Gene 13336 (Tetrahymena)

13336

Species: Tetrahymena
Alias: 38.m00171, PreTt13336, 267, 13336, TTHERM_00359230
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
13336.AA Protein None 802 None Fasta, JSON
13336.kin_dom Protein Kinase Domain None 213 None Fasta, JSON
13336.kin_dom2 Protein Kinase Domain None 214 None Fasta, JSON
13336.NA RNA None 2409 None Fasta, JSON

Protein domain

Protein domains of 13336.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13336.AA C8 42-275 57 5.1e-119 401.7 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-275
Range on HMM: 1-226/226
Sequence Identity: 57% (142 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTNKEDKNSIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEKSYFVMEME
|.||.|||.|||..||.|.|.|.||...|||....||.|.. |||..|||||.|.|.|.||.||.|.|||.|.|..||....|||.|.|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCQQNLKQLFDFLRSTQLP-AKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCHSQTYGFTIKLCKKFEFLQNLSIQKIIENQGDLGFASAVTKSK
||.||||||.|..| .|..  ||.||||||||..|.|..|.|||||||||||||||| .|.|||.||||                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYISKK----GTDAYFAPEVENG------QSRIQSDLFSLGLVL
||..|||    ||.||||||.|..      |.||||||||.||||
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13336.AA Ciliate-C8 51-275 54 2.7e-117 395.97 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-275
Range on HMM: 1-238/238
Sequence Identity: 54% (138 aa)

GAYAVVLRAQNTKENRTVALKFLTYTNKEDKNSIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEK---SYFVMEMELCQQN-
||...||.|||.|.||.|||||.. .||..|| .|...|||||...|.|..|.|.|| ||||||||..||.|||.|.| |.||   |.||||||.|||| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRSTQLP-AKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCHSQTYGFTIKLCKKFEFLQNLSIQKIIENQGDLGFASAVTKSKSHYI
 |||.||..| .|..  ...||||||||....|.||..||||||||||||||| .|.|..|||||. |     . .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTDAY-----------FAPEVENGQSRIQSDLFS-------LGLVL
|||  |||.|           ||||||..|||||||.||       .||||
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13336.AA C2 51-288 37 3.7e-59 200.72 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-288
Range on HMM: 1-245/245
Sequence Identity: 37% (96 aa)

GAYAVVLRAQNTKENRTVALKFLTYTNKEDKNSIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEE-DEDGNEKVVLTDE--------KSYFVMEME
|| . || | | |.||.||||  .  .  | |  ... |||....... . ....|| .||| ... |  ||| .|. .  ..        |. .|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCQQNLKQLFDFLRSTQ-LPAKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCHSQTYGFTIKLC-KKFEFLQNLSIQKIIENQGDLGFASAVTKS
 || |||| |. .|  .  | ...|.|.||||. . | || ..| |||||| |||.  .|    |||||    .. |.          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KS-HYISK-KGTDAY----FAPEVENGQSRIQSDLFS-LGLVLLELDNLKVLNENW
||  ..|| |.| .|    |||||. .  . .||||| .|.||||||| .  . . 
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 13336.AA Pkinase 42-209 19 5.6e-23 82.33 Pfam 1-154 (293) Show / Hide 
Range on Protein: 42-209
Range on HMM: 1-154/293
Sequence Identity: 19% (34 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTNKEDKNSIESLK-KEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEKSYFVMEM
.   . .  |....| .... .....||.| . . .....  .. ..  | ...... .... |  |..|.                     |..  | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCQQNLKQLFDFL------RSTQL--PAKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCHSQTYGFTIKLC
|.|.  |. ..|        |.. .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|. .  . . ..|.|
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 13336.AA CMGC 42-209 16 1.2e-21 67.12 In-house 1-246 (513) Show / Hide 
Range on Protein: 42-209
Range on HMM: 1-246/513
Sequence Identity: 16% (41 aa)

FSNFEYLSNGAYAVVLRAQN--------------TKENRTVALKFLT---YTNK-----EDKNSIESLKKEYEMLQKFS---------------QSDF-L
. . ...  |.|.|| ....              .. |. ||.| .    |..      |  .   .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYECFYLMEENVEEDEDGNE-KVVLTDEKSYFVMEMELCQQNLKQLFDFLRS-------TQLPAKE------------IKEII-----AIQMLEGLN-
|. |..||  ... .|.|| .. .     .  .. . .|.....|.|. .  .          |.  .            || ..     . |.|.||. 
VKLYDIFYHKNSDGNEYEDKHIIS---Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPHNFLVCHSQTY----------------GFTIKLC
  .| ..  |.|||.|| | |..|  ..                 ...|.|
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 13336.AA CAMK 47-209 15 3.6e-19 57.74 In-house 1-238 (425) Show / Hide 
Range on Protein: 47-209
Range on HMM: 1-238/425
Sequence Identity: 15% (39 aa)

YLSNGAYAVVLRAQNTKEN------------RTVALKFLTYTNKEDKN-------------------------SIESLKKEYEMLQKFS------QSDFL
 |  |....| ...... .            . || |..  .   ||.                         . .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYECFYL-----------MEENVEEDEDGNEKVVLT-DEKSYFVM-EMELCQQN--LKQLFDFLRST----------------QLPAKEIKEIIAIQM
.. || .               ...         |. | |.. |.||  ||.|.    .  |||....                  .. .| . ..  |.
IKLYEVYEDPHYFKNTNDYET-SKQ---------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QI

LEGLNNLHVKNIMHRDIKPHNFLVCHSQTYG-------------FTIKLC
..... .| .||.|||.|| | |.... .               ..||..
CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 13336.AA STE 42-209 19 4.6e-17 56.89 In-house 1-189 (359) Show / Hide 
Range on Protein: 42-209
Range on HMM: 1-189/359
Sequence Identity: 19% (41 aa)

FSNFEYLSNGAYAVVLRAQNT------KENRT---------VALKFLTYTNKE--------------DKNSIESLKKEYEMLQKFSQ-SDFLVNVYECFY
. . | . .||. .| .| |       | ...         .| | . . |..              ... .....|| ....|... ... |. | |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEENVEEDEDGNEKVVLTDEKSYFVMEMELCQ-QNLKQLFDFLRSTQLP------------AKEIKEIIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVC
   .|             ......  . ||..    | .. .   ... |             ..|. .|. | |.| |. || ..|.|||||| | |. 
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIA-YICRQILKGLLYYLHSHHIIHRDIKPANILL-

HSQTYGFTIKLC
        .|||
--------VKLC
Kinase 13336.AA S_TKc 42-341 18 6e-16 56.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-341
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTNKEDKNSIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEKSYFVMEME
.   . .  ||...| .....| .| ||.| .           |....| ..|.|  . ...|. |..|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCQQNLKQLFDFLRSTQ-------LPAKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCHSQTYGFTIKLC-----KKFEFLQNLSIQKIIENQGD
.| ..|  |||.... .       .|  ... ... |....|. .| ..|.|||.|| | |...      .||.|     ...                 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------

LGFASAVTKSKSHYISKKGTDAYFAPEVENGQSRIQSDLFSLGLVLLELDNLKVLNENWIDFNIKKEIHEGKAIASNYQIDRNSNIYKIAQICLKPNYLE
               .  ||  | ||||  | ..  .|  |.| .| |.   . . .   .. . | |               .    . . ||. .  .
--------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEK

RTTSGDLLS--------ELI
| |  ..|         . .
RPTA-EALQDEWDIKCHPWF
Kinase 13336.AA Ciliate-E1 136-269 20 2.7e-14 43.33 In-house 72-202 (202) Show / Hide 
Range on Protein: 136-269
Range on HMM: 72-202/202
Sequence Identity: 20% (32 aa)

FVMEMELCQQNLKQLFD---------FLRSTQLPAKEI-KEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCHSQTYGFTIKLCKKFEFLQNLSIQKIIE
..  .|.|...||. ..          ....|   ..  |. |..|...||. || .||.||||||.| |....  | ..                    
CIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------------------

NQGDLGFASAVTKSKSHYISKKGTDAYFAPEVE--------NGQ--SRIQSDLF
   |.| ..   ... ... .||   |..|. .        | .    ..||..
---DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 13336.AA Ciliate-E2 140-278 23 6.8e-13 40.58 In-house 113-289 (365) Show / Hide 
Range on Protein: 140-278
Range on HMM: 113-289/365
Sequence Identity: 23% (48 aa)

MELCQQNLKQLFDFLRSTQLPAKEI---------KEI--IAIQMLE---------------GLNNLHVKN-IMHRDIKPHNFLVCHSQTYGFTIKLCKKF
||.||.  . |||.... ..  ...         |||  |  | |.               .|. || || |.|||||| | |.                
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------

EFLQNLSIQKIIENQGDLGFASAVTKS---------KSHYISKK-----------------------GTDAYFAPEVENGQSR----------IQSDLFS
         |||    |.|..  ....            |.  |                       ||  | |||. ||..            ..|..|
--------IKII----DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGLVLLEL
|| .| |.
LGVILYEM
Kinase 13336.AA STE20 42-115 16 6.5e-10 32.72 In-house 1-82 (288) Show / Hide 
Range on Protein: 42-115
Range on HMM: 1-82/288
Sequence Identity: 16% (14 aa)

FSNFEYLSNGAYAVVLRAQNTKENRT----VALKFLTYTNKEDK-NSIESLKKEYEMLQKFSQSDFLVNVYECFYLM----EE
. ..| . .|.| .| .| ... ..     || | . . ..... ...|...||. .....  .   |. |.... .    .|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDE
Kinase 13336.AA Ciliate-E1 48-112 19 4.9e-08 22.72 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 19% (13 aa)

LSNGAYAVVLRAQNTKEN-RTVALKFLTYTNKEDKNSIESLKKEYE-MLQKFSQSDFLVNVYECFYL
..|| ...|..| . . | . ||.|.  .  ....|......|||  ... | . . ..........
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 13336.AA TKL 168-209 26 1.3e-07 23.52 In-house 137-196 (364) Show / Hide 
Range on Protein: 168-209
Range on HMM: 137-196/364
Sequence Identity: 26% (16 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLVCHSQT----------YGFTIKLC
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|.|
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC
Kinase 13336.AA Ciliate-E2 42-116 15 2.3e-07 21.35 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 15% (17 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTN--------KED----------KNSIESLKKEYEMLQ---------------KFSQSDFLVNVYE
.   . . .|....| .... |... .|.|. . ..        | .          || ||..|.|  ...               .. ....... ||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEN
||. . .|
CFQEKDDN
Kinase 13336.AA TKL 228-278 17 3.3e-05 14.73 In-house 196-282 (364) Show / Hide 
Range on Protein: 228-278
Range on HMM: 196-282/364
Sequence Identity: 17% (15 aa)

GDLGFASAVTKSKS-------------------HYISKKGTDAYFAPEV-----------------ENGQSRIQSDLFSLGLVLLEL
.|.|..  ...|..                   . ... || .. ||||                 ....   ..| .| |.|| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 13336.AA STE20 171-193 52 0.000946 9.93 In-house 125-147 (288) Show / Hide 
Range on Protein: 171-193
Range on HMM: 125-147/288
Sequence Identity: 52% (12 aa)

QMLEGLNNLHVKNIMHRDIKPHN
..|.||. || ..|.|||||  |
EVLQGLDYLHSNHIIHRDIKADN
Kinase 13336.AA STE 229-278 20 0.002384 7.83 In-house 190-261 (359) Show / Hide 
Range on Protein: 229-278
Range on HMM: 190-261/359
Sequence Identity: 20% (15 aa)

DLGFASAVTKS----------------KSHYISKKGTDAYFAPEVENG-QSR------IQSDLFSLGLVLLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|  |||....|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 13336.AA TKL 48-107 10 0.055901 2.93 In-house 1-91 (364) Show / Hide 
Range on Protein: 48-107
Range on HMM: 1-91/364
Sequence Identity: 10% (10 aa)

LSNGAYAVVLRAQNTKEN--------RTVALKFLTYTN----------------------KEDKNSIESLKKEYEMLQKFSQ-SDFLVNVY
.  |....| ...   ..        ..|| | .  .|                      .....| .  ..|.|.... .   . .|  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase 13336.AA Pkinase 228-278 29 0.067047 7.8 Pfam 154-205 (293) Show / Hide 
Range on Protein: 228-278
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASAV-TKSKSHYISKKGTDAYFAPEV--ENGQSRIQSDLFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  ..      .| .|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 13336.AA C8 427-639 50 4.7e-104 351.99 In-house 1-226 (226) Show / Hide 
Range on Protein: 427-639
Range on HMM: 1-226/226
Sequence Identity: 50% (115 aa)

VNNFQILSFGCFGMVLSTKKAKLNNKEIVLKIQKIVNEQEIQNEIRIMQLLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSLIQSIIIYCKIGSLQD-
.||||.||||..||||..|..| .|.|||||.||..|.|.|||...||. ...|.|.|.||.||.|.....|.|.|||.||||  . ..   |  .... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQL-QIKLCDFGLSAQLGKDCEQIESLDM--VGNWAYMA
          |.||..|...||.|.|..||.|.||.||||||.||.||||| .|||||||.|.. .|||||||...|..|....|.| .|  .|.|||.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILTKQDDQYKIYSKKSDSYSVGLLL
|||..|||.|||.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13336.AA Ciliate-C8 436-639 39 1.4e-93 317.21 In-house 1-238 (238) Show / Hide 
Range on Protein: 436-639
Range on HMM: 1-238/238
Sequence Identity: 39% (97 aa)

GCFGMVLST------KKAKLNNKEIVLKIQKIVNEQEIQNEIRIMQLLKTPLVVQLYDNYVIEKVTAPEK-----------------YVVFELEKCSLIQ
| |||||..      .| .|...|.|.||||...|.||.....||| ...|.|||.||..........|.                 ..|.|.|||.   
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQN-

SIIIYCKIGSLQDYLER-QTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLD-GNQLQIKLCD------FGLSAQLGKDCE-------
        ..|..|..| . |....|...|..|| |.||||||.|||||.||||| .|||||.| ..|..|||||      ||...|| |...       
--------CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKF

--QIESLDM--VGNWAYMAPEILTK-QDDQYKIYSKKSDSYSVGLLL
  ... ..|  .|||.|.|||...| ...|..|.|||||||||||.|
KGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13336.AA C2 436-639 27 6.9e-38 127.05 In-house 1-232 (245) Show / Hide 
Range on Protein: 436-639
Range on HMM: 1-232/245
Sequence Identity: 27% (69 aa)

GCFGMVLSTKKAKLNNKEIVLKIQKIVN-----EQEIQNEIRIMQLLK-TPLVVQLYD-NYVIEKVTAP------------EK----------YVVFELE
| ||.|| .   |  |....||||..       ..|.|.|..||. ..  |.....|.  |. ..                |.           ||.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSLIQSIIIYCKIGSLQDYLERQTKEG-EFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQL-QIKLCD----------FGLSAQLGK
.|.             |. |..|..|.  ......|  .| |..||.||.|.|.|.||||| .|||. .| ...  |||||          |  .  | .
FCQGN-----------LKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKY

DCEQIESLDMVGNWAY----MAPEILTKQDDQYKIYSKKSDSYS-VGLLL
. ..|    ...  .|    .|||.      . .|| |.|| .| ||. |
NKSRIHFSKFKWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVL
Kinase 13336.AA TKL 517-639 27 2.6e-28 99.07 In-house 119-279 (364) Show / Hide 
Range on Protein: 517-639
Range on HMM: 119-279/364
Sequence Identity: 27% (46 aa)

YCKIGSLQDYLERQTKEGEFSDEEKLNIALQIIDSVNYIHCFN--------IIHRDIKSDNFLVCLDGN-----------QLQIKLCDFGLSAQLGKDCE
||. ||| .||           . ....||.|   .|| |  |        |||||.||.| ||  ...           .  .|.||||||  . .. .
YCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN

QIESLDM-----------------VGNWAYMAPEILTKQDDQYK-----------IYSKKSDSYSVGLLL
.  .  .                 .|. ..||||.| .|..  .            ||.|.| || |..|
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 13336.AA CAMK 432-639 18 3.1e-27 84.21 In-house 1-324 (425) Show / Hide 
Range on Protein: 432-639
Range on HMM: 1-324/425
Sequence Identity: 18% (63 aa)

ILSFGCFGMVLSTKKAKLNN-----------KEIVLKI---QKIV----------------------------NEQEIQNEIRIMQL-------LKTPLV
.|  | || |   .  . ..           ..   ||   .|.                             .......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYVIEKV--------TAPE--------KYVVFELEKCSLIQSIIIYCKIG----SLQDYLERQTK------------EGEFSDEEKLNIALQIID
..||. |  ...        |            | |.|         |  ||  |     | ||. ....            .| |. .|   .  ||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVME---------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICS

SVNYIHCFNIIHRDIKSDNFLVCLDG--------------NQLQIKLCDFGLSAQLGKDCEQI---------------------ESLDMVGNWAYMA-PE
 |.|.|  ||.|||.| .| |.. ..              |. .||..|||..... .. ..                         ...|  .||| ||
AVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

ILTK-QDDQY--------KIYSKKSDSYSVGLLL
.| . . ...        . |..|.|  |.| .|
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 13336.AA Pkinase 517-639 31 7.1e-24 85.49 Pfam 81-202 (293) Show / Hide 
Range on Protein: 517-639
Range on HMM: 81-202/293
Sequence Identity: 31% (41 aa)

YCKIG----SLQDYLERQTKEGEF--SDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQL--QIKLCDFGLSAQLGKDCEQIESLDMVGNW
||  |    .| ||...  ..| |  |..|  ....||.  ..|.|  .|||||.|..|.|.  . ...   .|.|||||..|.     .    . .|  
YCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

AYMAPEILTKQDDQYKIYSKKSDSYSVGLLL
 |||||..      .. |..|.| .|.|..|
WYMAPEVIR----GGQYYGPKVDMWSCGCIL
Kinase 13336.AA STE 517-639 27 2e-23 79.67 In-house 118-258 (359) Show / Hide 
Range on Protein: 517-639
Range on HMM: 118-258/359
Sequence Identity: 27% (41 aa)

YCKIGSLQDYLER--QTKE---------GEFSDEEKLNIALQIIDS-VNYIHCFNIIHRDIKSDNFLVCLDGNQLQIKLCDFGLSAQLGKDCE-------
|.  ||| | ...   ...         . |. ..   |. ||.    .|.|  .|||||||..| |.        .||||||...|| ...        
YMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNI

-------QIESLDMVGNWAYMAPEILTKQDDQ-YKIYSKKSDSYSVGLLL
       | ..  .||   .||||......    | |. |.| .|.|...
IDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 13336.AA S_TKc 427-711 23 3.7e-23 84.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 427-711
Range on HMM: 1-231/231
Sequence Identity: 23% (70 aa)

VNNFQILSFGCFGMVLSTKKAKLNNKEIVLKIQKIVNEQEIQNEIRIMQLLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSLIQSIIIYCKI--GSLQ
    ...  | || |   .. |  ...  .|| |    . |..||.|..  . | .|.||| ..       . |.|.|            ||    |.| 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVME------------YCDGDLGDLF

DYLERQTKEGE---FSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQLQIKLCDFGLSAQLGKDCEQIESLDMVGNWAYMAPEILTKQDD
||.... ..|    |.  .   .. ||.. ..|.|  .|||||.| .| |..      .||.|||||..||           ..|   |||||.|     
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----

QYKIYSK-KSDSYSVG-LLLSLLDNYLILKEIVGTTFINMTLEQYDEPFKKQNINIKQDTEIFKFIKLLVVWERVNRASLSIIIE----QNSKKFK
    |.| |.| .|.| .|  .|  |      . ..| ..                  . |   ||. . ...  .| .   . .     ..  . 
---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13336.AA Ciliate-E2 517-639 26 4.3e-23 76.11 In-house 115-286 (365) Show / Hide 
Range on Protein: 517-639
Range on HMM: 115-286/365
Sequence Identity: 26% (48 aa)

YCKIGSLQDYLERQ-TKE-------GEFSDEEKLNIALQIID---------------SVNYIHCFN-IIHRDIKSDNFLVCLDGNQLQIKLCDFGLSAQL
||. |.|.||.. . .|.       . |...| ..|  ||..                ..|.|  | ||||||| .| |.        ||..||||| ..
YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKY

GKD---------CEQIESLD---------------------MVGNWAYMAPEILTKQDDQ----YKIYSKKSDSYSVGLLL
 .|         |. .                          .|.  ||||||| .....     | |..|.| .|.| .|
DDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 13336.AA Ciliate-E1 433-633 22 1.3e-20 64.12 In-house 1-202 (202) Show / Hide 
Range on Protein: 433-633
Range on HMM: 1-202/202
Sequence Identity: 22% (50 aa)

LSFGCFGMVLSTKKAKLNNKEIVLKIQKIV---NEQEIQNEIRIMQLLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSLIQSIIIYCKIGSLQDYLE-
.. |.|..|.  |. . |.... .||...    |....|.||.  ....  .  . |  ..|.         ....... ..  |. .|.  ||.|||. 
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIID---------YIKIDQNYICIIIFECCC-CSLKDYLQN

---------RQTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQLQIKLCDFGLSA--QLGKDCEQ---IESLDMVGNWAYMAPE
          |.....|....|..|. |.|| ....| .|||||||| .| |.. . .....   |||.|   .. .. ..    .   .  .. |. ||
HNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPE

ILTKQDDQYKIYSKKSDSY
  . ...|  ....||| |
Q-EHNKNQ--KINYKSDIY
Kinase 13336.AA STE20 553-636 40 2.8e-16 56.26 In-house 131-214 (288) Show / Hide 
Range on Protein: 553-636
Range on HMM: 131-214/288
Sequence Identity: 40% (36 aa)

NYIHCFNIIHRDIKSDNFLVCLDGNQLQIKLCDFGLSAQLGK---DCEQI-ESLDMVGNWAYMAPEILTKQDDQYKIYSKKSDSYSVG
.|.|  .|||||||.|| |.  ||   ..||.|||..||| |   |  .  .   .||   .||||.. ....  | |  |.| .|.|
DYLHSNHIIHRDIKADNILLTEDG---EVKLADFGVCAQLTKHGRD-TMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLG
Kinase 13336.AA CMGC 522-589 19 3.6e-14 42.04 In-house 140-251 (513) Show / Hide 
Range on Protein: 522-589
Range on HMM: 140-251/513
Sequence Identity: 19% (22 aa)

SLQDYLERQT--KEG----EFSDEE------------KLNIA------LQIIDSVN--YIHCFN--IIHRDIKSDNFLVCLDGNQ---------------
.| .|....   . |    ..|. .            . ..        ||. ...  |.|  .  |||||.|  | |.. ..                 
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ

--LQIKLCDFGLS
   ..|.|||||.
KNGRLKICDFGLA
Kinase 13336.AA TyrKc 427-710 20 1.1e-11 -33.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 427-710
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

VNNFQILSFGCFGMVLSTKKAKLNNKEIVL--KIQKIVNEQEIQNEIRIMQLL--KTPLVVQLYDNYVIEKV-----TAPEKYVVFELEKCSLIQSIIIY
.   ..|  |.|| |    |....  . |   ....   .... .|.|||  |  . | .|.||   |. .       ..  ..|.|            |
ITLGKKLGEGAFGEVY---KGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVME------------Y

CKIGSLQDYLERQTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQLQIKLCDFGLSAQLGKD------CEQIE-----SLDMVG
.. |.|.||| .  ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..   ..| .|||||  .. |       . .      . ... 
MPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

NWAYMAPEILTKQDDQYKIYSKKSDSYSVGLLL-------SLLDNY-----LILKEIVGTTFINMTLEQYDE----PFKKQNINIKQDTEIFKFIKLLVV
    |||| .     .|.... ||| .| | ..                  .  .|..      . ..| ..     |          .|... .|    
PIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWH

WERVNRASLSIIIEQNSKKF
 .  .| . | |     ..|
EDPEDRPTFSEI----HECF
Kinase 13336.AA Pkinase_Tyr 517-589 32 1.1e-05 19.94 Pfam 88-158 (270) Show / Hide 
Range on Protein: 517-589
Range on HMM: 88-158/270
Sequence Identity: 32% (24 aa)

YCKIGSLQDYLERQ-TKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKSDNFLVCLDGNQLQIKLCDFGLS
|.. |.| ||| .. . .. .. ...|....|| .  .| .  |.||||.   | ||     ....| |||||.
YMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLA
Kinase 13336.AA CMGC 427-505 15 9.3e-05 10.54 In-house 1-136 (513) Show / Hide 
Range on Protein: 427-505
Range on HMM: 1-136/513
Sequence Identity: 15% (21 aa)

VNNFQILSFGCFGMVLSTKKAKLN-------------NKEIVLKIQKIVNEQEIQ---------------NEIRIMQLLK-----------------TPL
  . . .  | .|.| . .  . |             |... .|. | .   |.|                ||.|.. |.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYVIEKVTAP-------------EKYVVFEL
.|.||| .. .. . .             . | |||.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEY
Kinase 13336.AA Ciliate-E2 427-489 18 0.000473 9.78 In-house 1-101 (365) Show / Hide 
Range on Protein: 427-489
Range on HMM: 1-101/365
Sequence Identity: 18% (19 aa)

VNNFQILSFGCFG-----MVLSTKKA-----------------KLNNKEIVLKIQK------IVNEQEIQNEIR----------IMQLLKTPLVVQLYDN
 .  ... .|.||      | ...|                  | ..|.. .||.|      | .|. | .||.          |...|. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

Y
.
F
Kinase 13336.AA STE20 457-492 27 0.006812 6.76 In-house 34-76 (288) Show / Hide 
Range on Protein: 457-492
Range on HMM: 34-76/288
Sequence Identity: 27% (12 aa)

KIQKIVN-------EQEIQNEIRIMQLLKTPLVVQLYDNYVIE
|. .. .       ...||.||.||. .| | .|. |. |. .
KKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKD
Kinase 13336.AA Pkinase 427-487 27 0.317916 5.41 Pfam 1-67 (293) Show / Hide 
Range on Protein: 427-487
Range on HMM: 1-67/293
Sequence Identity: 27% (19 aa)

VNNFQILSFGCFGMVLSTKKAKLNNKE--IVLKIQKIVNEQEIQN-------EIRIMQLLKTPLVVQLYD
    ...  | || |   .|..  . .   ..|| | ..| . ..       ||.||. |. | .|.|||
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYD