Gene 20619 (Tetrahymena)

20619

Species: Tetrahymena
Alias: 12.m00293, 20619, 3700.m00016, 531, PreTt20619, TTHERM_00147610
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
20619.AA Protein None 2452 None Fasta, JSON
20619.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
20619.NA RNA None 7359 None Fasta, JSON

Protein domain

Protein domains of 20619.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 20619.AA HEAT 78-108 22 0.243733 8.5 Pfam 1-31 (31) Show / Hide 
Range on Protein: 78-108
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

FRSKIWSHIKSKNILVREAALSFFDQYMQHI
. . . .......  |||||.. . | ..|.
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 20619.AA HEAT 431-461 22 6.253214 3.62 Pfam 1-31 (31) Show / Hide 
Range on Protein: 431-461
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

LKDNVLDYLDNKNKIIRKAAAKAGCLLCVKK
. . .|  |. ..  .|.||... . || . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 20619.AA HEAT 475-501 22 45.589923 0.63 Pfam 1-26 (31) Show / Hide 
Range on Protein: 475-501
Range on HMM: 1-26/31
Sequence Identity: 22% (6 aa)

ILEKFMSVAVSDAEDEIRQTMLKSLNE
||. ..  . .| ..|.|.. ...| .
ILPHLL-KCLNDPDWEVREAACWCLGQ
HEAT 20619.AA HEAT 512-542 32 0.185572 8.91 Pfam 1-31 (31) Show / Hide 
Range on Protein: 512-542
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

YLKKLFFCVNDSNLEVQQLALTTLCRLSKYN
 |  |. | ||.. ||.. |. .|..|... 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 20619.AA HEAT 642-673 25 0.000443 17.99 Pfam 1-31 (31) Show / Hide 
Range on Protein: 642-673
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

IFPIFLSAMQDKSSTFKRESAVKSLVEILKNT
|.|..|....|. .   ||.|...|...... 
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
DUF3385 20619.AA DUF3385 676-724 32 6.4e-13 47.24 Pfam 1-52 (181) Show / Hide 
Range on Protein: 676-724
Range on HMM: 1-52/181
Sequence Identity: 32% (17 aa)

VVLPYYKYPNFLEIVFSLMKNE-VNTEMRYQCMRLIGCVGAIDHFFYK--KV
|. |||.||. |...|.. |.|  | ..|. .....|  ||.| ...|   .
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEI
DUF3385 20619.AA DUF3385 882-949 22 3e-06 23.68 Pfam 92-171 (181) Show / Hide 
Range on Protein: 882-949
Range on HMM: 92-171/181
Sequence Identity: 22% (18 aa)

DYYTRTTIKAVLK-ILYDQSLNEHHE-LAIKTL----NCIV--NLLKSRT-KNFLDLLIPVLCKVLE--QD-NIREDILN
.||  . |..... || |.|| .||   .. .       |     . ..    ||.  ||.. .|.   .. ..|| ...
EYYPTVVINSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQ
FAT 20619.AA FAT 1459-1620 23 4.6e-23 77.46 Pfam 1-190 (408) Show / Hide 
Range on Protein: 1459-1620
Range on HMM: 1-190/408
Sequence Identity: 23% (50 aa)

MDVAAKAAMNLGKWEE--LEQFAENLS-----------DENTN-----DKSFWLAAVCL--KSKNYE--KSKVYIHESIQKLDNKVSG-LVFESYNRAFE
 . || || .||.|.|  .... ...            ||..      |.||  |  ||  . ....    . || . .| || . .  |. |||||.  
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

SILRLQQLFEMQEILEMK-IY-----------QEKIGQMMQREGMDRHKLQIEQELKRQNLKDIWADRLRGN-PKELDTWQQILSVRQIYLS--------
 . |.|.| |..|| ..|              .||. .|                      .. | .||.|   . .. ||.||..||...|        
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHM----------------------RQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMN

------KKEDLQ
      ..||..
SFCYRGPHEDMW
FAT 20619.AA FAT 1670-1783 21 1.2e-16 56.01 Pfam 287-408 (408) Show / Hide 
Range on Protein: 1670-1783
Range on HMM: 287-408/408
Sequence Identity: 21% (28 aa)

KNEKKIEKKQVA-KMYLKMGIWMRET-----GEELDKQKIKKIEEYFEKSKEFKSDYYK-TWHHFALLNFDVLDMMD-----------EIDTREKLDYIL
.| .. ..|. | . |.| | |...      .. .. .... | ... .  .|  . ||  ||. || || |....            .    . .... 
TNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTH----MIIQHVV

NALEGFMKSISIGTSSEHKSPYLFQDCLRLLQ
.|...| .||. . .        .|| ||||.
PAVKCFFHSIALSQG-----SNSRQDTLRLLW
HEAT 20619.AA HEAT 1813-1843 16 2.43271 5.04 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1813-1843
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

VVPQIIARISDSKSGVQKILHELLIHISNHH
..| ..  ..|. . |..   . | ... |.
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Rapamycin_bind 20619.AA Rapamycin_bind 1890-1906 64 8.9e-07 23.02 Pfam 1-17 (100) Show / Hide 
Range on Protein: 1890-1906
Range on HMM: 1-17/100
Sequence Identity: 64% (11 aa)

ELNRAAILLKEQWHEGI
|| | |||. |.||||.
ELIRVAILWHEMWHEGL
Rapamycin_bind 20619.AA Rapamycin_bind 1932-1993 40 7.2e-22 70.73 Pfam 39-100 (100) Show / Hide 
Range on Protein: 1932-1993
Range on HMM: 39-100/100
Sequence Identity: 40% (25 aa)

ELHETMTLQPESLSEISFHQNFGGIINEAEAWIQRFSITENPICIYQAFDIYSQIYQKLKPQ
.||| ..  ||...||||.| ||   .|| .| |..  |..  |  ||.||| |.......|
PLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase 20619.AA FRAP 2060-2319 81 9.3e-213 713.1 In-house 1-251 (251) Show / Hide 
Range on Protein: 2060-2319
Range on HMM: 1-251/251
Sequence Identity: 81% (212 aa)

EYFFLLKGHEDIRQDERVMQLFGLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGWVQNCDTLQILIRDYRKAFNIKYGAELTLMNDFNIYNFYDSS
||.||||||||||||||||||||||||||.||.|||||.|||.|||||||||.|||.|||..||||.||||||||...|.|..|         ||..|..
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE---------YNIMDRM

FNDYNKLPLLNKVEIFRYIMQNTLGEDLKKLLWLKSPNSEIWLERRTNYTRSLATMSIAGYILGLGDRHLSNIMLQRQTGKIVHIDFGDCFEVAMRRESL
.|||..|||.||||||||||.||.||||||||||||||||||.||||||||||||||.|||||||||||.|||||||.||||||||||||||||||||..
CNDYDHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKF

PEKVPFRLTRMLVNAMEACGIEGNYRNTCELVVKVIRENKESLIAVLEAFVYDPLFYWIV
|||.||||||||||||||||||||||||||||.|||||.|||..||||||||||||||..
PEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 20619.AA PIKK 2031-2309 47 8.20000000001e-164 550.51 In-house 1-290 (290) Show / Hide 
Range on Protein: 2031-2309
Range on HMM: 1-290/290
Sequence Identity: 47% (137 aa)

KITCFQPKLEVLPSKTHPRKICIYGSDSKEYFFLLKGHEDIRQDERVMQLFGLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGWVQNCDTLQILIR
 |  . . ..|...|. |.|| | |.| |||..|.|||||.|||.||||||.|.|..||...|.||. |.|..||.||.|...||..||.||.||. ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DYRKAFNIKYGAELTLMNDF-----------NIYNFYDSSFNDYNKLPLLNKVEIFRYIMQNTLGEDLKKLLWLKSPNSEIWLERRTNYTRSLATMSIAG
.......|..  |.. ....           ........ ...|...|| .|||.||..||||.....||..|.|.|..|||.|||.|||||.|.|...|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHLSNIMLQRQTGKIVHIDFGDCFEVAMRRESLPEKVPFRLTRMLVNAMEACGIEGNYRNTCELVVKVIRENKESLIAVLEAF
|||||||||..|||...|||.|||||||.|||.||.|.. ||||||||||..||||...|.||..|..|| |....|...|.|..|.|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 20619.AA PI3_PI4_kinase 2060-2319 27 2.3e-85 294.7 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2060-2319
Range on HMM: 1-300/300
Sequence Identity: 27% (88 aa)

EYFFLLKGHEDIR--QDERVMQLF-----------------------GLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGWVQNCDTLQILIRDYR-
.| |..||..| |  ||.|.||..                       .|.|...... .. .. .... |..||.. . |...|| ||.|.. ..| |. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

----KAFNI-------KYGAELTLMNDFNIYNFYDSSFNDYNKLPLLNKVEIFRYIMQNTLGEDLKKLLWLKSPNS-EIWLERRTNYTRSLATMSIAGYI
    |.||.       .... ..||                    ...|||.|.. . .| ...| ...| ..|.  |.|.|.|.|..||.| |....||
KCKHKHFNKEHKMWMKMWPDWWHLM--------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYI

LGLGDRHLSNIML--QRQTGKIVHIDFGDCFE-VAMRRESLPEKVPFRLTR------MLVNAM------EACGIEGNYRNTCELVVKVIRENKESLIAVL
||.||||..|||.   . ||...|||||.||. ..| ..  ||.||||.|.      ..|.||      .  | .| .| .|. .  ..|.........|
LGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLL

-------EAFVYDPLFYWIV
       |..|.|.|. |  
KKAVMRGECMVHDGLPMWRS
Kinase 20619.AA PI3Kc 2062-2368 26 1e-81 278.74 SMART 1-336 (336) Show / Hide 
Range on Protein: 2062-2368
Range on HMM: 1-336/336
Sequence Identity: 26% (90 aa)

FFLLKGHEDIRQDERVMQLFGLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGWVQNCDTLQILIRDYRKAFNIKYGAELTLMND------------
 ...|...| |||.|.||.|.|.|...|...|...  | ...|..||.. |.|...|| ||.||  . . |.|  ..    .   | |            
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

FNIYNFYDSSFNDYNKLPLLNKVEIFRYIMQNTLGEDLKKLLWLKSPNS-EIWLERRTNYTRSLATMSIAGYILGLGDRHLSNIMLQRQTGKIVHIDFGD
  .  . ..   .|  . ...... |.    .. ...|.. .| ..|.. |.| |.|.|.|||.| .....||||.||||..|||| ..||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVAMRRESLP----EKVPFRLTRMLVNAME----ACGIEGNYRNTCELVVKVIRENKESLIAVLEAFVYDPL-FYWIVF---------TMSGDLDSMK
.|. .....  .    |.||||||...|..|.      | .|..| .|. . ...|..........|..||||. . |  .         ..  |    .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDH---L

SPQEAKNGISR-RNSQIISNNSGNINSFDYKEFETEQNE
| .|| . . .    ..|... .  ..  | .|.. .. 
SDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 20619.AA ATM 2200-2317 50 1.9e-43 136.42 In-house 132-248 (304) Show / Hide 
Range on Protein: 2200-2317
Range on HMM: 132-248/304
Sequence Identity: 50% (60 aa)

IWLERRTNYTRSLATMSIAGYILGLGDRHLSNIMLQRQTGKIVHIDFGDCFEVAMRRESLPEKVPFRLTRMLVNAMEACGIEGNYRNTCELVVKVIRENK
|| |.|  |||| || || ||||||||||  ||..  |   .|||| |  ||   .    || ||||||| .|  |   |.|| .|  ||  . |.|  .
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

ESLIAVLEAFVYDPLFYW
| |. . |  .||||| |
ETLLTIVEVLLYDPLFDW
Kinase 20619.AA ATR 2196-2309 36 5.9e-35 116.25 In-house 155-267 (267) Show / Hide 
Range on Protein: 2196-2309
Range on HMM: 155-267/267
Sequence Identity: 36% (42 aa)

PNSEIWLERRTNYTRSLATMSIAGYILGLGDRHLSNIMLQRQTGKIVHIDFGDCFEVAMRRESLPEKVPFRLTRMLVNAMEACGIEGNYRNTCELVVKVI
| .. |   | || || | ... |||.||||||  ||.... .| .||.|.   |    . |  || ||||||. .|..| . . .| .|  || .....
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCM

RENKESLIAVLEAF
|.... ...|...|
RDHRDDIMSVWDCF
Kinase 20619.AA DNAPK 2199-2319 35 2.9e-22 77.69 In-house 181-301 (301) Show / Hide 
Range on Protein: 2199-2319
Range on HMM: 181-301/301
Sequence Identity: 35% (43 aa)

EIWLERRTNYTRSLATMSIAGYILGLGDRHLSNIMLQRQTGKIVHIDFGDCFEVAMRRESLPEKVPFRLTRMLVNAMEACGIEGNYRNTCELVVKVIREN
| .|  |  . |. |   | ..||| ||||| | |    .| |. ||||  |  |      ||  ||||||  .| |   .| | ..       . .|  
ETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKD

KESLIAVLEAFVYDPLFYWIV
.  |.   . |. ||.| |  
RNILTNFCDVFINDPSFDWKN
Kinase 20619.AA DNAPK 2030-2125 36 2.5e-20 70.54 In-house 2-97 (301) Show / Hide 
Range on Protein: 2030-2125
Range on HMM: 2-97/301
Sequence Identity: 36% (35 aa)

IKITCFQPKLEVLPSKTHPRKICIYGSDSKEYFFLLKGHEDIRQDERVMQLFGLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGWVQNCDTL
..|  |  .  |. |   |..| | | | .|  |. || || ||| |. |||   |  .      | . |    |.|||.    ||. || |  .|
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase 20619.AA ATR 2031-2126 33 2.2e-19 62.3 In-house 2-97 (267) Show / Hide 
Range on Protein: 2031-2126
Range on HMM: 2-97/267
Sequence Identity: 33% (32 aa)

KITCFQPKLEVLPSKTHPRKICIYGSDSKEYFFLLKGHEDIRQDERVMQLFGLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGWVQNCDTLQ
 |. |.  .|.| |  .|.|| . ||| | |  . | ..|.|.| | |.   |||....   | ... . .  |..|||  . ... ||.|  ||.
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR
Kinase 20619.AA ATM 2064-2118 49 1.2e-17 52.63 In-house 3-57 (304) Show / Hide 
Range on Protein: 2064-2118
Range on HMM: 3-57/304
Sequence Identity: 49% (27 aa)

LLKGHEDIRQDERVMQLFGLINRLLQNNTETQKKGLSITRYSIIPLSMKTGLLGW
| || .|.|||  . | | . | ||| |||| |. | |  | ..||| . | | |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
Kinase 20619.AA SMG1 2039-2119 39 1.6e-17 54.5 In-house 1-81 (242) Show / Hide 
Range on Protein: 2039-2119
Range on HMM: 1-81/242
Sequence Identity: 39% (33 aa)

LEVLPSKTHPRKICIYGSDSKEYFFLLKGHEDIRQDERVMQLFGLINRLLQ--NNTETQKKGLSITRYSIIPLSMKTGLLGWV
. .|| || |.|.   ||| | | .| || ||.  |||.||   ..| .    |  || .       ||. ||  . ||. ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR--FHARHYSVTPLGTRSGLIQWV
Kinase 20619.AA SMG1 2178-2251 44 6.7e-16 49.02 In-house 160-233 (242) Show / Hide 
Range on Protein: 2178-2251
Range on HMM: 160-233/242
Sequence Identity: 44% (33 aa)

IMQNTLGEDLKKLLWLKSPNSEIWLERRTNYTRSLATMSIAGYILGLGDRHLSNIMLQRQTGKIVHIDFGDCFE
.|  |    | | ||      . |      | || | ||. |||.||||||| |...   || .||||.  |||
LMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
FATC 20619.AA FATC 2420-2452 57 5.2e-16 54.32 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2420-2452
Range on HMM: 1-33/33
Sequence Identity: 57% (19 aa)

EQLSYVDQVNKLILQATSDENICQAYIGWGPFW
| ||  .||..|| .||. ||.||.|||| |.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW