Gene 23998 (Tetrahymena)

23998

Species: Tetrahymena
Alias: 257.m00023, 782, 23998, PreTt23998, TTHERM_01153640
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
23998.AA Protein None 1287 None Fasta, JSON
23998.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
23998.kin_dom2 Protein Kinase Domain None 221 None Fasta, JSON
23998.NA RNA None 3864 None Fasta, JSON

Protein domain

Protein domains of 23998.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23998.AA C8 147-361 61 1.9e-122 413.1 In-house 1-226 (226) Show / Hide 
Range on Protein: 147-361
Range on HMM: 1-226/226
Sequence Identity: 61% (140 aa)

LQNFEYLSSGAYALVLKAKNIKKNRIVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDQDVEEDKDGKEKIIITDEKSFFVMEME
..||.|||.|||..||||||.|.|| ..|||..|..|.  ..|||..||||..|.|.|.||.||.|||||.| ...||.|...|||..|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDYLRKTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAVTKSKSYYLSKK----GTDTYFAP
|||||||||.|..|..|.. |.|.||||||||..|.|..|.||||||||||||||||..|.|||.||.||.||||.|.|.|| ..|||    ||..||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEKG------QSRIQSDLFSLGLVL
|.||.      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 23998.AA Ciliate-C8 156-361 55 3.1e-119 402.43 In-house 1-238 (238) Show / Hide 
Range on Protein: 156-361
Range on HMM: 1-238/238
Sequence Identity: 55% (132 aa)

GAYALVLKAKNIKKNRIVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDQDVEEDKDGKEKIIITDEK---SFFVMEMELCEQN-
||...||||.|.|.||.|||||..|..|.  ...|...||||....|.|..|.|.|||||||| ....||.|| .||. |.||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRKTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICD------LGFASAVTKSKSYYLSKK--GTDTY---
 |||.||..||.|.. ||..||||||||....|.||..|||||||||||||||..|.|..|||.||      .||||...|.||.|.|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEKGQSRIQSDLFS-------LGLVL
        |||||||.|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23998.AA C2 156-374 39 2.2e-67 229.19 In-house 1-245 (245) Show / Hide 
Range on Protein: 156-374
Range on HMM: 1-245/245
Sequence Identity: 39% (96 aa)

GAYALVLKAKNIKKNRIVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDQDVEE-DKDGKEKIIITDE--------KSFFVMEME
|| .||||| | |.||.||||   | | . ..| ... |||....... . ....||..|||  .. |  | |  |..   ..        |.|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDYLRKTQ-LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICD----------LGFASAVTKSKSYYLSKK--
 |. |||| |. .|| .  |.|..|.|.||||. . | ||...| |||||| |||.  .|    |||.||          . |||.. ..||.   .|  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDTY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLNVLNENW
.| .|    |||||...  . .||||| .|.||||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 23998.AA Pkinase 147-364 25 3.6e-33 118.36 Pfam 1-205 (293) Show / Hide 
Range on Protein: 147-364
Range on HMM: 1-205/293
Sequence Identity: 25% (58 aa)

LQNFEYLSSGAYALVLKAKNIKKNRIVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMDQDVEEDKDGKEKIIITDEKSFFVMEM
..  . . ||... | |..... ..|||.| .   ...  | .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEQN--LKQLFDYLR---KTQL--PSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAV-TKSKSYYLSKKGTDT
|.||    .  ||||..   .. .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|||| |.|  . . ..| . .  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EKGQSRIQSDLFSLGLVLLEL
| ||||  .       .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 23998.AA CMGC 147-319 16 8.2e-26 81.02 In-house 1-251 (513) Show / Hide 
Range on Protein: 147-319
Range on HMM: 1-251/513
Sequence Identity: 16% (43 aa)

LQNFEYLSSGAYALVLKAKN--------------IKKNRIVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
 .. ... .|.|. | |...              .. |.|||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMDQDVEEDKDGKEKIIITDEKSFFVMEMELCEQNLKQLFDYLRK-------TQLPSQE------------IKEII-----AIQMLEGLN-
.|. ||.||  ...  .....|..|    .   . . .|.....|.|. .  ..         |.  .            || ..     . |.|.||. 
IVKLYDIFY-HKNSDGNEYEDKHII-SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-TLHIKN--IMHRDIKPHNFLVCPSQTY----------------GFTIKICDLGFA
  .| ..  |.|||.|| | |...  ..                 ...|||| |.|
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 23998.AA CAMK 152-343 14 5.1e-25 76.95 In-house 1-291 (425) Show / Hide 
Range on Protein: 152-343
Range on HMM: 1-291/425
Sequence Identity: 14% (45 aa)

YLSSGAYALVLKAKNIKKN------------RIVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | ...... .            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MDQDVEEDKDGKEKIIITDEKSFFVMEM---ELCEQN--LKQLFDYLRKT----------------QLPSQEIKEIIAIQ
.. |. .               ...          .. . .....| |   |.|.    .  ||||...                  .. .| . ..  |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-Q

MLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYG-------------FTIKICDLGFASAVTKSKSYYLS-----------------------KKGTDTYFA
...... .| .||.|||.|| | |.. . .               ..|||.| |||  ........                           ||  | |
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEV
 |||
APEV
Kinase 23998.AA STE 147-364 19 6.6e-25 84.95 In-house 1-261 (359) Show / Hide 
Range on Protein: 147-364
Range on HMM: 1-261/359
Sequence Identity: 19% (55 aa)

LQNFEYLSSGAYALVLKAKNI------KKNRI---------VALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYDCF
... | . .||.  | ||.|.      |....         .| | .    |..|.              . .....|| ....|... ... |. |.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YLMDQDVEEDKDGKEKIIITDEKSFFVMEMELCE-QNLKQLFDYLRKTQLPS-----------QEIKEIIAIQMLEG-LNTLHIKNIMHRDIKPHNFLVC
.  . .             .....   . ||...   | .. .   ... |             ..  .|. | |.| |. || ..|.|||||| | |. 
FKEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-

PSQTYGFTIKICDLGFASAVTKS----------------KSYYLSKKGTDTYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
        .|.|| |... .|.|                ..   .  ||  . |||| .. ..       ...|  |||....|.
--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 23998.AA S_TKc 147-427 22 3.8e-24 87.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 147-427
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

LQNFEYLSSGAYALVLKAKNIKKNRIVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDQDVEEDKDGKEKIIITDEKSFFVMEME
 .  . . .||.. | |....| .||||.| .           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEQNLKQLFDYLRKTQ-------LPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAVTKSKSYYLSKKGTDTYF
.|...|  ||||..| .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||||| |.|  .        .  ||  | 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYM

APEVEKGQSRIQSDLFSLGLVLLELDNLNVLNENWIDFDIKGEIYQGRGIASKYQIDRNSNIYKIAEICLKPNYLERTTSGDLLS--------ELI
||||  | ..  .|  |.| .| |.     . .         ....  |          .    . . ||. .  .| |  ..|         . .
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23998.AA Ciliate-E2 245-364 24 3e-22 73.14 In-house 113-289 (365) Show / Hide 
Range on Protein: 245-364
Range on HMM: 113-289/365
Sequence Identity: 24% (47 aa)

MELCEQNLKQLFDYLRKTQLPSQEI---------KEI--IAIQMLE---------------GLNTLHIKN-IMHRDIKPHNFLVCPSQTYGFTIKICDLG
||.|..  . ||||... .. ....         |||  |  | |.               .|. || || |.|||||| | |.         |||.|.|
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

FASAVTKS---------KSYYLSKK-----------------------GTDTYFAPEVEKGQSR----------IQSDLFSLGLVLLEL
..  ....            |.  |                       ||  | |||. .|..            ..|..||| .| |.
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 23998.AA Ciliate-E3 229-365 29 4.7e-19 56.31 In-house 68-202 (202) Show / Hide 
Range on Protein: 229-365
Range on HMM: 68-202/202
Sequence Identity: 29% (42 aa)

KEKIIITDEKSFFVMEMELCEQNLKQLFDYLRKTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYG-FTIKICDLGFASAVTKSKS
.. .   . |. |.  .|.|.    .|  |...  .  ..|.. |.||...|.  .| ||| | |||| |.||  .. ..  .|||||.| .    | | 
HDQYYDQQNKMIFIV-QEYCSN--GDLYHYIKQQNKTQNIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKG

YYLSK-KGTDTYFA-PEVEK-GQSRIQSDLFSLGLVLLELD
.   .  |.  ..| ||. . .|    ||. |.| |...| 
HTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 23998.AA Ciliate-E1 231-355 22 8.8e-19 58.07 In-house 62-202 (202) Show / Hide 
Range on Protein: 231-355
Range on HMM: 62-202/202
Sequence Identity: 22% (32 aa)

KIIITDEKSFFVMEMELCEQNLKQLFD----------YLRKTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFAS
..|. |.  ...  .|.|...||. ..          . .. .  ... |. |..|...||. ||..||.||||||.| |.. .  | ..    |.| ..
DYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISK

AVTKSKSYYLSKKGTDTYFAPEVEKG----------QSRIQSDLF
   ... ..  .||  .|..|. ..           .  ..||..
FLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 23998.AA TKL 273-364 21 3.4e-18 62.14 In-house 137-282 (364) Show / Hide 
Range on Protein: 273-364
Range on HMM: 137-282/364
Sequence Identity: 21% (32 aa)

IAIQMLEGLNTLHI--------KNIMHRDIKPHNFLVCPSQT----------YGFTIKICDLGFASAVTKSKSYYLS-------------------KKGT
.|...  |.| ||         ..| |||.|..| ||    |          .  ..||||.|..  ...|..   .                   . ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DTYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
  . ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 23998.AA TyrKc 147-426 20 6.8e-10 -62.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 147-426
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

LQNFEYLSSGAYALVLKAKNIKKNRIVALKFLTCTSKEGLKGIESLKKEYELLQKF-SQSDFLVNVYDCFYLMDQDVEEDKDGKEKIIITDEKSFFVMEM
..  . | .||.  | |.. .   . || | |   .      .| . .| ... |.  . . .|. | .                   . .|  . ||| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----------FMYIEPLMIVMEY

ELCEQNLKQLFDYLRKTQL-PSQEIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAVTKS------KSYYLSKK--GTD
  .  .||   |||||..   . . .  ...|  .| . || ||. |||.   | ||   .    |.||.| | . ...        |.|| .|.  |..
-MPHGDLK---DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

T-----YFAPEVE-KGQSRIQSDLFSLGLVLLELDNL-NVLNEN-----WIDFDIKGEIYQGRGIASKYQIDR---------NSNIYKIAEICLKPNYLE
|       |||.  .|   ..|| .| | .. |.  .     ..       ....   . ||.      | .           . .|.| . | . .  .
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RTTSGDLLSEL
| |  .. ...
RPTFSEIHECF
Kinase 23998.AA Ciliate-E1 153-217 22 1.7e-08 24.2 In-house 1-66 (202) Show / Hide 
Range on Protein: 153-217
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

LSSGAYALVLKAKNIKKN-RIVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFYL
...| ...|.|||... | . ||.|.  |  ..    .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 23998.AA Ciliate-E2 147-221 13 7.4e-05 12.58 In-house 1-107 (365) Show / Hide 
Range on Protein: 147-221
Range on HMM: 1-107/365
Sequence Identity: 13% (15 aa)

LQNFEYLSSGAYALVLKAKNIKKNRIVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
    . . .|... | |.|..|... .|.|. . .                 .. .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMDQD
||. .|..
CFQEKDDN
Kinase 23998.AA Ciliate-E3 153-216 23 0.004032 5.92 In-house 7-72 (202) Show / Hide 
Range on Protein: 153-216
Range on HMM: 7-72/202
Sequence Identity: 23% (16 aa)

LSSGAYALVLKAKNIKKNRIVALKFLTCTSKEG---LKGIESLKKEYELLQKFSQSDFLVNVYDCFY
|  | . .| || .   |..|| | ..|. .     .     . .|  . |..  | ..| ..| .|
LGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYY
Kinase 23998.AA Pkinase_Tyr 308-339 28 2.836864 1.55 Pfam 147-176 (270) Show / Hide 
Range on Protein: 308-339
Range on HMM: 147-176/270
Sequence Identity: 28% (9 aa)

GFTIKICDLGFASAVTKSKSYYLSKKGTDTYF
....|||| | | ..  ...|| ..|.... .
NNVVKICDFGLARDI-YNDDYY-YRKRGGGKL
Kinase 23998.AA C8 513-732 46 2.1e-101 343.17 In-house 1-226 (226) Show / Hide 
Range on Protein: 513-732
Range on HMM: 1-226/226
Sequence Identity: 46% (114 aa)

VNNFQILNFGNYGMVLSTKKVEFNNKEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCS-----------CSLQE-
.||||.|.||.|||||..|.|. .|.|||||.||....|.|||...||.....|.|.|.||.|..|.....|.|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQGKDRELSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EVKLCDFGLSTQLEKNCEQIEILDVNYLVNMQLSR
          |.||. |. ..|.|.|..||||.||.||||||.||.||||||.|||||||.|.. |.||||||...|..||...|.. ..|         
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT--------

NFNISQMVGNWAYMAPEILTKNKDDQYKIYSKKSDSYSVGLLL
       .|.|||.||||..| .|.|||.|...||..||||.|
-------CGTWAYFAPEIEKK-QDNQYKQYRIQSDLFSVGLVL
Kinase 23998.AA Ciliate-C8 522-732 38 6.9e-99 334.82 In-house 1-238 (238) Show / Hide 
Range on Protein: 522-732
Range on HMM: 1-238/238
Sequence Identity: 38% (98 aa)

GNYGMVLST------KKVEFNNKEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEK-----------------YVVFELEKCS--C
|..||||..      .||.....|.|.||||...|.||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQEYLER-QGKDRELSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLEVKLCD------FGLSTQLEKNCE---------QIEILDV
.|..|..| . |. ..|...|..||||.||||||.|||||.||||||.|||||.| ..|...||||      ||...||.||..         .......
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

NYLVNMQLSRNFNISQMVGNWAYMAPEILTKNKDDQYKIYSKKSDSYSVGLLL
..               .|||.|.|||...| ...|..|.|||||||||||.|
YF---------------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23998.AA C2 537-745 28 6.7e-41 137.5 In-house 15-245 (245) Show / Hide 
Range on Protein: 537-745
Range on HMM: 15-245/245
Sequence Identity: 28% (69 aa)

NKEIVLKIQKIVD-----EQEIQNEIRIMQQLK-TPLVVQLYD-------NYII------EKATAPEK----------YVVFELEKCSCSLQEYLERQGK
|....||||.. .     ..|.|.|..||.|..  |.....|.       . ..      |.    |.           ||.|.|.|.. |. |..|. |
NRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEFCQGNLKQYFNRCRK

DR-ELSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EVKLCDFGLSTQLEKNCEQIEILDVNYLVNMQLSRN-FNISQMVGNWAY--
.  ......|  .|||..||.||.|.|.|.||||||.|||. .| ...  .||||. .  |  |        |.     .... .  ..|....  .|  
QNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQK-K-------CDFDFASKLKYNKSRIHFSKFKWTQQYYQ

--MAPEILTKNKDDQYKIYSKKSDSYS-VGLLLSLLDNYLNLKENT
  .|||.       . .|| |.|| .| ||. |  |||      . 
HIFAPEV-------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 23998.AA CAMK 518-732 18 2.8e-31 97.46 In-house 1-324 (425) Show / Hide 
Range on Protein: 518-732
Range on HMM: 1-324/425
Sequence Identity: 18% (59 aa)

ILNFGNYGMVLSTKKVEFNN-----------KEIVLKI---QKIV----------------------------DEQEIQNEIRIMQQ-------LKTPLV
.|  |..| |   .  . ..           ..   ||   .|.                             |......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYIIEKA--------TAP------EKYVVFEL---EKCSC-----SLQEYLERQGK------------DRELSDEEKLNIAIQVIDSVNYIHCFN
..||. |  ..         |        .|.... .   | ||       | .|. ..|.            .. .. .|   .  |... |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNFLVCLDG--------------NQLEVKLCDFGLSTQLEKNCEQIEILDVNYLVNMQLS------RNFNISQMVGNWAYMA-PEILTKNKD
|.|||.||.| |.. ..              |.  .|..|||........ ..  . |..    |  .       .   . ..|  .||| ||.| ... 
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

DQY--------KIYSKKSDSYSVGLLL
...        . |..|.|  |.| .|
CNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 23998.AA S_TKc 516-804 21 6.6e-26 93.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 516-804
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FQILNF---GNYGMVLSTKKVEFNNKEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCSC---SLQEYLERQGKDR
..||.    | .| |   ....  ...  .|| |    . |..||.|... . | .|.||| .         ... . .| |.    .| .|....|. .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---LSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEVKLCDFGLSTQLEKNCEQIEILDVNYLVNMQLSRNFNISQMVGNWAYMAPE
    ..  .   .. |... ..|.|  .|||||.||.| |..      ..|.|||||..||                          . ..|   |||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------------------TTFCGTPWYMAPE

ILTKNKDDQYKIYSK-KSDSYSVG-LLLSLLDNYLNLKENTGFTFMMMTLNQFQEPFKKQKINIKRDTEIFKFIQLLVVWERVKRASLSIIVE----QNS
.|          |.| |.| .|.| .|  .|  |     .   .| ..                  . |   ||. . ...  || .   . .     ..
VL---------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

KKFK
  . 
HPWF
Kinase 23998.AA CMGC 513-670 15 3.7e-25 78.82 In-house 1-257 (513) Show / Hide 
Range on Protein: 513-670
Range on HMM: 1-257/513
Sequence Identity: 15% (41 aa)

VNNFQILNFGNYGMVLSTKKVE-------------FNNKEIVLKIQKIVDEQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  | ||.| . .  .              .|... .|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYIIEKATAPEK-----------YVVFELEKCSCSLQEYLERQG------KDRELSDEE------------KLNIA------IQVIDSVN--YI
.|.||| .  .. . .|.           .. .  | . ..| .|....       . ..||. .            . ..        |.. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LEVKLCDFGLSTQLEKN
|  .  |||||.|| | |.. ..                    ..|.|||||.......
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 23998.AA Ciliate-E2 513-732 21 1.9e-24 80.82 In-house 1-286 (365) Show / Hide 
Range on Protein: 513-732
Range on HMM: 1-286/365
Sequence Identity: 21% (65 aa)

VNNFQILNFGNYG-----MVLSTKKVE-----------------FNNKEIVLKIQKIVDEQEIQNEIRIMQ----------------QLKTPLVVQLYDN
 .  ... .||.|      | ...| .                 ...|.. .||.|  . ..| .||.||.                ||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YIIEKATAPEKYVVFELEKCSC-SLQEYLERQGKDR--------ELSDEEKLNIAIQVID---------------SVNYIHCFN-IIHRDIKPDNFLVCL
.. ..    .... . .| |.  .|..|.. . | |         ....| ..|  |...                ..|.|  | ||||||||.| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEVKLCDFGLSTQL-EKNCEQIEILDVNY-LVNMQLSRNFNISQM------------VGNWAYMAPEILTKNKDD---QYKIYSKKSDSYSVGLLL
      .|..|||||... ..|..... .  .. . . .  ..  .. |            .|.  ||||||| . |.|   . | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 23998.AA Ciliate-E1 519-670 26 7.9e-24 74.68 In-house 1-162 (202) Show / Hide 
Range on Protein: 519-670
Range on HMM: 1-162/202
Sequence Identity: 26% (45 aa)

LNFGNYGMVLSTKKVEFNNKEIVLKIQKIVDEQE-------IQNEIRIMQQLKTPL-VVQLYDNYIIEKATAPEKYVVFELEKCSCSLQEYLE-------
.  | ...|.  |. . |.... .||... . ..       |.... ||. .|.   ..|..| ..|...    .  .. .|.|.|||..||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQGKDRELSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEVKLCDFGLSTQLEKN
    | .. ......|..|..| || ....| .|||||||||.| |.. . ...  ..||||.| .| .|
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNY--VYCDFGISKFLKNN
Kinase 23998.AA Pkinase 513-732 24 1.7e-23 84.19 Pfam 1-202 (293) Show / Hide 
Range on Protein: 513-732
Range on HMM: 1-202/293
Sequence Identity: 24% (57 aa)

VNNFQILNFGNYGMVLSTKKVEFNNKEIVLKIQKIVDEQEIQN-------EIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCSC-----SLQE
    ...  |..| |   ...  ..|. ..|| | ..| . ..       ||.||. |. | .|.||| .        .... . .| | .     .| .
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQGKDREL--SDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL--EVKLCDFGLSTQLEKNCEQIEILDVNYLVNMQLSRNFNISQM
|...  ... .  |..|  ... |..  ..|.|  .|||||.||.|.|.  . ...   ||.|||||. |..                  . .|   .  
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------------------Y-NNS-MTTF

VGNWAYMAPEILTKNKDDQYKIYSKKSDSYSVGLLL
.|   |||||..       .. |..|.| .|.|..|
CGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCIL
Kinase 23998.AA STE 514-732 20 7e-23 77.7 In-house 1-258 (359) Show / Hide 
Range on Protein: 514-732
Range on HMM: 1-258/359
Sequence Identity: 20% (59 aa)

NNF-QILNFGNYGMVLSTKKVE-----FNNKE---------IVLKIQKIVD--------------------EQEIQNEIRIMQQLK--TPLVVQLYDNYI
  . ...  |..| |   ....      ....         .  |. .. .                    .|.|..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQEYLE-RQGKDRELS----------DEEKLNIAIQVIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLEVKLCD
 |   .    | ... |.  ..  || . .. . |. ..|.           ..   |. |..    .|.|  .||||||||.| |.        |||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSTQLEK-----------NCEQIEILDVNYLVNMQLSRNFNISQMVGNWAYMAPEILTKNKDDQY-KIYSKKSDSYSVGLLL
||...||..           .|    |          ...  .   .||   .||||....|. . . | |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDC----I----------ETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTI
Kinase 23998.AA TKL 616-732 23 8.6e-23 78.9 In-house 134-279 (364) Show / Hide 
Range on Protein: 616-732
Range on HMM: 134-279/364
Sequence Identity: 23% (36 aa)

KLNIAIQVIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLEVKLCDFGLSTQLEKNCEQIEIL-------DVNYLVNMQLSR
....|...   .|| |  |        |||||.|..| ||  ...           .  .|.||||||. .... ..  .                | ..
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE------HQ-NN

NFNISQMVGNWAYMAPEILTKN-KDDQY---------KIYSKKSDSYSVGLLL
. . .  .|. ..||||.| .. .....         . ||.|.| || |..|
RKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 23998.AA Ciliate-E3 551-670 38 2.3e-18 54.15 In-house 47-159 (202) Show / Hide 
Range on Protein: 551-670
Range on HMM: 47-159/202
Sequence Identity: 38% (47 aa)

QEIQNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCSC-SLQEYLERQGKDRELSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCL
|. |.|.   ||..   ||. .| |  ..       .| |.  ||  .|..|.    |. ... .. . |.||.| ..  ||  |||| ||||||.||  
QKTQQEFQNCQQINSQNVVKCHDQYYDQQNKM--IFIVQEY--CSNGDLYHYI----KQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDK

DGNQLEVKLCDFGLSTQLEKN
  ||| .| ||||.| || ||
NNNQLIIKICDFGESKQLRKN
Kinase 23998.AA Pkinase_Tyr 551-664 29 0.001787 12.39 Pfam 48-158 (270) Show / Hide 
Range on Protein: 551-664
Range on HMM: 48-158/270
Sequence Identity: 29% (35 aa)

QEIQNEIRIMQQL-KTPLVVQLYDNYIIEKATAP-EKYVVFELEKCSCSLQEYLERQ-GKDRELSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNFLV
..  .|..|| || . | .|.||   .. .   | . |.|.|. ..  .| .|| ..   .. |. ...|....|. .  .| .  |.||||.   | ||
EDFMREAKIMKQLGHHPNIVRLY--GVCTDQGEPNQIYIVMEYMPHG-DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLV

CLDGNQLEVKLCDFGLS
     .. || |||||.
TE---NNVVKICDFGLA