Gene 12562 (Tetrahymena)
12562
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 12562.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12562.AA | Ciliate-E1 | 329-392 | 19 | 0.276488 | 0.52 | In-house | 2-66 (202) | Show / Hide |
Range on Protein: 329-392 Range on HMM: 2-66/202 Sequence Identity: 19% (13 aa) KVIGCGFVQKATKQIGQDKKHYLILILTRFI--KIQNSHKNLELLKFLKTLHETKQQIQIDDTFQL . . ..| || .| .... ....|...|. .... .. | |..| . . ...||| |.... GNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI |
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| Kinase | 12562.AA | Ciliate-B2 | 432-565 | 43 | 4e-69 | 161.7 | In-house | 1-137 (197) | Show / Hide |
Range on Protein: 432-565 Range on HMM: 1-137/197 Sequence Identity: 43% (60 aa) YYLEKYIAEGGFGIVFDGK-IYQNNKIQEVIFKIQFT-DEQNTNESEEEFLIMKGFEKNINLINAIDYKKIDQNVSVILMEKCECNLNNKLKQLQERN-Q ||| |||..||.|....| . . |...|||.| .. . .| ..| ||| ||.||| . ||. .|.... |. |||||| | . |...| . YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKC FSFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNILI | |...||.|||||| .|.| |.||||||.|||. FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF |
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| Kinase | 12562.AA | Ciliate-E1 | 438-568 | 43 | 5.7e-44 | 140.94 | In-house | 1-145 (202) | Show / Hide |
Range on Protein: 438-568 Range on HMM: 1-145/202 Sequence Identity: 43% (63 aa) IAEGGFGIVFDGKIYQNN--KIQEVIFKIQF--TDEQNTNESEEEFLIMKGFEKNINLINAIDYKKIDQN-VSVILMEKCECNLNNKLK---------QL |..|.|.|||..|...|| .....|....| .......|..|...||| |.|....|. |||.||||| ...|..|.|.|.|...|. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC Q-ERNQFSFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNILINRY | . |||.|.|...|||.|||||| |..|.|||.||||.|||||.. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ |
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| Kinase | 12562.AA | Ciliate-B2 | 566-599 | 33 | 1.5e-12 | 25.71 | In-house | 159-197 (197) | Show / Hide |
Range on Protein: 566-599 Range on HMM: 159-197/197 Sequence Identity: 33% (13 aa) NRYVKGFTPSYAPEEVIKGK-----VSDINYESDVFSLG . ..|||| .||. | .. |. |.. ||..|.| QIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 12562.AA | Ciliate-E2 | 432-599 | 18 | 7.8e-12 | 36.88 | In-house | 1-283 (365) | Show / Hide |
Range on Protein: 432-599
Range on HMM: 1-283/365
Sequence Identity: 18% (54 aa)
YYLEKYIAEGGFGIVFDGKIYQNNK------IQEVI---------FKIQFTDEQNTNESEEEFLIM-KGFEKNIN-------------------LINAID
| . | | .|.||.|. .| ....| |. . .||.. . .... |.. . . . || .|. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE
YKK-IDQNVSVILMEKCECN------LNNKLKQLQERN---QFSFTQLLKIIFDLID---------------GLILLRIYK-IIHLDIKPTNILINRYVK
. . .|.| . || |. . |||.|...|.. .|. . ..|. ... .| | . ||| |||| |||. .|
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---IK
----GF-----------------------------------------------TPSYAPEEVIKGKVSD-------INYESDVFSLG
|. || | . |...|| | .|..|..|||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG
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| Kinase | 12562.AA | Ciliate-E2-Unclassified | 432-599 | 21 | 1.5e-11 | 36.31 | In-house | 1-257 (352) | Show / Hide |
Range on Protein: 432-599
Range on HMM: 1-257/352
Sequence Identity: 21% (55 aa)
YYLEKYIAEGGFGIVFDGKIYQNN---------KIQEVIFKIQ-FTDEQNTNESEEEFLIMKGFEKN---------------INLINAIDYKKIDQNVSV
| . | | .||||.|. . ... |||.. |.. . | . || .|.. ..| . . ..... ..... .||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI-Y
ILMEKCE-------CNLNNK--------LKQLQERNQFSFTQLL-----KIIFDLIDGL-ILLRIYKIIHLDIKPTNILI---NR--YVK----------
| ||.|| .. ..| .....|..|. | . ... ...|| | . .||| |||| |||. .. |.|
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
-------------------------GFTPSYA----PEEVIKGKVSDIN--YESDVFSLG
||.| . ||..|. | |..|..|||
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
|
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| Kinase | 12562.AA | S_TKc | 432-653 | 18 | 1.8e-10 | -23.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 432-653 Range on HMM: 1-231/231 Sequence Identity: 18% (48 aa) YYLEKYIAEGGFGIVFDGKIYQNNKIQEVIFKIQFTDEQNTNESEEEFLIMKGFEKNINLINAIDYKKIDQNVSVILMEKCEC---NLNNKLKQLQE--- | . . | .|.|| |. | . .. ..| || . . | |.| . |... .|. . . || |. .| .|. . YEILRKIGKGAFGKVY--KCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL RNQFSFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNILINR-------------YVKGFTPSYAPEEVIKGKVSDINY-ESDVFSLGKTL------EIV | .|. . ... ....| . .||| |.|| |||... . || | . ||. .. ..|. |.| .| . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPP FKEYEKLKIFNQNEKAMLEKFKQILKDYALREQVSERKTCLELHK--------AFY | . ..|.. . .|. . . |. ..| |. |. . . FP--QMQMMFKKIG---SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 12562.AA | CMGC | 432-566 | 15 | 1.3e-08 | 23.43 | In-house | 1-218 (513) | Show / Hide |
Range on Protein: 432-566 Range on HMM: 1-218/513 Sequence Identity: 15% (34 aa) YYLEKYIAEGGFGIVFDGKIYQNNKI------------QEVIFKIQFTDEQNTNESE-------------EEFLIMKGFE---------------KNIN- | |.| || .|.|. .. ..|. ..| |. . .. .... | |.| . |. | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LINAIDYKKIDQ---------------NVSV-ILMEKCECNLNNKLKQLQE-------------------------RNQFSFTQLLKIIFDLIDGLI--L ... .|. . .. .... . .| ....| . .|. | |. . ... .. || IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY LRIYK--IIHLDIKPTNILIN . . ||| |.|| ||||| CHSHWGNIIHRDLKPENILIN |
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| Kinase | 12562.AA | Ciliate-E5 | 441-564 | 31 | 2.4e-08 | 23.08 | In-house | 10-135 (271) | Show / Hide |
Range on Protein: 441-564 Range on HMM: 10-135/271 Sequence Identity: 31% (40 aa) GGFGIVFDGKIYQNNKIQEVIFKI-QFTDEQNTNESEEEFLIMKGFEKN--INLINAIDYKKIDQNVSVILMEKCECNLNNKL-KQLQERNQFSFTQLLK ||.|.| | .|.| .. || . .. || |.| | . | . . |.. . | | ||.|.|.| . | | . . . . .... GGSGMVMKGCSEWNDKP--IAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQKHQDIYQ IIFDLIDGLILLRIYKIIHLDIKPTNIL | .|. || . |||||||| ||| ICLQLVKGLQDIHQKNIIHLDIKPANIL |
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| Kinase | 12562.AA | Ciliate-E1 | 569-596 | 35 | 5.9e-07 | 19.18 | In-house | 169-202 (202) | Show / Hide |
Range on Protein: 569-596 Range on HMM: 169-202/202 Sequence Identity: 35% (12 aa) VKGFTPSYAPEEVIK------GKVSDINYESDVF .||.| .|.|.|... | |||.||.. YKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 12562.AA | STE | 432-570 | 18 | 2e-06 | 18.55 | In-house | 1-187 (359) | Show / Hide |
Range on Protein: 432-570 Range on HMM: 1-187/359 Sequence Identity: 18% (36 aa) YYLEKYIAEGGFGIVFDGKIY------QNNKI-------QEVIFKIQFTDEQNTNESE-------------------EEFLIMKGFEK-NINLINAIDYK . . . | .|.|| |. .. ..... . . |. ...|... | .| ||| . . | .. ... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY KID------QNVSVILMEKCEC-NLNNKLKQLQERNQ-----------FSFTQLLKIIFDLIDG-LILLRIYKIIHLDIKPTNILINRYVK . . | || .. | .|. .... |. .|. .|..... | | .| .||| |||| |||. || FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---VK |
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| Kinase | 12562.AA | Ciliate-E3 | 432-565 | 23 | 3e-06 | 15.67 | In-house | 1-136 (202) | Show / Hide |
Range on Protein: 432-565 Range on HMM: 1-136/202 Sequence Identity: 23% (33 aa) YYLEKYIAEGGFGIVFDGKIYQNNKIQEVIFKIQFTDEQNT-------NESEEEFLIMKGFE-KNINLINAIDYKKIDQNVSVILMEKCEC-NLNNKLKQ | . .. |.||.|. | . . |.| | .....|. ... || . .. .|.. . . |.. .. .. .| |. .| . .|| YTVQQILGCGQFGRVY--KAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIV-QEYCSNGDLYHYIKQ LQERNQFSFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNILI . . ...|. .| |.| . .||| |||| |||. QNKTQN----IIYDICIQIIQGMIAIHEKNIIHSDIKPDNILV |
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| Kinase | 12562.AA | Ciliate-C8 | 441-564 | 22 | 5e-06 | 18.02 | In-house | 1-151 (238) | Show / Hide |
Range on Protein: 441-564 Range on HMM: 1-151/238 Sequence Identity: 22% (34 aa) GGFGIVFD---GKIYQNNKIQEVIFKIQFTDEQNTNESEEEFLIMKGFEKNINLINAID------YKKIDQ------------N----VSVILMEKCE-- |.||.| | . .... . . |. | .|. .||. | . ... | .| .. . .|. ||||. GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQ-FCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQN CNLNNKLKQLQERN-QFSFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNIL |||.. ...... . ..| . ..| ||.. | . |.| |||| |.| CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFL |
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| Kinase | 12562.AA | TyrKc | 432-652 | 18 | 3.4e-05 | -138.59 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 432-652 Range on HMM: 1-280/280 Sequence Identity: 18% (53 aa) YYLEKYIAEGGFGIVFDGKIYQNNKIQEVIFKIQFTDEQNTNESEEEFLIMKGF-EKNINLINAIDYKKIDQ------NVSVILMEKCEC-NLNNKLKQL |.| . || ||.|. |. . ..| | | . .| ||. . .. |... . . .. |.|| .. .|.. |. ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH QERNQFSFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNILINRY--VK----GFTPSYAPE-------EVIKGK---VSD------------INYE--- ... .. .||.. .. .| | ..|| |. |.|... || | . . .... | .. ||| RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT --SDV----------FSLGKTLE-------IVFKE-YEKLKIFNQNEKAML----------EKFKQILKDYALREQVSERKTCLELHKAF ||| |..|.. . .| .|..| . .. .. || |. .|. ..| | |.|. | TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC-WHEDPEDRPTFSEIHECF |
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| Kinase | 12562.AA | C8 | 436-565 | 21 | 8.9e-05 | 12.64 | In-house | 5-156 (226) | Show / Hide |
Range on Protein: 436-565 Range on HMM: 5-156/226 Sequence Identity: 21% (33 aa) KYIAEGGFGIVFDGKIYQNNKIQEVIFKIQFTDEQNTNESEEEFL-------IMKGFEKNINL--INAIDYKKI--DQNV----------SVILME--KC .|. |..|.| .| ..|. |.. |.| ...... .|. ... .. .| . .|... ... | .|| | QYLSFGAYGMVLKAKNVKDNR--EIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELC ECNLNNKLKQLQERNQF-SFTQLLKIIFDLIDGLILLRIYKIIHLDIKPTNILI | ||.. .......| | . ..| .|||. . . .|.| |||| |.|. EQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLV |
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| Kinase | 12562.AA | Ciliate-E3 | 571-605 | 33 | 0.008112 | 4.96 | In-house | 169-202 (202) | Show / Hide |
Range on Protein: 571-605 Range on HMM: 169-202/202 Sequence Identity: 33% (12 aa) GFTPSYAPEEVIKGKVSDINYESDVFSLGKTL-EIV |.|| ||. |. . . | ||| |.| . ... GWTPFYAAPEQND--QQQISKESDYYSVGAVFCQLC |
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| Kinase | 12562.AA | C8 | 573-602 | 30 | 0.011002 | 5.28 | In-house | 194-226 (226) | Show / Hide |
Range on Protein: 573-602 Range on HMM: 194-226/226 Sequence Identity: 30% (10 aa) TPSYAPEEVIKG---KVSDINYESDVFSLGKTL | | |..|. .. . . .||.||.| | TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 12562.AA | Ciliate-C8 | 580-602 | 40 | 0.034069 | 4.08 | In-house | 212-238 (238) | Show / Hide |
Range on Protein: 580-602 Range on HMM: 212-238/238 Sequence Identity: 40% (11 aa) EVIKG---KVSDINY-ESDVFSLGKTL ||.|. . ||| .||..|.| | EVEKKQSRIQSDIFSKKSDSYSVGLVL |
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