29569

Species: Tetrahymena
Alias: PreTt29569, TTHERM_01008650, 194.m00025, 29569, 830
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
29569.AA Protein None 2086 None Fasta, JSON
29569.kin_dom Protein Kinase Domain None 212 None Fasta, JSON
29569.NA RNA None 6261 None Fasta, JSON

Protein domain

Protein domains of 29569.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29569.AA ATR 1770-2027 53 6.4e-148 497.72 In-house 1-267 (267) Show / Hide
Range on Protein: 1770-2027
Range on HMM: 1-267/267
Sequence Identity: 53% (142 aa)

VYMEKFDDVVRIMSSKQKPKLLTVQCSDGTKKKFLIKSQTQ-SENVYEQRTSELISFLNLILYKEQLGFYEMPSYTILRLNSQSCIVEWVDDTLTLKTIL
 |.  |||.| |..| |||| .... |||     . | . .   .  |.|..|||.|.|...|.|...||.|..|....||.|.||.|||..|.||..||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

DQLWQEKKQKSQFYQLKLDSDKLSREEWNKQKSL--------PSVFQDFFNQRFLDSQQWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEI
|.||.||||..|||||....||.|||||.|||..        |..|.|.||.||.|.||||...|||.|.||.||..||.|||||||||||||.|||||.
DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC

VHIDYALIFGSGKQLNVPETIPFRLTKNMEFALGSFKSYGLFRKAMIDICMCFSKHLDDIIGFWDCF
||.||..||.||.|..|||..|||||.||.|..|..|.|||||.|...|.||...|.|||...||||
VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase 29569.AA PIKK 1771-2027 30 1.2e-107 363.92 In-house 1-290 (290) Show / Hide
Range on Protein: 1771-2027
Range on HMM: 1-290/290
Sequence Identity: 30% (90 aa)

YMEKFDDVVRIMSSKQKPKLLTVQCSDGTKKKFLIKSQTQSENVYEQRTSELISFLNLILYKE---QLGFYEMPSYTILRLNSQSCIVEWVDDTLTLKTI
.   .|..| .| .||||| ..   .||    .| |  . .    .||...|....| .|.|.   |  ......|.. .........||||...|||.|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQ--DQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI

LDQLWQEK-------------------------------KQKSQFYQLKLDSDKLSREEWNKQKSLPSVFQDFFNQRFLDSQQWYTAKENYLRTYASWCI
..|..|.|                               .|....||.. ...|........|...|..|...|...|.|...|....|||.|.||..|.
YKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

LGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSGKQ-LNVPETIPFRLTKNMEFALGSFKSYGLFRKAMIDICMCFSKHLDDIIGFWDCF
 || .||||||..||.|....|||||||....|.|..| |.|||..|||||.||..|.|... .|.||.......||...| .........|
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase 29569.AA PI3_PI4_kinase 1816-2027 19 1.3e-37 136.08 Pfam 17-290 (300) Show / Hide
Range on Protein: 1816-2027
Range on HMM: 17-290/300
Sequence Identity: 19% (54 aa)

EQRTSELI-----------------------SFLNLILYKEQLGFY---EMPSYTILRLNSQSCIVEWVDDTLTLKTILDQLWQEKK------QKSQFYQ
..|. ..|                       .. | .. |. . .     |  | .. ..... ..|||....|...|..  . ..|      .. ....
DMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKMWMK

LKLDSD------KLSREEWNKQKSLPSVFQDFFNQRFLDS-QQWYTAKENYLRTYASWCILGYLIGLGDRHTDNILI--KKINGEIVHIDYALIFG--SG
...| .      |. ..| .. |  . .. ..|   . |    | .|..|. | .| .|...|..|.|||| |||..  .| .|...|||. ..|.   .
MWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKM

KQLNVPETIPFRLTK------NMEFAL------GSFKSYGLFRKAMIDICMCFSKHLDDIIGFW-------DCF
| ...||..|||.|.      .|  |.      . .. ||.||. . ..   ...|.. .. ..       .|.
KHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM

Kinase 29569.AA ATM 1905-2004 44 3.5e-25 77.07 In-house 118-217 (304) Show / Hide
Range on Protein: 1905-2004
Range on HMM: 118-217/304
Sequence Identity: 44% (44 aa)

VFQDFFNQRFLDSQQWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSGKQLNVPETIPFRLTKNMEFALGSFKSYGLFRK
||  |   .|||   |.  .  | |  |   | ||..||||||  ||||     |.||||    |  || |  |||.|||||. .   .|     | ||.
VFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRR





Kinase 29569.AA SMG1 1920-1979 53 1.7e-20 64.44 In-house 183-242 (242) Show / Hide
Range on Protein: 1920-1979
Range on HMM: 183-242/242
Sequence Identity: 53% (32 aa)

WYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSGKQLNVPE
|.     | |  |   . ||.||||||| ||.||    ||.|||||   |  || |||||
WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE

Kinase 29569.AA PI3Kc 1802-2085 20 1.2e-19 72.52 SMART 1-336 (336) Show / Hide
Range on Protein: 1802-2085
Range on HMM: 1-336/336
Sequence Identity: 20% (70 aa)

KFLIKSQTQSENVYEQRTSELISFLNLILYKE----QLGFYEMPSYTILRLNSQSCIVEWVDDTLTLKTILDQLWQEKK---------------------
 .. |   .     ..|. ....  | |. |.    .. .. |  | .. ..... ..||| .. || .|.. .  .||                     
AVIFKCGDDLRQ--DMRMMQMFRLMNKIWQKDKECRRRDLH-MRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKN

-----------QKSQFYQLKLDSDKLSREEWNKQKSLPSVFQDFFNQRFLDSQ-QWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHID
           ..  .|| .  . .|  .| .  .  | |..|.| ..| |.   |..|..|. | .| .|. .|. |.||||.|||.... .|...|||
MYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID

YALIFGSGKQLNVP-----ETIPFRLTKNMEFALG----SFKSYGLFRKAMIDICMCFSKHLDDIIGFWDCF-TNEL-EGCKKTNFNQLCNQIKNRIKMT
.  |||.|. . ..     |. |||||..|  . |      . .|.||. .  . . . || . |.     .   ..   ...      ......|.   
FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLD

NFKSTEEGIDSLIQ-----ISKDDYC-----LRDMFKGWWPH
. .| || .    |     . ... .     . .||  |  .
H-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase 29569.AA DNAPK 1924-2030 36 2e-18 63.52 In-house 187-294 (301) Show / Hide
Range on Protein: 1924-2030
Range on HMM: 187-294/301
Sequence Identity: 36% (39 aa)

KENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFG-SGKQLNVPETIPFRLTKNMEFALGSFKSYGLFRKAMIDICMCFSKHLDDIIG
.| . |.||  || ..  | |||| .| ..   ||.|. ||.   ||  .  | |||  |||||      .   |  |...  ||   | | |     . 
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTN

FWDCFTNE
| | | |.
FCDVFIND

Kinase 29569.AA FRAP 1920-1987 43 2.7e-14 49.02 In-house 133-201 (251) Show / Hide
Range on Protein: 1920-1987
Range on HMM: 133-201/251
Sequence Identity: 43% (30 aa)

WYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSG-KQLNVPETIPFRLTK
|.  . || |  |   . ||..||||||  ||.. .  | |||||.   |    .    || ||||||.
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR

Kinase 29569.AA DNAPK 1770-1806 29 0.087578 2.05 In-house 2-38 (301) Show / Hide
Range on Protein: 1770-1806
Range on HMM: 2-38/301
Sequence Identity: 29% (11 aa)

VYMEKFDDVVRIMSSKQKPKLLTVQCSDGTKKKFLIK
| .  ||. | .| |  .|| . .   |     |..|
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYK

Kinase 29569.AA DNAPK 1855-1878 48 0.147838 1.21 In-house 88-112 (301) Show / Hide
Range on Protein: 1855-1878
Range on HMM: 88-112/301
Sequence Identity: 48% (12 aa)

VEWVDDTLTLKTILDQLWQEKK-QK
.|||| | .|| || .  |.|  .|
IEWVDNTVVLKDILNNEMQQKMGKK

Kinase 29569.AA SMG1 1779-1806 39 0.153529 0.69 In-house 1-28 (242) Show / Hide
Range on Protein: 1779-1806
Range on HMM: 1-28/242
Sequence Identity: 39% (11 aa)

VRIMSSKQKPKLLTVQCSDGTKKKFLIK
. |.  | ||| |    |||    .| |
ITILPTKTKPKKLLFLGSDGKSYPYLFK