------GFSIKLCDLGFASAVS
   .| ..  |.|||.||.| |... .|.                 . .|.|| |.| ...
LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYH
Kinase 14779.AA STE 42-259 16 3.6e-22 75.17 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 16% (48 aa)

FKNFEYLSNGAYA-LILKADNS-----QQNRK---------VALKFLGSSNQK----------DQNG----IESLKKEYEMLQKFSQ-SECLVNVYDCFY
... | . .||.    .....      . ...         .| | .  .|..          ..|     .....|| ....|... ..  |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEKEDEDDDGNDIIVQTEAKSYFVMEMELCE-NNLKQFFDILRKQQVPPP------KEMKEIIA----IQMIEG-LNNLHVKNIMHRDIKPQNFLVCP
   ..             ......  . ||...   | .. .   . . | .      . ..| .      | ..| |. || ..|.||||||.| |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SNEYGFSIKLCDLGFASAVSR-----------------SKSFVSKKGTDAYFAPEVEAG-QSR------IQSDLFSLGLILLEL
       .|||| |... ..                  ..   .  ||  . ||||  . ..       ...|  |||. ..|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 14779.AA Ciliate-E1 48-250 21 1.3e-21 67.39 In-house 1-202 (202) Show / Hide 
Range on Protein: 48-250
Range on HMM: 1-202/202
Sequence Identity: 21% (48 aa)

LSNGAYALILKADNSQQN-RKVALKFLGSSNQKDQNGIESLKKEYE-MLQKFSQSECLVNVYDCFY---------LMEEKEDEDDDGNDIIVQTEAKSYF
..|| .....|| . ..| ..||.|.     . .|| .....|||  ... | . .......|...         ..|. .... | ..           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

VMEMELCENNLKQFFDILRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCDLGFAS-AVSRSKSFVSKKGTDAYFA
        | | . .......|     . |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   . ... . .||   |..
--------NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYY

PEVEAG----------QSRIQSDLF
|. .            .  ..||..
PPEQYNCPEQEHNKNQKINYKSDIY
Kinase 14779.AA CAMK 47-256 15 4e-21 64.17 In-house 1-324 (425) Show / Hide 
Range on Protein: 47-256
Range on HMM: 1-324/425
Sequence Identity: 15% (53 aa)

YLSNGAYALILKADNSQQN------------RKVALKF-------------------LGSSNQKD------QNGIESLKKEYEMLQKFS------QSECL
 |  |...   .. . . .            .||| |.                   .  |..|.      ..  .....|.|...| .      . ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEEKEDEDDDGNDIIVQTEAKSYFVM-EMELCENN--LKQFFDILRKQ---------------QVPPPKEMKEIIAIQMI
.. |. .               .|         ..  .. . |.||  ||.|..   .   || ....                  . .| . ..  |..
IKLYEVYEDPHYFKNTNDYET-SKQ--------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QIC

EGLNNLHVKNIMHRDIKPQNFLVCPSNEYG-------------FSIKLCDLGFASAVSRSK------------------------SFVSKKGTDAYFA-P
.... .| .||.|||.|| | |.. .|.               . ||..| |||  . ...                         .    || .| | |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EVEAG-------------QSRI--QSDLFSLGLIL
||  |             .  .  ..|  |.| ||
EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 14779.AA Ciliate-E2 169-259 25 8.5e-21 68.11 In-house 165-289 (365) Show / Hide 
Range on Protein: 169-259
Range on HMM: 165-289/365
Sequence Identity: 25% (35 aa)

IAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCPSNEYGFSIKLCDLGFASAV----------SRSKSFVSKK-----------------------GTDAYF
.. ..|..|. || || |.||||||.| |.         ||..|.|..  .          ...| .   |                       ||  | 
YIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM

APEVEAGQSR----------IQSDLFSLGLILLEL
|||.  |..            ..|..||| || |.
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 14779.AA Ciliate-E3 125-260 29 3.6e-20 59.82 In-house 69-202 (202) Show / Hide 
Range on Protein: 125-260
Range on HMM: 69-202/202
Sequence Identity: 29% (42 aa)

DIIVQTEAKSYFVMEMELCEN-NLKQFFDILRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYG-FSIKLCDLGFASAVSRSK
|.... . |..|.  .|.|.| .|. .   . |.|     .... |.||.|.|.  .| ||| | ||||.|.||  .....   || ||.| .   .  |
DQYYDQQNKMIFIV-QEYCSNGDLYHYIKQQNKTQ----NIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNK

--SFVSKKGTDAYFA-PEVEA-GQSRIQSDLFSLGLILLELD
  .     |.  ..| ||.   .|    ||. |.| ....| 
GHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 14779.AA TKL 169-259 20 4.8e-19 65.22 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 20% (30 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCPSNE----------YGFSIKLCDLGFASAVSRSKS--------------------FVSKKGT
.|...  |.| ||         ..| |||.|..| ||   ..          .   .|.||.|..  .|.|..                      .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EAGQSRIQSDLFSLGLILLEL
 .. ||||                 . ..   ..| .| |..| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 14779.AA S_TKc 42-323 20 1.2e-16 62.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

FKNFEYLSNGAYALILKADNSQQNRKVALKFLGSSNQKDQNGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKEDEDDDGNDIIVQTEAKSYFVMEME
..  . .  ||..   |. .   .|.||.| .           |....| ..|.|  . . .|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCENNLKQFFDILRKQQVP------PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCDLGFASAVSRSKSFVSKKGTDAYFA
.|...|   ||...|.. .      |. . . ... |....|. .| ..|.|||.||.| |..        ||.|| |.|  .       .  ||  | |
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA

PEVEAGQSRIQSDLFSLGLILLELDNLKALNENWIDTNIKYYLFNGEEIPKEKYQIDKNSNIYKIAKICLRHRYLDRTTAGELLS--------SLI
|||  | ..  .|  |.| || |.   . . .     ...  . .              .    . . ||.    .| || |.|           .
PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14779.AA TyrKc 42-322 18 1.4e-09 -67.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FKNFEYLSNGAYALILKADNSQQNRKVALKFLGSSNQKDQNGIESLKKEYEMLQKF-SQSECLVNVYDCFYLMEEKEDEDDDGNDIIVQTEAKSYFVMEM
 .  . | .||.  . |.  .   ..|| | | ..       .| . .| ... |.  . ...|. | .    ...              ... ...  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------------FMYIEPLMIV-M

ELCEN-NLKQFFDILRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSNEYGFSIKLCDLGFASAVSRS-------KSFVSKK--GT
|.... .||..   ||| .   . . .  ...|  .| . || ||. |||.   | ||   .     .| .| | . ..          .  ..|.  |.
EYMPHGDLKDY---LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

D-----AYFAPEVE-AGQSRIQSDLFSLGLILLELDNL-KALNEN-----WIDTNIKYYLFNGEEIPKEKY-----QIDKNSNIYKIAKICLRHRYLDRT
.        |||.   |   ..|| .| |  . |.  . .   ..       .. .  |. .|.  |. ..          . .|.| | | ..   || 
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TAGELLSSL
|  |. . .
TFSEIHECF
Kinase 14779.AA Ciliate-E2 42-116 12 0.000342 10.27 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 12% (13 aa)

FKNFEYLSNGAYALILKADNSQQNRKVALK-----------------FLGSSNQKDQNGIESLKKEYEMLQ---------------KFSQSECLVNVYDC
.|  . . .|... . |. . ......|.|                 ..   ... .|.||..|.|  ...               .. ..  ... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYLMEEK
|. . ..
FQEKDDN
Kinase 14779.AA Ciliate-E3 42-116 23 0.001128 7.67 In-house 1-77 (202) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-77/202
Sequence Identity: 23% (18 aa)

FKNFEYLSNGAYALILKADNSQQNRKVALKFLGSSNQKD---QNGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEK
.     | .| . .  || ..|.|..|| | .  .||..         . .|  . |..  |. .| ..| .|  . |
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNK
Kinase 14779.AA Ciliate-C8 418-584 35 7.9e-79 268.19 In-house 1-238 (238) Show / Hide 
Range on Protein: 418-584
Range on HMM: 1-238/238
Sequence Identity: 35% (84 aa)

GGFGMVLAT------KKVKLDNKEIVLKIQKIEDEQQIQNEISIMQKLKEPLVVQLYDSYIIESNIGPDR-----------------YSVFELEKCS--C
|.|||||..      .||.|...|.|.||||...|..|.....|||....|.|||.||...... . ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-QNKEGKLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLD-GKQPEIKLCD------FGLSAQIPDNKN---------SIQT---
.|..|..| ..|.. .... |..||||.||||||.|.|||.||||||.||||..| ..||.|||||      ||...|.|.||.         ..|.   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

-------------------IDSDSYS-------VGLLL
                   | || .|       |||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 14779.AA C8 409-572 48 9.5e-78 264.61 In-house 1-186 (226) Show / Hide 
Range on Protein: 409-572
Range on HMM: 1-186/226
Sequence Identity: 48% (90 aa)

SDNFQILNFGGFGMVLATKKVKLDNKEIVLKIQKIEDEQQIQNEISIMQKLKEPLVVQLYDSYIIESNIGPDRYSVFELEKCS-----------CSLDE-
..|||.|.||..||||..|.|| ||.|||||.||....|.|||..|||.....|.|.|.||.|..| ......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQNKEGKLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQP-EIKLCDFGLSAQIPDNKNSIQT
          |.||.||........|..||||.||.|||||..||.||||||.||||.||.... ||||||||...|...||..||.
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQS
Kinase 14779.AA C2 418-572 29 1.6e-43 146.56 In-house 1-195 (245) Show / Hide 
Range on Protein: 418-572
Range on HMM: 1-195/245
Sequence Identity: 29% (58 aa)

GGFGMVLATKKVKLDNKEIVLKIQKIED-----EQQIQNEISIMQKLK-EPLVVQLYDSYIIESNIGPD-------------R----------YSVFELE
|.||.|| .   | .|....||||....     ....|.|..||....  |.....|...    |   |             .            |.|.|
GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLERQNKEG-KLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQ-PEIKLCD----------FGLSAQIPDNKNSIQT
.|.. |  |..|. |.   .... | ..|||..||.||.|.|.|.||||||.|||. .| .. | |||||          |  .  .. ||. | .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHF
Kinase 14779.AA CAMK 414-569 18 8.4e-28 86.08 In-house 1-252 (425) Show / Hide 
Range on Protein: 414-569
Range on HMM: 1-252/425
Sequence Identity: 18% (48 aa)

ILNFGGFGMVLATKKVKLDN-----------KEIVLKI---QKIE----------------------------DEQQIQNEISIMQK-------LKEPLV
.|  |.|| |   .  .  .           ..   ||   .|.                             |......||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYIIESN--------IGP------DRYSVFEL---EKCSC-----SLDEYLERQNK------------EGKLNEDNKFQIAIQIIDSVNYIHQFN
..||. |  ...                 |.. .. .   | ||       | .|. .. .            .|...|.   ..  ||.. |.|.|. |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVYLDGKQPE--------------IKLCDFGLSAQIPDNKNS
|.|||.|||| |.  ...  .              ||..|||.........|.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENN
Kinase 14779.AA Ciliate-E1 415-579 25 9.5e-27 84.28 In-house 1-177 (202) Show / Hide 
Range on Protein: 415-579
Range on HMM: 1-177/202
Sequence Identity: 25% (48 aa)

LNFGGFGMVLATKKVKLDNKEIVLKIQKIEDEQ-------QIQNEISIMQKLKEPL-VVQLYDSYIIESNIGPDRYSVFELEKCSCSLDEYLE-------
.  |.|..|.  |. .  .... .||..... .       .|.....||. .|.   ..|..| ..|..|..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKEGKLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSA--QIPDNKNSIQTIDSDSYS
    |..........| ||..|.|| ....||.|||||||||.| |.. . ..   ..||||.|   .  .|... ..   ..|.
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHYYY
Kinase 14779.AA CMGC 409-560 16 2.2e-23 72.92 In-house 1-251 (513) Show / Hide 
Range on Protein: 409-560
Range on HMM: 1-251/513
Sequence Identity: 16% (41 aa)

SDNFQILNFGGFGMVLATKK-------------VKLDNKEIVLKIQKIEDEQQIQ---------------NEISIMQKLK-----------------EPL
 .. . .  | .|.|   .               . .|... .|. | .   ..|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIES--NIGP---------DRYSVFELEKCSCSLDEYLERQN--KEG----KLNEDN------------KFQIA------IQIIDSVN--YI
.|.|||..  .   . ..         ...  .  | . ..| .|.....  . |    .|.|              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCDFGLS
|. .  |||||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 14779.AA STE 421-563 29 2.4e-20 68.63 In-house 39-197 (359) Show / Hide 
Range on Protein: 421-563
Range on HMM: 39-197/359
Sequence Identity: 29% (50 aa)

GMVLATKKVKLDNKEIV--------LKIQKIEDEQQIQNEISIMQKLK--EPLVVQLYDSYIIESNI--GPDRYSVFELEKCSC-SLDEYLERQNKEGK-
| . | |...|.|..          |..  .|..|||..||.||.|..   | .|. |..|. |..     |   .. .| ..  |||. ...  . || 
GEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKP

----------LNEDNKFQIAIQIIDS-VNYIHQFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQI
          ..|.    |. ||.    .|.|. .|||||||| | |.        .||||||...|.
LNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQL
Kinase 14779.AA Pkinase 437-563 28 4.7e-20 71.98 Pfam 31-162 (293) Show / Hide 
Range on Protein: 437-563
Range on HMM: 31-162/293
Sequence Identity: 28% (40 aa)

VLKIQKIEDEQQIQN----EISIMQKLKEPLVVQLYDSYIIESNIGPDRYSVFELEKCSC-----SLDEYLERQNKEGKL--NEDNKFQIAIQIIDSVNY
..| ...........    ||.||..|. | .|.|||..        ...  . .| | .     .| .|...  ..|..   |.    .. ||.  ..|
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEY

IHQFNIIHRDIKPENFLVYLDGKQPEI----KLCDFGLSAQI
.|. .|||||.||||.|  .| ....|    |.|||||..|.
CHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQF
Kinase 14779.AA S_TKc 412-656 22 2.8e-19 71.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 412-656
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

FQILNF---GGFGMVLATKKVKLDNKEIVLKIQKIEDEQQIQNEISIMQKLKEPLVVQLYDSYIIESNIGPDRYSVFELEKCSC---SLDEYLERQNKEG
..||.    |.|| |   ...| ....  .|| |    ..|..||.|..| . | .|.|||..          .  . .| |.    .| .|.......|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

K---LNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKNSIQTI-------------DSDSYSVGLLLALLDN
.   ..|     .. ||.. ..|.|. .|||||.|||| |.       .||.|||||..|.   .  . |               .| .|.| .|. .  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLC

----YQDLKENTVSNFALMTQKQLDKPFEKSNILINKNSEIYKFINLLVVSDSVQRASLYDIVE-QSD---AKFI
    ..        . ..| .| .              .|   ||. . . |  .| .  .. . ..|     ..
GYPPFP--------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14779.AA Ciliate-E2 409-563 23 3e-18 59.25 In-house 1-206 (365) Show / Hide 
Range on Protein: 409-563
Range on HMM: 1-206/365
Sequence Identity: 23% (52 aa)

SDNFQILNFGGFG-----MVLATKKV-----------------KLDNKEIVLKIQKIEDEQQIQNEISIMQ----------------KLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.|  . .|| .||.||.                .|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IESNIGPDRYSVFELEKCSC-SLDEYLE----RQNKE----GKLNEDNKFQIAIQIID---------------SVNYIHQFN-IIHRDIKPENFLV
..   ..||       . .| |.  .| .|..     .|.|    ....|    .|  ||..                ..|.|. | |||||||||| |.
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF

YLDGKQPEIKLCDFGLSAQI
        ||..||||| ..
--------IKIIDFGLSKKY
Kinase 14779.AA Ciliate-E3 488-574 43 1.6e-14 41.98 In-house 84-167 (202) Show / Hide 
Range on Protein: 488-574
Range on HMM: 84-167/202
Sequence Identity: 43% (38 aa)

EKCSC-SLDEYLERQNKEGKLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKNSIQTID
| ||  .| .|.  |||     .    .|.|||| ..  ||. |||| ||||.|.||     |  || ||||.| |   ||  ..| .
EYCSNGDLYHYIKQQNKT----QNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY
Kinase 14779.AA TKL 493-560 27 2.3e-14 48.11 In-house 124-201 (364) Show / Hide 
Range on Protein: 493-560
Range on HMM: 124-201/364
Sequence Identity: 27% (24 aa)

S-LDEYLERQNKEGKLNEDNKFQIAIQIIDSVNYIHQFN--------IIHRDIKPENFLVYLDGKQPE-----------IKLCDFGLS
| |. ..           . ....|..|   .|| |. |        |||||.|..| ||  ...              .|.||||||
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS
Kinase 14779.AA C8 573-584 66 0.001077 8.83 In-house 215-226 (226) Show / Hide 
Range on Protein: 573-584
Range on HMM: 215-226/226
Sequence Identity: 66% (8 aa)

IDSDSYSVGLLL
| ||..||||.|
IQSDLFSVGLVL