Gene 13347 (Tetrahymena)

13347

Species: Tetrahymena
Alias: PreTt13347, TTHERM_00360330, 38.m00182, 13347, 266
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
13347.NA RNA None 3780 None Fasta, JSON
13347.AA Protein None 1259 None Fasta, JSON
13347.kin_dom Protein Kinase Domain None 199 None Fasta, JSON
13347.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of 13347.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13347.AA C8 42-256 62 8.20000000001e-123 414.31 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 62% (141 aa)

FSNFEYLNNGAYAVVLRAYNTKKNRTVALKFLTYTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNKKVVLTDEKSFFVMEME
|.||.||..|||..||.|.|.|.||...|||....||.|...|||..|||||.|.|.|.||.||.|.|||.|.|..||....|.|.|.|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCQQNLKQLFDFLRSTQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCDLGFASAVTKSKSHYISKK----RTDAYFAP
||.||||||.|..| .|.. |||.||||||||..|.|..|.||||||||||||||||..|.|||.|||||.||||.|.|.|||..|||     |.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEKG------QSRIQSDLFSLGLVL
|.||.      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13347.AA Ciliate-C8 51-256 57 6.1e-120 404.77 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 57% (137 aa)

GAYAVVLRAYNTKKNRTVALKFLTYTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNKKVVLTDEK---SFFVMEMELCQQN-
||...||.|.|.|.||.|||||.. .||..||..|...|||||...|.|..|.|.|| ||||||||..||.|||.|.| |.||   ||||||||.|||| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRSTQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCD------LGFASAVTKSKSHYISKK--RTDAY---
 |||.||..| .|.. |...||||||||....|.||..|||||||||||||||..|.|..||||||      .||||...|.||||.|||   ||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEKGQSRIQSDLFS-------LGLVL
        |||||||.|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13347.AA C2 51-269 39 5.5e-65 220.9 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 39% (96 aa)

GAYAVVLRAYNTKKNRTVALKFLTYTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEE-DEDGNKKVVLTDE--------KSFFVMEME
|| . || |.| |.||.||||  .  .  | || ... |||....... . ....|| .||| ... |  ||| . . .  ..        |.|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCQQNLKQLFDFLRSTQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCD----------LGFASAVTKSKS-HYISK-K
 || |||| |. .|  .  |....|.|.||||. . | || ..| |||||| |||.  .|    ||||||          . |||.. ..||  ..|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

RTDAY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLKVLNENW
 | .|    |||||...  . .||||| .|.||||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 13347.AA Pkinase 42-259 21 7.8e-28 99.5 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 21% (49 aa)

FSNFEYLNNGAYAVVLRAYNTKKNRTVALKFLTYTNKEDKNGIESLK-KEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNKKVVLTDEKSFFVMEM
.   . .  |....| .... . ...||.| . . .....  .. ..  | ...... .... |  |..|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCQQNLKQLFDFL------RSTQL--PSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCDLGFASAV-TKSKSHYISKKRTD
|.|.  |. ..|        |.. .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|.|| |.|  . . ..| . .   | 
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

AYFAPEV--EKGQSRIQSDLFSLGLVLLEL
 | ||||  .       .| .|.|..| |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 13347.AA CMGC 42-226 15 7e-27 84.6 In-house 1-287 (513) Show / Hide 
Range on Protein: 42-226
Range on HMM: 1-287/513
Sequence Identity: 15% (46 aa)

FSNFEYLNNGAYAVVLRAYN--------------TKKNRTVALKFLT---YTNKED----KNGIE-SLKKEYEMLQKFS---------------QSDF-L
. . ...  |.|.|| ....              .. |. ||.| .    |.. .     |.|.  .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYECFYLMEENVEEDEDGNK-KVVLTDEKSFFVMEMELCQQNLKQLFDFLRS-------TQLPSKE------------IKEII-----AIQMLEGLN-
|. |..||  ... .|.|| .. .     .   . . .|.....|.|. .  .          |.  .            || ..     . |.|.||. 
VKLYDIFYHKNSDGNEYEDKHIIS---Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPHNFLVCPSQTY----------------GFTIKLCDLGFASAVTKS------------------------KSHYIS
  .| ..  |.|||.|| | |...  ..                 ...|.|| |.| .. .                          .||..
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV
Kinase 13347.AA STE 42-259 20 1.8e-24 83.42 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 20% (57 aa)

FSNFEYLNNGAYAVVLRAYNT------KKNRT---------VALKFLTYTNKE----------DKNG----IESLKKEYEMLQKFSQ-SDFLVNVYECFY
. . | . .||. .| .|.|       |....         .| | . . |..          ..|     .....|| ....|... ... |. | |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEENVEEDEDGNKKVVLTDEKSFFVMEMELCQ-QNLKQLFDFLRSTQLPSK-----------EIKEIIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVCP
   .|             .....   . ||..    | .. .   ... | .           ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFTIKLCDLGFASAVTKSKSHY-----------ISKKR-----TDAYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
       .|||| |... .|.| ..            ...||     |  . |||| .. ..       ...|  |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 13347.AA CAMK 47-221 16 1e-21 66.14 In-house 1-250 (425) Show / Hide 
Range on Protein: 47-221
Range on HMM: 1-250/425
Sequence Identity: 16% (42 aa)

YLNNGAYAVVLRAYNTKKN------------RTVALKFLTYTNKEDKN-------------------------GIESLKKEYEMLQKFS------QSDFL
 |  |....| ...... .            . || |..  .   ||.                           .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYECFYL-----------MEENVEEDEDGNKKVVLT-DEKSFFVM-EMELCQQN--LKQLFDFLRST----------------QLPSKEIKEIIAIQM
.. || .               ...         |. | |.. ..||  ||.|.    .  |||....                  .. .| . ..  |.
IKLYEVYEDPHYFKNTNDYET-SKQ---------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QI

LEGLNNLHVKNIMHRDIKPHNFLVCPSQTYG-------------FTIKLCDLGFASAVTKSK
..... .| .||.|||.|| | |.. . .               ..||..| |||  .....
CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE
Kinase 13347.AA Ciliate-E2 140-259 23 1.6e-20 67.15 In-house 113-289 (365) Show / Hide 
Range on Protein: 140-259
Range on HMM: 113-289/365
Sequence Identity: 23% (44 aa)

MELCQQNLKQLFDFLRSTQLPSKEI---------KEI--IAIQMLE---------------GLNNLHVKN-IMHRDIKPHNFLVCPSQTYGFTIKLCDLG
||.||.  . |||.... .. ....         |||  |  | |.               .|. || || |.|||||| | |.         ||..|.|
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

FASAVTKS---KSHYISKKR-----------------------------TDAYFAPEVEKGQSR----------IQSDLFSLGLVLLEL
..  ....   ..|  .                                |  | |||. .|..            ..|..||| .| |.
LSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 13347.AA S_TKc 42-322 19 7.9e-20 73.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)

FSNFEYLNNGAYAVVLRAYNTKKNRTVALKFLTYTNKEDKNGIESLKKEYEMLQKFSQSDFLVNVYECFYLMEENVEEDEDGNKKVVLTDEKSFFVMEME
.   . .  ||...| .....| .| ||.| .           |....| ..|.|  . ...|. |..|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCQQNLKQLFDFLRSTQ-------LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCDLGFASAVTKSKSHYISKKRTDAYF
.| ..|  |||.... .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||.|| |.|  .        .   |  | 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYM

APEVEKGQSRIQSDLFSLGLVLLELDNLKVLNENWIDYFTKGEIYQGKSIASNYQIDRNSNIYKIAQICLKPNYLERTTSGDLLS--------ELI
||||  | ..  .|  |.| .| |.   . . .      .  ....             .    . . ||. .  .| |  ..|         . .
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13347.AA Ciliate-E3 149-260 32 1.3e-17 51.77 In-house 90-202 (202) Show / Hide 
Range on Protein: 149-260
Range on HMM: 90-202/202
Sequence Identity: 32% (38 aa)

QLFDFLRSTQLPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYG-FTIKLCDLGFASAVTKSK--SHYISKKRTDAYFAPEVEK-GQSR
.|  ....  .   .|.. |.||...|.  .| ||| | |||| |.||  .. ..  .|| ||.| .    | |  .|      |  | |||. . .|  
DLYHYIKQQNKTQNIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQIS

IQSDLFSLGLVLLELD
  ||. |.| |...| 
KESDYYSVGAVFCQLC
Kinase 13347.AA TKL 168-259 20 7.5e-17 57.22 In-house 137-282 (364) Show / Hide 
Range on Protein: 168-259
Range on HMM: 137-282/364
Sequence Identity: 20% (30 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLVCPSQT----------YGFTIKLCDLGFASAVTKSKS-------------------HYISKKRT
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|.||.|..  ...|..                   . ...  |
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
 .. ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 13347.AA Ciliate-E1 131-250 22 1.9e-16 50.43 In-house 67-202 (202) Show / Hide 
Range on Protein: 131-250
Range on HMM: 67-202/202
Sequence Identity: 22% (31 aa)

DEKSFFVMEMELCQQNLKQLFD---------FLRSTQLPSKEI-KEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCDLGFASAVTKS
|.  ...  .|.|...||. ..          ....|   ..  |. |..|...||. || .||.||||||.| |.. .  | ..    |.| ..   ..
DQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNN

KSHYISKKRTDAYFAPEVEKG----------QSRIQSDLF
. ... .|    |..|. ..           .  ..||..
QNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 13347.AA Ciliate-E1 48-112 19 8.7e-08 21.91 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 19% (13 aa)

LNNGAYAVVLRAYNTKKN-RTVALKFLTYTNKEDKNGIESLKKEYE-MLQKFSQSDFLVNVYECFYL
. || ...|..|.. . | . ||.|.  .  ....| .....|||  ... | . . ..........
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 13347.AA Ciliate-E2 42-116 15 6.2e-07 19.83 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 15% (17 aa)

FSNFEYLNNGAYAVVLRAYNTKKNRTVALKFLTYTN--------KED----------KNGIESLKKEYEMLQ---------------KFSQSDFLVNVYE
.   . . .|....| .. . |... .|.|. . ..        | .          ||.||..|.|  ...               .. ....... ||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEN
||. . .|
CFQEKDDN
Kinase 13347.AA Ciliate-E3 42-111 19 9e-06 14.31 In-house 1-72 (202) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-72/202
Sequence Identity: 19% (14 aa)

FSNFEYLNNGAYAVVLRAYNTKKNRTVALKFLTYTNKED---KNGIESLKKEYEMLQKFSQSDFLVNVYECFY
.     |..| . .| .|...  |. || | .. .|. .         . .|  . |..  | ..| ... .|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYY
Kinase 13347.AA C8 407-608 49 2.3e-103 349.68 In-house 1-226 (226) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-226/226
Sequence Identity: 49% (112 aa)

VNNFQILSFGSFGMVLSTKKVNLNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCS-----------CSLQD-
.||||.||||..||||..|.|. .|.|||||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLEGNQL-QIKLCDFGLSAQLGKDSEQIESLDI--IGNQAYTA
          |.||..|...||.|.|..||.|.||.||||||.||.||||||.||||||..|.. .|||||||...|..|. ..|.| ..  .|..|| |
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILTKEDDQYKIYSKKSDSYSVGLLL
|||..|.|.|||.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13347.AA Ciliate-C8 416-608 40 5.6e-98 331.81 In-house 1-238 (238) Show / Hide 
Range on Protein: 416-608
Range on HMM: 1-238/238
Sequence Identity: 40% (97 aa)

GSFGMVLST------KKVNLNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.|...|.|.||||...|.||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLE-GNQLQIKLCD------FGLSAQLGKDSE---------QIESLDI
.|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.. ..|..|||||      ||...|| |. .         ... .. 
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNQAYTAPEILTK-EDDQYKIYSKKSDSYSVGLLL
  .|| .|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13347.AA C2 416-608 30 5.8e-47 158.48 In-house 1-232 (245) Show / Hide 
Range on Protein: 416-608
Range on HMM: 1-232/245
Sequence Identity: 30% (72 aa)

GSFGMVLSTKKVNLN-NKEIVLKIQKIVN-----EQEIQNEIRIMQQLK-TPLVVQLYD-NYVIEKVTAP------------EK----------YVVFEL
|.||.||  |  | . |....||||..       ..|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.
GAFGLVL--KAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQ

EKCSCSLQDYLERQTKEG-EFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLEGNQL-QIKLCD----------FGLSAQLGKDSEQIESLDI
|.|.. |. |..|..|.  ......|  .| |..||.||.|.|.|.||||||.|||. .  ...  |||||          |  .  | .. ..|    .
EFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKF

IGNQAY----TAPEILTKEDDQYKIYSKKSDSYS-VGLLL
 . |.|    .|||.      . .|| |.|| .| ||. |
KWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVL
Kinase 13347.AA CAMK 412-608 19 1.9e-33 104.57 In-house 1-324 (425) Show / Hide 
Range on Protein: 412-608
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ILSFGSFGMVLSTKKVNLNN-----------KEIVLKI---QKIV----------------------------NEQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  | ..           ..   ||   .|.                             .......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYVIEKV--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQTK------------EGEFSDEEKLNIALQIIDSVNYIHCFN
..||. |  ...        |        .|.... .   | ||       | ||. ....            .| |. .|   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNFLVCLEG--------------NQLQIKLCDFGLSAQLGKDSEQI---------------------ESLDIIGNQAYTA-PEILTKE----
|.|||.||.| |..  .              |. .||..|||..... .....                         .  |  .| | ||.| ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DDQYKIYSKKSDSYSVGLLL
     |.. . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 13347.AA S_TKc 407-680 22 6.3e-30 106.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 407-680
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

VNNFQILSFGSFGMVLSTKKVNLNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC---SLQDYLERQTKEG
    ...  |.|| |   ....  ...  .|| |    . |..||.|... . | .|.||| ..        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLEGNQLQIKLCDFGLSAQLGKDSEQIESLDIIGNQAYTAPEILTKEDDQYKIYSK-KS
    |.  .   .. ||.. ..|.|  .|||||.||.| |..      .||.|||||..||           ..|   | |||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLTLLDNYLILKEIVGATFINMTLEQYDEPFKKQNINIKQNTEIFKFIKLLVVWERVRRASLSIIVE----QNSKKFK
| .|.| .|  .|  |      . ..| ..                    |   ||. . ...  .| .   . .     ..  . 
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13347.AA Ciliate-E1 413-602 26 1.5e-28 90.25 In-house 1-202 (202) Show / Hide 
Range on Protein: 413-602
Range on HMM: 1-202/202
Sequence Identity: 26% (55 aa)

LSFGSFGMVLSTKKVNLNNKEIVLKIQKIV---NEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVV-FELEKCSCSLQDYLE----------R
.. |||..|.  |. | |.... .||...    |....|.||.  ....  .  . |  ..|.     . |.  . .|.|.|||.|||.           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

QTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLEGNQLQIKLCDFGLSAQLGKDSEQIESLDIIGNQAYTAPEILTKED--DQYKIYS
|.....|....|..|. |.|| ....| .|||||||||.| |.. . .....   |||.| .| . ..|    .   .  |  ... ..|   .. ....
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN

KKSDSY
.||| |
YKSDIY
Kinase 13347.AA Pkinase 407-608 27 4.2e-28 100.45 Pfam 1-202 (293) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-202/293
Sequence Identity: 27% (60 aa)

VNNFQILSFGSFGMVLSTKKVNLNNKEIVLKIQKIVNEQEIQN-------EIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC-----SLQD
    ...  |||| |   .... ..|. ..|| | ..| . ..       ||.||. |. | .|.||| .        .... . .| | .     .| |
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQTKEGEF--SDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLEGNQL--QIKLCDFGLSAQLGKDSEQIESLDIIGNQAYTAPEILTKEDD
|...  ..| |  |..|  ....||.  ..|.|  .|||||.||.|.|.  . ...   .|.|||||..|.     .    .. |   | |||..     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

QYKIYSKKSDSYSVGLLL
 .. |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 13347.AA STE 408-608 21 4.3e-27 92.79 In-house 1-258 (359) Show / Hide 
Range on Protein: 408-608
Range on HMM: 1-258/359
Sequence Identity: 21% (57 aa)

NNF-QILSFGSFG-MVLSTKKVNL-------------NNKEIVLKIQKIVN--------------------EQEIQNEIRIMQQLK--TPLVVQLYDNYV
  . ...  |.||  ..  .. |              ... .  |. .. |                    .|.|..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEK--VTA-PEKYVVFELEKCSC-SLQDYLER--QTKE---------GEFSDEEKLNIALQIIDS-VNYIHCFNIIHRDIKPDNFLVCLEGNQLQIKLCD
 |     .  | ... |.  ..  || | ...   ...         . |. ..   |. ||.    .|.|  .||||||||.| |.        .||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSAQLGKD--------------SEQIESLDIIGNQAYTAPEILTKEDDQ-YKIYSKKSDSYSVGLLL
||...|| ..              . | ..  ..| . . |||......    | |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 13347.AA CMGC 407-558 16 2.4e-26 82.78 In-house 1-251 (513) Show / Hide 
Range on Protein: 407-558
Range on HMM: 1-251/513
Sequence Identity: 16% (42 aa)

VNNFQILSFGSFGMVLSTKKVNLN-------------NKEIVLKIQKIVNEQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  . |             |... .|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYVIEKVTAPEK-----------YVVFELEKCSCSLQDYLERQT--KEG----EFSDEE------------KLNIA------LQIIDSVN--YI
.|.||| .. .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLEGNQ-----------------LQIKLCDFGLS
|  .  |||||.|| | |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 13347.AA Ciliate-E2 407-608 21 1.2e-25 85.05 In-house 1-286 (365) Show / Hide 
Range on Protein: 407-608
Range on HMM: 1-286/365
Sequence Identity: 21% (65 aa)

VNNFQILSFGSFG-----MVLSTKKVN-----------------LNNKEIVLKIQK------IVNEQEIQNEIR----------IMQQLKTPLVVQLYDN
 .  ... .|.||      | ...|                    ..|.. .||.|      | .|. | .||.          |..||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKVTAPEKYVVFELEKCSC-SLQDYLERQ-TKE-------GEFSDEEKLNIALQIID---------------SVNYIHCFN-IIHRDIKPDNFLVCL
.  ..    .... . .| |.  .|.||.. . .|.       . |...| ..|  ||..                ..|.|  | ||||||||.| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

EGNQLQIKLCDFGLSAQLGKD-------SEQIESLDII-----------------------GNQAYTAPEILTKEDDQ----YKIYSKKSDSYSVGLLL
      ||..||||| .. .|       ... . ..                         |.  | ||||| .....     | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 13347.AA TKL 510-608 24 2.3e-23 80.97 In-house 134-279 (364) Show / Hide 
Range on Protein: 510-608
Range on HMM: 134-279/364
Sequence Identity: 24% (36 aa)

KLNIALQIIDSVNYIHCFN--------IIHRDIKPDNFLVCLEGN-----------QLQIKLCDFGLSAQLGKDSEQIE-----------------SLDI
....||.|   .|| |  |        |||||.|..| ||   ..           .  .|.||||||  . .....                   .  .
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

IGNQAYTAPEILTKEDDQYK-----------IYSKKSDSYSVGLLL
.|. .. |||.| ....  .            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 13347.AA Ciliate-E3 445-612 36 4.7e-17 49.97 In-house 47-202 (202) Show / Hide 
Range on Protein: 445-612
Range on HMM: 47-202/202
Sequence Identity: 36% (61 aa)

QEIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC-SLQDYLERQTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCL
|. |.|.   ||..   ||. .| |. ..       .| |.  ||  .|. |.  | |    . .. . |. ||| ..  ||  |||| ||||||.||  
QKTQQEFQNCQQINSQNVVKCHDQYYDQQNKM--IFIVQEY--CSNGDLYHYIKQQNK----TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDK

EGNQLQIKLCDFGLSAQLGKDSEQIESLDIIGNQAYTAPEILTKEDDQYKIYSKKSDSYSVGLLLTLLD
. ||| || ||||.| || |.   .  ..      | |||.     ...   || || ||||  . .| 
NNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ-----NDQQQISKESDYYSVGAVFCQLC
Kinase 13347.AA TyrKc 407-675 20 2.6e-11 -39.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 407-675
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

VNNFQILSFGSFGMVLSTKKVNLNNKEIVL--KIQKIVNEQEIQNEIRIMQQL--KTPLVVQLYDNYVIEKV-----TAPEKYVVFELEKCSCSLQDYLE
.   ..|  | || |   .       . |   ....   .... .|.||| .|  . | .|.||   |. .       ..  ..|.|. .   .|.||| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

RQTKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLEGNQLQIKLCDFGLSAQLGKD------SEQIESLD-IIGNQ----AYTAPEILT
.  ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..   ..| .|||||  .. |      .. . .     |.       .||| . 
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KEDDQYKIYSKKSDSYSVGLLLT------LLDNY------LILKEIVGATFINMTLEQYDE----PFKKQNINIKQNTEIFKFIKLLVVWERVRRASLSI
    .|.... ||| .| | ..           .      .  .|..      . ..| ..     |          .|... .|     .   | . | 
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSE

IVEQN
|.|. 
IHECF
Kinase 13347.AA Pkinase_Tyr 445-558 30 0.000379 14.67 Pfam 48-158 (270) Show / Hide 
Range on Protein: 445-558
Range on HMM: 48-158/270
Sequence Identity: 30% (36 aa)

QEIQNEIRIMQQL-KTPLVVQLYDNYVIEKVTAP-EKYVVFELEKCSCSLQDYLERQ-TKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLV
..  .|..|| || . | .|.||   |. .   | . |.|.|. ..  .| ||| .. . .. .. ...|....|| .  .| .  |.||||.   | ||
EDFMREAKIMKQLGHHPNIVRLY--GVCTDQGEPNQIYIVMEYMPHG-DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLV

CLEGNQLQIKLCDFGLS
     ....| |||||.
TE---NNVVKICDFGLA