Gene 7218 (Tetrahymena)
7218
Sequence
Protein domains of 7218.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| VWA | 7218.AA | VWA | 146-331 | 12 | 4.3e-05 | 24.18 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 146-331
Range on HMM: 1-193/193
Sequence Identity: 12% (28 aa)
DCDLLFIMDCTGSM-SSYINMCRTQLFLIVEQVKKQFQKSTLKIGFVGFRDFGDNNQFEIYQF-TTEYDKLKSFINSVS--------ATGGNDTAEDVAG
. |. |..|..||| . .. .. . .||| . .| |.| | .. .. . .. .|.... |.... ..|| .|. .
WLDIVFVIDGSGSMGPNNFQQVKQFI-KFVEQLD------GDRVGIVQFSD----DVRVEFPLNYQDKDDVLKAIDNLQYKGKHDYFMGGGTNTG-ALQY
AFEK--ALEMNWTCEA----------KYAILITDAYPHGNKYCKSNSGDRYPSGDPNGRVPENQIIQMIKKG-ITFYGLDVSS-TSNQMYSIFNQVVLR-
|... . ... .| | |..|| |.. |.. . .... .. .. ....|.. .. | . .
AMQNLFHERQG-RRGAGRPTKFWNVPKVIIVFTDGYSNDG---------------PHDPEDIRKAARELRRSGVKIFVIGVGNDDM-ELRQIASCP-GEH
------------QTGKNMDRISM
. . . ...
HFFDVYDYDDLPDIFQHIIDWLC
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| Kinase | 7218.AA | VWL | 679-885 | 49 | 3.1e-128 | 384.22 | In-house | 1-206 (206) | Show / Hide |
Range on Protein: 679-885 Range on HMM: 1-206/206 Sequence Identity: 49% (104 aa) IKTTLTVNKEKFSEGAMREAFKASDQDFDIELVAKLHKEIELNR-KYNF--LKNELTALILAQFFLTEFNQRILFTMDESELPPQILRFVDCYIYEVKEE ||| . ... |.||||| |. | | .|||. | ... | | . . .. |. .|| |. . ...||.||.||||||... IKTKVRISNIPFAEGAMRYAYHAKDTYLNQKMVAKQYKKQHKQNPKINKEDMIKDIESQFVCQHIVNCFNDRV---SEHVQTTANILNFVHCYIYEVTHH GERNSYFYSVENFMKGDFQKYNNNAGYVIDGDMRKESQLSQAFSHFTWQYSQGNCMVVDLQGTEDGQLTDPQIHTLKKTKKFGQGDLGYEGILRFFRTHT ...|...|.|||...||.||||||||.....|| ...||||||||||||||||.||.|||||.|||.|||||||.|....|||||.|||||.||||.||. YNHNIKYYFVENYIEGDYQKYNNNAGWCNQTDM-EYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQ CTAFCKSLQL |...|..||| CNKYCQKLQL |
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| Kinase | 7218.AA | Alpha | 679-880 | 42 | 2.5e-105 | 300.68 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 679-880 Range on HMM: 1-215/215 Sequence Identity: 42% (91 aa) IKTTLTVNKEKFSEGAMREAFKASDQDFDIELVAKLHKEIELNRKYNFLKNE--LTALILAQFFLTEFNQRILFTMDESEL----PPQILRFVDCYIYEV ..| . .. |.||||| |..| | ..|.|.|| .... ||. . . .... ..||||| .. | |..||.|||||. QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYEL KEEGERNSYFYSVENFMKGDFQKYNNNAGYVI-DGDMRKESQLSQAFSHFTWQYSQGNCMVVDLQ-GTEDGQLTDPQIHT---LKKTKKFGQGDLGYEGI ......|...|||||.|.|..||||||||.|. ..|.....||.|||||.|||||.|..|||||| |.....|||||||. |....|||.|..||||. IHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGM LRFFRTH--TCTAFC .|||.|| .|...| FRFFYTHHVQCNHYC |
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| Kinase | 7218.AA | Alpha_kinase | 690-880 | 31 | 2.6e-60 | 209.97 | Pfam | 1-225 (225) | Show / Hide |
Range on Protein: 690-880
Range on HMM: 1-225/225
Sequence Identity: 31% (72 aa)
FSEGAMREAFKASDQ-----DFDIELVAKLHKEIELNRKY--------NFLKNELTALILAQFFLTEFNQRILFTMDESELPPQILRFVDCY-IYEVKEE
|..||||..|.. |. . .|||..|.|. | . . ... . ...| . .|||.. |.. ||....|.||. .||.. .
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIK-NYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQ----EHNNPPPPIEFYDCCIVYELEDH
GERNSY-------------FYSVENFMKG-DFQKYNNNAGYV--IDGDMRKESQLSQAFSHFTWQYSQGNCMVVDLQGTE-DG---QLTDPQIHTLKKTK
. .| ....|....| .|.|||||.|.| . . . |..|||||||...|.|. ||.|.|| .. |||||||| . .
NKPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD-GN
K---F--GQGDLGYEGILRFFR-THTCTAFC
| |.|.||.|||..|| .| |. .|
YEMDFDEGMGNLGQEGIEKFFQNQHKCNHIC
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| Alpha_kinase | 7218.AA | Alpha_kinase | 671-880 | 24 | 5.2e-50 | 173.37 | SMART | 1-255 (255) | Show / Hide |
Range on Protein: 671-880 Range on HMM: 1-255/255 Sequence Identity: 24% (65 aa) EPQLVQNQIKTTLTVNKEKFSEGAMREAFKASDQ-------DFDIELVAKLHKEIELNRK--YNFLK-------NELTALILAQFFLTEFNQRILFTMDE . . .. . . . |..||||..... | . |.|||..| . ... .. . . . ... . .|||| .. . . DNKWTCQETCVKI-KEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQ-EAQ-HNP SELPPQILRFVDCYIYEVK-----EEGERNSYF----------------YSVENFMKGDFQKYNNNAGYVIDGDMRKE--------SQLSQAFSHFTWQY .. . |..||. . . |. .|. ...| ||.|.|.||||| |.|.| ... . .. |||||.|... CP---KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEW SQGNCMVVDLQGT---EDG--QLTDPQIHTLKK-TKKFGQGDLGYEGILRFFRTHTCTAFC | .. .|.|.|| .. .||||||| .. ...||.| || ||| .|| || | ..| SNHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC |
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| Kinase | 7218.AA | Alpha-Unclassified | 784-880 | 30 | 3.3e-25 | 79.03 | In-house | 109-215 (215) | Show / Hide |
Range on Protein: 784-880 Range on HMM: 109-215/215 Sequence Identity: 30% (34 aa) SVENFMKGDFQKYNNNAG----YVIDGDMRKESQLSQAFSHFTWQYSQGNCMVVDLQG--TEDG----QLTDPQIHTLKKTKKFG--QGDLGYEGILRFF ||| . | | ||.|| | | . . |. ....|.|.| . . |.|||| .| . ..|||||||.. .... .. |. .| ..| SVEPYLIGEFVKYSNNTGKEINFVKWEY--EAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR--QRYQGFKTNCGMRFIDYWF RTH--TCTAFC | | ..| NNHHVQCNHYC |
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| Kinase | 7218.AA | ChaK | 782-880 | 36 | 1.8e-13 | 49.6 | In-house | 119-219 (219) | Show / Hide |
Range on Protein: 782-880 Range on HMM: 119-219/219 Sequence Identity: 36% (38 aa) FYSVENFMKGDFQKYNNNAGYVIDGDMRKESQLSQAFSHFTWQYSQGNCMVVDLQGTEDGQLTDPQI--HTLKKTKK--FGQGDLGYEGILRFFRTHTCT ....|..| |.| ||||| | | | . ||||.|. | | .|.|||| . |||| . |. . || || . | | | | WFTIEKCMTGEFRKYNNNNGDEIIPTNTLE-EIMLAFSHWTYEYTRGELLVLDLQGVGE-NLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCN AFC . | SCC |
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