Gene 14782 (Tetrahymena)

14782

Species: Tetrahymena
Alias: 242.m00029, 788, PreTt14782, TTHERM_01119420, 14782
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
14782.AA Protein None 2290 None Fasta, JSON
14782.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
14782.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
14782.NA RNA None 6873 None Fasta, JSON

Protein domain

Protein domains of 14782.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14782.AA C8 42-256 61 4.5e-121 408.52 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 61% (140 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLGSSNKEDKAGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEYDDEDDDGNKIIVQTENKSYFVMEME
|.||.|||.|||..||||.|...||...|||. ..||.|. .|||..|||||.|.|.|....||.|||||.|.|  .|....|..|||||.||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAP
|||.|||||.|..|..|....||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEAG------QSRIQSDLFSLGLVL
|.|..      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 14782.AA Ciliate-C8 51-256 55 1.6e-119 403.42 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 55% (133 aa)

GAYALVLKAQNSQQNRQVALKFLGSSNKEDKAGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEYDDEDDDGNKIIVQTENK---SYFVMEMELCENN-
||...||||||..|||.|||||. ..||..|...|...|||||...|.|....|.|||||||||| ..||||||..||||..|   |.||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDAY---
 |||.||..||.|..| ..||||||||||...|.||..|||||||||.||||| ...|...|||||      .||||...|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEAGQSRIQSDLFS-------LGLVL
        ||||||..|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 14782.AA C2 51-269 39 5e-65 221.06 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 39% (98 aa)

GAYALVLKAQNSQQNRQVALKFLGSSNKEDKAGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEE-YDDEDDDGNKIIVQTEN--------KSYFVMEME
|| .||||| | .|||.||||     .  | .| ..  |||....... .  ...||..||| ..  .||| | . .... ||        |. .|.|.|
GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD----------LGFASAVSKSKS--FMSK-K
 |. |||| |. .|||.  | ..||.|.||||. . | || ..| ||||||.|||.  ...    |||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEAGQSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||. .  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 14782.AA CMGC 42-220 16 3.9e-28 88.79 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 16% (43 aa)

FKNFEYLSSGAYALVLKAQN--------------SQQNRQVALKFLGSSNKEDKAGIESMK-------------KEYEMLQKFS---------------Q
... ... .|.|. | |...               . |..||.| .    |...   | .|              | ..|....               .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKI----KNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNK

SEC-LVNVYDCFYLMEEYDDEDDDGNKIIVQTENKSYFVMEMELCENNLKQLFDFLR------KQQVPPPKE------------MKEII-----AIQMIE
 .  .|. ||.||  ..  .|..| ..|  .  .  .. . .|.....|.|. .  .      ...  .. .             | ..     . |...
HHNNIVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILR

GLN--NLHVKN--IMHRDIKPQNFLVCASKEY----------------GFSIKLCDLGFASAVSK
||.   .| ..  |.|||.||.| |..  .|.                 . .|.|| |.| ....
GLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 14782.AA Pkinase 42-259 22 4.5e-28 100.33 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 22% (52 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLGSSNKEDKAGIESMK-KEYEMLQKFSQSECLVNVYDCFYLMEEYDDEDDDGNKIIVQTENKSYFVMEM
..  . . ||... | |...   ...||.| .  ......  ..  .  | ...... .... |  ||.|.                     |..  | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCENN--LKQLFDFLR--KQQVP--PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDA
|.||.   .  |||...  .. .   ...| | ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  ...  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EAGQSRIQSDLFSLGLVLLEL
| ||||  ..      .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 14782.AA CAMK 47-238 15 6.9e-25 76.52 In-house 1-291 (425) Show / Hide 
Range on Protein: 47-238
Range on HMM: 1-291/425
Sequence Identity: 15% (45 aa)

YLSSGAYALVLKAQNSQQN------------RQVALKF-------------------LGSSNKED------KAGIESMKKEYEMLQKFS------QSECL
 | .|... | .... . .            ..|| |.                   .  |.. .          .....|.|...| .      . ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYLME---------EYDDEDDDGNKIIVQTENKSYFVM-EMELCENN--LKQLFDFLRKQ---------------QVPPPKEMKEIIAIQMIEG
.. |. .  ..           ..       ..  .... |.||  ||.|..   .  |||.....                  . .| . ..  |....
IKLYEVYEDPHYFKNTNDYET-SKQ------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QICSA

LNNLHVKNIMHRDIKPQNFLVCASKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYFA-PEV
.. .| .||.|||.|| | |.. ...               . ||..| |||  . ...                         .    || .| | |||
VHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase 14782.AA Ciliate-E1 48-250 20 6e-24 75.07 In-house 1-202 (202) Show / Hide 
Range on Protein: 48-250
Range on HMM: 1-202/202
Sequence Identity: 20% (47 aa)

LSSGAYALVLKA-QNSQQNRQVALKFLGSSNKEDKAGIESMKKEYE-MLQKFSQSECLVNVYDCFY---------LMEEYDDEDDDGNKIIVQTENKSYF
...| ...|.|| |......|||.|.     ....  ... .|||  ... | . .......|...         ..|...... | ..           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

VMEMELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFAS-AVSKSKSFMSKKGTDAYFA
        | | .... ....|     . |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   ..... . .||   |..
--------NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYY

PEVEAG----------QSRIQSDLF
|. .            .  ..||..
PPEQYNCPEQEHNKNQKINYKSDIY
Kinase 14782.AA Ciliate-E2 129-259 23 1.2e-23 78.07 In-house 102-289 (365) Show / Hide 
Range on Protein: 129-259
Range on HMM: 102-289/365
Sequence Identity: 23% (47 aa)

QTENKSYFVMEMELCENNLKQLFDFLRKQQVPPPKE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCASKE
|....... . ||.|.   . |||......   ..|        .|||  |  | ..               .|. || || |.||||||.| |.     
QEKDDNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

YGFSIKLCDLGFASAVSKS----------KSFMSKK-----------------------GTDAYFAPEVEAGQSR----------IQSDLFSLGLVLLEL
    ||..|.|..  ....          | .|  |                       ||  | |||.  |..            ..|..||| .| |.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 14782.AA STE 42-259 18 1.8e-22 76.23 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 18% (52 aa)

FKNFEYLSSGAYALVLKAQNS------QQNRQ---------VALKFLGSSNKE--------------DKAGIESMKKEYEMLQKFSQ-SECLVNVYDCFY
... | . .||.  | || |       . ...         .| | .  .|..              ..  ... .|| ....|... ..  |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEYDDEDDDGNKIIVQTENKSYFVMEMELCE-NNLKQLFDFLRKQQVPPP------KEMKEIIA----IQMIEG-LNNLHVKNIMHRDIKPQNFLVCA
   .              ..|...  . ||...   | .. .   . . | .      . ..| .      | ..| |. || ..|.||||||.| |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SKEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEVEAG-QSR------IQSDLFSLGLVLLEL
       .|||| |... ...                 ..   .  ||  . ||||  . ..       ...|  |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 14782.AA Ciliate-E3 125-260 31 1.3e-21 64.44 In-house 69-202 (202) Show / Hide 
Range on Protein: 125-260
Range on HMM: 69-202/202
Sequence Identity: 31% (45 aa)

KIIVQTENKSYFVMEMELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYG-FSIKLCDLGFASAVSKSK-
..... .||..|.  .|.|.|   .|  ... ||.    .... |.||.|.|.  .| ||| | ||||.|.||  .|...   || ||.| .   .| | 
DQYYDQQNKMIFIV-QEYCSN--GDLYHYIK-QQNKTQNIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKG

-SFMSKKGTDAYFA-PEVEA-GQSRIQSDLFSLGLVLLELD
 .     |.  ..| ||.   .|    ||. |.| |...| 
HTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 14782.AA TKL 169-259 21 3.2e-20 69.5 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (32 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCASKE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EAGQSRIQSDLFSLGLVLLEL
 .. ||||                 . ..   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 14782.AA S_TKc 42-323 20 2e-19 71.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLGSSNKEDKAGIESMKKEYEMLQKFSQSECLVNVYDCFYLMEEYDDEDDDGNKIIVQTENKSYFVMEME
..  . . .||.. | |...   .|.||.| .           |....| ..|.|  . . .|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCENNLKQLFDFLRKQQVP------PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFA
.|...|  |||...|.. .      |. . . ... |....|. .| ..|.|||.||.| |..        ||.|| |.|  .      ..  ||  | |
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA

PEVEAGQSRIQSDLFSLGLVLLELDNLKTLNENWIDTKTKNYLFNGEEIPKEKYQIDQNSNIYKIAKICLKPWYLDRTTTGELLS--------QLI
|||  | ..  .|  |.| .| |.   ... .   . .. . .                .    . . ||.    .| |  |.|         . .
PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14782.AA Ciliate-E2 42-111 14 2.8e-05 14.04 In-house 1-102 (365) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-102/365
Sequence Identity: 14% (15 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALK-----------------FLGSSNKEDKAGIESMKKEYEMLQ---------------KFSQSECLVNVYDC
.|  . . .|... | |... ....|.|.|                 ..   .   | .||..|.|  ...               .. ..  ... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY
|.
FQ
Kinase 14782.AA Ciliate-E3 42-111 23 0.001153 7.64 In-house 1-72 (202) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-72/202
Sequence Identity: 23% (17 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLGSSNKED---KAGIESMKKEYEMLQKFSQSECLVNVYDCFY
.     |  | . .| || ..|.|..|| | .  .|. .         . .|  . |..  |. .| ..| .|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYY
Kinase 14782.AA TKL 48-107 13 0.288135 0.33 In-house 1-91 (364) Show / Hide 
Range on Protein: 48-107
Range on HMM: 1-91/364
Sequence Identity: 13% (12 aa)

LSSGAYALVLKAQNSQQN--------RQVALKFLGSSNKEDKAGIES----------------------MKKEYEMLQKFSQ-SECLVNVY
. ||... | |..  ...        . || | . | |   .  ..                        ..|.|.... .   . .|  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase 14782.AA C8 388-589 48 3.3e-102 345.86 In-house 1-226 (226) Show / Hide 
Range on Protein: 388-589
Range on HMM: 1-226/226
Sequence Identity: 48% (111 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYVIENKIGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..||||..|..| |..|||||.||....|.|||..|||.....|.|.|.||.||.|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLDRQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQP-EIKLCDFGLSAQIPDNKDSIQAIES--IGNLGYSA
          |..|.||..||....| .||||.||.|||||..||.||||||.||||.||.... ||||||||...|...||..|| ...  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKQDNELKIYSKKSDSYSVGLLL
|||..||||..|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 14782.AA Ciliate-C8 397-589 41 3e-99 336.03 In-house 1-238 (238) Show / Hide 
Range on Protein: 397-589
Range on HMM: 1-238/238
Sequence Identity: 41% (99 aa)

GSFGMVLAT------KKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYVIENKIGPDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|. |.....|||....|.|||.||........ ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLDR-QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQPEIKLCD------FGLSAQIPDNKD---------SIQAIES
.|..|.|| ..|........| .||||.||||||.| |||.||||||.||||..| ..||.|||||      ||...|.|.||.         ..| ||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL
  .||.||.|||...| ......|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 14782.AA C2 397-602 28 2.6e-45 152.75 In-house 1-245 (245) Show / Hide 
Range on Protein: 397-602
Range on HMM: 1-245/245
Sequence Identity: 28% (73 aa)

GSFGMVLATKKAKLDKKEIVLKIQKIED-----EQHIQNEISIMQKLK-EPLVVQLYDSYVIENKIGPD-------------R----------YSVFELE
|.||.|| .   | ......||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLDRQNKDG-QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQ-PEIKLCD----------FGLSAQIPDNKDSIQAIESI
.|.. |  |..|. |.  ..... | ..|||..||.||.| |.|.||||||.|||. .| .. | |||||          |  .  .. ||  |   .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKQDNELKIYSKKSDSYS-VGLLLVFLDNYQDLKKNA
.   |    .|||.      . .|| |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 14782.AA CAMK 393-589 19 1.7e-34 108.01 In-house 1-324 (425) Show / Hide 
Range on Protein: 393-589
Range on HMM: 1-324/425
Sequence Identity: 19% (65 aa)

ILSFGSFGMVLATKKAKLDK-----------KEIVLKI---QKIE----------------------------DEQHIQNEISIMQK-------LKEPLV
.|  |||| |   .  .  .           ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYV------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQFNDDDKYQIAIQIIDSVNYIHSF
..||. |               .|  .   |.. .. .   | ||       | .|. .. .            .| |. ..  ..  ||.. |.|.|| 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIIHRDIKPENFLVYLDGKQPE--------------IKLCDFGLSAQIPDNKDSI---------------------QAIESIGNLGYSA-PEILNKQ---
||.|||.|||| |.  ...  .              ||..|||...........                         .. | ..| | ||.||..   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DNELKIYSKKSDSYSVGLLL
      |.| . |..|.|  |.| .|
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 14782.AA S_TKc 388-661 25 1.8e-34 121.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 388-661
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYVIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG
    ...  |.|| |   .. | ....  .|| |    .||..||.|..| . | .|.|||...         .  . .| |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---FNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILNKQDNELKIYSK-KS
    |.  .   .. ||.. ..|.|| .|||||.|||| |.       .||.|||||..|.            .| . | |||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVGLLLVFLDNYQDLKKNAPFTFLLMTKKQLDKPFEKSKIKINKNSEIYKFINLLVVSDSSQRASLYDIVE-QSD---TKFL
| .|.| .|  .     |    ||        |... |.| .      .|   ||. . . | ..| .  .. . ..|     ..
DWWSCGCILYEM-----LCGYPPFP-------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14782.AA Ciliate-E1 394-583 26 9.4e-29 90.87 In-house 1-202 (202) Show / Hide 
Range on Protein: 394-583
Range on HMM: 1-202/202
Sequence Identity: 26% (57 aa)

LSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQH-------IQNEISIMQKLKEPL-VVQLYDSYVIENKIGPDRYSVFELEKCSCSLDEYLD-------
.. |||..|.  |. .  .... .||..... .        |.....||. .|.   ..|..| . |.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSA-QIPDNKDSIQAIESIGNLGYSAPEILNK---QDN
    |....||... | ||..|.|| ....|..|||||||||.| |.. . ..   ..||||.|  ..  .....|  ..     |. || .|    . |
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQ--YKGYTHYYYPPEQYNCPEQEHN

ELKIYSKKSDSY
. .....||| |
KNQKINYKSDIY
Kinase 14782.AA Ciliate-E2 388-589 22 3.5e-26 86.85 In-house 1-286 (365) Show / Hide 
Range on Protein: 388-589
Range on HMM: 1-286/365
Sequence Identity: 22% (69 aa)

TNNFQILSFGSFG-----MVLATKKA-----------------KLDKKEIVLKIQK------IEDEQHIQNEIS----------IMQKLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.|      |. |.|| .||           |...|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YV--IENKIGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQFNDDDKYQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFL
.    .|.|       . .| |.  .| .|.   ...       . ..|..    .|  ||..                ..|.|| | |||||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLDGKQPEIKLCDFGLSAQIPDNKD-------SIQAIESI-----------------------GNLGYSAPEILNKQDNE----LKIYSKKSDSYSVGL
.        ||..||||| .. |. .       .   ..                         |..|| ||||||.....     | |..|.| .|.| 
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 14782.AA CMGC 391-539 16 4.8e-25 78.46 In-house 1-251 (513) Show / Hide 
Range on Protein: 391-539
Range on HMM: 1-251/513
Sequence Identity: 16% (41 aa)

FQILS---FGSFGMVLATKKAKLD-------------KKEIVLKIQKIEDEQHIQ---------------NEISIMQKLK-----------------EPL
..|..    |..|.|   .  . .             .... .|. | .   ..|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYVIEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QFNDDD------------KYQIA------IQIIDSVN--YI
.|.|||... .|  . ..         ...  .  | . ..| .|.....  . |     ...              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCDFGLS
|| .  |||||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 14782.AA Pkinase 388-589 27 1.6e-24 87.76 Pfam 1-202 (293) Show / Hide 
Range on Protein: 388-589
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

TNNFQILSFGSFGMVLATKKAKLDKKE--IVLKIQKIEDEQHIQN-------EISIMQKLKEPLVVQLYDSYVIENKIGPDRYSVFELEKCSC-----SL
    ...  |||| |   .|..  . .   ..|| | ..| . ..       ||.||..|. | .|.|||..        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLDRQNKDGQF--NDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEI----KLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILN
 .|. .  ..| |   ...   .. ||.  ..|.|| .|||||.||||.|  .| ....|    |.|||||..|.  .  .  .    | ..| |||...
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR

KQDNELKIYSKKSDSYSVGLLL
    . . |..|.| .|.|..|
----GGQYYGPKVDMWSCGCIL
Kinase 14782.AA TKL 491-589 26 1.5e-22 78.06 In-house 134-279 (364) Show / Hide 
Range on Protein: 491-589
Range on HMM: 134-279/364
Sequence Identity: 26% (39 aa)

KYQIAIQIIDSVNYIHSFN--------IIHRDIKPENFLVYLDGKQPE-----------IKLCDFGLSAQIP---DNKDSI--------------QAIES
. ..|..|   .|| || |        |||||.|..| ||  ...              .|.||||||  .    ...|.               . .  
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

IGNLGYSAPEILNKQDN-----------ELKIYSKKSDSYSVGLLL
.|.... |||.|..|.|           . . ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 14782.AA STE 494-590 30 6.6e-22 74.23 In-house 156-259 (359) Show / Hide 
Range on Protein: 494-590
Range on HMM: 156-259/359
Sequence Identity: 30% (35 aa)

IAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSI--------------QAIESIGNLGYSAPEILNKQDNE-LKIYS
|. ||.    .|.|| .|||||||| | |.        .||||||...|. |. ..|              .    .|   . |||.......   | |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLLV
 |.| .|.|....
TKCDIWSLGCTII
Kinase 14782.AA Ciliate-E3 492-593 43 1.2e-16 48.72 In-house 106-202 (202) Show / Hide 
Range on Protein: 492-593
Range on HMM: 106-202/202
Sequence Identity: 43% (44 aa)

YQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILNKQDNELKIYSKKSDSYSVGLLLVF
|.|.|||| ..  ||. |||| ||||.|.||     |  || ||||.| |   ||  ...        |.|||.. .|       || || ||||  .  
YDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQ-----ISKESDYYSVGAVFCQ

LD
| 
LC
Kinase 14782.AA TyrKc 388-656 21 1.3e-10 -51.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 388-656
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKL--KEPLVVQLYDSYVIENKIG-----PDRYSVFELEKCSCSLDEYL-DR
    ..|  | || |    |....  .   |  | . .. . .|..|| ||  . | .|.||   |.  . .     .  . |.|. .   .|..|| ..
ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDN------KDSIQA---IESI--GNLGYSAPEILNK
..|   .. .|. ....|| .  .|.|| |.||||.   | ||  ..    .| .|||||  | |       || . .     .     .   ||| .  
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

QDNELKIYSKKSDSYSVGLLL--VF---LDNYQDL----KKNAPFTFLLMTKKQLDKPFE----KSKIKINKNSEIYKFINLLVVSDSSQRASLYDIVEQ
     .... ||| .| | ..  .|      | .     ..|.    .... . ...| .     .       .|.|. .      | ..| .  .|.|.
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

S
 
F
Kinase 14782.AA STE 388-456 16 2.3e-05 15.07 In-house 1-112 (359) Show / Hide 
Range on Protein: 388-456
Range on HMM: 1-112/359
Sequence Identity: 16% (18 aa)

TNNFQILSFGSFG-MVLATKKAKL-------------DKKEIVLKIQKI--------------------EDEQHIQNEISIMQKLK--EPLVVQLYDSYV
  . ...  |.||  ..| .. .               .. .  |. ..                    |..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE-------NKI
 |       ...
KEGHNHKNDDEL