Gene 6998 (Tetrahymena)

6998

Species: Tetrahymena
Alias: 258.m00017, TTHERM_01156760, PreTt06998, 6998, 778
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
6998.AA Protein None 1242 None Fasta, JSON
6998.kin_dom Protein Kinase Domain None 202 None Fasta, JSON
6998.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
6998.NA RNA None 3729 None Fasta, JSON

Protein domain

Protein domains of 6998.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6998.AA C8 42-256 61 5.6e-121 408.22 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 61% (140 aa)

FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEKSFFVMEME
|.. .|||.|||..||||||...|| ..|||....|..| ..||||.|||||.|.| |.||.||.|||||.|.|..||....|||...|||||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCKQNLKQLFDFFRNTQSP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKSKSHYLSKK----GTDAYFAP
||.||||||.|..||.| . ..|.|| |||||..|.|..|.||||||||||||||| ..|.|||.|||||.||||.|.|.|||..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEKG------QSRIQSDIFSLGLVL
|.||.      |.|||||.||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 6998.AA Ciliate-C8 51-256 55 8.9e-120 404.23 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 55% (132 aa)

GAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEK---SFFVMEMELCKQN-
||...||||.|...||.|||||....|... |..|...|||||...| |..|.|.||||||||||...||..||.|.. |.||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFFRNTQSP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCD------LGFASAVTKSKSHYLSKK--GTDAY---
 |||.||..|..||.  ...||.|||||....|.||..||||||||||||||...|.|..||||||      .||||...|.||||.|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEKGQSRIQSDIFS-------LGLVL
        |||||||.||||||||||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 6998.AA C2 51-269 37 2e-67 229.32 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 37% (93 aa)

GAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEK---------SFFVMEME
|| .||||| | ..||.||||  .  .. | || ... |||......  . ....||..||| ... | ..| |.  . ..|.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCKQNLKQLFDFFRNTQ-SPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCD----------LGFASAVTKSKS-HYLSK-K
 |. |||| |.  |. .  | ...|...||||. . | || ..| |||||| |||.. .|    ||||||          . |||.. ..||  . || |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEKGQSRIQSDIFS-LGLVLLELDNLNVLNDNW
.| .|    |||||...  . .||.|| .|.||||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 6998.AA Pkinase 42-259 23 1.4e-31 112.78 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 23% (55 aa)

FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIK-KEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEKSFFVMEM
.. .. . ||... | |...  ...|||.| .   ....   .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCKQNLKQLFDFF------RNTQS--PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAV-TKSKSHYLSKKGTD
|.|   |. ..| |      |..    ...|.| ..  |.|.||. .| ..|.|||.|| |.|..   . . ..|.|| |.|  . . ..| . .  || 
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

AYFAPEV--EKGQSRIQSDIFSLGLVLLEL
 | ||||  .       .|..|.|..| |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 6998.AA CMGC 42-224 15 7.9e-28 87.77 In-house 1-285 (513) Show / Hide 
Range on Protein: 42-224
Range on HMM: 1-285/513
Sequence Identity: 15% (47 aa)

FQDLEYLSSGAYALVLKAKN--------------TQENRIVALKFLTST-NQEDAN------GIE-SIKKEYEMLQKFG---------------QSDF-L
.. .... .|.|. | |...              .. |.|||.| . .  ..|.|       |.  ..  | ..|...                . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYDCFYLMEEDVEEDE-----EGNEKTILTEEKSFFVMEMELCKQNLKQLFDFFR-------NTQSPPNE------------IKEVI-----AIQMLE
|. ||.||  ..| .|.|               .   . . .|.. ..|.|. .  .       .   .. .            ||  .     . |.|.
VKLYDIFYHKNSDGNEYEDKHIIS-------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILR

GLN--NLHVKN--IMHRDIKPHNFLVSPSQTY----------------GFTIKLCDLGFASAVTKS------------------------KSHY
||.   .| ..  |.|||.|| | |...  ..                 ...|.|| |.| .. .                          .||
GLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHY
Kinase 6998.AA STE 42-259 20 3.9e-27 92.92 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 20% (57 aa)

FQDLEYLSSGAYALVLKAKNT------QENRI---------VALKFLTSTNQE----------DANG----IESIKKEYEMLQKFGQ-SDFLVNVYDCFY
....| . .||.  | ||.|       . ...         .| | .   |..          . |     ...|.|| ....|. . ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEDVEEDEEGNEKTILTEEKSFFVMEMELCK-QNLKQLFDFFRNTQSPP-----------NEIKEVIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVSP
   ..             .....   . ||..    | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFTIKLCDLGFASAVTKS----------------KSHYLSKKGTDAYFAPEVEKG-QSR------IQSDIFSLGLVLLEL
       .|||| |... .|.|                ...  .  ||  . |||| .. ..       ...|| |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 6998.AA Ciliate-E2 42-259 17 4.3e-26 86.54 In-house 1-289 (365) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-289/365
Sequence Identity: 17% (57 aa)

FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTN------------------QEDANGIESIKKEYEMLQ---------------KFGQSDFLVNVYD
.  .. . .|... | |.|. .... .|.|. . ..                  .   |.||.||.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFY-------------LMEEDVEE-----DEEGNEK----TILTEEKSFFVMEMELC----KQNLKQLFDFFRNTQSPPNEIKEVIAIQMLEGLNNLHVK
||.             .   | ..     .   |..      .||..  ..|.  |     |.                    | .. .....|. || |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA--------------------EFYIACIILALEYLHSK

N-IMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKS---------KSHYLSKK-----------------------GTDAYFAPEVEKGQSR-----
| |.|||||| | |.         ||..|.|..  ....            |.  |                       ||  | |||. .|..      
NNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK

-----IQSDIFSLGLVLLEL
      ..||.||| .| |.
QKGYDYKCDIWSLGVILYEM
Kinase 6998.AA S_TKc 42-322 21 1.9e-22 81.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEKSFFVMEME
.. |. . .||.. | |....  .||||.| .           |.|..| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCKQNLKQLFDFFRNTQS-------PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKSKSHYLSKKGTDAYF
.| ..|  |||. .. ..       |. ... ... |....|. .| ..|.|||.|| | |..       .||.|| |.|  .        .  ||  | 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYM

APEVEKGQSRIQSDIFSLGLVLLELDNLNVLNDNWIDLDTKAEIHKGKAIASKYQIDRKSNIYKIAEICLKPNYLERKSSGDLLY--------ELI
||||  | ..  .|. |.| .| |.     . .     . .. ..| .           .    . . ||. .  .| .  ..|         . .
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6998.AA CAMK 47-256 14 4.7e-22 67.23 In-house 1-324 (425) Show / Hide 
Range on Protein: 47-256
Range on HMM: 1-324/425
Sequence Identity: 14% (48 aa)

YLSSGAYALVLKAKNTQEN------------RIVALKFLTSTNQED-------------------------ANGIESIKKEYEMLQKFG------QSDFL
 | .|... | ...... .            . || |..  .   |                         ..  .....|.|...|        .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY-------LMEEDVEEDEEG-NEKT-ILTEEKSFFVMEM---ELCKQN--LKQLFDFFR-NTQ---------------SPPNEIKEVIAIQML
.. |. .                .. . . .. .  . .....| |   |.|     .  |||. . ...                .  | . ..  |..
IKLYEVYEDPHYFKNT-------ND-YET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QIC

EGLNNLHVKNIMHRDIKPHNFLVSPSQTYG-------------FTIKLCDLGFASAVTKSKSHYLS-----------------------KKGTDAYFA-P
.... .| .||.|||.|| | |.. . .               ..||..| |||  ...... .                           || .| | |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EVEKG-------------QSRI--QSDIFSLGLVL
|| .|             .  .  ..|. |.| .|
EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 6998.AA TKL 168-259 21 5.5e-21 72.32 In-house 137-282 (364) Show / Hide 
Range on Protein: 168-259
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLVSPSQT----------YGFTIKLCDLGFASAVTKSKS-------------------HYLSKKGT
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|.||.|..  ...|..                   .  .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EKGQSRIQSDIFSLGLVLLEL
 .. ||||                 ....   ..|..| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 6998.AA Ciliate-E3 162-260 36 3.7e-19 56.65 In-house 103-202 (202) Show / Hide 
Range on Protein: 162-260
Range on HMM: 103-202/202
Sequence Identity: 36% (37 aa)

NEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKSKSHYLSK-KGTDAYFA-PEVEK-GQSRIQSDIFSLGLVLLE
|.|.. |.||...|.  .| ||| | |||| |.||. ..    .|| ||.| .    | | |   .  |.  ..| ||. . .|    ||. |.| |...
NIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQ-LIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQ

LD
| 
LC
Kinase 6998.AA Ciliate-E1 131-250 22 1.6e-16 50.63 In-house 67-202 (202) Show / Hide 
Range on Protein: 131-250
Range on HMM: 67-202/202
Sequence Identity: 22% (32 aa)

EEKSFFVMEMELCKQNLKQLFD---------FFRNTQSPPNEI-KEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKS
..  ...  .|.|...||. ..          ....|   ..  |. |..|...||. || .||.||||||.| |.. .  | ..    |.| ..   ..
DQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNN

KSHYLSKKGTDAYFAPEVEKG----------QSRIQSDIF
. ..  .||   |..|. ..           .  ..|||.
QNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 6998.AA Ciliate-E1 48-112 22 2.5e-07 20.39 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

LSSGAYALVLKAKNTQEN-RIVALKFLTSTNQEDANGIESIKKEYE-MLQKFGQSDFLVNVYDCFYL
...| ...|.|||. . | . ||.|.     ... | .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 6998.AA Ciliate-E3 42-111 24 4e-06 15.56 In-house 1-72 (202) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-72/202
Sequence Identity: 24% (18 aa)

FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQED---ANGIESIKKEYEMLQKFGQSDFLVNVYDCFY
.  .  |  | . .| || ..| |..|| | .. .|| .           .|  . |..  | ..| ..| .|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYY
Kinase 6998.AA TKL 48-77 26 0.268825 0.44 In-house 1-38 (364) Show / Hide 
Range on Protein: 48-77
Range on HMM: 1-38/364
Sequence Identity: 26% (10 aa)

LSSGAYALVLKAKNTQEN--------RIVALKFLTSTN
. ||... | |.|  ...        . || | . |.|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHN
Kinase 6998.AA C8 390-591 48 2.8e-103 349.43 In-house 1-226 (226) Show / Hide 
Range on Protein: 390-591
Range on HMM: 1-226/226
Sequence Identity: 48% (110 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCS-----------CSLQD-
.||||.|.||..||||..|.|. .|.||.||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCDFGLSVQLGKDCEQIEVQCM--VGNMTYSA
          |.||..|...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. ||||||||.. |..|....|. . |  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEIIAKEDDQNKIYSKKSDSYSVGLLL
|||..|.|.|.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 6998.AA Ciliate-C8 399-591 40 1e-98 334.25 In-house 1-238 (238) Show / Hide 
Range on Protein: 399-591
Range on HMM: 1-238/238
Sequence Identity: 40% (97 aa)

GSFGMVLST------KKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.|...|...||||.....||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLD-GNQLEIKLCD------FGLSVQLGKDCE---------QIEVQCM
.|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..|||||      ||.. || |...         ......|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNMTYSAPEIIAK-EDDQNKIYSKKSDSYSVGLLL
  .||..|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 6998.AA C2 399-591 30 1.5e-48 163.94 In-house 1-232 (245) Show / Hide 
Range on Protein: 399-591
Range on HMM: 1-232/245
Sequence Identity: 30% (73 aa)

GSFGMVLSTKKVNLN-NKEIALKIQKIVN-----DQEIQNEIRIMQQLK-TPLVVQLYD-HYVIEKATAP------------EK----------YVVFEL
|.||.||  |  | . |...|||||..        .|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.
GAFGLVL--KAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQ

EKCSCSLQDYLERQTKEG-EFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCD----------FGLSVQLGKDCEQIEVQCM
|.|.. |. |..|..|.  ......|  .| |..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  | .. ..| .. .
EFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKF

VGNMTY----SAPEIIAKEDDQNKIYSKKSDSYS-VGLLL
..  .|    .|||..       .|| |.|| .| ||. |
KWTQQYYQHIFAPEVYQ------NIYKKNSDLFSTVGYVL
Kinase 6998.AA CAMK 395-591 19 4.7e-38 119.7 In-house 1-324 (425) Show / Hide 
Range on Protein: 395-591
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ILNFGSFGMVLSTKKVNLNN-----------KEIALKI---QKIV----------------------------NDQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  | ..           .. | ||   .|.                             . .....||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDHYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQTK------------EGEFSDEQKLNIALQIIDSVNYIHCFN
..||..|  ..         |        .|.... .   | ||       | ||. ....            .| |. ..   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVCLDG--------------NQLEIKLCDFGLSVQLGKDCEQI---------------------EVQCMVGNMTYSA-PEIIAKE----
|.|||.|||| |.. ..              |.  ||..|||.. .. .. ..                        . ..|   | | ||.. ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DDQNKIYSKKSDSYSVGLLL
     |.... |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 6998.AA S_TKc 393-661 24 2e-32 114.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 393-661
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FQILNF---GSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC---SLQDYLERQTKEG
..||.    |.|| |   ....  ... |.|| |    . |..||.|... . | .|.|||...        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSK-KS
    |.  .   .. ||.. ..|.|  .|||||.|||| |..      .||.|||||. ||           ..|   | |||..         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILNEIVGITFPSMAFEQQNEPFNNINIKRNSEIFKFIKLLVVWERVNRASLSTIVE----QNTNQFK
| .|.| .|  .|  |                 |... |..|     .|   ||. . ...  .| .   . .     .  .. 
DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6998.AA Ciliate-E1 396-585 28 1.1e-31 100.46 In-house 1-202 (202) Show / Hide 
Range on Protein: 396-585
Range on HMM: 1-202/202
Sequence Identity: 28% (60 aa)

LNFGSFGMVLSTKKVNLNNKEIALKIQKIV---N----DQEIQNEIRIMQQLKTPL-VVQLYDHYVIEKATAPEKYVVFELEKCSCSLQDYLE-------
.  |||..|.  |. | |....|.||...    |    ..||.... ||. .|.   ..|..| . |...    .  .. .|.|.|||.|||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEII---AKEDDQ
    |.....|...||..|. |.|| ....| .|||||||||.| |.. . ... .   |||.| .| .  .|  ..    .. |. ...      | ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

NKIYSKKSDSY
|.....||| |
NQKINYKSDIY
Kinase 6998.AA Pkinase 390-591 27 9.2e-30 106.32 Pfam 1-202 (293) Show / Hide 
Range on Protein: 390-591
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQN-------EIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-----SLQD
    ...  |||| |   .... ..|. |.|| | ... . ..       ||.||. |. | .|.||| .        .... . .| | .     .| |
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQTKEGEF--SDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL--EIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDD
|...  ..| |  |...  ....||.  ..|.|  .|||||.||||.|.  . ...   .|.|||||. |.     .   .  .|   | |||.|     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

QNKIYSKKSDSYSVGLLL
 .. |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 6998.AA CMGC 390-541 17 1.5e-29 93.53 In-house 1-251 (513) Show / Hide 
Range on Protein: 390-541
Range on HMM: 1-251/513
Sequence Identity: 17% (44 aa)

VNNFQILNFGSFGMVLSTKKVNLN-------------NKEIALKIQKIVNDQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  . |             |...|.|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDHYVIEKATAPEK-----------YVVFELEKCSCSLQDYLERQT--KEG----EFSDEQ------------KLNIA------LQIIDSVN--YI
.|.|||... .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPENFLVCLDGNQ-----------------LEIKLCDFGLS
|  .  |||||.|||| |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 6998.AA Ciliate-E2 390-591 22 1.3e-27 91.79 In-house 1-286 (365) Show / Hide 
Range on Protein: 390-591
Range on HMM: 1-286/365
Sequence Identity: 22% (67 aa)

VNNFQILNFGSFG-----MVLSTKKVN-----------------LNNKEIALKIQKIVNDQEIQNEIRIMQ----------------QLKTPLVVQLYDH
 .  ... .|.||      | ...|                    ..|..|.||.|  . ..| .||.||.                ||. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKATAPEKYVVFELEKCSC-SLQDYLERQ-TKE-------GEFSDEQKLNIALQIID---------------SVNYIHCFN-IIHRDIKPENFLVCL
.  ..    .... . .| |.  .|.||.. . .|.       . |.... ..|  ||..                ..|.|  | |||||||||| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEIKLCDFGLSVQLGKD---CEQIEVQCM---------------------------VGNMTYSAPEIIAKEDDQN----KIYSKKSDSYSVGLLL
      ||..||||| .. .|   . .  .||                            .|.  | ||||. .....|    | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 6998.AA STE 391-591 22 4.8e-25 85.44 In-house 1-258 (359) Show / Hide 
Range on Protein: 391-591
Range on HMM: 1-258/359
Sequence Identity: 22% (60 aa)

NNF-QILNFGSFG-MVLSTKKVNL-------------NNKEIALKIQKIVN--------------------DQEIQNEIRIMQQLK--TPLVVQLYDHYV
  . ...  |.||  ..  .. |              ... .| |. .. |                     |.|..||.||....   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQDYLER--QTKE---------GEFSDEQKLNIALQIIDS-VNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCD
 |   .    | ... |.  ..  || | ...   ...         . |. .|   |. ||.    .|.|  .|||||||| | |.        .||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSVQLGKDCE------------QIEVQC--MVGNMTYSAPEIIAKEDDQ-NKIYSKKSDSYSVGLLL
||.. || ...              .  ..  .||   . |||.| ...   .| |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 6998.AA TKL 491-591 24 1.5e-24 85.37 In-house 132-279 (364) Show / Hide 
Range on Protein: 491-591
Range on HMM: 132-279/364
Sequence Identity: 24% (36 aa)

EQKLNIALQIIDSVNYIHCFN--------IIHRDIKPENFLVCLDGN-----------QLEIKLCDFGLSVQLGKDCEQIEVQCM---------------
.|....||.|   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  . .. ..   . .               
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

--VGNMTYSAPEIIAKEDDQNK-----------IYSKKSDSYSVGLLL
  .|.  . |||.. .... ..            ||.|.| || |..|
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 6998.AA Ciliate-E3 394-595 35 1.2e-16 48.65 In-house 5-202 (202) Show / Hide 
Range on Protein: 394-595
Range on HMM: 5-202/202
Sequence Identity: 35% (75 aa)

QILNFGSFGMVLSTKKVNLNNKEIALKIQ--KIVND-------QEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-SLQDYLERQT
|||. |.|| |      . ||...| | .  .  ..       |. |.|.   ||..   ||. .| |. ..       .| |.  ||  .|. |.  | 
QILGCGQFGRVYKAFDFQ-NNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKM--IFIVQEY--CSNGDLYHYIKQQN

KEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDC--EQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSKK
|    . .  . |. ||| ..  ||  |||| ||||.|.||    ||| || ||||.| || |.    .   | .     |.|||.    .||..| || 
K----TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWT--PFYAAPEQ----NDQQQI-SKE

SDSYSVGLLLSLLD
|| ||||  . .| 
SDYYSVGAVFCQLC
Kinase 6998.AA TyrKc 390-656 19 2.8e-11 -40.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 390-656
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQK-IVNDQEIQNEIRIMQQL--KTPLVVQLYDHYVIEK----ATAPEKYVVFELEKCSCSLQDYLERQ
.   ..|  | || |   .       . | |  |     ... .|.||| .|  . | .|.||  .....      ..  ..|.|. .   .|.||| . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

TKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKD------CEQIEV----QCM-VGNMTYSAPEIIAKE
 ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..    .| .|||||  .. |       . . .    ..  .      ||| |   
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

DDQNKIYSKKSDSYSVGLLL-----------SL-----LDNYLILNEIVGITFPSMAFE----QQNEPFNNINIKRNSEIFKFIKLLVVWERVNRASLST
  . .... ||| .| | ..           .      ..|. ... .     .    .         |        .|... .|     .  .| . |.
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----F----VCCPDEMYQIMKQCWHEDPEDRPTFSE

IVEQN
|.|. 
IHECF