Gene 28243 (Tetrahymena)

28243

Species: Tetrahymena
Alias: 472.m00003, 28243, 1157, n.28243, TTHERM_01569160, PreTt28243
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
28243.AA Protein None 1238 None Fasta, JSON
28243.kin_dom Protein Kinase Domain None 202 None Fasta, JSON
28243.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
28243.NA RNA None 4200 None Fasta, JSON

Protein domain

Protein domains of 28243.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28243.AA C8 132-365 57 5.1e-119 401.71 In-house 1-226 (226) Show / Hide 
Range on Protein: 132-365
Range on HMM: 1-226/226
Sequence Identity: 57% (140 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTNQEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEKSYFVIEME
|.||.|||.|||..||.|.|.|.||...|||....|..|...|||..|||||.|.|.|.||.||.|.|||.|.|..||....|||.|.|.|||.|| |||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCQQNLKQLFDFLKSTQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFEFLQNLSIQKIFENQGDLGFASAVTKSK
||.||||||.|... .|.. |||.||||||||..|.|..|.||||||||||||||||..|.|||.||||                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYISKK----GTDAYFAPEVENG------QSRIQSDLFSLGLVL
||..|||    ||.||||||.|..      |.||||||||.||||
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 28243.AA Ciliate-C8 141-365 54 9.5e-118 397.49 In-house 1-238 (238) Show / Hide 
Range on Protein: 141-365
Range on HMM: 1-238/238
Sequence Identity: 54% (136 aa)

GAYAVVLRAQNTKENRTVALKFLTYTNQEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEK---SYFVIEMELCQQN-
||...||.|||.|.||.|||||.. .|...||..|...|||||...|.|..|.|.|| ||||||||..||.|||.|.| |.||   |.||.|||.|||| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLKSTQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFEFLQNLSIQKIFENQGDLGFASAVTKSKSHYI
 |||.||... .|.. |...||||||||....|.||..|||||||||||||||..|.|..|||||. |     . .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTDAY-----------FAPEVENGQSRIQSDLFS-------LGLVL
|||  |||.|           ||||||..|||||||.||       .||||
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 28243.AA C2 141-378 37 2.3e-60 204.88 In-house 1-245 (245) Show / Hide 
Range on Protein: 141-378
Range on HMM: 1-245/245
Sequence Identity: 37% (96 aa)

GAYAVVLRAQNTKENRTVALKFLTYTNQEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEE-DEDGNEKVVLTDE--------KSYFVIEME
|| . || | | |.||.||||  .  .. | || ... |||....... . ....|| .||| ... |  ||| .|. .  ..        |. .|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCQQNLKQLFDFLKSTQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-KKFEFLQNLSIQKIFENQGDLGFASAVTKS
 || |||| |. ..  .  |....|.|.||||. . | || ..| |||||| |||.  .|    |||||    .. |.          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KS-HYISK-KGTDAY----FAPEVENGQSRIQSDLFS-LGLVLLELDNLKVLNENW
||  ..|| |.| .|    |||||. .  . .||||| .|.||||||| .  . . 
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 28243.AA CMGC 132-299 16 1e-23 74.02 In-house 1-246 (513) Show / Hide 
Range on Protein: 132-299
Range on HMM: 1-246/513
Sequence Identity: 16% (42 aa)

FSNFEYLSNGAYAVVLRAQN--------------TKENRTVALKFLT---YTNQED----KNGIE-SLKKEYEMLQKFS---------------QSDF-L
. . ...  |.|.|| ....              .. |. ||.| .    |..|.     |.|.  .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYECFYLMEENVEEDEDGNE-KVVLTDEKSYFVIEMELCQQNLKQLFDFLKS-------TQLPSKE------------IKEII-----AIQMLEGLN-
|. |..||  ... .|.|| .. .     .  .. . .|.....|.|. .  .          |.  .            || ..     . |.|.||. 
VKLYDIFYHKNSDGNEYEDKHIIS---Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPHNFLVCPSQTY----------------GFTIKLC
  .| ..  |.|||.|| | |...  ..                 ...|.|
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 28243.AA Pkinase 132-299 18 8e-22 78.25 Pfam 1-154 (293) Show / Hide 
Range on Protein: 132-299
Range on HMM: 1-154/293
Sequence Identity: 18% (32 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTNQEDKNGIESLK-KEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEKSYFVIEM
.   . .  |....| .... .....||.| . . .....  .. ..  | ...... .... |  |..|.                     |..  . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCQQNLKQLFDFL------KSTQL--PSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC
|.|.  |. ..|        ... .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|.|
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 28243.AA CAMK 137-299 13 1.3e-18 55.96 In-house 1-238 (425) Show / Hide 
Range on Protein: 137-299
Range on HMM: 1-238/425
Sequence Identity: 13% (34 aa)

YLSNGAYAVVLRAQNTKEN------------RTVALKFLTYTNQEDKN-------------------------GIESLKKEYEMLQKFS------QSDFL
 |  |....| ...... .            . || |..  .   ||.                           .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYECFYL-----------MEENVEEDEDGNEKVVLTDEKSYFVIEM---ELCQQN--LKQLFDFLKST----------------QLPSKEIKEIIAIQ
.. || .               ...          |  . ...... |   |.|.    .  |||....                  .. .| . ..  |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-Q

MLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYG-------------FTIKLC
...... .| .||.|||.|| | |.. . .               ..||..
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 28243.AA STE 132-299 19 2.8e-17 57.65 In-house 1-189 (359) Show / Hide 
Range on Protein: 132-299
Range on HMM: 1-189/359
Sequence Identity: 19% (42 aa)

FSNFEYLSNGAYAVVLRAQNT------KENRT---------VALKFLTYTNQE----------DKNG----IESLKKEYEMLQKFSQ-SDFLVNVYECFY
. . | . .||. .| .| |       | ...         .| | . . |..          ..|     .....|| ....|... ... |. | |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEENVEEDEDGNEKVVLTDEKSYFVIEMELCQ-QNLKQLFDFLKSTQLPSK-----------EIKEIIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVCP
   .|             ......  | ||..    | .. .  .... | .           ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFTIKLC
       .|||
-------VKLC
Kinase 28243.AA S_TKc 132-431 17 9.4e-16 54.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 132-431
Range on HMM: 1-231/231
Sequence Identity: 17% (56 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTNQEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNEKVVLTDEKSYFVIEME
.   . .  ||...| .....| .| ||.| .           |....| ..|.|  . ...|. |..|.                      ... . ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCQQNLKQLFDFLKSTQ-------LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-----KKFEFLQNLSIQKIFENQGD
.| ..|  |||..|. .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||.|     ...                 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------

LGFASAVTKSKSHYISKKGTDAYFAPEVENGQSRIQSDLFSLGLVLLELDNLKVLNENWIDYFTKGEIYQGKSIASNYQIDRNSNIYKIAQICLKPNYLE
               .  ||  | ||||  | ..  .|  |.| .| |.   . . .      .  ....             .    . . ||. .  .
--------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEK

RTTSGDLLS--------ELI
| |  ..|         . .
RPTA-EALQDEWDIKCHPWF
Kinase 28243.AA Ciliate-E1 226-359 21 2.4e-14 43.48 In-house 72-202 (202) Show / Hide 
Range on Protein: 226-359
Range on HMM: 72-202/202
Sequence Identity: 21% (33 aa)

FVIEMELCQQNLKQLFD---------FLKSTQLPSKEI-KEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFEFLQNLSIQKIFE
..| .|.|...||. ..          ....|   ..  |. |..|...||. || .||.||||||.| |.. .  | ..                    
CIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------------------

NQGDLGFASAVTKSKSHYISKKGTDAYFAPEVE--------NGQ--SRIQSDLF
   |.| ..   ... ... .||   |..|. .        | .    ..||..
---DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 28243.AA Ciliate-E2 223-368 21 3.1e-13 41.77 In-house 106-289 (365) Show / Hide 
Range on Protein: 223-368
Range on HMM: 106-289/365
Sequence Identity: 21% (45 aa)

KSYFVIEMELCQQNLKQLFDFLKSTQLPSKEI---------KEI--IAIQMLE---------------GLNNLHVKN-IMHRDIKPHNFLVCPSQTYGFT
.... . ||.||.  . |||..|. .. ....         |||  |  | |.               .|. || || |.|||||| | |.         
DNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------

IKLCKKF----------EFLQNLSIQKIFENQG--------DLGFASAVTKSKSHYISKK-----------GTDAYFAPEVENGQSR----------IQS
||..             . .. ....|.. . .        ...                           ||  | |||. ||..            ..
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD---------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC

DLFSLGLVLLEL
|..||| .| |.
DIWSLGVILYEM
Kinase 28243.AA Ciliate-E2 132-206 14 4e-08 23.95 In-house 1-107 (365) Show / Hide 
Range on Protein: 132-206
Range on HMM: 1-107/365
Sequence Identity: 14% (16 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTVALKFLTYTN------------------QEDKNGIESLKKEYEMLQ---------------KFSQSDFLVNVYE
.   . . .|....| .... |... .|.|. . ..                  .  ||.||..|.|  ...               .. ....... ||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEN
||. . .|
CFQEKDDN
Kinase 28243.AA Ciliate-E2-Unclassified 132-283 18 1.4e-07 22.37 In-house 1-174 (352) Show / Hide 
Range on Protein: 132-283
Range on HMM: 1-174/352
Sequence Identity: 18% (37 aa)

FSNFEYLSNGAYAVVLRAQNTKENRTV-----ALKFLTYTNQEDKNG---------IESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNE--
.   . . .|....| ..|. |..  .     . |.  |  .  .|          ....|| | .  |                           ..  
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K---------------------------YNKI

------------KVVLTDE---KSYFVIEMELC-QQNLKQLFDFLKS---------------TQLPSKEIK----EIIAIQMLEGLNNLHVKN-IMHRDI
            .|.. ..   | .. | ||.| ...|.|     |.                ... ...|    . .. | |.||. || || | ||||
MQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDI

KPHN
|| |
KPEN
Kinase 28243.AA Ciliate-E1 138-202 19 1.6e-07 21.06 In-house 1-66 (202) Show / Hide 
Range on Protein: 138-202
Range on HMM: 1-66/202
Sequence Identity: 19% (13 aa)

LSNGAYAVVLRAQNTKEN-RTVALKFLTYTNQEDKNGIESLKKEYE-MLQKFSQSDFLVNVYECFYL
..|| ...|..| . . | . ||.|.  .  ....| .....|||  ... | . . ..........
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 28243.AA TKL 258-286 35 4.3e-07 21.59 In-house 137-173 (364) Show / Hide 
Range on Protein: 258-286
Range on HMM: 137-173/364
Sequence Identity: 35% (13 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLV
.|...  |.| ||         ..| |||.|..| ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV
Kinase 28243.AA TKL 318-368 17 3.3e-05 14.73 In-house 196-282 (364) Show / Hide 
Range on Protein: 318-368
Range on HMM: 196-282/364
Sequence Identity: 17% (15 aa)

GDLGFASAVTKSKS-------------------HYISKKGTDAYFAPEV-----------------ENGQSRIQSDLFSLGLVLLEL
.|.|..  ...|..                   . ... || .. ||||                 ....   ..| .| |.|| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 28243.AA Ciliate-E2-Unclassified 319-368 21 0.000112 12.17 In-house 190-263 (352) Show / Hide 
Range on Protein: 319-368
Range on HMM: 190-263/352
Sequence Identity: 21% (16 aa)

DLGFASAVTKS---------------KSHYISKKGTDAYF----APEVENG-QSR----IQSDLFSLGLVLLEL
|.|...   ..               . .. .. ||  |     ||||  | .      ...| .||| .| |.
DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase 28243.AA STE 319-368 20 0.002384 7.83 In-house 190-261 (359) Show / Hide 
Range on Protein: 319-368
Range on HMM: 190-261/359
Sequence Identity: 20% (15 aa)

DLGFASAVTKS----------------KSHYISKKGTDAYFAPEVENG-QSR------IQSDLFSLGLVLLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|  |||....|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 28243.AA Pkinase 318-368 29 0.067047 7.8 Pfam 154-205 (293) Show / Hide 
Range on Protein: 318-368
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASAV-TKSKSHYISKKGTDAYFAPEV--ENGQSRIQSDLFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  ..      .| .|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 28243.AA C8 516-717 50 7.79999999999e-104 351.26 In-house 1-226 (226) Show / Hide 
Range on Protein: 516-717
Range on HMM: 1-226/226
Sequence Identity: 50% (114 aa)

VNNFQILSFGCFGMVLSTKKVKLNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTQLVVQLYDNYVIEKVTAPEKYVVFELEKCS-----------CSLQD-
.||||.||||..||||..|.|| .|.|||||.||..|.|.|||...||.......|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQAKEGEFSDEEKLNIALQIIDSVNFIHCFNIIHRDIKPDNFLVCLDGNQL-QIKLCDFGLSAQLGKDCEQIESLDM--KGNWAYMA
          |.||. |...||.|.|..||.|.||.||.|||.||.||||||.|||||||.|.. .|||||||...|..|....|.| .|   |.|||.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILTKKDDQYKIYSKKSDSYSVGLLL
|||..|.|.|||.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 28243.AA Ciliate-C8 525-717 41 4.4e-99 335.49 In-house 1-238 (238) Show / Hide 
Range on Protein: 525-717
Range on HMM: 1-238/238
Sequence Identity: 41% (98 aa)

GCFGMVLST------KKVKLNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTQLVVQLYDNYVIEKVTAPEK-----------------YVVFELEKCS--C
| |||||..      .||.|...|.|.||||...|.||.....|||......|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QAKEGEFSDEEKLNIALQIIDSVNFIHCFNIIHRDIKPDNFLVCLD-GNQLQIKLCD------FGLSAQLGKDCE---------QIESLDM
.|..|..| . |....|...|..|| |.|||||..|||||.||||||.|||||.| ..|..|||||      ||...|| |...         ... ..|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--KGNWAYMAPEILTK-KDDQYKIYSKKSDSYSVGLLL
   |||.|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 28243.AA C2 525-717 29 1.1e-42 143.64 In-house 1-232 (245) Show / Hide 
Range on Protein: 525-717
Range on HMM: 1-232/245
Sequence Identity: 29% (70 aa)

GCFGMVLSTKKVKLNNKEIVLKIQKIVN-----EQEIQNEIRIMQQLK-TQLVVQLYD-NYVIEKVTAP------------EK----------YVVFELE
| ||.|| .   |  |....||||..       ..|.|.|..||.|..   .....|.  |. ..                |.           ||.|.|
GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLQDYLERQAKEG-EFSDEEKLNIALQIIDSVNFIHCFNIIHRDIKPDNFLVCLDGNQL-QIKLCD----------FGLSAQLGKDCEQIESLDMK
.|.. |. |..|. |.  ......|  .| |..||.|..|.|.|.||||||.|||. .| ...  |||||          |  .  | .. ..|    .|
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNWAY----MAPEILTKKDDQYKIYSKKSDSYS-VGLLL
.  .|    .|||.      . .|| |.|| .| ||. |
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVL
Kinase 28243.AA CAMK 521-717 18 1.3e-30 95.33 In-house 1-324 (425) Show / Hide 
Range on Protein: 521-717
Range on HMM: 1-324/425
Sequence Identity: 18% (61 aa)

ILSFGCFGMVLSTKKVKLNN-----------KEIVLKI---QKIV----------------------------NEQEIQNEIRIMQQ-------LKTQLV
.|  | || |   .  . ..           ..   ||   .|.                             .......||.||..       |.   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYVIEKV--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQAK------------EGEFSDEEKLNIALQIIDSVNFIHCFN
..||. |  ...        |        .|.... .   | ||       | ||. .. .            .| |. .|   .  ||.. |...|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNFLVCLDG--------------NQLQIKLCDFGLSAQLGKDCEQI---------------------ESLDMKGNWAYMA-PEILTKK----
|.|||.||.| |.. ..              |. .||..|||..... .. ..                         .. |  .||| ||.| .|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DDQYKIYSKKSDSYSVGLLL
     |.. . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 28243.AA Ciliate-E1 522-711 25 1.3e-28 90.39 In-house 1-202 (202) Show / Hide 
Range on Protein: 522-711
Range on HMM: 1-202/202
Sequence Identity: 25% (55 aa)

LSFGCFGMVLSTKKVKLNNKEIVLKIQKIV---N----EQEIQNEIRIMQQLKTQL-VVQLYDNYVIEKVTAPEKYVVFELEKCSCSLQDYLE-------
.. |.|..|.  |. . |.... .||...    |    ..||.... ||. .|..  ..|..| . |..     .  .. .|.|.|||.|||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQ----NYICIIIFECCCCSLKDYLQNHNRLEY

---RQAKEGEFSDEEKLNIALQIIDSVNFIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSA--QLGKDCEQ---IESLDMKGNWAYMAPEILTKKD
    | ....|....|..|. |.|| .. .| .|||||||||.| |.. . .....   |||.|   .. .. ..    .   .. .. |. ||  . ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

DQYKIYSKKSDSY
.|  ....||| |
NQ--KINYKSDIY
Kinase 28243.AA S_TKc 516-789 22 1.6e-27 98.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 516-789
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

VNNFQILSFGCFGMVLSTKKVKLNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTQLVVQLYDNYVIEKVTAPEKYVVFELEKCSC---SLQDYLERQAKEG
    ...  | || |   ...|  ...  .|| |    . |..||.|... .   .|.||| ..        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEEKLNIALQIIDSVNFIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLGKDCEQIESLDMKGNWAYMAPEILTKKDDQYKIYSK-KS
    |.  .   .. ||.. ....|  .|||||.||.| |..      .||.|||||..||           . |   |||||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILKEIVGTTFINMTLEQYDEPFKKQNINIKQDTEIFKFIKLLVVWERVNRASLSVIIE----QNSKKFK
| .|.| .|  .|  |      . ..| ..                  . |   ||. . ...  .| .   . .     ..  . 
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28243.AA Pkinase 544-717 26 3.9e-25 89.97 Pfam 31-202 (293) Show / Hide 
Range on Protein: 544-717
Range on HMM: 31-202/293
Sequence Identity: 26% (50 aa)

VLKIQKIVNEQEIQN----EIRIMQQLKTQLVVQLYDNYVIEKVTAPEKYVVFELEKCSC-----SLQDYLERQAKEGEF--SDEEKLNIALQIIDSVNF
..| ...  ......    ||.||. |.   .|.||| .        .... . .| | .     .| ||...  ..| |  |..|  ....||.  ...
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEY

IHCFNIIHRDIKPDNFLVCLDGNQL--QIKLCDFGLSAQLGKDCEQIESLDMKGNWAYMAPEILTKKDDQYKIYSKKSDSYSVGLLL
.|  .|||||.||.|.|.  . ...   .|.|||||..|.     .    .  |   |||||..      .. |..|.| .|.|..|
CHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCIL
Kinase 28243.AA CMGC 516-667 16 1.3e-24 77.03 In-house 1-251 (513) Show / Hide 
Range on Protein: 516-667
Range on HMM: 1-251/513
Sequence Identity: 16% (41 aa)

VNNFQILSFGCFGMVLSTKKVKLN-------------NKEIVLKIQKIVNEQEIQ---------------NEIRIMQQLK-----------------TQL
  . . .  | .|.| . .  . |             |... .|. | .   |.|                ||.|...|.                    
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYVIEKVTAPEK-----------YVVFELEKCSCSLQDYLERQA--KEG----EFSDEE------------KLNIA------LQIIDSVN--FI
.|.||| .. .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LQIKLCDFGLS
|  .  |||||.|| | |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 28243.AA TKL 619-717 24 1.3e-24 85.49 In-house 134-279 (364) Show / Hide 
Range on Protein: 619-717
Range on HMM: 134-279/364
Sequence Identity: 24% (36 aa)

KLNIALQIIDSVNFIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLQIKLCDFGLSAQLGKDCEQIESLDM-----------------
....||.|   .|. |  |        |||||.|..| ||  ...           .  .|.||||||  . .. ..  .  .                 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

KGNWAYMAPEILTKKDDQYK-----------IYSKKSDSYSVGLLL
 |. ..||||.| ....  .            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 28243.AA Ciliate-E2 516-717 22 4.2e-24 79.63 In-house 1-286 (365) Show / Hide 
Range on Protein: 516-717
Range on HMM: 1-286/365
Sequence Identity: 22% (67 aa)

VNNFQILSFGCFG-----MVLSTKKV-----------------KLNNKEIVLKIQK------IVNEQEIQNEIR----------IMQQLKTQLVVQLYDN
 .  ... .|.||      | ...|                  | ..|.. .||.|      | .|. | .||.          |..||.   ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKVTAPEKYVVFELEKCSC-SLQDYLERQAKE--------GEFSDEEKLNIALQIID---------------SVNFIHCFN-IIHRDIKPDNFLVCL
.  ..    .... . .| |.  .|.||.. . |         . |...| ..|  ||..                ....|  | ||||||||.| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLQIKLCDFGLSAQLGKD-------CEQIESLDMK-----------------------GNWAYMAPEILTKKDDQ----YKIYSKKSDSYSVGLLL
      ||..||||| .. .|        .. . .. |                       |.  ||||||| .|...     | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 28243.AA STE 539-717 22 6e-21 70.8 In-house 29-258 (359) Show / Hide 
Range on Protein: 539-717
Range on HMM: 29-258/359
Sequence Identity: 22% (54 aa)

NNKE---------IVLKIQKIVN--------------------EQEIQNEIRIMQQLK--TQLVVQLYDNYVIEK--VTA-PEKYVVFELEKCSC-SLQD
....         .  |. .. |                    .|.|..||.||....   . .|. |. |. |     .  | ... |.  ..  || |
TGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEY--MDGGSLDD

YLE------------RQAKEGEFSDEEKLNIALQIIDS-VNFIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLGKDCE--------------Q
 ..            ||. .. |. ..   |. ||.    ...|  .||||||||.| |.        .||||||...|| ...               |
IIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQ

IESLDMKGNWAYMAPEILTKKDDQ-YKIYSKKSDSYSVGLLL
 ..  . |   .||||.... .    | |. |.| .|.|...
QKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 28243.AA Ciliate-E2-Unclassified 534-717 22 5.2e-20 66.11 In-house 33-260 (352) Show / Hide 
Range on Protein: 534-717
Range on HMM: 33-260/352
Sequence Identity: 22% (52 aa)

KKVKLNNKEIVLKIQKIVNEQEIQNEI---------RIMQQLKTQLVVQLYDNYVIEKVTAP--EKYVVFELEKC-SCSLQDYLERQAK-----------
||.. ... .... . |.||... |..         .||||    . ..... ... .. .   .... . .|.|   .|..|.. . |           
KKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQ----ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHN

---EGEFSDEEKL-----NIALQIIDSVNFIHCFN-IIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLGKDCE-------------QIESLDMKGNWAY
     .|.... .     ... ||..  ...|  | ||||||||.| |.  .|. ..||..|||.| ..... .             | .. .. |.  |
MKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNY

M----APEILTK-KDDQYKIYSKKSDSYSVGLLL
|    |||.| . . |. |   .|.| .|.| .|
MPQYTAPEVLQGQNYDHSKA--YKCDIWSLGVIL
Kinase 28243.AA TyrKc 516-788 19 1.9e-11 -37.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 516-788
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

VNNFQILSFGCFGMVLSTKKVKLNNKEIVL--KIQKIVNEQEIQNEIRIMQQL--KTQLVVQLYDNYVIEKV-----TAPEKYVVFELEKCSCSLQDYLE
.   ..|  |.|| |   .       . |   ....   .... .|.||| .|  . . .|.||   |. .       ..  ..|.|. .   .|.||| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

RQAKEGEFSDEEKLNIALQIIDSVNFIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLGKD------CEQIESL---DMK--GNWAYMAPEILT
.  ..  .. ...|....|| .  ...|  |.||||.   | ||  ..   ..| .|||||  .. |       . . .    . |       |||| . 
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KKDDQYKIYSKKSDSYSVGLLL-------SLLDNY-----LILKEIVGTTFINMTLEQYDE----PFKKQNINIKQDTEIFKFIKLLVVWERVNRASLSV
    .|.... ||| .| | ..                  .  .|..      . ..| ..     |          .|... .|     .  .| . | 
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSE

IIEQNSKKF
|     ..|
I----HECF
Kinase 28243.AA CAMK 956-981 21 0.078709 0.87 In-house 356-401 (425) Show / Hide 
Range on Protein: 956-981
Range on HMM: 356-401/425
Sequence Identity: 21% (10 aa)

YLLIQFVTYSYIQS-------------WNNISDE-------GAKDL
.  |.   |... .             |..||||        .|||
FEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDL