Gene 14781 (Tetrahymena)
14781
Sequence
Protein domains of 14781.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14781.AA | Ciliate-C8 | 95-336 | 50 | 9.90000000001e-109 | 367.53 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 95-336 Range on HMM: 1-238/238 Sequence Identity: 50% (129 aa) GDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMFSQSEFLVNFYDCFYLMEEKEDEDTDGNDIIVQTGVK---SFFVMEMELCENN- | ...|||.|... |||||||. ..|...||..|...|||||.. |.|..|.|..|||||||||...|| ||||.|||| .| ||||||||.|..| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC -LKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFSIKLCI---QLFLFYIIFNKYLLNLGDLGFASAVSKSKS- |||.||..||.|..| ..|||||||||||..|.||..|||||||||.||||| ...|...||||. | .|.||||...|.|| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQ---------------CDFGFASQLPKNKSH FLSKVKKQIIIFIGFNIFYNFQKGTAAYFAPEVEEGKSRIQSDLFS-------LGLAL ..|| .|. . | ... |. .|||||||...||||||.|| .|| | YHSKKFKGTDQYIEMYF-----CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
|||||||||
| Kinase | 14781.AA | C8 | 86-336 | 51 | 4.5e-107 | 362.03 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 86-336 Range on HMM: 1-226/226 Sequence Identity: 51% (132 aa) FKNYEYLSNGDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMFSQSEFLVNFYDCFYLMEEKEDEDTDGNDIIVQTGVKSFFVMEME |.|..|||.| ....|||.|... |...|||. ..|..|...|||..|||||.|.|.|..|.|| |||||.|.|...|. ..|..|||| .||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFSIKLCIQLFLFYIIFNKYLLNLGDLGFASAVSKSKS |||.|||||.|..|..|....||||||||||||||.|..|.||||||||||.|||||....|||.|||| |.||||.|||.|| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC------------------DFGFASQVSKNKS -FLSKVKKQIIIFIGFNIFYNFQKGTAAYFAPEVEEG------KSRIQSDLFSLGLAL ..|| .. || ||||||.|.. ..||||||||.|| | HIQSKKMNT--------------CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
|||||||||
| Kinase | 14781.AA | C2 | 95-349 | 34 | 1.3e-57 | 195.34 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 95-349 Range on HMM: 1-245/245 Sequence Identity: 34% (92 aa) GDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMFSQSEFLVNFYDCFYLMEE-KEDEDTDGNDIIVQTGV--------KSFFVMEME | ...|||.| .. |.|||| .. | || ... |||.... .. . .....|..||| .. ||||| | ...... |.|.|.|.| GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFSIKLCIQLFLFYIIFNKYLLNLGDLGFASAVSKSKS |. |||| |. .|||. | ..||.|.||||.|. | || ..| ||||||||||. ... ||||.. . . . . FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K----------------CDFD FLSKVKKQIIIFIGFNIFYNFQKGTAAY----FAPEVEEGKSRIQSDLFS-LGLALLELDNLKTLNENW | ||.|.. . | . .|.| .| |||||... . .||||| .|. |||||| .. . . FASKLKYNKSR-----IHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
|||||||||
| Kinase | 14781.AA | Ciliate-E1 | 92-257 | 22 | 2e-18 | 56.9 | In-house | 1-159 (202) | Show / Hide |
Range on Protein: 92-257
Range on HMM: 1-159/202
Sequence Identity: 22% (40 aa)
LSNGDCAIILKAYNSQKS-RKVALKFLGSSNQKDKNGIESLKKEYE-MLQMFSQSEFLVNFYDCFY---------LMEEKEDEDTDGNDIIVQTGVKSFF
..||. .|..||.. . . ..||.|. . ..| .....||| ... | . . .....|... ..|. .....| ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------
VMEMELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFS-IKLCIQL
| | .... ....| . |. |..|.||||. || .||.||||||.| |.. ...| .. . .. .|
--------NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFL
|
|||||||||
| Kinase | 14781.AA | Pkinase | 86-241 | 20 | 3.6e-15 | 54.7 | Pfam | 1-141 (293) | Show / Hide |
Range on Protein: 86-241 Range on HMM: 1-141/293 Sequence Identity: 20% (34 aa) FKNYEYLSNGDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLK-KEYEMLQMFSQSEFLVNFYDCFYLMEEKEDEDTDGNDIIVQTGVKSFFVMEM .. . . | . |... ...||.| . ...|.. .. .. | ...... .... | .||.|. |. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCENN--LKQLFDFLR--KQQVP--PPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLV |.||. . |||... .. . ...| | .. |.. ||. .| ..|.|||.||.|.|. EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILI |
|||||||||
| Kinase | 14781.AA | S_TKc | 86-403 | 17 | 1e-14 | 38.92 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 86-403 Range on HMM: 1-231/231 Sequence Identity: 17% (58 aa) FKNYEYLSNGDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMFSQSEFLVNFYDCFYLMEEKEDEDTDGNDIIVQTGVKSFFVMEME .. . . | . |... |.||.| . |....| ..|.. . ...|..||.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCENNLKQLFDFLRKQQVP------PPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFSIKLCIQLFLFYIIFNKYLLNLGDLGFASA .|...| |||...|.. . |. . . ... |....|. .| ..|.|||.||.| |... . ..| |.| YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------------------------HIKICDFGLARQ VSKSKSFLSKVKKQIIIFIGFNIFYNFQKGTAAYFAPEVEEGKSRIQSDLFSLGLALLELDNLKTLNENWIDTKTKNYLFNGEEIPKEKYQIDKNSNIYK . . . || | |||| | .. .| |.| | |. ... . . .. . . . L------------------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKD IAKICLQPWYLDRITAGELLS--------SLI . . ||| .|.|| |.| . FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 14781.AA | Ciliate-B2 | 184-250 | 38 | 1.7e-14 | 30.42 | In-house | 80-146 (197) | Show / Hide |
Range on Protein: 184-250 Range on HMM: 80-146/197 Sequence Identity: 38% (26 aa) MELCENNLKQLFDFLRKQQ-VPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFS || || ||| . . ||| . . . .| |.|||| ....||.| ||||.| |. . .| .. MEKCECSLKQELQKIQKQQKCFNNQKLYQMI-FQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYC |
|||||||||
| Kinase | 14781.AA | CMGC | 86-254 | 15 | 1.1e-13 | 40.37 | In-house | 1-246 (513) | Show / Hide |
Range on Protein: 86-254 Range on HMM: 1-246/513 Sequence Identity: 15% (38 aa) FKNYEYLSNGDCAIILKAYN--------------SQKSRKVALK-----FLGSSNQK---DKNGIE-SLKKEYEMLQMFS---------------QSEF- ... ... | .. |... . ..||.| | .| |.|. . | ..|.... . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LVNFYDCFYLMEEKEDEDTDGNDIIVQTGVKSFFVMEMELCENNLKQLFDFLR------KQQVPPPKE------------MKEII-----AIQMIDGLN- .|. ||.|| ... .|. | . | . . . .|.....|.|. . . ... .. . | .. . |.. ||. IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL -NLHVKN--IMHRDIKPSNFLVCTSKEY----------------GFSIKLC .| .. |.|||.||.| |.. .|. . .|.| KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC |
|||||||||
| Kinase | 14781.AA | CK1-Unclassified | 213-241 | 62 | 6.3e-13 | 34.51 | In-house | 109-137 (244) | Show / Hide |
Range on Protein: 213-241 Range on HMM: 109-137/244 Sequence Identity: 62% (18 aa) IAIQMIDGLNNLHVKNIMHRDIKPSNFLV || |||. . .|| ||. |||||| |||. IADQMIQRIEYLHNKNFIHRDIKPDNFLM |
|||||||||
| Kinase | 14781.AA | Ciliate-E2 | 184-333 | 21 | 1.2e-12 | 39.68 | In-house | 113-283 (365) | Show / Hide |
Range on Protein: 184-333
Range on HMM: 113-283/365
Sequence Identity: 21% (44 aa)
MELCENNLKQLFDFLRKQQVPPPKE--------MKEI--IAIQMID---------------GLNNLHVKN-IMHRDIKPSNFLVCTSKEYGFSIKLCIQL
||.|. . |||...... ..| .||| | | .. .|. || || |.||||||.| |.
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------
FLFYIIFNKYLLNLGDLGFASAVSKS--KSFLSKVKKQIIIFIG---------------FNIFYNFQKGTAAYFAPEVEEGKSR----------IQSDLF
. . |.|.. .... . . |. ....| . .|.|... ||. | |||. .||. ..|..
-----------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTIC-GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW
SLG
|||
SLG
|
|||||||||
| Kinase | 14781.AA | Ciliate-E3 | 169-241 | 35 | 3.8e-10 | 28.13 | In-house | 69-136 (202) | Show / Hide |
Range on Protein: 169-241 Range on HMM: 69-136/202 Sequence Identity: 35% (26 aa) DIIVQTGVKSFFVMEMELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLV |.... |. |. .|.|.| .| ... ||. .... |.||.| |. .| ||| | ||||.|.|| DQYYDQQNKMIFIV-QEYCSN--GDLYHYIK-QQNKTQNIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV |
|||||||||
| Kinase | 14781.AA | Ciliate-A1 | 184-241 | 36 | 1.6e-08 | 25.08 | In-house | 80-134 (301) | Show / Hide |
Range on Protein: 184-241 Range on HMM: 80-134/301 Sequence Identity: 36% (21 aa) MELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLV || |. .. ||.. | || |.| |. .| .||.|||.|| | |. MEYCQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILI |
|||||||||
| Kinase | 14781.AA | TyrKc | 86-402 | 16 | 3e-06 | -122.53 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 86-402 Range on HMM: 1-280/280 Sequence Identity: 16% (57 aa) FKNYEYLSNGDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMF-SQSEFLVNFYDCFYLMEEKEDEDTDGNDIIVQTGVKSF----- . . | .| .. |. . ..|| | | .. .| . .| ... .. . . .|..| . ... | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------------------FMYIEP FVMEMELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIDGLNNLHVKNIMHRDIKPSNFLVCTSKEYGFSIKLCIQLFLFYIIFNKYLLNLGDLGFASA . ||.... | |.||| . . . . ...| .| . || ||. |||. | || . .| | . . LMIVMEYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------------TVKISDFGLSRD VSKS-------KSFLSK---VKKQ-IIIFIGFNIFYNFQKGTAAYFAPEVE-EGKSRIQSDLFSLGLALLELDNL-KTLNEN-----WIDTKTKNYLFNG . . .| .| . | |||. .|| ..|| .| | . |. . .. .. .. .|. .| IYDDDQQGESKDYYRKKEHKGGKTMLPIR---------------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG EEIPKEKY-----QIDKNSNIYKIAKICLQPWYLDRITAGELLSSL . |. .. . .|.| | | . || | |. . . YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | 14781.AA | Ciliate-E2 | 86-160 | 13 | 0.000423 | 9.95 | In-house | 1-107 (365) | Show / Hide |
Range on Protein: 86-160 Range on HMM: 1-107/365 Sequence Identity: 13% (14 aa) FKNYEYLSNGDCAIILKAYNSQKSRKVALK-----------------FLGSSNQKDKNGIESLKKEYEMLQ---------------MFSQSEFLVNFYDC .| . . .| ... |. . .. ...|.| .. ... ||.||..|.| ... . .. .....|.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FYLMEEK |. . .. FQEKDDN |
|||||||||
| Kinase | 14781.AA | Ciliate-A1 | 309-339 | 31 | 0.000483 | 9.58 | In-house | 181-221 (301) | Show / Hide |
Range on Protein: 309-339 Range on HMM: 181-221/301 Sequence Identity: 31% (13 aa) GTAAYFAPEV----------EEGKSRIQSDLFSLGLALLEL |. | .|| |.| |||..|||. ...| GNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL |
|||||||||
| Kinase | 14781.AA | Ciliate-E3 | 86-160 | 24 | 0.000708 | 8.31 | In-house | 1-77 (202) | Show / Hide |
Range on Protein: 86-160 Range on HMM: 1-77/202 Sequence Identity: 24% (19 aa) FKNYEYLSNGDCAIILKAYNSQKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMFSQ--SEFLVNFYDCFYLMEEK . | .| . ||...| ..|| | . .||.. | ..| |...| |...| .| .| . | YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNK |
|||||||||
| Kinase | 14781.AA | Ciliate-B2 | 326-333 | 62 | 0.00751 | 2.42 | In-house | 190-197 (197) | Show / Hide |
Range on Protein: 326-333 Range on HMM: 190-197/197 Sequence Identity: 62% (5 aa) QSDLFSLG ||| .|.| QSDIYSMG |
|||||||||
| Kinase | 14781.AA | Ciliate-A1 | 86-123 | 15 | 0.013775 | 4.55 | In-house | 1-39 (301) | Show / Hide |
Range on Protein: 86-123 Range on HMM: 1-39/301 Sequence Identity: 15% (6 aa) FKNYEYLSNGDCAIILKAYNSQKSR-KVALKFLGSSNQK . . | ....||..| .. ....| . .| . YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE |
|||||||||
| Kinase | 14781.AA | Ciliate-B2 | 86-154 | 22 | 0.019954 | 1.4 | In-house | 1-69 (197) | Show / Hide |
Range on Protein: 86-154 Range on HMM: 1-69/197 Sequence Identity: 22% (16 aa) FKNYEYLSNGDCAIILKAY--NS-QKSRKVALKFLGSSNQKDKNGIESLKKEYEMLQMFSQSEFLVNFYDCF . .|. .| | .| . | .| .. . .|.| . . ||. |.. |.. ..|| ... | . | . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQH---EIKIMKMFEYNINVVKYIDHI |
|||||||||
| Kinase | 14781.AA | Ciliate-E3 | 315-340 | 29 | 0.021364 | 3.63 | In-house | 176-202 (202) | Show / Hide |
Range on Protein: 315-340 Range on HMM: 176-202/202 Sequence Identity: 29% (8 aa) APEVEE-GKSRIQSDLFSLGLALLELD |||. . .. ||. |.| ...| APEQNDQQQISKESDYYSVGAVFCQLC |
|||||||||
| Kinase | 14781.AA | Ciliate-E1 | 334-378 | 12 | 0.082383 | 2.25 | In-house | 153-202 (202) | Show / Hide |
Range on Protein: 334-378 Range on HMM: 153-202/202 Sequence Identity: 12% (6 aa) LALLELDNLKTLNENWIDTKTKNYLFNGEEI-----PKEKYQIDKNSNIY ... . ....... .. |..| . . ......|...|.|| FGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
|||||||||