Gene 21704 (Tetrahymena)

21704

Species: Tetrahymena
Alias: PreTt21704, 346.m00019, n.21704, 1156, 21704, TTHERM_01361490
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
21704.NA RNA None 3344 None Fasta, JSON
21704.AA Protein None 913 None Fasta, JSON
21704.kin_dom Protein Kinase Domain None 199 None Fasta, JSON
21704.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of 21704.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21704.AA C8 42-256 60 3.2e-120 405.72 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 60% (136 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEEQEDEDEDGNNIIVQTGVKSFFVMEME
|.||.|||.|||..||||.|.|.||...|||. ..|..|...|||..|||||.|.|.|..|.||.|||||.|.|...|....|..|||| .||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEKNLKQLFDFLRKQQVPPPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDLYFAP
|||.|||||.|..|..|....||.|||||||||.|.|..|.||||||||||.|.|||....|||.|||||.||||.|||.|| ..|||    ||. ||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEEG------KSRIQSDLFSLGLVL
|.|..      ..||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 21704.AA Ciliate-C8 51-256 54 6.2e-117 394.78 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 54% (130 aa)

GAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEEQEDEDEDGNNIIVQTGVK---SFFVMEMELCEKN-
||...||||.|.||||.|||||. ..|....|..|...|||||...|.|..|.|.||||||||||...||.|||..|||| .|   ||||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRKQQVPPPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDLY---
 |||.||..||.|..| ...|||||||||...|.||..|||||||||.|.|||....|...|||||      .||||...|.|| ..|||  ||| |   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEEGKSRIQSDLFS-------LGLVL
        ||||||...||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 21704.AA C2 51-269 40 1.2e-67 230.14 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 40% (99 aa)

GAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEE-QEDEDEDGNNIIVQTGV--------KSFFVMEME
|| .|||||.| ||||.||||     .. | || ... |||....... . ....||..||| .. .|||||| ......           |.|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEKNLKQLFDFLRKQQVPPPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCD----------LGFASAVSKSKS--FMSK-K
 |..|||| |. .|||.  | ...|.|.||||. . | || ..| ||||||.| |.  ...    |||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDLY----FAPEVEEGKSRIQSDLFS-LGLVLLELDNLKTLNENW
.|  |    |||||...  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 21704.AA Pkinase 42-259 22 5.4e-27 96.53 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 22% (52 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLK-KEYEMLQKFSQSQFLVNVYDCFYLMEEQEDEDEDGNNIIVQTGVKSFFVMEM
..  . . ||... | |... . ...||.| .  ......  .. ..  | ...... .. . |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEKN--LKQLFDFLR--KQQVP--PPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDL
|.||.   .  |||...  .. .   ...|.| ..  |...||. .| ..|.|||.||.| |.    . . ..|.|| |.|      ..  ...  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EEGKSRIQSDLFSLGLVLLEL
| ||||  .  .    .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 21704.AA CMGC 42-220 16 8.3e-27 84.35 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 16% (42 aa)

FQNFEYLSSGAYSLVLKAYN--------------SKQNRQVALKFLGSSNQEDNNGI---------ESLKKEYEMLQKFS----------------QSQF
... ... .|.|. | |...               . |..||.| . .   ... .           .   | ..|....                .   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEQEDEDEDGNNIIVQTGVKSFFVMEMELCEKNLKQLFDFLR------KQQVPPPKE------------IKEII-----AIQMIEGLN-
.|. ||.||  ... .|.|| . |  .      . . .|.....|.|. .  .      ...  .. .            || ..     . |...||. 
IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPQNYLVCPSEEY----------------GFSIKLCDLGFASAVSK
  .| ..  |.|||.||.| |...  |.                 . .|.|| |.| ....
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 21704.AA Ciliate-E2 150-259 24 1.7e-21 70.54 In-house 121-289 (365) Show / Hide 
Range on Protein: 150-259
Range on HMM: 121-289/365
Sequence Identity: 24% (44 aa)

LFDFLRKQQVPPPKE--------IKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNYLVCPSEEYGFSIKLCDLGFASAVSKS--
|||......   ..|        .|||  |  | ..               .|. || || |.||||||.| |.         ||..|.|..  ....  
LFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQ

--------KSFMSKK-----------------------GTDLYFAPEVEEGKSR----------IQSDLFSLGLVLLEL
        | .|  |                       ||  | |||. .||.            ..|..||| .| |.
NRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 21704.AA Ciliate-A1 140-259 28 3.9e-21 68.65 In-house 80-221 (301) Show / Hide 
Range on Protein: 140-259
Range on HMM: 80-221/301
Sequence Identity: 28% (43 aa)

MELCEKNLKQLFDFLRKQQVPPPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCDLGFASAVSKSK-----------------
|| |....  ||..          || ||   |.|||.  .| .||.|||.|||| |.   . .    |.||||       ..                 
MEYCQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDVNGCSFSKQVNK

--SFMSKKGTDLYFAPEV----------EEGKSRIQSDLFSLGLVLLEL
     .| |. .| .||            |.|   |||..|||.....|
HYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL
Kinase 21704.AA S_TKc 42-323 21 4.1e-21 77.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEEQEDEDEDGNNIIVQTGVKSFFVMEME
..  . . .||.. | |... | .|.||.| .           |....| ..|.|  .  ..|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEKNLKQLFDFLRKQQVP------PPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCDLGFASAVSKSKSFMSKKGTDLYFA
.|. .|  |||...|.. .      |. ... ... |....|. .| ..|.|||.||.| |..        ||.|| |.|  .      ..  ||  | |
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA

PEVEEGKSRIQSDLFSLGLVLLELDNLKTLNENWIDTKIKYQLFNGENIPKEKYQIDTNSNIYKIAQICLKPRYLDRTTAGELLS--------QLI
|||  | ..  .|  |.| .| |.   ... .   . ..  ..                .    . . ||.    .| || |.|         . .
PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21704.AA CAMK 47-256 15 4.1e-21 64.12 In-house 1-324 (425) Show / Hide 
Range on Protein: 47-256
Range on HMM: 1-324/425
Sequence Identity: 15% (51 aa)

YLSSGAYSLVLKAYNSKQN------------RQVALKF-------------------LGSSNQED------NNGIESLKKEYEMLQKFS------QSQFL
 | .|... | .... . .            ..|| |.                   .  |.. .       .  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY------------LMEEQEDEDEDGNNIIVQTGVKSFFVMEM---ELCEKN--LKQLFDFLRKQ---------------QVPPPKEIKEIIAI
.. |. .               . |           |    .....| |   |.|.    .  |||.....                  . .| . ..  
IKLYEVYEDPHYFKNTNDYET-SKQ-----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-

QMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDLYF
|...... .| .||.|||.|| | |.. ...               . ||..| |||  . ...                         .    ||  | 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVEEG-------------KSRI--QSDLFSLGLVL
| ||| .|             |  .  ..|  |.| .|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 21704.AA TKL 169-259 21 2e-17 59.29 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (32 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNYLVCPSEE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DLYFAPEV-----------------EEGKSRIQSDLFSLGLVLLEL
  . ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 21704.AA STE 168-259 26 3.8e-17 57.2 In-house 155-261 (359) Show / Hide 
Range on Protein: 168-259
Range on HMM: 155-261/359
Sequence Identity: 26% (31 aa)

IIAIQMIEG-LNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDLYFAPEVEEG-KSR----
.|. | ..| |. || ..|.||||||.| |.         .|||| |... ...                 ..   .  ||  . |||| .. ..     
YICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

--IQSDLFSLGLVLLEL
  ...|  |||....|.
YDTKCDIWSLGCTIIEM
Kinase 21704.AA Ciliate-E1 135-250 25 1.8e-16 50.5 In-house 71-202 (202) Show / Hide 
Range on Protein: 135-250
Range on HMM: 71-202/202
Sequence Identity: 25% (34 aa)

FFVMEMELCEKNLKQLFD---------FLRKQQVPPPKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNYLVCPSEEYGFSIKLCDLGFAS-AVSKSKSF
...  .|.|...||. ..          ....|     . |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   ..... 
ICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQ

MSKKGTDLYFAPEVEEG----------KSRIQSDLF
. .||   |..|. .            |  ..||..
CQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 21704.AA Ciliate-E1 48-112 23 1.3e-08 24.59 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 23% (16 aa)

LSSGAYSLVLKAYNSKQN-RQVALKFLGSSNQEDNNGIESLKKEYE-MLQKFSQSQFLVNVYDCFYL
...| .|.|.||.. ..| .|||.|.     ... | .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 21704.AA STE 42-119 18 2.3e-07 22.22 In-house 1-111 (359) Show / Hide 
Range on Protein: 42-119
Range on HMM: 1-111/359
Sequence Identity: 18% (20 aa)

FQNFEYLSSGAYSLVLKAYNS------KQNRQ---------VALKFLGSSNQE----------DNNG----IESLKKEYEMLQKFSQ-SQFLVNVYDCFY
... | . .||.  | ||.|       | ...         .| | .  .|..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LM---EEQEDE
     ....||
KEGHNHKNDDE
Kinase 21704.AA Ciliate-E2 42-116 14 1.9e-05 14.64 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (15 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALK-----------------FLGSSNQEDNNGIESLKKEYEMLQ---------------KFSQSQFLVNVYDC
.   . . .|... | |. . |...|.|.|                 ..   ..  .|.||..|.|  ...               .. .. .... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYLMEEQ
|. . ..
FQEKDDN
Kinase 21704.AA Ciliate-A1 42-79 22 0.002675 7.01 In-house 1-39 (301) Show / Hide 
Range on Protein: 42-79
Range on HMM: 1-39/301
Sequence Identity: 22% (9 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQ--VALKFLGSSNQE
.     . .| .. |..||.. || .  ...| .  .| |
YHVVQLIDKGSFGVVMRAYDI-QNQKKYLCCKIIICTNFE
Kinase 21704.AA C8 409-610 48 1.5e-101 343.66 In-house 1-226 (226) Show / Hide 
Range on Protein: 409-610
Range on HMM: 1-226/226
Sequence Identity: 48% (110 aa)

SNNFQILSFGSFGMVLATKKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENKLGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..||||..|..| ||.|||||.||....| |||..|||.....|.|.|.||.|..|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQNKDGQLNEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQA-EIKLCDFGLSAQIPDNKDSIQTIEH--IGNLGYSA
          |.||.||..|.....|...|||.||.|||||..||.||||||.||||.||...  ||||||||...|...||..||....  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKQDNELKSYTKKSDSYSVGLLL
|||..||||..| |...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 21704.AA Ciliate-C8 418-610 39 2.1e-98 333.22 In-house 1-238 (238) Show / Hide 
Range on Protein: 418-610
Range on HMM: 1-238/238
Sequence Identity: 39% (94 aa)

GSFGMVLAT------KKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENKLGPDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|..|.....|||....|.|||.||.......  ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-QNKDGQLNEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLD-GKQAEIKLCD------FGLSAQIPDNKD---------SIQTIEH
.|..|..| ..|....... |...|||.||||||.|.|||.||||||.||||..| ..| .|||||      ||...|.|.||.         ..|.||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-QDNELKSYTKKSDSYSVGLLL
  .||.||.|||...| ...... ..||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 21704.AA C2 418-623 28 1.5e-44 150.09 In-house 1-245 (245) Show / Hide 
Range on Protein: 418-623
Range on HMM: 1-245/245
Sequence Identity: 28% (73 aa)

GSFGMVLATKKAKLDNKEIVLKIQKIED-----EQLIQNEISIMQKLK-EPLVVQLYDSYIIENKLGPD-------------R----------YSVFELE
|.||.|| .   | .|....||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLERQNKDG-QLNEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQA-EIKLCD----------FGLSAQIPDNKDSIQTIEHI
.|.. |  |..|. |.  ..... | .||||..||.||.|.|.|.||||||.|||. .| ..   |||||          |  .  .. ||  | . .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKQDNELKSYTKKSDSYS-VGLLLALLDNYQDLKTNT
.   |    .|||.      . . | |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 21704.AA S_TKc 409-681 23 6.7e-34 119.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 409-681
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

SNNFQILSFGSFGMVLATKKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENKLGPDRYSVFELEKCSC---SLDEYLERQNKDG
    ...  |.|| |   .. | ....  .|| |    . |..||.|..| . | .|.|||..          .  . .| |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---LNEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNKDSIQTIEHIGNLGYSAPEILNKQDNELKSYTK-KS
    ..|     .. ||.. ..|.|. .|||||.|||| |.       .||.|||||..|.            .| . | |||.|        .|.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVGLLLALLDN----YQDLKTNTTSIFALMTQQQLDKPFEKSNIQINKNSEIYKFINLLVVSDSAQRASLYDIVQ-----KRDKIF
| .|.| .|. .      ..    .   .| ..                   .|   ||. . . | ..| .  .. |     | .  |
DWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21704.AA CAMK 414-610 19 1.5e-33 104.98 In-house 1-324 (425) Show / Hide 
Range on Protein: 414-610
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ILSFGSFGMVLATKKAKLDN-----------KEIVLKI---QKIE----------------------------DEQLIQNEISIMQK-------LKEPLV
.|  |||| |   .  .  .           ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYIIEN--------------KLGPDRYSVFEL---EKCSC-----SLDEYLERQNK------------DGQLNEDNKFQMAIQIIDSVNYIHQFN
..||. |  ..                 .|.. .. .   | ||       | .|. .. .            .| ..|.   ..  ||.. |.|.|. |
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVYLDG--------------KQAEIKLCDFGLSAQIPDNKDSI---------------------QTIEHIGNLGYSA-PEILNKQ----
|.|||.|||| |.  ..              ... ||..|||...........                         .  | ..| | ||.||..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DNELKSYTKKSDSYSVGLLL
     |.| . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 21704.AA Ciliate-E1 415-604 26 4.5e-30 95.21 In-house 1-202 (202) Show / Hide 
Range on Protein: 415-604
Range on HMM: 1-202/202
Sequence Identity: 26% (57 aa)

LSFGSFGMVLATKKAKLDNKEIVLKIQKIEDEQ-------LIQNEISIMQKLKEPL-VVQLYDSYIIENKLGPDRYSVFELEKCSCSLDEYLE-------
.. |||..|.  |. .  .... .||..... .       .|.....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKDGQLNEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSA-QIPDNKDSIQTIEHIGNLGYSAPEILN--KQDNE
    |....|.....| |...|.|| ....||.|||||||||.| |.. . ..   ..||||.|  ..  .....|   .. .  |. || .|   | ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHY--YYPPEQYNCPEQ-EH

LKS--YTKKSDSY
 |.  ...||| |
NKNQKINYKSDIY
Kinase 21704.AA STE 410-610 21 7.4e-29 99.08 In-house 1-258 (359) Show / Hide 
Range on Protein: 410-610
Range on HMM: 1-258/359
Sequence Identity: 21% (58 aa)

NNF-QILSFGSFG-MVLATKKAKL-------------DNKEIVLKIQKI--------------------EDEQLIQNEISIMQKLK--EPLVVQLYDSYI
  . ...  |.||  ..| .. .               .. .  |. ..                    |..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEN--KLGPDRYSVFELEKCSC-SLDEYLERQNKDGQ-----------LNEDNKFQMAIQIIDS-VNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDF
 |.  .   |   .. .| ..  |||. ...  . |.           ..|.    .. ||.    .|.|. .|||||||| | |.        .|||||
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDF

GLSAQIPDNKDSI--------------QTIEHIGNLGYSAPEILNKQDNE-LKSYTKKSDSYSVGLLL
|...|. |. ..|              ..   .|   . |||.......   | |. |.| .|.|...
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 21704.AA Ciliate-E2 409-610 21 3e-26 87.09 In-house 1-286 (365) Show / Hide 
Range on Protein: 409-610
Range on HMM: 1-286/365
Sequence Identity: 21% (64 aa)

SNNFQILSFGSFG-----MVLATKKA-----------------KLDNKEIVLKIQKIEDEQLIQNEISIMQ----------------KLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.|  . . | .||.||.                .|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKLGPDRYSVFELEKCSC-SLDEYLE--RQN-------KDGQLNEDNKFQMAIQIID---------------SVNYIHQFN-IIHRDIKPENFL
..   .|..       . .| |.  .| .|..  ...       . ....|    ..  ||..                ..|.|. | |||||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLDGKQAEIKLCDFGLSAQIPDNKD--------SIQTIEH----------------------IGNLGYSAPEILNKQDNE----LKSYTKKSDSYSVGL
.        ||..||||| .. |. .         . .  .                      .|..|| ||||||.....     | |..|.| .|.| 
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 21704.AA Pkinase 409-611 27 3e-24 86.84 Pfam 1-203 (293) Show / Hide 
Range on Protein: 409-611
Range on HMM: 1-203/293
Sequence Identity: 27% (62 aa)

SNNFQILSFGSFGMVLATKKAKLDNKE--IVLKIQKIEDEQLIQN-------EISIMQKLKEPLVVQLYDSYIIENKLGPDRYSVFELEKCSC-----SL
    ...  |||| |   .|..  . .   ..|| | ..|   ..       ||.||..|. | .|.|||..        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLERQNKDGQL--NEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEI----KLCDFGLSAQI-PDNKDSIQTIEHIGNLGYSAPEIL
 .|...  ..| .   |.    .. ||.  ..|.|. .|||||.||||.|  .| .. .|    |.|||||..|.   |.   .|.   | ..| |||..
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTF--CGTPWYMAPEVI

NKQDNELKSYTKKSDSYSVGLLLA
.    . . |..|.| .|.|..|.
R----GGQYYGPKVDMWSCGCILY
Kinase 21704.AA CMGC 412-560 17 2e-23 73.05 In-house 1-251 (513) Show / Hide 
Range on Protein: 412-560
Range on HMM: 1-251/513
Sequence Identity: 17% (44 aa)

FQILS---FGSFGMVLATKKAKLD-------------NKEIVLKIQKIEDEQLIQ---------------NEISIMQKLK-----------------EPL
..|..    |..|.|   .  . .             |... .|. | .    .|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIENKLGP-----------DRYSVFELEKCSCSLDEYLERQN--KDG----QLNEDN------------KFQMA------IQIIDSVN--YI
.|.|||..  .|  |.           ...  .  | . ..| .|.....  . |     |.|              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQFN--IIHRDIKPENFLVYLDGKQ-----------------AEIKLCDFGLS
|. .  |||||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 21704.AA TKL 493-610 24 1.5e-22 78.05 In-house 124-279 (364) Show / Hide 
Range on Protein: 493-610
Range on HMM: 124-279/364
Sequence Identity: 24% (40 aa)

S-LDEYLERQNKDGQLNEDNKFQMAIQIIDSVNYIHQFN--------IIHRDIKPENFLVYLDGK-----------QAEIKLCDFGLSAQIP---DNKDS
| |. ..           . ....|..|   .|| |. |        |||||.|..| ||  ...           .  .|.||||||  .    ...|.
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

I--------------QTIEHIGNLGYSAPEILNKQDN-----------ELKSYTKKSDSYSVGLLL
               .|.  .|.... |||.|..|.|           . ..|..|.| || |..|
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 21704.AA Ciliate-A1 518-681 26 1.4e-15 49.47 In-house 109-301 (301) Show / Hide 
Range on Protein: 518-681
Range on HMM: 109-301/301
Sequence Identity: 26% (52 aa)

QIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNK----------------DSIQTIEHIGNLGYSAPEI--LNKQDNELKS--Y
|||  .  ||  ||.|||.||.| |.  | |   .|.||.|.| | . |.                   .|..  ||| | .||   .   |  ..    
QIIEGYADIHDHNILHRDLKPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKI

TKKSDSYSVGLLLALLDN---YQDLKTNTTSIFALMTQQ-Q----------LDKP-FEKSNIQINKNSEIYKFINLLVVSDSAQRASLYDIVQKRDKIF
 |.|| ||.|. .  | .            .|| .  |  |          . |  |.   .| ..  |.   |. .   .  .| || ....  ..||
YKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPP--MQEPRFEELQNLIFKMMQYEPNNRCSLQQCIDC-LYIF
Kinase 21704.AA TyrKc 409-677 20 1.7e-10 -52.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 409-677
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

SNNFQILSFGSFGMVLATKKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKL--KEPLVVQLYDSYIIENKLG-----PDRYSVFELEKCSCSLDEYLERQ
    ..|  | || |    |....  .   |  | . .. . .|..|| ||  . | .|.||   ..  . .     .  . |.|. .   .|..|| . 
ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

NKDGQLNEDNKFQMAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDN------KDSIQT---IEHI--GNLGYSAPEILNKQ
 ..  |. . . ....|| .  .|.|. |.||||.   | ||  ..    .| .|||||  | |       || . .           .   ||| .   
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

DNELKSYTKKSDSYSVGLLL----ALLDNYQDL-----KTNTTSIFALMTQQQLDKPFE----KSNIQINKNSEIYKFINLLVVSDSAQRASLYDIVQKR
    . .| ||| .| | ..     . .          ..|.  |  ...   ...| .     .       .|.|. .      | ..| .  .|... 
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
LRR_RI 21704.AA LRR_RI 723-750 32 6e-06 27.07 SMART 1-28 (28) Show / Hide 
Range on Protein: 723-750
Range on HMM: 1-28/28
Sequence Identity: 32% (9 aa)

NYNIVTIDLGENRIGDEGAKDLATGIAQ
| .. ...|. | .||||.. |. |...
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 21704.AA LRR_RI 753-780 28 0.003044 16.3 SMART 1-28 (28) Show / Hide 
Range on Protein: 753-780
Range on HMM: 1-28/28
Sequence Identity: 28% (8 aa)

NITSLTLDLRYNSIGAQGAKDLATGIAQ
| . ..|.|..| .|. |.. |. |...
NCSLRELWLSNNKLGDEGCRQLCEGLKH