Gene 6257 (Tetrahymena)

6257

Species: Tetrahymena
Alias: TTHERM_00481250, 375, 58.m00229, PreTt06257, 3719.m00085, 6257
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: VWL

Sequence

Name Sequence Type Origin Length Description Download
6257.AA Protein None 862 None Fasta, JSON
6257.kin_dom Protein Kinase Domain None 203 None Fasta, JSON
6257.NA RNA None 2589 None Fasta, JSON

Protein domain

Protein domains of 6257.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ZnF_C3H1 6257.AA ZnF_C3H1 6-33 21 0.006209 12.85 SMART 1-31 (31) Show / Hide 
Range on Protein: 6-33
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

IQKHLPCHDY-HMG---NCTLTKAQCPYSHEG
  |. || ..  .|   .|   . .|...|  
RYKTPPCKYFMRRGPPWYCPYGD-RCKFAHPP
ZnF_C3H1 6257.AA ZnF_C3H1 48-74 25 0.003045 15.32 SMART 1-31 (31) Show / Hide 
Range on Protein: 48-74
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

PHKLVDCPLF-LNN---CCPKGENCSYRHKS
  | ..|. | ..     ||.|..| ..|  
RYKTPPCKYFMRRGPPWYCPYGDRCKFAHPP
VWA 6257.AA VWA 151-337 14 0.000352 14.72 SMART 1-193 (193) Show / Hide 
Range on Protein: 151-337
Range on HMM: 1-193/193
Sequence Identity: 14% (32 aa)

SLDLCFVVDISGSM-SSWMNHVVQYVGNTLNTIYQQFPAITLRVAFSGYRDINDFEQYVQVDF-TRNIEDFKTRLSKVS---CGGGGGDWPEDVTGGLNN
 ||..||.|.||||  .....| | . . .....      . ||.  .. |    ...| ... ... .|.. .. ...        . .. .   .|. 
WLDIVFVIDGSGSMGPNNFQQVKQFI-KFVEQLD------GDRVGIVQFSD----DVRVEFPLNYQDKDDVLKAIDNLQYKGKHDYFMGGGTNTG-ALQY

ALNF------GWGSAA----------KQLIFIA-DYPAHGLKYHDNLIDNYPKGCPNGLKLEDLMSQFSFKKIDFTVVEVSQ-STKKMFQIMTQYYG---
|..       |    |          | .|...  |.  |           |... . .|  . . .     .   |. |..  . .. || ..  |   
AMQNLFHERQG-RRGAGRPTKFWNVPKVIIVFTDGYSNDG-----------PHDPEDIRKAARELRRSG---VKIFVIGVGNDDM-ELRQIASCP-GEHH

---------QNLVIKNLLDNNE
         ..  .. ..|. .
FFDVYDYDDLPDIFQHIIDWLC
VWA 6257.AA VWA 153-180 32 0.000588 13.71 Pfam 1-30 (190) Show / Hide 
Range on Protein: 153-180
Range on HMM: 1-30/190
Sequence Identity: 32% (10 aa)

DLCFVVDISGSMSS---WMNHVVQYVGNTLN
|..||.|.||||..   .   | ... | ..
DIVFVIDGSGSMGEQNRFEK-VKDFIKNFVE
Kinase 6257.AA VWL 547-749 64 4.3e-186 559.5 In-house 1-206 (206) Show / Hide 
Range on Protein: 547-749
Range on HMM: 1-206/206
Sequence Identity: 64% (133 aa)

LGTKVRISNLVFSEGAMRYAYHAKDLYLNQKMVAKQYKKPEKQT-KISIEEMKRDIISQIVCKYIVKEFNSKLVEIEQSEALILQFIDCYIYETTHPYNA
..|||||||..|.||||||||||||.|||||||||||||..||. ||..|.|..||.||.||..||..||....|..|..|.||.|..|||||.||.||.
IKTKVRISNIPFAEGAMRYAYHAKDTYLNQKMVAKQYKKQHKQNPKINKEDMIKDIESQFVCQHIVNCFNDRVSEHVQTTANILNFVHCYIYEVTHHYNH

SPRYY-FEKYIDGTYEKFNNNAGYVSQTDNPYSSLAQALSHFSWQISKGYLAIVDLQGNQEGILTDPQVHCLDQ-EKFGDGNLGYEGILRFFSTHDCNDH
...|| .|.||.|.|.|.|||||...|||..|..|.||.|||.||.|.||..|||||||..|.|||||.||||| .|||.|||||||.||||.||.||..
NIKYYFVENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKY

CKKLQL
|.||||
CQKLQL
Kinase 6257.AA Alpha 547-744 48 3.7e-139 398.69 In-house 1-215 (215) Show / Hide 
Range on Protein: 547-744
Range on HMM: 1-215/215
Sequence Identity: 48% (105 aa)

LGTKVRISNLVFSEGAMRYAYHAKDLYLNQKMVAKQYKKPEKQTKISIEEMKRDIISQIVCKYIVKEFNSKLVEIEQSEAL-------ILQFIDCYIYET
..||...|...|.|||||||.||.|..|.||||.||.||..|..|........|...|.||...|.|||..|.|.|.....       |.||..|||||.
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYEL

THPYNASPRYY-FEKYIDGTYEKFNNNAGYVS-QTDN-PYSSLAQALSHFSWQISKGYLAIVDLQ-GNQEGILTDPQVHC---LDQ-EKFGDGNLGYEGI
.|..|....|| .|.|..|.|.|.|||||.|. .||.  .. |.||.||..||.|.|.|..|||| |..|..|||||.||   ||| .||||||.||||.
IHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGM

LRFFSTH--DCNDHC
.|||.||   ||..|
FRFFYTHHVQCNHYC
Kinase 6257.AA Alpha_kinase 558-744 31 4.4e-72 250.59 Pfam 1-225 (225) Show / Hide 
Range on Protein: 558-744
Range on HMM: 1-225/225
Sequence Identity: 31% (71 aa)

FSEGAMRYAYHAKDL-----YLNQKMVAKQYKKPEKQTKIS--I----EEMKRDIISQIVCKYIVKEFNSKLVEIEQSEALILQFIDCY-IYETTHPYN-
|..||||......|.     ..||..|||.||| . .....  |    .....|. .|..|......||.||   ....  ...|.||. .||  .. . 
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIK-NYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQ-EHNNPPPPIEFYDCCIVYELEDHNKP

-------------ASPRYYFEKYIDG-TYEKFNNNAGYV---SQTDNPYSSLAQALSHFSWQISKGYLAIVDLQGNQ-EG---ILTDPQVHCLDQEK---
             . . .| | ||.|  ..|.|||.|.|    ....|. ...||.|||....| |.. ..|.||    .   .|||||.|. |..    
DCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYEMD

F--GDGNLGYEGILRFFS-THDCNDHC
|  |.||||.|||..||. .| ||..|
FDEGMGNLGQEGIEKFFQNQHKCNHIC
Alpha_kinase 6257.AA Alpha_kinase 541-744 27 3e-53 184.16 SMART 1-255 (255) Show / Hide 
Range on Protein: 541-744
Range on HMM: 1-255/255
Sequence Identity: 27% (72 aa)

EIKTFYLGTKVRI-SNLVFSEGAMRYAYHAKDL-------YLNQKMVAKQYKKPEKQTKISIEEMKR--------DIISQIVCKYIVKEFNSKLVEIEQS
. | .   | |.|   . |..|||| .|...|.         ....|||..||. |.|. ..|            |.  | .||....|||. .. .. .
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTW-DEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNPC

EALILQFIDCYIYETT----------HPYNASPR------------YYFEKYIDGTYEKFNNNAGYVSQTDNPYS---------SLAQALSHFSWQISKG
.  . .||.||. . .          .||..|.|            .  | .. | ..|.||| |.|.  .....          ..|| ||.....|..
P-KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNH

YLAIVDLQGN---QEG--ILTDPQVHCLD--QEKFGDGNLGYEGILRFFSTHDCNDHC
 . ..|.||    .    ..||||.|  |   ..||.|||| ||| .||.|| ||..|
QMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase 6257.AA Alpha-Unclassified 652-744 28 2.1e-22 69.73 In-house 111-215 (215) Show / Hide 
Range on Protein: 652-744
Range on HMM: 111-215/215
Sequence Identity: 28% (30 aa)

EKYIDGTYEKFNNNAG----YVSQTDNPYSSLAQALSHFSWQISKGYLAIVDLQG----NQEGI--LTDPQVHCLDQEKFG--DGNLGYEGILRFFSTH-
| |. | . |..|| |     |   .  |  . .. .|...| . . . ..||||    |  ..  .||||.| ..| ...  ..| |. .| ..|. | 
EPYLIGEFVKYSNNTGKEINFVKWEYEAY-QYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQ-RYQGFKTNCGMRFIDYWFNNHH

-DCNDHC
  ||  |
VQCNHYC
Kinase 6257.AA ChaK 652-744 35 7.6e-11 39.15 In-house 123-219 (219) Show / Hide 
Range on Protein: 652-744
Range on HMM: 123-219/219
Sequence Identity: 35% (35 aa)

EKYIDGTYEKFNNNAGYVSQTDNPYSSLAQALSHFSWQISKGYLAIVDLQGNQEGILTDPQVHCLDQEK-----FGDGNLGYEGILRFFSTHDCNDHC
||.. | . |.||| |      |    .  | ||. .   .| | ..||||  |  |||| |   .. .     ||  ||| . |  |   | ||  |
EKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGE-NLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC