Gene 6258 (Tetrahymena)

6258

Species: Tetrahymena
Alias: TTHERM_00481260, 6258, 3719.m00086, 58.m00230, PreTt06258, 374
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: VWL

Sequence

Name Sequence Type Origin Length Description Download
6258.AA Protein None 865 None Fasta, JSON
6258.kin_dom Protein Kinase Domain None 203 None Fasta, JSON
6258.NA RNA None 2598 None Fasta, JSON

Protein domain

Protein domains of 6258.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ZnF_C3H1 6258.AA ZnF_C3H1 6-33 21 0.018053 9.15 SMART 1-31 (31) Show / Hide 
Range on Protein: 6-33
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

IQKHLPCHDY-HMG---QCLLPKAQCPYSHDG
  |. || ..  .|   .|   . .|...|. 
RYKTPPCKYFMRRGPPWYCPYGD-RCKFAHPP
ZnF_C3H1 6258.AA ZnF_C3H1 48-74 29 0.00121 18.52 SMART 1-31 (31) Show / Hide 
Range on Protein: 48-74
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

PHKLVDCPLF-LNN---CCPRGDNCSYRHKK
  | ..|. | ..     ||.||.| ..| .
RYKTPPCKYFMRRGPPWYCPYGDRCKFAHPP
Kinase 6258.AA VWL 550-752 64 5.1e-186 559.27 In-house 1-206 (206) Show / Hide 
Range on Protein: 550-752
Range on HMM: 1-206/206
Sequence Identity: 64% (132 aa)

LGTKVRLSNLVFSEGAMRYAYHAKDLYLNQKMVAKQYKKPEKQT-KISIEEMKRDIISQIVCKYIVKEFNSKLVEIEKSEALILQFIDCYIYETTHPYNS
..||||.||..|.||||||||||||.|||||||||||||..||. ||..|.|..||.||.||..||..||....|.....|.||.|..|||||.||.||.
IKTKVRISNIPFAEGAMRYAYHAKDTYLNQKMVAKQYKKQHKQNPKINKEDMIKDIESQFVCQHIVNCFNDRVSEHVQTTANILNFVHCYIYEVTHHYNH

SPRYY-FEKYIDGTYEKFNNNAGYVSQTDNLYSPLAQALSHFSWQISKGYLAIVDLQGNHEGILTDPQVHCLDQ-EKFGDGNLGYEGILRFFSTHECNDY
...|| .|.||.|.|.|.|||||...|||. |..|.||.|||.||.|.||..|||||||..|.|||||.||||| .|||.|||||||.||||.||.||.|
NIKYYFVENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKY

CRKLQL
|.||||
CQKLQL
Kinase 6258.AA Alpha 550-747 49 4.4e-140 401.38 In-house 1-215 (215) Show / Hide 
Range on Protein: 550-747
Range on HMM: 1-215/215
Sequence Identity: 49% (106 aa)

LGTKVRLSNLVFSEGAMRYAYHAKDLYLNQKMVAKQYKKPEKQTKISIEEMKRDIISQIVCKYIVKEFNSKLVEIEKSEAL-------ILQFIDCYIYET
..||...|...|.|||||||.||.|..|.||||.||.||..|..|........|...|.||...|.|||..|.|.|.....       |.||..|||||.
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYEL

THPYNSSPRYY-FEKYIDGTYEKFNNNAGYVS-QTDN-LYSPLAQALSHFSWQISKGYLAIVDLQ-GNHEGILTDPQVHC---LDQ-EKFGDGNLGYEGI
.|..|....|| .|.|..|.|.|.|||||.|. .||.  ...|.||.||..||.|.|.|..|||| |..|..|||||.||   ||| .||||||.||||.
IHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGM

LRFFSTH--ECNDYC
.|||.||  .||.||
FRFFYTHHVQCNHYC
Kinase 6258.AA Alpha_kinase 561-747 30 4.8e-70 243.69 Pfam 1-225 (225) Show / Hide 
Range on Protein: 561-747
Range on HMM: 1-225/225
Sequence Identity: 30% (70 aa)

FSEGAMRYAYHAKDL-----YLNQKMVAKQYKKPEKQTKIS--I----EEMKRDIISQIVCKYIVKEFNSKLVEIEKSEALILQFIDCY-IYETTHPYN-
|..||||......|.     ..||..|||.||| . .....  |    .....|. .|..|......||.||   ....  ...|.||. .||  .. . 
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIK-NYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQ-EHNNPPPPIEFYDCCIVYELEDHNKP

-------------SSPRYYFEKYIDG-TYEKFNNNAGYV---SQTDNLYSPLAQALSHFSWQISKGYLAIVDLQGNH-EG---ILTDPQVHCLDQEK---
               . .| | ||.|  ..|.|||.|.|    .... .  ..||.|||....| |.. ..|.||    .   .|||||.|. |..    
DCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYEMD

F--GDGNLGYEGILRFFS-THECNDYC
|  |.||||.|||..||. .|.||..|
FDEGMGNLGQEGIEKFFQNQHKCNHIC
Alpha_kinase 6258.AA Alpha_kinase 544-747 27 5.2e-53 183.35 SMART 1-255 (255) Show / Hide 
Range on Protein: 544-747
Range on HMM: 1-255/255
Sequence Identity: 27% (71 aa)

EIKTFYLGTKVRL-SNLVFSEGAMRYAYHAKDL-------YLNQKMVAKQYKKPEKQTKISIEEMKR--------DIISQIVCKYIVKEFNSKLVEIEKS
. | .   | |..   . |..|||| .|...|.         ....|||..||. |.|. ..|            |.  | .||....|||. .. .. .
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTW-DEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNPC

EALILQFIDCYIYETT----------HPYNSSPR------------YYFEKYIDGTYEKFNNNAGYVSQTDNLYS---------PLAQALSHFSWQISKG
.  . .||.||. . .          .||. |.|            .  | .. | ..|.||| |.|.  .. ..          ..|| ||.....|..
P-KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNH

YLAIVDLQGN---HEG--ILTDPQVHCLD--QEKFGDGNLGYEGILRFFSTHECNDYC
 . ..|.||    .    ..||||.|  |   ..||.|||| ||| .||.||.||..|
QMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase 6258.AA Alpha-Unclassified 655-747 27 7.6e-25 77.83 In-house 111-215 (215) Show / Hide 
Range on Protein: 655-747
Range on HMM: 111-215/215
Sequence Identity: 27% (29 aa)

EKYIDGTYEKFNNNAG---YVSQTDNLYSPLAQALSHFSWQISKGYLAIVDLQG----NHEGI--LTDPQVHCLDQEKFG--DGNLGYEGILRFFSTH--
| |. | . |..|| |    . ...    .. .. .|...| . . . ..||||    |  ..  .||||.| ..| ...  ..| |. .| ..|. |  
EPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQ-RYQGFKTNCGMRFIDYWFNNHHV

ECNDYC
.|| ||
QCNHYC
Kinase 6258.AA ChaK 655-747 35 1.1e-10 38.49 In-house 123-219 (219) Show / Hide 
Range on Protein: 655-747
Range on HMM: 123-219/219
Sequence Identity: 35% (35 aa)

EKYIDGTYEKFNNNAGYVSQTDNLYSPLAQALSHFSWQISKGYLAIVDLQGNHEGILTDPQVHCLDQEK-----FGDGNLGYEGILRFFSTHECNDYC
||.. | . |.||| |      |    .  | ||. .   .| | ..||||  |  |||| |   .. .     ||  ||| . |  |   | ||  |
EKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGE-NLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC