Gene 17858 (Tetrahymena)

17858

Species: Tetrahymena
Alias: 807, PreTt17858, TTHERM_01082840, 17858, 224.m00028
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
17858.AA Protein None 1041 None Fasta, JSON
17858.kin_dom Protein Kinase Domain None 169 None Fasta, JSON
17858.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
17858.NA RNA None 3126 None Fasta, JSON

Protein domain

Protein domains of 17858.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17858.AA Ciliate-C8 51-285 53 1.4e-111 376.96 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-285
Range on HMM: 1-238/238
Sequence Identity: 53% (136 aa)

GAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEK---SYFVMEMELCQQN-
||...||.|||.|.||.|||||..|.||..||..|...|||||...|.|..|.|.|.||||||||...||.|||.|.| |.||   |.||||||.|||| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRNAQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFQFLQKLSIQKIIQNQGDLGFASAVTKSKSHYI
 |||.||..|. |.. |...||||||||....|.||..|||||||||||||||..|.|..|||||. |     . .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTEAY-----------FAPEIEKGQSRIQ-DQFYLSSIIQKCQMKIGLTL
|||  ||..|           ||||.||.||||| |.| . | ..    . || |
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSY----SVGLVL
Kinase 17858.AA C8 42-274 57 2.3e-111 376.3 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-274
Range on HMM: 1-226/226
Sequence Identity: 57% (140 aa)

FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEKSYFVMEME
|.||.|||.|||..||.|.|.|.|| ..|||..|.||.|...|||..|||||.|.|.|.||.||. ||||.|.|..||....|||.|.|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCQQNLKQLFDFLRNAQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFQFLQKLSIQKIIQNQGDLGFASAVTKSK
||.||||||.|..|| |.. |||.||||||||..|.|..|.||||||||||||||||..|.|||.||||                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYISKK----GTEAYFAPEIEKG------QSRIQ-DQFYLSSII
||..|||    || |||||||||.      |.||| | | .  . 
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 17858.AA C2 51-260 37 9.8e-55 185.4 In-house 1-216 (245) Show / Hide 
Range on Protein: 51-260
Range on HMM: 1-216/245
Sequence Identity: 37% (86 aa)

GAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEE-DEDGNEKVVLTDE--------KSYFVMEME
|| .||| | | |.||.||||   | .  | || ..  |||....... . ....|...||| ... |  ||| .|. .  ..        |. .|.|.|
GAFGLVLKAFNKKQNRHVALKIQEC-QSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCQQNLKQLFDFLRNAQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-KKFQFLQKLSIQKIIQNQGDLGFASAVTKS
 || |||| |. .|. .  |....|.|.||||. . | || ..| |||||| |||.  .|    |||||    |. ||          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KS-HYISK-KGTEAY----FAPEIEKG
||  ..|| |.|..|    ||||....
KSRIHFSKFKWTQQYYQHIFAPEVYQN
Kinase 17858.AA CMGC 42-209 16 2.8e-23 72.52 In-house 1-246 (513) Show / Hide 
Range on Protein: 42-209
Range on HMM: 1-246/513
Sequence Identity: 16% (42 aa)

FSNFEYLSSGAYALVLRAQN--------------TKENRIVALKFLTCT-NKED------KNGIE-SMKKEYEMLQKFS---------------QSDF-L
. . ... .|.|. | ....              .. |.|||.| .    ..|.      |.|.  .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVFDCFYLMEEDVEEDEDGNE-KVVLTDEKSYFVMEMELCQQNLKQLFDFLR-------NAQLPSKE------------IKEII-----AIQMLEGLN-
|. .|.||  ..| .|.|| .. .     .  .. . .|.....|.|. .  .       .  |.  .            || ..     . |.|.||. 
VKLYDIFYHKNSDGNEYEDKHIIS---Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPHNFLVCPSQTY----------------GFTIKLC
  .| ..  |.|||.|| | |...  ..                 ...|.|
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 17858.AA Pkinase 42-209 20 1.2e-18 67.07 Pfam 1-154 (293) Show / Hide 
Range on Protein: 42-209
Range on HMM: 1-154/293
Sequence Identity: 20% (36 aa)

FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMK-KEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEKSYFVMEM
.   . . ||... | .... ....|||.| .   .....  ..  .  | ...... .... |  .|.|.                     |..  | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCQQNLKQLFDFL------RNAQL--PSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC
|.|.  |. ..|        |.  .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|.|
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 17858.AA CAMK 47-209 14 2e-17 52.01 In-house 1-238 (425) Show / Hide 
Range on Protein: 47-209
Range on HMM: 1-238/425
Sequence Identity: 14% (37 aa)

YLSSGAYALVLRAQNTKEN------------RIVALKFLTCTNKEDKN-------------------------GIESMKKEYEMLQKFS------QSDFL
 | .|... | ...... .            . || |..  .   ||.                           .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVFDCFYL-----------MEEDVEEDEDGNEKVVLT-DEKSYFVM-EMELCQQN--LKQLFDFLRNA----------------QLPSKEIKEIIAIQM
.. .. .               ...         |. | |.. |.||  ||.|.    .  |||...                   .. .| . ..  |.
IKLYEVYEDPHYFKNTNDYET-SKQ---------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QI

LEGLNNLHVKNIMHRDIKPHNFLVCPSQTYG-------------FTIKLC
..... .| .||.|||.|| | |.. . .               ..||..
CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 17858.AA STE 42-209 18 1e-13 44.94 In-house 1-189 (359) Show / Hide 
Range on Protein: 42-209
Range on HMM: 1-189/359
Sequence Identity: 18% (40 aa)

FSNFEYLSSGAYALVLRAQNTK---------------ENRIVALKFLTCTNKE----------DKNG----IESMKKEYEMLQKFSQ-SDFLVNVFDCFY
. . | . .||.  | .| | |                ..|.| | .   |..          ..|     ... .|| ....|... ... |. ..|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEDVEEDEDGNEKVVLTDEKSYFVMEMELCQ-QNLKQLFDFLRNAQLPSK-----------EIKEIIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVCP
   ..             ......  . ||..    | .. .     . | .           ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFTIKLC
       .|||
-------VKLC
Kinase 17858.AA S_TKc 42-322 16 1.9e-13 20.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-231/231
Sequence Identity: 16% (54 aa)

FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEKSYFVMEME
.   . . .||.. | .....| .||||.| .           |....| ..|.|  . ...|. .|.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCQQNLKQLFDFLRNAQ-------LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-----KKFQFLQKLSIQKIIQNQGD
.| ..|  |||.... .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||.|     ...                 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------

LGFASAVTKSKSHYISKKGTEAYFAPEIEKGQSR----------------IQDQFYLSSIIQKCQMKIGLTLLQKKRFTKEKQQLQ--TKICLKPNYLER
               .  ||  | |||.  | ..                     .    .|.   |||             ...    . ||. .  .|
--------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKR

TSSGDLLS--------ELI
 .  ..|         . .
PTA-EALQDEWDIKCHPWF
Kinase 17858.AA Ciliate-E1 136-222 26 5.4e-12 35.74 In-house 72-169 (202) Show / Hide 
Range on Protein: 136-222
Range on HMM: 72-169/202
Sequence Identity: 26% (26 aa)

FVMEMELCQQNLKQLFD----------FLRNAQLPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFT-IKLCKKFQFLQKLSIQK
..  .|.|...||. ..          . .| .  . . |. |..|...||. || .||.||||||.| |.. .  | .. . ..|...  |. ..|.
CIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY
Kinase 17858.AA Ciliate-A1 140-196 39 8.1e-12 36.45 In-house 80-134 (301) Show / Hide 
Range on Protein: 140-196
Range on HMM: 80-134/301
Sequence Identity: 39% (23 aa)

MELCQQNLKQLFDFLRNAQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLV
|| || ..  ||..  .   .   || ||   |. ||.  .| .||.|||.|| | |.
MEYCQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILI
Kinase 17858.AA Ciliate-E2 140-209 30 6e-10 30.32 In-house 113-198 (365) Show / Hide 
Range on Protein: 140-209
Range on HMM: 113-198/365
Sequence Identity: 30% (30 aa)

MELCQQNLKQLFDFLRNAQLPSKEI---------KEI--IAIQMLE---------------GLNNLHVKN-IMHRDIKPHNFLVCPSQTYGFTIKLC
||.||.  . |||...| .. ....         |||  |  | |.               .|. || || |.|||||| | |.         ||..
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKII
Kinase 17858.AA Ciliate-E1 48-112 20 8.6e-08 21.93 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 20% (14 aa)

LSSGAYALVLRAQNTKEN-RIVALKFLTCTNKEDKNGIESMKKEYE-MLQKFSQSDFLVNVFDCFYL
...| ...|..| . . | . ||.|.  |  ....| ... .|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 17858.AA TKL 168-196 35 4.3e-07 21.59 In-house 137-173 (364) Show / Hide 
Range on Protein: 168-196
Range on HMM: 137-173/364
Sequence Identity: 35% (13 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLV
.|...  |.| ||         ..| |||.|..| ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV
Kinase 17858.AA Ciliate-E2 42-116 12 2e-06 18.48 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 12% (14 aa)

FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTN--------KED----------KNGIESMKKEYEMLQ---------------KFSQSDFLVNVFD
.   . . .|... | .... |... .|.|. . ..        | .          ||.||..|.|  ...               .. ....... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEED
||. . ..
CFQEKDDN
Kinase 17858.AA Ciliate-A1 42-79 23 0.002009 7.44 In-house 1-39 (301) Show / Hide 
Range on Protein: 42-79
Range on HMM: 1-39/301
Sequence Identity: 23% (9 aa)

FSNFEYLSSGAYALVLRAQNTKENR-IVALKFLTCTNKE
.     . .| .  |.|| .   ..  ...| . |||.|
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE
Kinase 17858.AA TKL 48-104 11 0.270526 0.43 In-house 1-88 (364) Show / Hide 
Range on Protein: 48-104
Range on HMM: 1-88/364
Sequence Identity: 11% (10 aa)

LSSGAYALVLRAQNTKEN--------RIVALKFLTCTNKEDKNGIES----------------------MKKEYEMLQKFSQ-SDFLV
. ||... | ...   ..        . || | .  .|   .. ..                        ..|.|.... .   . .|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIV
Kinase 17858.AA C8 407-608 48 7.1e-104 351.39 In-house 1-226 (226) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-226/226
Sequence Identity: 48% (109 aa)

VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCS-----------CSLQD-
.||||.||||..||||..|.|. .|.|||||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-QIKLCDFGLSAQLEKNCEQIEILDW--VGNIGYMA
          |.||. |...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. .|||||||...|..||...|.. ..  .|. .|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILTKKEHENKIYSKKSDSYSVGLLL
|||..|.....|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 17858.AA Ciliate-C8 416-608 41 7.4e-101 341.38 In-house 1-238 (238) Show / Hide 
Range on Protein: 416-608
Range on HMM: 1-238/238
Sequence Identity: 41% (98 aa)

GSFGMVLST------KKVELSNKEIVLKIQKIVNEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.| ..|.|.||||...|. |.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLQIKLCD------FGLSAQLEKNCE---------QIEILDW
.|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..|||||      ||...||.||..         .......
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNIGYMAPEILTK-KEHENKIYSKKSDSYSVGLLL
  .||.||.|||...| ......|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 17858.AA C2 416-621 28 1.3e-44 150.35 In-house 1-245 (245) Show / Hide 
Range on Protein: 416-621
Range on HMM: 1-245/245
Sequence Identity: 28% (71 aa)

GSFGMVLSTKKVELSNKEIVLKIQKIVN-----EQTIQNEIRIMQQLK-TPLVVQLYD-NYVIEKVTAP------------EK----------YVVFELE
|.||.|| .   . .|....||||..       .. .|.|..||.|..  |.....|.  |. ..                |.           ||.|.|
GAFGLVLKAFNKK-QNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLQDYLERQAKEG-EFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-QIKLCD----------FGLSAQLEKNCEQIEILDWV
.|.. |. |..|. |.  ......|  .| |..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  |..| ..| .   .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNIGYMAPEILTKKEHENKIYSKKSDSYS-VGLLLSLLDNYLILKEKE
.   |.  . ... | . .|| |.|| .| ||. |  |||  .   ..
WTQQYY--QHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 17858.AA CAMK 412-608 20 1e-35 112.06 In-house 1-324 (425) Show / Hide 
Range on Protein: 412-608
Range on HMM: 1-324/425
Sequence Identity: 20% (65 aa)

ILSFGSFGMVLSTKKVELSN-----------KEIVLKI---QKIV----------------------------NEQTIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  .  .           ..   ||   .|.                             ... ...||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYVIEKV--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQAK------------EGEFSDEEKLNIALQIIDSVNYIHCFN
..||. |  ...        |        .|.... .   | ||       | ||. .. .            .| |. .|   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNFLVCLDG--------------NQLQIKLCDFGLSAQLEKNCEQI---------------------EILDWVGNIGYMA-PEILTKKEHEN
|.|||.||.| |.. ..              |. .||..|||........ ..                         ...|  .||| ||.| .| | |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

KI---------YSKKSDSYSVGLLL
.          |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 17858.AA Pkinase 407-608 27 2.1e-31 112.13 Pfam 1-202 (293) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQN-------EIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC-----SLQD
    ...  |||| |   ...  ..|. ..|| | ..|   ..       ||.||. |. | .|.||| .        .... . .| | .     .| |
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQAKEGEF--SDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL--QIKLCDFGLSAQLEKNCEQIEILDWVGNIGYMAPEILTKKEH
|...  ..| |  |..|  ....||.  ..|.|  .|||||.||.|.|.  . ...   .|.|||||..|.. .  .    . .| ..|||||..     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

ENKIYSKKSDSYSVGLLL
... |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 17858.AA S_TKc 407-679 24 4.5e-29 103.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 407-679
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC---SLQDYLERQAKEG
    ...  |.|| |   .... ....  .|| |    ..|..||.|... . | .|.||| ..        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKNCEQIEILDWVGNIGYMAPEILTKKEHENKIYSK-KS
    |.  .   .. ||.. ..|.|  .|||||.||.| |..      .||.|||||..||            .|   |||||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILKEKEGYTFMTMTLKQYDEPFKKQKINIKRDTEIFKFIKLLVVWERVNRASLSIIVG-----QNSKNF
| .|.| .|  .|  |                 |... ||| .     . |   ||. . ...  .| .   .        .   |
DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17858.AA Ciliate-E1 413-602 26 2.4e-28 89.52 In-house 1-202 (202) Show / Hide 
Range on Protein: 413-602
Range on HMM: 1-202/202
Sequence Identity: 26% (54 aa)

LSFGSFGMVLSTKKVELSNKEIVLKIQKIV---NEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVV-FELEKCSCSLQDYLE----------R
.. |||..|.  |. . ..... .||...    |....|.||.  ....  .  . |  ..|.     . |.  . .|.|.|||.|||.           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

QAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKNCEQIEILDWVGNIGYMAPEIL---TKKEHENKIY
| ....|....|..|. |.|| ....| .|||||||||.| |.. . .....   |||.| .| .| .|    .   .  |  ...      .. .|...
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKI

SKKSDSY
..||| |
NYKSDIY
Kinase 17858.AA Ciliate-E2 407-608 23 1.1e-27 92.1 In-house 1-286 (365) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-286/365
Sequence Identity: 23% (69 aa)

VNNFQILSFGSFG-----MVLSTKKVE-----------------LSNKEIVLKIQK------IVNEQTIQNEIR----------IMQQLKTPLVVQLYDN
 .  ... .|.||      | ...| .                   .|.. .||.|      | .|. | .||.          |..||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKVTAPEKYVVFELEKCSC-SLQDYLERQAKE--------GEFSDEEKLNIALQIID---------------SVNYIHCFN-IIHRDIKPDNFLVCL
.  ..    .... . .| |.  .|.||.. . |         . |...| ..|  ||..                ..|.|  | ||||||||.| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLQIKLCDFGLSAQL-EKNCEQI------EILDWV-----------------------GNIGYMAPEILTKKEHEN----KIYSKKSDSYSVGLLL
      ||..||||| .. ..|....      ....                         |. |||||||| .|. .|    | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 17858.AA CMGC 407-558 15 2.4e-26 82.81 In-house 1-251 (513) Show / Hide 
Range on Protein: 407-558
Range on HMM: 1-251/513
Sequence Identity: 15% (40 aa)

VNNFQILSFGSFGMVLSTKKVE-------------LSNKEIVLKIQKIVNEQTIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  .              .|... .|. | .   ..|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYVIEKVTAPEK-----------YVVFELEKCSCSLQDYLERQA--KEG----EFSDEE------------KLNIA------LQIIDSVN--YI
.|.||| .. .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LQIKLCDFGLS
|  .  |||||.|| | |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 17858.AA STE 408-608 22 5.3e-26 88.86 In-house 1-258 (359) Show / Hide 
Range on Protein: 408-608
Range on HMM: 1-258/359
Sequence Identity: 22% (60 aa)

NNF-QILSFGSFG-MVLSTKKVEL-------------SNKEIVLKIQKIVN--------------------EQTIQNEIRIMQQLK--TPLVVQLYDNYV
  . ...  |.||  ..  ..                ... .  |. .. |                    .| |..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEK--VTA-PEKYVVFELEKCSC-SLQDYLE------------RQAKEGEFSDEEKLNIALQIIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLC
 |     .  | ... |.  ..  || | ..            ||. .. |. ..   |. ||.    .|.|  .||||||||.| |.        .|||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLC

DFGLSAQLEKNCE--------------QIEILDWVGNIGYMAPEILTKKEHE-NKIYSKKSDSYSVGLLL
|||...||....               | .   .||   .||||.... ..  .| |. |.| .|.|...
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 17858.AA TKL 510-608 25 3.1e-25 87.81 In-house 134-279 (364) Show / Hide 
Range on Protein: 510-608
Range on HMM: 134-279/364
Sequence Identity: 25% (37 aa)

KLNIALQIIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLQIKLCDFGLSAQLEKNCEQIEILD-----------------W
....||.|   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  .... ..  .                    
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

VGNIGYMAPEILTKKEHENK-----------IYSKKSDSYSVGLLL
.|....||||.| ...  ..            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 17858.AA Ciliate-A1 407-608 27 4e-17 54.8 In-house 1-218 (301) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-218/301
Sequence Identity: 27% (62 aa)

VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQ---NEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSCSLQDYLERQAKEG
    | .  |||| |.    .. . | . .|| .. |    .   .| |...|.  . |.  |.   ..  |       .  |.|   ..  .  | .  
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQ--LYYNTNNKECMFIIMEYCQYGNLFNYCYQND--

EFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKNC-------------------EQIEILDWVGNIGYMAPEI
  . ||   | .|||  .  ||  ||.|||.||.| |.   ..  ..|.||.|.| ||| |                    . .. .   ||  ||.|| 
YMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILI---HFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKG---GNLYYMSPEQ

----L-TKKEHENKIYSKKSDSYSVGLLL
    .  ..  ||||| |.|| ||.|. .
YQMHYRDQMFIENKIY-KQSDMYSLGCII
Kinase 17858.AA TyrKc 407-675 19 5.7e-11 -45.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 407-675
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

VNNFQILSFGSFGMVLSTKKVELSNKEIVL--KIQKIVNEQTIQNEIRIMQQL--KTPLVVQLYDNYVIEKV-----TAPEKYVVFELEKCSCSLQDYLE
.   ..|  | || |   .       . |   ....   .. . .|.||| .|  . | .|.||   |. .       ..  ..|.|. .   .|.||| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

RQAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKN------CEQIEI----LDW-VGNIGYMAPEILT
.  ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..   ..| .|||||  ..         . .          .  |  |||| . 
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KKEHENKIYSKKSDSYSVGLLL-----------SL-----LDNYLILKEKEGYTFMTMTLKQYDEP--FKKQKINIKRDTEIFKFIKLLVVWERVNRASL
      .... ||| .| | ..           .      ..|. ...  .    |      |  |  |          .|... .|     .  .| . 
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF------VCCPDEMYQIMKQCWHEDPEDRPTF

SIIVGQN
| |. . 
SEIHECF