Gene 29103 (Tetrahymena)

29103

Species: Tetrahymena
Alias: PreTt29103, 29103, 394.m00007, 84, TTHERM_01445920
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
29103.AA Protein None 700 None Fasta, JSON
29103.kin_dom Protein Kinase Domain None 214 None Fasta, JSON
29103.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
29103.NA RNA None 2103 None Fasta, JSON

Protein domain

Protein domains of 29103.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29103.AA C8 42-252 59 5e-114 385.11 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-252
Range on HMM: 1-226/226
Sequence Identity: 59% (135 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESTNKEDKDGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEKD----DGNDIIVQTENKSYFVMEME
|.||.|||.|||..||||.|...||...|||....||.|...|||..|||||.|.|.|....||.|||||.|.|.     ..|..|||||.||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCENNLKQLFDFLRKFQVPHQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYGFSVKLCDIGFASAVSKSKS-FMSKK----GTDAYFAP
|||.|||||.|..|. |.. .|..|||||||||.|.|..|.||||||||||.|| ||....|||..||||.||||.|||.|| ..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEAG------QSRIQSDLFSLGLVL
|.|..      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 29103.AA Ciliate-C8 51-252 53 8.9e-112 377.64 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-252
Range on HMM: 1-238/238
Sequence Identity: 53% (128 aa)

GAYALVLKAQNSQQNRQVALKFLESTNKEDKDGIESMKKEYEMLQKFSQSECLVNVYDCFYLM----EEKDDGNDIIVQTENK---SYFVMEMELCENN-
||...||||||..|||.|||||.|..||..|...|...|||||...|.|....|.||||||||    .|.|||||.||||..|   |.||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRKFQVPHQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYGFSVKLCD------IGFASAVSKSKS-FMSKK--GTDAY---
 |||.||..|| |.. ....|||||||||...|.||..|||||||||.|| || ...|....||||       ||||...|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEAGQSRIQSDLFS-------LGLVL
        ||||||..|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 29103.AA C2 51-265 36 1e-57 195.75 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-265
Range on HMM: 1-245/245
Sequence Identity: 36% (91 aa)

GAYALVLKAQNSQQNRQVALKFLESTNKEDKDGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDG-----NDIIVQTEN--------KSYFVMEME
|| .||||| | .|||.||||  |  .  |  | ..  |||....... .  ...||..||| ..|..      ...... ||        |. .|.|.|
GAFGLVLKAFNKKQNRHVALKIQE-CQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCENNLKQLFDFLRKFQVPHQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYGFSVKLCD----------IGFASAVSKSKS--FMSK-K
 |. |||| |. .|| .    . .|.|.||||. . | || ..| ||||||.|| .  ...    .||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEAGQSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||. .  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 29103.AA Pkinase 42-255 22 5.2e-25 89.5 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-255
Range on HMM: 1-205/293
Sequence Identity: 22% (51 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESTNKEDKDGIESMK-KEYEMLQKFSQSECLVNVYDCFYLMEEKDDGNDIIVQTENKSYFVMEMELCE
..  . . ||... | |...   ...||.| ..  .....  ..  .  | ...... .... |  ||.|.                 |..  | ||.||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----------------KDHIYMVMEYCE

NNLKQLFDFL------RKFQV--PHQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYGFSVKLCDIGFASA--VSKSKSFMSKKGTDAYF
. |. ..|        |.  .  .  . .| ..  |...||. .| ..|.|||.||.|...    . . .||.|| |.|      ..  ...  ||  | 
GGLY-VMDLFDYISTWRHGCFYFSE-WECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM

APEV--EAGQSRIQSDLFSLGLVLLEL
||||  ..      .| .|.|..| |.
APEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 29103.AA CAMK 47-234 15 1.1e-24 75.9 In-house 1-291 (425) Show / Hide 
Range on Protein: 47-234
Range on HMM: 1-291/425
Sequence Identity: 15% (45 aa)

YLSSGAYALVLKAQNSQQN------------RQVALKFLES----------------TNKEDKDG---------IESMKKEYEMLQKFS------QSECL
 | .|... | .... . .            ..|| |...                  .|. ...          .....|.|...| .      . ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYLME---------EKDDGNDIIVQTENKSYFVM-EMELCENN--LKQLFDFLRKF-----------QVPHQKKIKEIIAI----QMIEGLNNL
.. |. .  ..           ...  ..  .... |.||  ||.|..   .  |||....             |   ....|  |     |...... .
IKLYEVYEDPHYFKNTNDYET-SKQ--VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYC

HVKNIMHRDIKPQNFFVCASKEYG-------------FSVKLCDIGFASAVSKSK------------------------SFMSKKGTDAYFA-PEV
| .||.|||.|| |  .. ...               . .|..| |||  . ...                         .    || .| | |||
HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase 29103.AA CMGC 42-216 16 7e-24 74.55 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-216
Range on HMM: 1-256/513
Sequence Identity: 16% (42 aa)

FKNFEYLSSGAYALVLKAQN--------------SQQNRQVALKFLEST-NKED------KDGIE-SMKKEYEMLQKFS---------------QSEC-L
... ... .|.|. | |...               . |..||.| . .  ..|.      |||.  .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYDCFYLMEEKDDGND----IIVQTENKSYFVMEMELCENNLKQLFDFLR------KFQVPHQKK------------IKEII-----AIQMIEGLN--
|. ||.||  ... ....    |  .  .  .. . .|.....|.|. .  .      . .   . .            || ..     . |...||.  
VKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

NLHVKN--IMHRDIKPQNFFVCASKEY----------------GFSVKLCDIGFASAVSK
 .| ..  |.|||.||.|  ..  .|.                 . .|.|| |.| ....
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 29103.AA STE 42-255 18 2.7e-23 79.16 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-255
Range on HMM: 1-261/359
Sequence Identity: 18% (52 aa)

FKNFEYLSSGAYALVLKAQNS------QQNRQ---------VALKFLESTNKE--------------DKDGIESMKKEYEMLQKFSQ-SECLVNVYDCFY
... | . .||.  | || |       . ...         .| | ..  |..              ... ... .|| ....|... ..  |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEKDDGNDIIVQTENKSYFVMEMELCE-NNLKQLFDFLRKFQVPHQ------KKIKEIIA----IQMIEG-LNNLHVKNIMHRDIKPQNFFVCASKEY
   ..         ..|...  . ||...   | .. .   . . |..      ....| .      | ..| |. || ..|.||||||.| ..      
KEGHN---------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------

GFSVKLCDIGFASAVSK-----------------SKSFMSKKGTDAYFAPEVEAG-QSR------IQSDLFSLGLVLLEL
   ||||| |... ...                 ..   .  ||  . ||||  . ..       ...|  |||....|.
---VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 29103.AA Ciliate-E1 48-246 21 7.2e-22 68.23 In-house 1-202 (202) Show / Hide 
Range on Protein: 48-246
Range on HMM: 1-202/202
Sequence Identity: 21% (46 aa)

LSSGAYALVLKA-QNSQQNRQVALKFLESTNKEDKDGIESMKKEYE-MLQKFSQSECLVNVYDCFYLMEEKDDGNDIIVQTENKSYFVMEME-LCENNLK
...| ...|.|| |......|||.|. .   ..... ... .|||  ... | . .......|....   ..  . ||.... .  .  ... .  | | 
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI---DQNYICIIIFECCCCSLKDYLQNH--NRL-

QLFDFLRKFQVPHQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYGFSVKLCDIGFAS-AVSKSKSFMSKKGTDAYFAPEVEAG------
.... ... |  .. . |. |..|.|.||. || .||.||||||||  .. ...| ..    |.| ..   ..... . .||   |..|. .        
EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEH

----QSRIQSDLF
    .  ..||..
NKNQKINYKSDIY
Kinase 29103.AA Ciliate-E2 125-255 22 1.7e-21 70.51 In-house 102-289 (365) Show / Hide 
Range on Protein: 125-255
Range on HMM: 102-289/365
Sequence Identity: 22% (44 aa)

QTENKSYFVMEMELCENNLKQLFDFLRKFQVPHQKK--------IKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFFVCASKE
|....... . ||.|.   . |||......  ....        .|||  |  | ..               .|. || || |.||||||.| ..     
QEKDDNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

YGFSVKLCDIGFASAVSKS----------KSFMSKK-----------------------GTDAYFAPEVEAGQSR----------IQSDLFSLGLVLLEL
    .|..| |..  ....          | .|  |                       ||  | |||.  |..            ..|..||| .| |.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 29103.AA Ciliate-E3 121-256 31 9e-20 58.58 In-house 69-202 (202) Show / Hide 
Range on Protein: 121-256
Range on HMM: 69-202/202
Sequence Identity: 31% (45 aa)

DIIVQTENKSYFVMEMELCENNLKQLFDFLRKFQVPHQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYG-FSVKLCDIGFASAVSKSK-
|.... .||..|.  .|.|.|   .|  ...  |.  |  |.. |.||.|.|.  .| ||| | ||||.|. |  .|...   .| || | .   .| | 
DQYYDQQNKMIFIV-QEYCSN--GDLYHYIK-QQNKTQNIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKG

-SFMSKKGTDAYFA-PEVEA-GQSRIQSDLFSLGLVLLELD
 .     |.  ..| ||.   .|    ||. |.| |...| 
HTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 29103.AA TKL 165-255 21 3.8e-19 65.59 In-house 137-282 (364) Show / Hide 
Range on Protein: 165-255
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFFVCASKE----------YGFSVKLCDIGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| .|    .          .   .|.|| |..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EAGQSRIQSDLFSLGLVLLEL
 .. ||||                 . ..   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 29103.AA S_TKc 42-319 20 2.7e-16 61.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-319
Range on HMM: 1-231/231
Sequence Identity: 20% (59 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESTNKEDKDGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDGNDIIVQTENKSYFVMEMELCEN
..  . . .||.. | |...   .|.||.| .           |....| ..|.|  . . .|. ||.|.                  ... | ||.|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-----------------DHLYMVMEYCDG

NLKQLFDFLRKFQVP-----HQKKIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFFVCASKEYGFSVKLCDIGFASAVSKSKSFMSKKGTDAYFAPEVEA
.|  |||...| . .             .. |....|. .| ..|.|||.||.| ...        .|.|| |.|  .      ..  ||  | ||||  
DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-

GQSRIQSDLFSLGLVLLELDNLKTLNENWIDTKTKNYLFNGEEIPNEKYQIDKNSNIYKIAKICLKPWYLDRTTTGELLS--------QLI
| ..  .|  |.| .| |.   ... .   . .. . .                .    . . ||.    .| |  |.|         . .
GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29103.AA Ciliate-E2 42-116 14 1e-06 18.72 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (16 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESTN--------KED----------KDGIESMKKEYEMLQ---------------KFSQSECLVNVYD
.|  . . .|... | |... ....|.|.|. . ..        | .          |..||..|.|  ...               .. ..  ... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEK
||. . ..
CFQEKDDN
Kinase 29103.AA Ciliate-E3 42-116 23 0.000837 8.08 In-house 1-77 (202) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-77/202
Sequence Identity: 23% (18 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESTNKED---KDGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEK
.     |  | . .| || ..|.|..|| | .  .|. .         . .|  . |..  |. .| ..| .|  . |
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNK
Kinase 29103.AA TKL 48-107 13 0.022257 4.39 In-house 1-91 (364) Show / Hide 
Range on Protein: 48-107
Range on HMM: 1-91/364
Sequence Identity: 13% (12 aa)

LSSGAYALVLKAQNSQQN--------RQVALKFLESTNKEDKDGIES----------------------MKKEYEMLQKFSQ-SECLVNVY
. ||... | |..  ...        . || | . |.|   .. ..                        ..|.|.... .   . .|  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase 29103.AA Ciliate-E1 257-294 16 0.238701 0.73 In-house 160-202 (202) Show / Hide 
Range on Protein: 257-294
Range on HMM: 160-202/202
Sequence Identity: 16% (7 aa)

NLKTLNENWIDTKTKNYLFNGEEI-----PNEKYQIDKNSNIY
.......  ..  |..|  . .       .|....|...|.||
KNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 29103.AA C8 384-585 48 2.2e-100 339.81 In-house 1-226 (226) Show / Hide 
Range on Protein: 384-585
Range on HMM: 1-226/226
Sequence Identity: 48% (109 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..||||..|..| |..|||||.||....|.|||..|||.....|.|.|.||.|..|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLDRQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQP-EIKLCNFGLSAQIPDNKDSIQAIES--IGNLGYSA
          |..|.||..||....| .||||.||.|||||..||.||||||.||||.||.... ||||| ||...|...||..|| ...  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKQDNELKIYSKKSDSYSVGLLL
|||..||||..|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 29103.AA Ciliate-C8 393-585 41 2.1e-98 333.23 In-house 1-238 (238) Show / Hide 
Range on Protein: 393-585
Range on HMM: 1-238/238
Sequence Identity: 41% (98 aa)

GSFGMVLAT------KKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|. |.....|||....|.|||.||........ ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLDR-QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQPEIKLCN------FGLSAQIPDNKD---------SIQAIES
.|..|.|| ..|........| .||||.||||||.| |||.||||||.||||..| ..||.||||.      ||...|.|.||.         ..| ||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL
  .||.||.|||...| ......|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 29103.AA C2 393-598 28 1.2e-44 150.42 In-house 1-245 (245) Show / Hide 
Range on Protein: 393-598
Range on HMM: 1-245/245
Sequence Identity: 28% (72 aa)

GSFGMVLATKKAKLDKKEIVLKIQKIED-----EQHIQNEISIMQKLK-EPLVVQLYDSYIIENKIGPD-------------R----------YSVFELE
|.||.|| .   | ......||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLDRQNKDG-QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQ-PEIKLCN----------FGLSAQIPDNKDSIQAIESI
.|.. |  |..|. |.  ..... | ..|||..||.||.| |.|.||||||.|||. .| .. | ||||.          |  .  .. ||  |   .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKQDNELKIYSKKSDSYS-VGLLLAFLDNYQDLKKNA
.   |    .|||.      . .|| |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 29103.AA CAMK 389-585 19 1.2e-32 101.94 In-house 1-324 (425) Show / Hide 
Range on Protein: 389-585
Range on HMM: 1-324/425
Sequence Identity: 19% (64 aa)

ILSFGSFGMVLATKKAKLDK-----------KEIVLKI---QKIE----------------------------DEQHIQNEISIMQK-------LKEPLV
.|  |||| |   .  .  .           ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYI------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQFNDDDKYQIAIQIIDSVNYIHSF
..||. |               .|  .   |.. .. .   | ||       | .|. .. .            .| |. ..  ..  ||.. |.|.|| 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIIHRDIKPENFLVYLDGKQPE--------------IKLCNFGLSAQIPDNKDSI---------------------QAIESIGNLGYSA-PEILNKQ---
||.|||.|||| |.  ...  .              ||.. ||...........                         .. | ..| | ||.||..   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DNELKIYSKKSDSYSVGLLL
      |.| . |..|.|  |.| .|
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 29103.AA S_TKc 384-657 24 1e-30 109.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 384-657
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG
    ...  |.|| |   .. | ....  .|| |    .||..||.|..| . | .|.|||..          .  . .| |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---FNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNFGLSAQIPDNKDSIQAIESIGNLGYSAPEILNKQDNELKIYSK-KS
    |.  .   .. ||.. ..|.|| .|||||.|||| |.       .||.| |||..|.            .| . | |||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVGLLLAFLDNYQDLKKNAPFTFLLMTKKQFDKPFEKSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVE-QSD---TKFL
| .|.| .|. .     |    ||      .. |.|            .|   ||. . . |  .| .  .. . ..|     ..
DWWSCGCILYEM-----LCGYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29103.AA Ciliate-E1 390-579 26 2.4e-27 86.24 In-house 1-202 (202) Show / Hide 
Range on Protein: 390-579
Range on HMM: 1-202/202
Sequence Identity: 26% (56 aa)

LSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQH-------IQNEISIMQKLKEPL-VVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLD-------
.. |||..|.  |. .  .... .||..... .        |.....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNFGLSA-QIPDNKDSIQAIESIGNLGYSAPEILNK---QDN
    |....||... | ||..|.|| ....|..|||||||||.| |.. . ..   ..| ||.|  ..  .....|  ..     |. || .|    . |
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQ--YKGYTHYYYPPEQYNCPEQEHN

ELKIYSKKSDSY
. .....||| |
KNQKINYKSDIY
Kinase 29103.AA Ciliate-E2 384-585 22 7.4e-25 82.24 In-house 1-286 (365) Show / Hide 
Range on Protein: 384-585
Range on HMM: 1-286/365
Sequence Identity: 22% (68 aa)

TNNFQILSFGSFG-----MVLATKKA-----------------KLDKKEIVLKIQK------IEDEQHIQNEIS----------IMQKLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.|      |. |.|| .||           |...|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKIGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQFNDDDKYQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFL
..   .|.|       . .| |.  .| .|.   ...       . ..|..    .|  ||..                ..|.|| | |||||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLDGKQPEIKLCNFGLSAQIPDNKD-------SIQAIESI-----------------------GNLGYSAPEILNKQDNE----LKIYSKKSDSYSVGL
.        ||.. |||| .. |. .       .   ..                         |..|| ||||||.....     | |..|.| .|.| 
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 29103.AA CMGC 387-535 15 1.4e-22 70.16 In-house 1-251 (513) Show / Hide 
Range on Protein: 387-535
Range on HMM: 1-251/513
Sequence Identity: 15% (40 aa)

FQILS---FGSFGMVLATKKAKLD-------------KKEIVLKIQKIEDEQHIQ---------------NEISIMQKLK-----------------EPL
..|..    |..|.|   .  . .             .... .|. | .   ..|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QFNDDD------------KYQIA------IQIIDSVN--YI
.|.|||..  .|  . ..         ...  .  | . ..| .|.....  . |     ...              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCNFGLS
|| .  |||||.|||| |.  ...                   ..|.| |||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 29103.AA Pkinase 384-586 26 3.3e-21 76.07 Pfam 1-203 (293) Show / Hide 
Range on Protein: 384-586
Range on HMM: 1-203/293
Sequence Identity: 26% (60 aa)

TNNFQILSFGSFGMVLATKKAKLDKKE--IVLKIQKIEDEQHIQN-------EISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC-----SL
    ...  |||| |   .|..  . .   ..|| | ..| . ..       ||.||..|. | .|.|||..        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLDRQNKDGQF--NDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEI----KLCNFGLSAQIPDNKDSIQAIESIGNLGYSAPEILN
 .|. .  ..| |   ...   .. ||.  ..|.|| .|||||.||||.|  .| ....|    |.| |||..|.  .  .  .    | ..| |||...
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR

KQDNELKIYSKKSDSYSVGLLLA
    . . |..|.| .|.|..|.
----GGQYYGPKVDMWSCGCILY
Kinase 29103.AA TKL 487-585 26 5.1e-21 72.44 In-house 134-279 (364) Show / Hide 
Range on Protein: 487-585
Range on HMM: 134-279/364
Sequence Identity: 26% (38 aa)

KYQIAIQIIDSVNYIHSFN--------IIHRDIKPENFLVYLDGKQPE-----------IKLCNFGLSAQIP---DNKDSI--------------QAIES
. ..|..|   .|| || |        |||||.|..| ||  ...              .|.| ||||  .    ...|.               . .  
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

IGNLGYSAPEILNKQDN-----------ELKIYSKKSDSYSVGLLL
.|.... |||.|..|.|           . . ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 29103.AA STE 490-585 30 9.8e-21 70.02 In-house 156-258 (359) Show / Hide 
Range on Protein: 490-585
Range on HMM: 156-258/359
Sequence Identity: 30% (34 aa)

IAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNFGLSAQIPDNKDSI--------------QAIESIGNLGYSAPEILNKQDNE-LKIYS
|. ||.    .|.|| .|||||||| | |.        .|||.||...|. |. ..|              .    .|   . |||.......   | |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLL
 |.| .|.|...
TKCDIWSLGCTI
Kinase 29103.AA Ciliate-E3 488-589 42 5.9e-15 43.34 In-house 106-202 (202) Show / Hide 
Range on Protein: 488-589
Range on HMM: 106-202/202
Sequence Identity: 42% (43 aa)

YQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNFGLSAQIPDNKDSIQAIESIGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLLAF
|.|.|||| ..  ||. |||| ||||.|.||     |  || | ||.| |   ||  ...        |.|||.. .|       || || ||||  .  
YDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQ-----ISKESDYYSVGAVFCQ

LD
| 
LC
Kinase 29103.AA TyrKc 384-652 20 7.5e-10 -63.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 384-652
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKL--KEPLVVQLYDSYIIENKIG-----PDRYSVFELEKCSCSLDEYL-DR
    ..|  | || |    |....  .   |  | . .. . .|..|| ||  . | .|.||   ..  . .     .  . |.|. .   .|..|| ..
ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNFGLSAQIPDN------KDSIQA---IESI--GNLGYSAPEILNK
..|   .. .|. ....|| .  .|.|| |.||||.   | ||  ..    .| . ||||  | |       || . .     .     .   ||| .  
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

QDNELKIYSKKSDSYSVGLLL----AFLDNYQDL-----KKNAPFTFLLMTKKQFDKPFE----KSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVEQ
     .... ||| .| | ..     . .          ..|.    .... .  ..| .     .       .|.|. .      |  .| .  .|.|.
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

S
 
F
Kinase 29103.AA STE 384-452 16 2.3e-05 15.04 In-house 1-112 (359) Show / Hide 
Range on Protein: 384-452
Range on HMM: 1-112/359
Sequence Identity: 16% (18 aa)

TNNFQILSFGSFG-MVLATKKAKL-------------DKKEIVLKIQKI--------------------EDEQHIQNEISIMQKLK--EPLVVQLYDSYI
  . ...  |.||  ..| .. .               .. .  |. ..                    |..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE-------NKI
 |       ...
KEGHNHKNDDEL