Gene 17855 (Tetrahymena)

17855

Species: Tetrahymena
Alias: TTHERM_01627910, PreTt17855, 517.m00002, 17855, 49
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
17855.AA Protein None 947 None Fasta, JSON
17855.kin_dom Protein Kinase Domain None 201 None Fasta, JSON
17855.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
17855.NA RNA None 2844 None Fasta, JSON

Protein domain

Protein domains of 17855.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17855.AA C8 42-256 61 3.8e-122 412.11 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 61% (140 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME
|.||.|||.|||.. |||.|...||...|||  ..|..|...|||..|||||.|.|.|..|.||.|||||.|.|...|. ..|..|||||.||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCENNLKQLFDYLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAP
|||.|||||.|..|..|...|||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEAG------QSRIQSDLFSLGLVL
|.|..      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 17855.AA Ciliate-C8 51-256 57 6.4e-120 404.7 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 57% (136 aa)

GAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVK---SFFVMEMELCENN-
||... |||||..|||.|||||. ..|...||..|...|||||...|.|..|.|.||||||||||...|| ||||.||||..|   ||||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDAY---
 |||.||..||.|..||..||||||||||...|.||..|||||||||.|||||...||...|||||      .||||...|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEAGQSRIQSDLFS-------LGLVL
        ||||||..|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 17855.AA C2 51-269 41 2.2e-70 239.59 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 41% (102 aa)

GAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEE-KEDEDADGNDIIVQTEV--------KSFFVMEME
|| .| ||| | .|||.|||| |   .. | || ... |||....... . ....||..||| .. ||||| | ...... |         |.|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCENNLKQLFDYLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYGFSIKLCD----------LGFASAVSKSKS--FMSK-K
 |. |||| |. .|||.  |...||.|.||||. . | || ..| ||||||.|||.  ..|    |||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEAGQSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||. .  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 17855.AA Pkinase 42-259 23 1.1e-26 95.39 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 23% (53 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLK-KEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEM
..  . . ||...   |...   ...||.| |  ......  .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCENN--LKQLFDYLR--KQQVP--PSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYGFSIKLCDLGFASA--VSKSKSFMSKKGTDA
|.||.   .  ||||..  .. .   . .| | ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  ...  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EAGQSRIQSDLFSLGLVLLEL
| ||||  ..      .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 17855.AA CMGC 42-220 16 3.5e-24 75.58 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 16% (43 aa)

FKNFEYLSSGAYALLLKAQN--------------SQQNRQVALKFI--GSSNQED------KNGIE-SLKKEYEMLQKFS---------------QSEF-
... ... .|.|.   |...               . |..||.| |     ..|.      |.|.  .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEMELCENNLKQLFDYLRK-----QQVPPSKEM------------KEIIA------IQMIEGLN-
.|. ||.||  ... .|. | . |  .      . . .|.....|.|. .  ..     ...| |               .  .        |...||. 
IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPQNFLVCPSKQY----------------GFSIKLCDLGFASAVSK
  .| ..  |.|||.||.| |... ...                 . .|.|| |.| ....
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 17855.AA STE 42-259 17 7.9e-24 81.1 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 17% (51 aa)

FKNFEYLSSGAYALLLKAQNS------QQNRQ---------VALKFIGSSNQE----------DKNG----IESLKKEYEMLQKFSQ-SEFLVNVYDCFY
... | . .||.    || |       . ...         .| | .  .|..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEKEDEDADGNDIIVQTEVKSFFVMEMELCE-NNLKQLFD-YLRKQQVPPSKE-------MKEI--IAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCP
   ..             .. ..   . ||...   | .. . .  ...  ...         ..|  |. | ..| |. || ..|.||||||.| |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SKQYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEVEAG-QSR------IQSDLFSLGLVLLEL
       .|||| |... ...                 ..   .  ||  . ||||  . ..       ...|  |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 17855.AA Ciliate-E2 140-259 24 1.2e-23 78.05 In-house 113-289 (365) Show / Hide 
Range on Protein: 140-259
Range on HMM: 113-289/365
Sequence Identity: 24% (47 aa)

MELCENNLKQLFDYLRKQQVPPSKE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCPSKQYGFSIKLCDLG
||.|.   . ||||.....    .|        .|||  |  | ..               .|. || || |.||||||.| |.         ||..|.|
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

FASAVSKS----------KSFMSKK-----------------------GTDAYFAPEVEAGQSR----------IQSDLFSLGLVLLEL
..  ....          | .|  |                       ||  | |||.  |..            ..|..||| .| |.
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 17855.AA Ciliate-E1 48-250 22 3.2e-23 72.67 In-house 1-202 (202) Show / Hide 
Range on Protein: 48-250
Range on HMM: 1-202/202
Sequence Identity: 22% (48 aa)

LSSGAYALLLKA-QNSQQNRQVALKFIGSSNQEDKNGIESLKKEYE-MLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME-LCE
...| ... .|| |......|||.|.|    ....| .....|||  ... | . . .....|.... . .       . ||......  .  ... .  
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY-------ICIIIFECCCCSLKDYLQNH--

NNLKQLFDYLRKQQVPPSKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYGFSIKLCDLGFAS-AVSKSKSFMSKKGTDAYFAPEVEAG--
| | .... ....|   . . |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   ..... . .||   |..|. .    
NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP

--------QSRIQSDLF
        .  ..||..
EQEHNKNQKINYKSDIY
Kinase 17855.AA CAMK 47-238 16 1e-22 69.4 In-house 1-291 (425) Show / Hide 
Range on Protein: 47-238
Range on HMM: 1-291/425
Sequence Identity: 16% (49 aa)

YLSSGAYALLLKAQNSQQN------------RQVALKFIGSSNQEDKN-------------------------GIESLKKEYEMLQKFS------QSEFL
 | .|...   .... . .            ..|| |.|  .   ||.                           .....|.|...| .      . . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEEKEDEDADGNDIIVQTEVKSFFVMEM---ELCENN--LKQLFDYLRKQ-----------QVPPSKEMKEIIAI----Q
.. |. .               .|           |  . .....| |   |.|..   .  ||||....            |  .. ..|  |     |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQ

MIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYFA
...... .| .||.|||.|| | |.. ..                . ||..| |||  . ...                         .    || .| |
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEV
 |||
APEV
Kinase 17855.AA TKL 169-259 21 6.9e-20 68.3 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (32 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCPSKQ----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EAGQSRIQSDLFSLGLVLLEL
 .. ||||                 . ..   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 17855.AA S_TKc 42-323 21 3.1e-18 67.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSNQEDKNGIESLKKEYEMLQKFSQSEFLVNVYDCFYLMEEKEDEDADGNDIIVQTEVKSFFVMEME
..  . . .||..   |...   .|.||.| |           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCENNLKQLFDYLRKQQVPP-----SKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFAP
.|...|  ||||..|.. ..     .  .   .. |....|. .| ..|.|||.||.| |..        ||.|| |.|  .      ..  ||  | ||
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAP

EVEAGQSRIQSDLFSLGLVLLELDNLKTLNENWIDTKTKNHLFNGEEIPKEKYQIDKNSNIYKVAKICLKPWYLDRTTAGELLS--------KLI
||  | ..  .|  |.| .| |.   ... .   . .. ...                .      . ||.    .| || |.|           .
EVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17855.AA ULK 168-256 29 5.8e-16 52.28 In-house 134-246 (329) Show / Hide 
Range on Protein: 168-256
Range on HMM: 134-246/329
Sequence Identity: 29% (33 aa)

IIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSKQY--------GFSIKLCDLGFASAVSKS----KSFMSKK------GTDAYFAPEVEAGQ------S
.. .| ..|.  || .||.|||||||| |.   ...           .|..| |||  |...    . .|. .      ||  | ||..  ||      .
QFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYY

RIQSDLFSLGLVL
   .|..||| ..
DYKCDIWSLGCIF
Kinase 17855.AA Ciliate-E2 42-116 14 4e-06 16.91 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (16 aa)

FKNFEYLSSGAYALLLKAQNSQQNRQVALKFIGSSN------------------QEDKNGIESLKKEYEMLQ---------------KFSQSEFLVNVYD
.|  . . .|...   |... ....|.|.|.|   .                  .  ||.||..|.|  ...               .. .. .... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEK
||. . ..
CFQEKDDN
Kinase 17855.AA ULK 42-111 21 0.000947 9.07 In-house 1-88 (329) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-88/329
Sequence Identity: 21% (19 aa)

FKNFEYLSSGAYALLLKAQNSQQ----NRQVALKFIGSSNQEDKN-------GIESLKKEYEMLQKFS---QSEF----LVNVYDCFY
.   . | .|...   |. | ..    | .|| | | .. .  ||        ...||.| . ..|     ....     |  ||.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFE
Kinase 17855.AA Ciliate-E1 260-298 19 0.27843 0.51 In-house 157-202 (202) Show / Hide 
Range on Protein: 260-298
Range on HMM: 157-202/202
Sequence Identity: 19% (9 aa)

DNLKTLNENWIDTKTKNHLFNGEEIPK-------EKYQIDKNSNIY
..||  ... .. |   | .  .|  .       ....|...|.||
KFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 17855.AA C8 409-610 48 1.1e-101 344.14 In-house 1-226 (226) Show / Hide 
Range on Protein: 409-610
Range on HMM: 1-226/226
Sequence Identity: 48% (109 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..||||..|..| |..|||||.||....|.|.|..|||.....|.|.|.||.|..|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLDRQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQP-EIKLCDFGLSAQIPDNKDSIQAIES--IGNLGYSA
          |..|.||..||....| .||||.||.|||||..||.||||||.||||.||.... ||||||||...|...||..|| ...  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKQDNELKIYSKKSDSYSVGLLL
|||..||||..|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 17855.AA Ciliate-C8 418-610 42 2.5e-99 336.31 In-house 1-238 (238) Show / Hide 
Range on Protein: 418-610
Range on HMM: 1-238/238
Sequence Identity: 42% (100 aa)

GSFGMVLAT------KKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKLKEPLVVQLYDSYIIENKIGPDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|..||....|||....|.|||.||........ ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLDR-QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQPEIKLCD------FGLSAQIPDNKD---------SIQAIES
.|..|.|| ..|........| .||||.||||||.| |||.||||||.||||..| ..||.|||||      ||...|.|.||.         ..| ||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL
  .||.||.|||...| ......|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 17855.AA C2 418-623 28 6.8e-45 151.33 In-house 1-245 (245) Show / Hide 
Range on Protein: 418-623
Range on HMM: 1-245/245
Sequence Identity: 28% (72 aa)

GSFGMVLATKKAKLDKKEIVLKIQKIED-----EQQIKNEISIMQKLK-EPLVVQLYDSYIIENKIGPD-------------R----------YSVFELE
|.||.|| .   | ......||||....     .... .|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLDRQNKDG-QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQ-PEIKLCD----------FGLSAQIPDNKDSIQAIESI
.|.. |  |..|. |.  ..... | ..|||..||.||.| |.|.||||||.|||. .| .. | |||||          |  .  .. ||  |   .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKQDNELKIYSKKSDSYS-VGLLLAFLDNYQDLKKNA
.   |    .|||.      . .|| |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 17855.AA CAMK 414-610 19 8.2e-35 109.08 In-house 1-324 (425) Show / Hide 
Range on Protein: 414-610
Range on HMM: 1-324/425
Sequence Identity: 19% (65 aa)

ILSFGSFGMVLATKKAKLDK-----------KEIVLKI---QKIE----------------------------DEQQIKNEISIMQK-------LKEPLV
.|  |||| |   .  .  .           ..   ||   .|.                             |......||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYI------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQFNDDDKYQIAIQIIDSVNYIHSF
..||. |               .|  .   |.. .. .   | ||       | .|. .. .            .| |. ..  ..  ||.. |.|.|| 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIIHRDIKPENFLVYLDGKQPE--------------IKLCDFGLSAQIPDNKDSI---------------------QAIESIGNLGYSA-PEILNKQ---
||.|||.|||| |.  ...  .              ||..|||...........                         .. | ..| | ||.||..   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DNELKIYSKKSDSYSVGLLL
      |.| . |..|.|  |.| .|
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 17855.AA S_TKc 409-682 25 1.1e-33 119.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 409-682
Range on HMM: 1-231/231
Sequence Identity: 25% (74 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG
    ...  |.|| |   .. | ....  .|| |    ..|..||.|..| . | .|.|||..          .  . .| |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---FNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILNKQDNELKIYSK-KS
    |.  .   .. ||.. ..|.|| .|||||.|||| |.       .||.|||||..|.            .| . | |||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVGLLLAFLDNYQDLKKNAPFTFLLMTKKQLDKPFEKSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVQ-QSD---INFF
| .|.| .|. .     |    ||        |... |.| .      .|   ||. . . |  .| .  .. | ..|     .|
DWWSCGCILYEM-----LCGYPPFP-------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17855.AA Ciliate-E1 415-604 27 2.8e-29 92.63 In-house 1-202 (202) Show / Hide 
Range on Protein: 415-604
Range on HMM: 1-202/202
Sequence Identity: 27% (58 aa)

LSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQ-------QIKNEISIMQKLKEPL-VVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLD-------
.. |||..|.  |. .  .... .||..... .       .||....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSA-QIPDNKDSIQAIESIGNLGYSAPEILNK---QDN
    |....||... | ||..|.|| ....|..|||||||||.| |.. . ..   ..||||.|  ..  .....|  ..     |. || .|    . |
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQ--YKGYTHYYYPPEQYNCPEQEHN

ELKIYSKKSDSY
. .....||| |
KNQKINYKSDIY
Kinase 17855.AA Ciliate-E2 409-610 22 1.6e-26 88.08 In-house 1-286 (365) Show / Hide 
Range on Protein: 409-610
Range on HMM: 1-286/365
Sequence Identity: 22% (69 aa)

TNNFQILSFGSFG-----MVLATKKA-----------------KLDKKEIVLKIQKIEDEQQIKNEISIMQ----------------KLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.|  . .|||.||.||.                .|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKIGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQFNDDDKYQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFL
..   .|.|       . .| |.  .| .|.   ...       . ..|..    .|  ||..                ..|.|| | |||||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLDGKQPEIKLCDFGLSAQIPDNKD-------SIQAIESI-----------------------GNLGYSAPEILNKQDNE----LKIYSKKSDSYSVGL
.        ||..||||| .. |. .       .   ..                         |..|| ||||||.....     | |..|.| .|.| 
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 17855.AA CMGC 412-560 17 2.1e-24 76.32 In-house 1-251 (513) Show / Hide 
Range on Protein: 412-560
Range on HMM: 1-251/513
Sequence Identity: 17% (43 aa)

FQILS---FGSFGMVLATKKAKLD-------------KKEIVLKIQKIE-DEQQIK-------------NEISIMQKLK-----------------EPLV
..|..    |..|.|   .  . .             .... .|. | . .| | |              ||.|...|.                 .. .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLYDSYIIEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QFNDDD------------KYQIA------IQIIDSVN--YIH
|.|||..  .|  . ..         ...  .  | . ..| .|.....  . |     ...              .  .        ||. ...  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCDFGLS
| .  |||||.|||| |.  ...                   ..|.|||||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 17855.AA Pkinase 409-611 27 4.2e-24 86.29 Pfam 1-203 (293) Show / Hide 
Range on Protein: 409-611
Range on HMM: 1-203/293
Sequence Identity: 27% (62 aa)

TNNFQILSFGSFGMVLATKKAKLDKKE--IVLKIQKIEDEQQIKN-------EISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC-----SL
    ...  |||| |   .|..  . .   ..|| | ..|   |.       ||.||..|. | .|.|||..        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLDRQNKDGQF--NDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEI----KLCDFGLSAQIPDNKDSIQAIESIGNLGYSAPEILN
 .|. .  ..| |   ...   .. ||.  ..|.|| .|||||.||||.|  .| ....|    |.|||||..|.  .  .  .    | ..| |||...
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR

KQDNELKIYSKKSDSYSVGLLLA
    . . |..|.| .|.|..|.
----GGQYYGPKVDMWSCGCILY
Kinase 17855.AA TKL 512-610 26 1.5e-22 78.06 In-house 134-279 (364) Show / Hide 
Range on Protein: 512-610
Range on HMM: 134-279/364
Sequence Identity: 26% (39 aa)

KYQIAIQIIDSVNYIHSFN--------IIHRDIKPENFLVYLDGKQPE-----------IKLCDFGLSAQIP---DNKDSI--------------QAIES
. ..|..|   .|| || |        |||||.|..| ||  ...              .|.||||||  .    ...|.               . .  
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

IGNLGYSAPEILNKQDN-----------ELKIYSKKSDSYSVGLLL
.|.... |||.|..|.|           . . ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 17855.AA STE 515-610 31 7.7e-22 73.97 In-house 156-258 (359) Show / Hide 
Range on Protein: 515-610
Range on HMM: 156-258/359
Sequence Identity: 31% (35 aa)

IAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDNKDSI--------------QAIESIGNLGYSAPEILNKQDNE-LKIYS
|. ||.    .|.|| .|||||||| | |.        .||||||...|. |. ..|              .    .|   . |||.......   | |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLL
 |.| .|.|...
TKCDIWSLGCTI
Kinase 17855.AA ULK 514-610 28 9.8e-14 44.41 In-house 134-246 (329) Show / Hide 
Range on Protein: 514-610
Range on HMM: 134-246/329
Sequence Identity: 28% (33 aa)

QIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPE-----------IKLCDFGLSAQIPDNKDSIQ-AIESI------GNLGYSAPEILNKQDNELK
|. .||.    ..|. |||||||||.|  . .. .||            .|..|||.. .. ......| .          |   | ||.||..|  . .
QFFKQILNGFKELHKHNIIHRDIKPQN--ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKP

IYSKKSDSYSVGLLL
 |..|.| .|.| ..
YYDYKCDIWSLGCIF
Kinase 17855.AA TyrKc 409-677 20 8.4e-11 -47.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 409-677
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQQIKNEISIMQKL--KEPLVVQLYDSYIIENKIG-----PDRYSVFELEKCSCSLDEYL-DR
    ..|  | || |    |....  .   |  | . .. . .|..|| ||  . | .|.||   ..  . .     .  . |.|. .   .|..|| ..
ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCDFGLSAQIPDN------KDSIQA---IESI--GNLGYSAPEILNK
..|   .. .|. ....|| .  .|.|| |.||||.   | ||  ..    .| .|||||  | |       || . .     .     .   ||| .  
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

QDNELKIYSKKSDSYSVGLLL----AFLDNYQDL-----KKNAPFTFLLMTKKQLDKPFE----KSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVQQ
     .... ||| .| | ..     . .          ..|.    .... . ...| .     .       .|.|. .      |  .| .  .|...
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

S
 
F
Kinase 17855.AA STE 409-477 16 2e-06 19.25 In-house 1-112 (359) Show / Hide 
Range on Protein: 409-477
Range on HMM: 1-112/359
Sequence Identity: 16% (19 aa)

TNNFQILSFGSFG-MVLATKKAKL-------------DKKEIVLKIQKI--------------------EDEQQIKNEISIMQKLK--EPLVVQLYDSYI
  . ...  |.||  ..| .. .               .. .  |. ..                    |..|||..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE-------NKI
 |       ...
KEGHNHKNDDEL
Kinase 17855.AA ULK 418-471 28 7e-05 13.08 In-house 10-87 (329) Show / Hide 
Range on Protein: 418-471
Range on HMM: 10-87/329
Sequence Identity: 28% (22 aa)

GSFGMVLATKKAKL----DKKEIVLKIQ---KIEDEQQ---------IKNEISIMQKLKEPL--------VVQLYDSY
|||| |   .. |     ..| .. .|.   .......         .|||| ||.||| |         .|.||| .
GSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF