Gene 3357 (Tetrahymena)

3357

Species: Tetrahymena
Alias: 509.m00002, 3357, 52, TTHERM_01615780, PreTt03357
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
3357.AA Protein None 881 None Fasta, JSON
3357.kin_dom Protein Kinase Domain None 199 None Fasta, JSON
3357.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
3357.NA RNA None 2645 None Fasta, JSON

Protein domain

Protein domains of 3357.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3357.AA C8 42-256 61 4.90000000001e-121 408.41 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 61% (140 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME
|.||.|||.|||.. |||.|...||...|||  ..|..|...|||..|||||.|.|.|..|.||.|||||.|.|...|. ..|..|||||.||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCENNLKQLFDFLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAP
|||.|||||.|..|..|...|||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEVG------QSRIQSDLFSLGLVL
|.| .      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 3357.AA Ciliate-C8 51-256 56 1.1e-118 400.55 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 56% (135 aa)

GAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVK---SFFVMEMELCENN-
||... |||||..|||.|||||. ..|...||..|...|||||...|.|..|.|.||||||||||...|| ||||.||||..|   ||||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDAY---
 |||.||..||.|..||..||||||||||...|.||..|||||||||.||||| ...|...|||||      .||||...|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEVGQSRIQSDLFS-------LGLVL
        |||||| .|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 3357.AA C2 51-269 41 2.2e-69 236.15 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 41% (101 aa)

GAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEE-KEDEDADGNDIIVQTEV--------KSFFVMEME
|| .| ||| | .|||.|||| |   .. | || ... |||....... . ....||..||| .. ||||| | ...... |         |.|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCENNLKQLFDFLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYGFSIKLCD----------LGFASAVSKSKS--FMSK-K
 |. |||| |. .|||.  |...||.|.||||. . | || ..| ||||||.|||.  ...    |||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEVGQSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||. .  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 3357.AA Pkinase 42-259 22 1.4e-25 91.57 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 22% (52 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLK-KEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEM
..  . . ||...   |...   ...||.| |  ......  .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCENN--LKQLFDFLR--KQQVP--PSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDA
|.||.   .  |||...  .. .   . .| | ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  ...  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EVGQSRIQSDLFSLGLVLLEL
| ||||  .       .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 3357.AA CMGC 42-220 16 8.1e-24 74.34 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 16% (44 aa)

FKNFEYLSSGAYALLLKAQN--------------SQQNRQVALKFI--GSSNQED------KNGIE-SLKKEYEMLQKFS---------------QSEF-
... ... .|.|.   |...               . |..||.| |     ..|.      |.|.  .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEMELCENNLKQLFDFLRK-----QQVPPSKEM------------KEIIA------IQMIEGLN-
.|. ||.||  ... .|. | . |  .      . . .|.....|.|. .  ..     ...| |               .  .        |...||. 
IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPQNFLVCTSKEY----------------GFSIKLCDLGFASAVSK
  .| ..  |.|||.||.| |..  .|.                 . .|.|| |.| ....
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 3357.AA Ciliate-E1 48-250 22 1e-23 74.31 In-house 1-202 (202) Show / Hide 
Range on Protein: 48-250
Range on HMM: 1-202/202
Sequence Identity: 22% (48 aa)

LSSGAYALLLKA-QNSQQNRQVALKFIGSSNQEDKNGIESLKKEYE-MLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME-LCE
...| ... .|| |......|||.|.|    ....| .....|||  ... | . . .....|.... . .       . ||......  .  ... .  
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY-------ICIIIFECCCCSLKDYLQNH--

NNLKQLFDFLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYGFSIKLCDLGFAS-AVSKSKSFMSKKGTDAYFAPEVEVG--
| | .... ....|   . . |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   ..... . .||   |..|. ..   
NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP

--------QSRIQSDLF
        .  ..||..
EQEHNKNQKINYKSDIY
Kinase 3357.AA CAMK 47-238 15 3.8e-23 70.81 In-house 1-291 (425) Show / Hide 
Range on Protein: 47-238
Range on HMM: 1-291/425
Sequence Identity: 15% (48 aa)

YLSSGAYALLLKAQNSQQN------------RQVALKFIGSSNQEDKN-------------------------GIESLKKEYEMLQKFS------QSEFL
 | .|...   .... . .            ..|| |.|  .   ||.                           .....|.|...| .      . . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEEKEDEDADGNDIIVQTEVKSFFVMEM---ELCENN--LKQLFDFLRKQ-----------QVPPSKEMKEIIAI----Q
.. |. .               .|           |  . .....| |   |.|..   .  |||.....            |  .. ..|  |     |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQ

MIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYFA
...... .| .||.|||.|| | |......               . ||..| |||  . ...                         .    || .| |
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEV
 |||
APEV
Kinase 3357.AA STE 42-259 17 6.6e-23 77.79 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 17% (51 aa)

FKNFEYLSSGAYALLLKAQNS------QQNRQ---------VALKFIGSSNQE----------DKNG----IESLKKEYEMLQKFSQ-SEFLVNVYDCFY
... | . .||.    || |       . ...         .| | .  .|..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEKEDEDADGNDIIVQTEVKSFFVMEMELCE-NNLKQLFD-FLRKQQVPPSKE-------MKEI--IAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCT
   ..             .. ..   . ||...   | .. .    ...  ...         ..|  |. | ..| |. || ..|.||||||.| |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SKEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEV-EVGQSR------IQSDLFSLGLVLLEL
       .|||| |... ...                 ..   .  ||  . |||| . ...       ...|  |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 3357.AA Ciliate-E2 140-259 24 7.8e-22 71.71 In-house 113-289 (365) Show / Hide 
Range on Protein: 140-259
Range on HMM: 113-289/365
Sequence Identity: 24% (46 aa)

MELCENNLKQLFDFLRKQQVPPSKE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCTSKEYGFSIKLCDLG
||.|.   . |||......    .|        .|||  |  | ..               .|. || || |.||||||.| |.         ||..|.|
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

FASAVSKS----------KSFMSKK-----------------------GTDAYFAPEVEVGQSR----------IQSDLFSLGLVLLEL
..  ....          | .|  |                       ||  | |||.  |..            ..|..||| .| |.
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 3357.AA TKL 169-259 21 6e-20 68.52 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (32 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCTSKE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EVGQSRIQSDLFSLGLVLLEL
 .. ||||                 . ..   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 3357.AA S_TKc 42-323 21 1e-17 66.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME
..  . . .||..   |...   .|.||.| |           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCENNLKQLFDFLRKQQVPP-----SKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFAP
.|...|  |||...|.. ..     .  .   .. |....|. .| ..|.|||.||.| |...       ||.|| |.|  .      ..  ||  | ||
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAP

EVEVGQSRIQSDLFSLGLVLLELDNLKTLNENWIDFKTKNYLFNGEEIPKEKYQIDQNSNIYKIAKICLKPWYLDRTTAGELLS--------KLI
||  | ..  .|  |.| .| |.   ... .   .... . .                .    . . ||.    .| || |.|           .
EVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3357.AA ULK 168-256 29 1.2e-16 54.73 In-house 134-246 (329) Show / Hide 
Range on Protein: 168-256
Range on HMM: 134-246/329
Sequence Identity: 29% (33 aa)

IIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCTSKEY--------GFSIKLCDLGFASAVSKS----KSFMSKK------GTDAYFAPEVEVGQ------S
.. .| ..|.  || .||.|||||||| |.   ...           .|..| |||  |...    . .|. .      ||  | ||..  ||      .
QFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYY

RIQSDLFSLGLVL
   .|..||| ..
DYKCDIWSLGCIF
Kinase 3357.AA Ciliate-E2 42-116 14 4e-06 16.91 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (16 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSN------------------QEDKNGIESLKKEYEMLQ---------------KFSQSEFLVNVYD
.|  . . .|...   |... ....|.|.|.|   .                  .  ||.||..|.|  ...               .. .. .... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEK
||. . ..
CFQEKDDN
Kinase 3357.AA ULK 42-111 21 0.000947 9.07 In-house 1-88 (329) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-88/329
Sequence Identity: 21% (19 aa)

FKNFEYLSSGAYALLLKAQNSQQ----NRQVALKFIGSSNQEDKN-------GIESLKKEYEMLQKFS---QSEF----LVNVYDCFY
.   . | .|...   |. | ..    | .|| | | .. .  ||        ...||.| . ..|     ....     |  ||.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFE
Kinase 3357.AA C8 409-610 47 3.2e-101 342.6 In-house 1-226 (226) Show / Hide 
Range on Protein: 409-610
Range on HMM: 1-226/226
Sequence Identity: 47% (108 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKLKEPLVVQLYDNYIIENKIGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..||||..|..| |..|||||.||....|.|.|..|||.....|.|.|.||.|..|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLDRQNKDGQFNDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQP-EIKLCDFGLSAQIPDNKDSIQAIES--IGNLGYSA
          |..|.||..||....| .||||.||.|||.|..||.||||||.||||.||.... ||||||||...|...||..|| ...  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKQDNELKIYSKKSDSYSVGLLL
|||..||||..|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 3357.AA Ciliate-C8 418-610 42 1.2e-98 334.09 In-house 1-238 (238) Show / Hide 
Range on Protein: 418-610
Range on HMM: 1-238/238
Sequence Identity: 42% (100 aa)

GSFGMVLAT------KKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKLKEPLVVQLYDNYIIENKIGPDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|..||....|||....|.|||.||........ ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLDR-QNKDGQFNDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLD-GKQPEIKLCD------FGLSAQIPDNKD---------SIQAIES
.|..|.|| ..|........| .||||.|||||| | |||.||||||.||||..| ..||.|||||      ||...|.|.||.         ..| ||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL
  .||.||.|||...| ......|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 3357.AA C2 418-621 29 9.5e-44 147.36 In-house 1-245 (245) Show / Hide 
Range on Protein: 418-621
Range on HMM: 1-245/245
Sequence Identity: 29% (74 aa)

GSFGMVLATKKAKLDKKEIVLKIQKIED-----EQQIKNEISIMQKLK-EPLVVQLYD-NYIIENKIGP------------DR----------YSVFELE
|.||.|| .   | ......||||....     .... .|..||....  |.....|.  |  .||.              ..            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLDRQNKDG-QFNDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQ-PEIKLCD----------FGLSAQIPDNKDSIQAIESI
.|.. |  |..|. |.  ..... | ..|||..||.|| | |.|.||||||.|||. .| .. | |||||          |  .  .. ||  |   .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKQDNELKIYSKKSDSYS-VGLLLALLDNYQ--DLKK
.   |    .|||.      . .|| |.|| .| ||. |  ||| |  ....
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 3357.AA CAMK 414-610 19 5.1e-32 99.9 In-house 1-324 (425) Show / Hide 
Range on Protein: 414-610
Range on HMM: 1-324/425
Sequence Identity: 19% (65 aa)

ILSFGSFGMVLATKKAKLDK-----------KEIVLKI---QKIE----------------------------DEQQIKNEISIMQK-------LKEPLV
.|  |||| |   .  .  .           ..   ||   .|.                             |......||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYI------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQFNDDDKYQIAIQIIDSVNYVHSF
..||. |               .|  .   |.. .. .   | ||       | .|. .. .            .| |. ..  ..  ||.. |.| || 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIIHRDIKPENFLVYLDGKQPE--------------IKLCDFGLSAQIPDNKDSI---------------------QAIESIGNLGYSA-PEILNKQ---
||.|||.|||| |.  ...  .              ||..|||...........                         .. | ..| | ||.||..   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DNELKIYSKKSDSYSVGLLL
      |.| . |..|.|  |.| .|
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 3357.AA S_TKc 409-682 24 2.1e-29 104.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 409-682
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKLKEPLVVQLYDNYIIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG
    ...  |.|| |   .. | ....  .|| |    ..|..||.|..| . | .|.||| .          .  . .| |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---FNDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILNKQDNELKIYSK-KS
    |.  .   .. ||.. ..| || .|||||.|||| |.       .||.|||||..|.            .| . | |||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVGLLLALLDN----YQDLKKSAPLTFLLMTKKQLDKPFEKSNIKINKNSEIYKFINLLVVSDSGQRASLYDIVQ-QSD---INFF
| .|.| .|. .      ..        .  .| || .              .|   ||. . . |  .| .  .. | ..|     .|
DWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3357.AA Ciliate-E1 415-604 27 2e-28 89.79 In-house 1-202 (202) Show / Hide 
Range on Protein: 415-604
Range on HMM: 1-202/202
Sequence Identity: 27% (58 aa)

LSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQ-------QIKNEISIMQKLKEPL-VVQLYDNYIIENKIGPDRYSVFELEKCSCSLDEYLD-------
.. |||..|.  |. .  .... .||..... .       .||....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKDGQFNDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSA-QIPDNKDSIQAIESIGNLGYSAPEILNK---QDN
    |....||... | ||..|.|| ....|..|||||||||.| |.. . ..   ..||||.|  ..  .....|  ..     |. || .|    . |
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQ--YKGYTHYYYPPEQYNCPEQEHN

ELKIYSKKSDSY
. .....||| |
KNQKINYKSDIY
Kinase 3357.AA Ciliate-E2 409-610 22 2.2e-25 84.06 In-house 1-286 (365) Show / Hide 
Range on Protein: 409-610
Range on HMM: 1-286/365
Sequence Identity: 22% (69 aa)

TNNFQILSFGSFG-----MVLATKKA-----------------KLDKKEIVLKIQKIEDEQQIKNEISIMQ----------------KLKEPLVVQLYDN
 .  ... .|.||      |  ..|                  | ..|.. .||.|  . .|||.||.||.                .|. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKIGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQFNDDDKYQIAIQIID---------------SVNYVHSFN-IIHRDIKPENFL
..   .|.|       . .| |.  .| .|.   ...       . ..|..    .|  ||..                ..| || | |||||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLDGKQPEIKLCDFGLSAQIPDNKD-------SIQAIESI-----------------------GNLGYSAPEILNKQDNE----LKIYSKKSDSYSVGL
.        ||..||||| .. |. .       .   ..                         |..|| ||||||.....     | |..|.| .|.| 
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 3357.AA CMGC 412-560 17 4.6e-22 68.47 In-house 1-251 (513) Show / Hide 
Range on Protein: 412-560
Range on HMM: 1-251/513
Sequence Identity: 17% (43 aa)

FQILS---FGSFGMVLATKKAKLD-------------KKEIVLKIQKIE-DEQQIK-------------NEISIMQKLK-----------------EPLV
..|..    |..|.|   .  . .             .... .|. | . .| | |              ||.|...|.                 .. .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLYDNYIIEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QFNDDD------------KYQIA------IQIIDSVN--YVH
|.||| .  .|  . ..         ...  .  | . ..| .|.....  . |     ...              .  .        ||. ...  | |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCDFGLS
| .  |||||.|||| |.  ...                   ..|.|||||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 3357.AA TKL 512-610 26 5.6e-22 75.92 In-house 134-279 (364) Show / Hide 
Range on Protein: 512-610
Range on HMM: 134-279/364
Sequence Identity: 26% (39 aa)

KYQIAIQIIDSVNYVHSFN--------IIHRDIKPENFLVYLDGKQPE-----------IKLCDFGLSAQIP---DNKDSI--------------QAIES
. ..|..|   .|| || |        |||||.|..| ||  ...              .|.||||||  .    ...|.               . .  
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

IGNLGYSAPEILNKQDN-----------ELKIYSKKSDSYSVGLLL
.|.... |||.|..|.|           . . ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 3357.AA Pkinase 409-611 27 5.4e-21 75.32 Pfam 1-203 (293) Show / Hide 
Range on Protein: 409-611
Range on HMM: 1-203/293
Sequence Identity: 27% (62 aa)

TNNFQILSFGSFGMVLATKKAKLDKKE--IVLKIQKIEDEQQIKN-------EISIMQKLKEPLVVQLYDNYIIENKIGPDRYSVFELEKCSC-----SL
    ...  |||| |   .|..  . .   ..|| | ..|   |.       ||.||..|. | .|.||| .        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLDRQNKDGQF--NDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQPEI----KLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILN
 .|. .  ..| |   ...   .. ||.  ..| || .|||||.||||.|  .| ....|    |.|||||..|.  .  .  .    | ..| |||...
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR

KQDNELKIYSKKSDSYSVGLLLA
    . . |..|.| .|.|..|.
----GGQYYGPKVDMWSCGCILY
Kinase 3357.AA STE 515-610 31 1.2e-20 69.67 In-house 156-258 (359) Show / Hide 
Range on Protein: 515-610
Range on HMM: 156-258/359
Sequence Identity: 31% (35 aa)

IAIQIIDS-VNYVHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSI--------------QAIESIGNLGYSAPEILNKQDNE-LKIYS
|. ||.    .| || .|||||||| | |.        .||||||...|. |. ..|              .    .|   . |||.......   | |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLL
 |.| .|.|...
TKCDIWSLGCTI
Kinase 3357.AA ULK 514-610 28 3.9e-13 42.29 In-house 134-246 (329) Show / Hide 
Range on Protein: 514-610
Range on HMM: 134-246/329
Sequence Identity: 28% (33 aa)

QIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQPE-----------IKLCDFGLSAQIPDNKDSIQ-AIESI------GNLGYSAPEILNKQDNELK
|. .||.    . |. |||||||||.|  . .. .||            .|..|||.. .. ......| .          |   | ||.||..|  . .
QFFKQILNGFKELHKHNIIHRDIKPQN--ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKP

IYSKKSDSYSVGLLL
 |..|.| .|.| ..
YYDYKCDIWSLGCIF
Kinase 3357.AA TyrKc 409-677 20 2.4e-10 -55.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 409-677
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKL--KEPLVVQLYDNYIIENKIG-----PDRYSVFELEKCSCSLDEYL-DR
    ..|  | || |    |....  .   |  | . .. . .|..|| ||  . | .|.||   ..  . .     .  . |.|. .   .|..|| ..
ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

QNKDGQFNDDDKYQIAIQIIDSVNYVHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDN------KDSIQA---IESI--GNLGYSAPEILNK
..|   .. .|. ....|| .  .| || |.||||.   | ||  ..    .| .|||||  | |       || . .     .     .   ||| .  
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

QDNELKIYSKKSDSYSVGLLL----ALLDNYQDL-----KKSAPLTFLLMTKKQLDKPFE----KSNIKINKNSEIYKFINLLVVSDSGQRASLYDIVQQ
     .... ||| .| | ..     . .          .. . .  .... . ...| .     .       .|.|. .      |  .| .  .|...
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

S
 
F
Kinase 3357.AA STE 409-477 16 5.2e-05 13.77 In-house 1-112 (359) Show / Hide 
Range on Protein: 409-477
Range on HMM: 1-112/359
Sequence Identity: 16% (19 aa)

TNNFQILSFGSFG-MVLATKKAKL-------------DKKEIVLKIQKI--------------------EDEQQIKNEISIMQKLK--EPLVVQLYDNYI
  . ...  |.||  ..| .. .               .. .  |. ..                    |..|||..||.||.|..   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE-------NKI
 |       ...
KEGHNHKNDDEL
Kinase 3357.AA ULK 418-471 28 8.2e-05 12.83 In-house 10-87 (329) Show / Hide 
Range on Protein: 418-471
Range on HMM: 10-87/329
Sequence Identity: 28% (22 aa)

GSFGMVLATKKAKL----DKKEIVLKIQ---KIEDEQQ---------IKNEISIMQKLKEPL--------VVQLYDNY
|||| |   .. |     ..| .. .|.   .......         .|||| ||.||| |         .|.||| .
GSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF
LRR_RI 3357.AA LRR_RI 723-750 32 0.165085 4.06 SMART 1-28 (28) Show / Hide 
Range on Protein: 723-750
Range on HMM: 1-28/28
Sequence Identity: 32% (9 aa)

NYNIVEIYLSNKNIQDEQLKQIAGALEK
| .. |..||| .. ||  .|.. .|. 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 3357.AA LRR_RI 753-780 32 0.306818 2.16 SMART 1-28 (28) Show / Hide 
Range on Protein: 753-780
Range on HMM: 1-28/28
Sequence Identity: 32% (9 aa)

NISSLFLGLSENNFKLEGVQYIATSLPR
| | . | || |..  ||.. .. .|  
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 3357.AA LRR_RI 813-840 28 0.017783 10.89 SMART 1-28 (28) Show / Hide 
Range on Protein: 813-840
Range on HMM: 1-28/28
Sequence Identity: 28% (8 aa)

NLTQLTLWMEQNNLNEEAAKYLALLLEK
| . ..|| ..|.| .| .. |. .|. 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 3357.AA LRR_RI 843-870 35 0.004713 14.96 SMART 1-28 (28) Show / Hide 
Range on Protein: 843-870
Range on HMM: 1-28/28
Sequence Identity: 35% (10 aa)

NLTYLDLNLSNNNLKLEGAKYIATSLEK
| . . |.||||.|  ||.. .. .|. 
NCSLRELWLSNNKLGDEGCRQLCEGLKH